A 59-year-old woman presented with erythema and pruritis of the breast 4.5 years after undergoing lumpectomy and radiation for breast cancer. Biopsy confirmed a diagnosis of angiosarcoma. This tumor stained positive f...A 59-year-old woman presented with erythema and pruritis of the breast 4.5 years after undergoing lumpectomy and radiation for breast cancer. Biopsy confirmed a diagnosis of angiosarcoma. This tumor stained positive for CD34 as well as 70% Ki67 prior to therapy initiation. A multidisciplinary approach yielded a plan for neoadjuvant chemoradiation and surgical resection including delayed completion transverse rectus abdominis flap for tissue coverage. Neoadjuvant therapy successfully decreased rates of cellular proliferation, as reflected by a Ki67 of 5%, at the time of resection. Pathophysiologically, angiosarcomas may be very aggressive and may develop following radiation for breast cancer. Such tumors may become more common as breast cancer therapies, which frequently include radiation therapy, improve with time. Early recognition of angiosarcoma is imperative for successful therapy. These tumors may present with a wide range of symptoms, but may be asymptomatic. Surgical resection is the preferred therapy, but early recognition is critical.展开更多
乳腺原发性血管肉瘤(primary breast angiosarcoma,PBA)是乳腺罕见的恶性肿瘤,其病理形态多样,常表现为异常增生的血管样结构。由于该病发病机制尚不明确,无特征临床表现,组织学变化大,术前活检及术中冰冻诊断困难。本文结合1例PBA病理...乳腺原发性血管肉瘤(primary breast angiosarcoma,PBA)是乳腺罕见的恶性肿瘤,其病理形态多样,常表现为异常增生的血管样结构。由于该病发病机制尚不明确,无特征临床表现,组织学变化大,术前活检及术中冰冻诊断困难。本文结合1例PBA病理诊断探讨该肿瘤的临床病理特点、可能发病机制、治疗及其预后。展开更多
放射相关性乳腺血管肉瘤(radiation-associated angiosarcoma of the breast,RAASB)是乳腺癌保乳术后放疗的罕见并发症,发病率约0.09%~0.16%[1],发病平均年龄58岁,主要发生于乳腺放疗区域的皮肤组织,也可继发于乳房间质,5年生存率40.5%...放射相关性乳腺血管肉瘤(radiation-associated angiosarcoma of the breast,RAASB)是乳腺癌保乳术后放疗的罕见并发症,发病率约0.09%~0.16%[1],发病平均年龄58岁,主要发生于乳腺放疗区域的皮肤组织,也可继发于乳房间质,5年生存率40.5%,10年生存率25.2%[2]。平均潜伏期大约在接受放射治疗后6年,亦有报告指出最早发生在放疗后1~2年,最晚在放疗后41年[3-5]。展开更多
文摘A 59-year-old woman presented with erythema and pruritis of the breast 4.5 years after undergoing lumpectomy and radiation for breast cancer. Biopsy confirmed a diagnosis of angiosarcoma. This tumor stained positive for CD34 as well as 70% Ki67 prior to therapy initiation. A multidisciplinary approach yielded a plan for neoadjuvant chemoradiation and surgical resection including delayed completion transverse rectus abdominis flap for tissue coverage. Neoadjuvant therapy successfully decreased rates of cellular proliferation, as reflected by a Ki67 of 5%, at the time of resection. Pathophysiologically, angiosarcomas may be very aggressive and may develop following radiation for breast cancer. Such tumors may become more common as breast cancer therapies, which frequently include radiation therapy, improve with time. Early recognition of angiosarcoma is imperative for successful therapy. These tumors may present with a wide range of symptoms, but may be asymptomatic. Surgical resection is the preferred therapy, but early recognition is critical.
文摘乳腺原发性血管肉瘤(primary breast angiosarcoma,PBA)是乳腺罕见的恶性肿瘤,其病理形态多样,常表现为异常增生的血管样结构。由于该病发病机制尚不明确,无特征临床表现,组织学变化大,术前活检及术中冰冻诊断困难。本文结合1例PBA病理诊断探讨该肿瘤的临床病理特点、可能发病机制、治疗及其预后。
文摘放射相关性乳腺血管肉瘤(radiation-associated angiosarcoma of the breast,RAASB)是乳腺癌保乳术后放疗的罕见并发症,发病率约0.09%~0.16%[1],发病平均年龄58岁,主要发生于乳腺放疗区域的皮肤组织,也可继发于乳房间质,5年生存率40.5%,10年生存率25.2%[2]。平均潜伏期大约在接受放射治疗后6年,亦有报告指出最早发生在放疗后1~2年,最晚在放疗后41年[3-5]。
