The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based inte...The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.展开更多
我轮1996年2月去巴西BREVES、VILA DO CONDE装捆装锯木,并先到BELEM港办进口手续。查阅英版港口资料,仅有BELEM 、VILA DO CONDE介绍,而无BREVES港资料,英版海图也没有。抵BELEM港后,根据代理安排,驶上述两港装货,现将有关港口情况汇总...我轮1996年2月去巴西BREVES、VILA DO CONDE装捆装锯木,并先到BELEM港办进口手续。查阅英版港口资料,仅有BELEM 、VILA DO CONDE介绍,而无BREVES港资料,英版海图也没有。抵BELEM港后,根据代理安排,驶上述两港装货,现将有关港口情况汇总如下,以示同行参考。 一、地理位置及贝伦引水站 BELEM、BREVES、VILA DO CONDE三港位于巴西北海岸亚马逊河支流帕腊河,属河口淡水港,GMT-3H,无季节变更。BELEM港（01°27′S,O48°29′W）引水站分为两个:外引水站SALINOPOLIS PILOT STATION（00°29′.5S,047°22′.5W）离岸边SALINOPOLIS灯台7.5nmile,距北界标灯浮lnmile;内引水站（01°06′S,048°29′.5W）。展开更多
基金supported by the National Natural Science Foundation of China(31972052,32021005,31820103010)the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501)the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.
文摘我轮1996年2月去巴西BREVES、VILA DO CONDE装捆装锯木,并先到BELEM港办进口手续。查阅英版港口资料,仅有BELEM 、VILA DO CONDE介绍,而无BREVES港资料,英版海图也没有。抵BELEM港后,根据代理安排,驶上述两港装货,现将有关港口情况汇总如下,以示同行参考。 一、地理位置及贝伦引水站 BELEM、BREVES、VILA DO CONDE三港位于巴西北海岸亚马逊河支流帕腊河,属河口淡水港,GMT-3H,无季节变更。BELEM港（01°27′S,O48°29′W）引水站分为两个:外引水站SALINOPOLIS PILOT STATION（00°29′.5S,047°22′.5W）离岸边SALINOPOLIS灯台7.5nmile,距北界标灯浮lnmile;内引水站（01°06′S,048°29′.5W）。
