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Path Planning and Tracking Control for Parking via Soft Actor-Critic Under Non-Ideal Scenarios 被引量:1
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作者 Xiaolin Tang Yuyou Yang +3 位作者 Teng Liu Xianke Lin Kai Yang Shen Li 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期181-195,共15页
Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adja... Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees. 展开更多
关键词 Automatic parking control strategy parking deviation(APS) soft actor-critic(SAC)
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Practical Prescribed Time Tracking Control With Bounded Time-Varying Gain Under Non-Vanishing Uncertainties
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作者 Dahui Luo Yujuan Wang Yongduan Song 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期219-230,共12页
This paper investigates the prescribed-time control(PTC) problem for a class of strict-feedback systems subject to non-vanishing uncertainties. The coexistence of mismatched uncertainties and non-vanishing disturbance... This paper investigates the prescribed-time control(PTC) problem for a class of strict-feedback systems subject to non-vanishing uncertainties. The coexistence of mismatched uncertainties and non-vanishing disturbances makes PTC synthesis nontrivial. In this work, a control method that does not involve infinite time-varying gain is proposed, leading to a practical and global prescribed time tracking control solution for the strict-feedback systems, in spite of both the mismatched and nonvanishing uncertainties. Different from methods based on control switching to avoid the issue of infinite control gain that involves control discontinuity at the switching point, in our method a softening unit is exclusively included to ensure the continuity of the control action. Furthermore, in contrast to most existing prescribed-time control works where the control scheme is only valid on a finite time interval, in this work, the proposed control scheme is valid on the entire time interval. In addition, the prior information on the upper or lower bound of gi is not in need,enlarging the applicability of the proposed method. Both the theoretical analysis and numerical simulation confirm the effectiveness of the proposed control algorithm. 展开更多
关键词 Adaptive control prescribed time control(PTC) strict-feedback systems tracking control
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Model-based risk assessment on dynamic control of twin-column continuous capture under feedstock variations
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作者 Yu Fan Liang-Zhi Qiao +1 位作者 Shan-Jing Yao Dong-Qiang Lin 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第10期22-30,共9页
Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous... Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area. 展开更多
关键词 Continuous chromatography Process control Feedstock variations Mechanistic modeling PURIFICATION
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A Loss-model-based Efficiency Optimization Control Method for Induction Traction System of High-speed Train under Emergency Self-propelled Mode
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作者 Yutong Zhu Yaohua Li 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第2期227-239,共13页
Increasing attention has been paid to the efficiency improvement of the induction traction system of high-speed trains due to the high demand for energy saving. In emergency self-propelled mode, however, the dc-link v... Increasing attention has been paid to the efficiency improvement of the induction traction system of high-speed trains due to the high demand for energy saving. In emergency self-propelled mode, however, the dc-link voltage and the traction power of the motor are significantly reduced, resulting in decreased traction efficiency due to the low load and low speed operations. Aiming to tackle this problem, a novel efficiency improved control method is introduced to the emergency mode of high-speed train traction system in this paper. In the proposed method, a total loss model of induction motor considering the behaviors of both iron and copper loss is established. An improved iterative algorithm with decreased computational burden is then introduced, resulting in a fast solving of the optimal flux reference for loss minimization at each control period. In addition, considering the parameter variation problem due to the low load and low speed operations, a parameter estimation method is integrated to improve the controller's robustness. The effectiveness of the proposed method on efficiency improvement at low voltage and low load conditions is demonstrated by simulated and experimental results. 展开更多
关键词 Efficiency optimization Induction motor Loss model control Motor drives Traction system
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Complete-basis-reprogrammable coding metasurface for generating dynamicallycontrolled holograms under arbitrary polarization states
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作者 Zuntian Chu Xinqi Cai +7 位作者 Ruichao Zhu Tonghao Liu Huiting Sun Tiefu Li Yuxiang Jia Yajuan Han Shaobo Qu Jiafu Wang 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第9期65-80,共16页
Reprogrammable metasurfaces,which establish a fascinating bridge between physical and information domains,can dynamically control electromagnetic(EM)waves in real time and thus have attracted great attentions from res... Reprogrammable metasurfaces,which establish a fascinating bridge between physical and information domains,can dynamically control electromagnetic(EM)waves in real time and thus have attracted great attentions from researchers around the world.To control EM waves with an arbitrary polarization state,it is desirable that a complete set of basis states be controlled independently since incident EM waves with an arbitrary polarization state can be decomposed as a linear sum of these basis states.In this work,we present the concept of complete-basis-reprogrammable coding metasurface(CBR-CM)in reflective manners,which can achieve independently dynamic controls over the reflection phases while maintaining the same amplitude for left-handed circularly polarized(LCP)waves and right-handed circularly polarized(RCP)waves.Since LCP and RCP waves together constitute a complete basis set of planar EM waves,dynamicallycontrolled holograms can be generated under arbitrarily polarized wave incidence.The dynamically reconfigurable metaparticle is implemented to demonstrate the CBR-CM’s robust capability of controlling the longitudinal and transverse positions of holograms under LCP and RCP waves independently.It’s expected that the proposed CBR-CM opens up ways of realizing more sophisticated and advanced devices with multiple independent information channels,which may provide technical assistance for digital EM environment reproduction. 展开更多
关键词 basis vector control reprogrammable metasurface dynamically-controlled holograms arbitrary polarization state broadband
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Hierarchical Controller Synthesis Under Linear Temporal Logic Specifications Using Dynamic Quantization
