The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith ...The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are derived.The results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.展开更多
Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein k...Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit （DNA-PKcs） to mediate the cellular response to DNA double strand break （DSB） caused by DNA-damaging metabolites. In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-（morpholin-4-yl）-benzo[h]chomen-4-one （NU7026）, as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. Moreover, hydroquinone increased the phos- phorylation of Akt to activate Akt, whereas co-treatment with NU7026 prevented the activation of Akt by hydroquinone. Lastly, hydroquinone and NU7026 exhibited synergistic effects on promoting apop- tosis by increasing the protein levels of pro-apoptotic proteins Bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein Bcl-2. Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage.展开更多
A two-dimensional numerical wave flume is developed to study the focused waves group propagation and the consequent breaking processes. The numerical model is based on the Reynolds-Averaged Navier-Stokes （PANS） equa...A two-dimensional numerical wave flume is developed to study the focused waves group propagation and the consequent breaking processes. The numerical model is based on the Reynolds-Averaged Navier-Stokes （PANS） equations, with the standard k - c turbulence model to simulate the turbulence effects. To track the complicated and broken free-surface, the Volume Of Fluid （VOF） method is employed. The numerical model combines the ＂Partial Cell Treatment （PCT）＂ method with the ＂Locally Relative Stationary （LRS）＂ concept to treat the moving wave paddle so that various waves can be generated directly in a fixed Cartesian grid system. The theoretical results of the linear and nonlinear waves are used to validate the numerical wave flume firstly, and then a plunging breaking wave created by a focused waves group is simulated. The numerical results are compared to the experimental data and other simulation results, with very good agreements. The turbulence intensity, the flow field and the energy dissipation in the breaking processes are analyzed based on the numerical results. It is shown that the present numerical model is efficient and accurate for studying the waves group generation, the waves packet propagation, and the wave breaking processes.展开更多
对低产停产的老井再次开发,压裂改造是一项行之有效的增产措施。室内评价了低分子聚合物压裂液体系的性能,结果表明,该压裂液具有较好的配伍性,在65℃下连续剪切1.5 h后粘度仍有102.5 m Pa·s,携砂性能良好,易破胶,低残渣。现场应...对低产停产的老井再次开发,压裂改造是一项行之有效的增产措施。室内评价了低分子聚合物压裂液体系的性能,结果表明,该压裂液具有较好的配伍性,在65℃下连续剪切1.5 h后粘度仍有102.5 m Pa·s,携砂性能良好,易破胶,低残渣。现场应用效果显示,已停产多年的七深8井恢复生产,累计产油1 200多吨。展开更多
Stokes drift is the main source of vertical vorticity in the ocean mixed layer. In the ways of Coriolis - Stokes forcing and Langmuir circulations, Stokes drift can substantially affect the whole mixed layer. A modifi...Stokes drift is the main source of vertical vorticity in the ocean mixed layer. In the ways of Coriolis - Stokes forcing and Langmuir circulations, Stokes drift can substantially affect the whole mixed layer. A modified Mellor-Yamada 2. 5 level turbulence closure model is used to parameterize its effect on upper ocean mixing conventionally. Results show that comparing surface heating with wave breaking, Stokes drift plays the most important role in the entire ocean mixed layer, especially in the subsurface layer. As expected, Stokes drift elevates both the dissipation rate and the turbulence energy in the upper ocean mixing. Also, ilffluence of the surface heating, wave breaking and wind speed on Stokes drift is investigated respectively. Research shows that it is significant and important to assessing the Stokes drift into ocean mixed layer studying. The laboratory observations are supporting numerical experiments quantitatively.展开更多
文摘The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are derived.The results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.
文摘Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit （DNA-PKcs） to mediate the cellular response to DNA double strand break （DSB） caused by DNA-damaging metabolites. In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-（morpholin-4-yl）-benzo[h]chomen-4-one （NU7026）, as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. Moreover, hydroquinone increased the phos- phorylation of Akt to activate Akt, whereas co-treatment with NU7026 prevented the activation of Akt by hydroquinone. Lastly, hydroquinone and NU7026 exhibited synergistic effects on promoting apop- tosis by increasing the protein levels of pro-apoptotic proteins Bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein Bcl-2. Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage.
基金supported by the National Natural Science Foundation of China(Grant No.51061130547)
文摘A two-dimensional numerical wave flume is developed to study the focused waves group propagation and the consequent breaking processes. The numerical model is based on the Reynolds-Averaged Navier-Stokes （PANS） equations, with the standard k - c turbulence model to simulate the turbulence effects. To track the complicated and broken free-surface, the Volume Of Fluid （VOF） method is employed. The numerical model combines the ＂Partial Cell Treatment （PCT）＂ method with the ＂Locally Relative Stationary （LRS）＂ concept to treat the moving wave paddle so that various waves can be generated directly in a fixed Cartesian grid system. The theoretical results of the linear and nonlinear waves are used to validate the numerical wave flume firstly, and then a plunging breaking wave created by a focused waves group is simulated. The numerical results are compared to the experimental data and other simulation results, with very good agreements. The turbulence intensity, the flow field and the energy dissipation in the breaking processes are analyzed based on the numerical results. It is shown that the present numerical model is efficient and accurate for studying the waves group generation, the waves packet propagation, and the wave breaking processes.
文摘对低产停产的老井再次开发,压裂改造是一项行之有效的增产措施。室内评价了低分子聚合物压裂液体系的性能,结果表明,该压裂液具有较好的配伍性,在65℃下连续剪切1.5 h后粘度仍有102.5 m Pa·s,携砂性能良好,易破胶,低残渣。现场应用效果显示,已停产多年的七深8井恢复生产,累计产油1 200多吨。
基金The National Science Fund for Distinguished Young Scholars of China under contract No40425015the Knowledge Innovation Programsof the Chinese Academy of Sciences under contract No kzcx2 -yw-201
文摘Stokes drift is the main source of vertical vorticity in the ocean mixed layer. In the ways of Coriolis - Stokes forcing and Langmuir circulations, Stokes drift can substantially affect the whole mixed layer. A modified Mellor-Yamada 2. 5 level turbulence closure model is used to parameterize its effect on upper ocean mixing conventionally. Results show that comparing surface heating with wave breaking, Stokes drift plays the most important role in the entire ocean mixed layer, especially in the subsurface layer. As expected, Stokes drift elevates both the dissipation rate and the turbulence energy in the upper ocean mixing. Also, ilffluence of the surface heating, wave breaking and wind speed on Stokes drift is investigated respectively. Research shows that it is significant and important to assessing the Stokes drift into ocean mixed layer studying. The laboratory observations are supporting numerical experiments quantitatively.