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作者 Wei Ren Zhuo-Rui Pan +1 位作者 Weiguo Xia Xi-Ming Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第10期2082-2098,共17页
Linear temporal logic(LTL)is an intuitive and expressive language to specify complex control tasks,and how to design an efficient control strategy for LTL specification is still a challenge.In this paper,we implement ... Linear temporal logic(LTL)is an intuitive and expressive language to specify complex control tasks,and how to design an efficient control strategy for LTL specification is still a challenge.In this paper,we implement the dynamic quantization technique to propose a novel hierarchical control strategy for nonlinear control systems under LTL specifications.Based on the regions of interest involved in the LTL formula,an accepting path is derived first to provide a high-level solution for the controller synthesis problem.Second,we develop a dynamic quantization based approach to verify the realization of the accepting path.The realization verification results in the necessity of the controller design and a sequence of quantization regions for the controller design.Third,the techniques of dynamic quantization and abstraction-based control are combined together to establish the local-to-global control strategy.Both abstraction construction and controller design are local and dynamic,thereby resulting in the potential reduction of the computational complexity.Since each quantization region can be considered locally and individually,the proposed hierarchical mechanism is more efficient and can solve much larger problems than many existing methods.Finally,the proposed control strategy is illustrated via two examples from the path planning and tracking problems of mobile robots. 展开更多
关键词 Abstraction-based control design dynamic quantization formal methods linear temporal logic(LTL)
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Mechanism,prevention,and control of mining-induced dynamic disasters in underground metal mines in China:Challenges and solutions
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作者 LI Peng CAI Mei-feng +3 位作者 MIAO Sheng-jun REN Fen-hua GORJIAN Mostafa PENG Chao 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2549-2606,共58页
Metal mineral resources play an indispensable role in the development of the national economy.Dynamic disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological ... Metal mineral resources play an indispensable role in the development of the national economy.Dynamic disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological problems to be solved urgently.In this article,the occurrence status and grand challenges of some typical dynamic disasters involving roof falling,spalling,collapse,large deformation,rockburst,surface subsidence,and water inrush in metal mines in China are systematically presented,the characteristics of mining-induced dynamic disasters are analyzed,the examples of dynamic disasters occurring in some metal mines in China are summarized,the occurrence mechanism,monitoring and early warning methods,and prevention and control techniques of these disasters are highlighted,and some new opinions,suggestions,and solutions are proposed simultaneously.Moreover,some shortcomings in current disaster research are pointed out,and the direction of efforts to improve the prevention and control level of dynamic disasters in China’s metal mines in the future is prospected.The integration of forward-looking key innovative theories and technologies in the abovementioned aspects will greatly enhance the cognitive level of disaster prevention and mitigation in China’s metal mining industry and achieve a significant shift from passive disaster relief to active disaster prevention. 展开更多
关键词 underground metal mines dynamic disasters MECHANISM monitoring and early warning prevention and control
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A new optimal adaptive backstepping control approach for nonlinear systems under deception attacks via reinforcement learning
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作者 Wendi Chen Qinglai Wei 《Journal of Automation and Intelligence》 2024年第1期34-39,共6页
In this paper,a new optimal adaptive backstepping control approach for nonlinear systems under deception attacks via reinforcement learning is presented in this paper.The existence of nonlinear terms in the studied sy... In this paper,a new optimal adaptive backstepping control approach for nonlinear systems under deception attacks via reinforcement learning is presented in this paper.The existence of nonlinear terms in the studied system makes it very difficult to design the optimal controller using traditional methods.To achieve optimal control,RL algorithm based on critic–actor architecture is considered for the nonlinear system.Due to the significant security risks of network transmission,the system is vulnerable to deception attacks,which can make all the system state unavailable.By using the attacked states to design coordinate transformation,the harm brought by unknown deception attacks has been overcome.The presented control strategy can ensure that all signals in the closed-loop system are semi-globally ultimately bounded.Finally,the simulation experiment is shown to prove the effectiveness of the strategy. 展开更多
关键词 Nonlinear systems Reinforcement learning Optimal control Backstepping method
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Guaranteed Cost Attitude Tracking Control for Uncertain Quadrotor Unmanned Aerial Vehicle Under Safety Constraints
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作者 Qian Ma Peng Jin Frank L.Lewis 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1447-1457,共11页
In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is studied.First,an augmented system is constructed by the tracking error system a... In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is studied.First,an augmented system is constructed by the tracking error system and reference system.This transformation aims to convert the tracking control prob-lem into a stabilization control problem.Then,control barrier function and disturbance attenuation function are designed to characterize the violations of safety constraints and tolerance of uncertain disturbances,and they are incorporated into the reward function as penalty items.Based on the modified reward function,the problem is simplified as the optimal regulation problem of the nominal augmented system,and a new Hamilton-Jacobi-Bellman equation is developed.Finally,critic-only rein-forcement learning algorithm with a concurrent learning tech-nique is employed to solve the Hamilton-Jacobi-Bellman equa-tion and obtain the optimal controller.The proposed algorithm can not only ensure the reward function within an upper bound in the presence of uncertain disturbances,but also enforce safety constraints.The performance of the algorithm is evaluated by the numerical simulation. 展开更多
关键词 Attitude tracking control quadrotor unmanned aerial vehicle(QUAV) reinforcement learning safety constraints uncertain disturbances.
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A finite-time fuzzy adaptive output-feedback fault-tolerant control for underactuated wheeled mobile robots systems
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作者 Pingfan Liu Shaocheng Tong 《Journal of Automation and Intelligence》 2024年第2期111-118,共8页
This paper investigates the adaptive fuzzy finite-time output-feedback fault-tolerant control (FTC) problemfor a class of nonlinear underactuated wheeled mobile robots (UWMRs) system with intermittent actuatorfaults. ... This paper investigates the adaptive fuzzy finite-time output-feedback fault-tolerant control (FTC) problemfor a class of nonlinear underactuated wheeled mobile robots (UWMRs) system with intermittent actuatorfaults. The UWMR system includes unknown nonlinear dynamics and immeasurable states. Fuzzy logic systems(FLSs) are utilized to work out immeasurable functions. Furthermore, with the support of the backsteppingcontrol technique and adaptive fuzzy state observer, a fuzzy adaptive finite-time output-feedback FTC scheme isdeveloped under the intermittent actuator faults. It is testifying the scheme can ensure the controlled nonlinearUWMRs is stable and the estimation errors are convergent. Finally, the comparison results and simulationvalidate the effectiveness of the proposed fuzzy adaptive finite-time FTC approach. 展开更多
关键词 underactuated wheeled mobile robots system FINITE-TIME Fuzzy adaptive fault-tolerant control OUTPUT-FEEDBACK Intermittent actuator faults
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Adaptive Sensor-Fault Tolerant Control of Unmanned Underwater Vehicles With Input Saturation
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作者 Xuerao Wang Qingling Wang +2 位作者 Yanxu Su Yuncheng Ouyang Changyin Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期907-918,共12页
This paper investigates the tracking control problem for unmanned underwater vehicles(UUVs)systems with sensor faults,input saturation,and external disturbance caused by waves and ocean currents.An active sensor fault... This paper investigates the tracking control problem for unmanned underwater vehicles(UUVs)systems with sensor faults,input saturation,and external disturbance caused by waves and ocean currents.An active sensor fault-tolerant control scheme is proposed.First,the developed method only requires the inertia matrix of the UUV,without other dynamic information,and can handle both additive and multiplicative sensor faults.Subsequently,an adaptive fault-tolerant controller is designed to achieve asymptotic tracking control of the UUV by employing robust integral of the sign of error feedback method.It is shown that the effect of sensor faults is online estimated and compensated by an adaptive estimator.With the proposed controller,the tracking error and estimation error can asymptotically converge to zero.Finally,simulation results are performed to demonstrate the effectiveness of the proposed method. 展开更多
关键词 Asymptotic stability fault-tolerant control input saturation robust integral of the sign of error unmanned underwater vehicle
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ON DE FINETTI'S OPTIMAL IMPULSE DIVIDEND CONTROL PROBLEM UNDER CHAPTER 11 BANKRUPTCY
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作者 王文元 明瑞星 胡亦钧 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期215-233,共19页
Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the... Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the reorganization process and the regulator's intervention documented in U.S.Chapter 11 bankruptcy.We do this by further accommodating the fixed transaction costs on dividends to imitate the real-world procedure of dividend payments.Incorporating the fixed transaction costs transforms the targeting optimal dividend problem into an impulse control problem rather than a singular control problem,and hence computations and proofs that are distinct from[44]are needed.To account for the financial stress that is due to the more subtle concept of Chapter 11 bankruptcy,the surplus process after dividends is driven by a piece-wise spectrally negative Lévy process with endogenous regime switching.Some explicit expressions of the expected net present values under a double barrier dividend strategy,new to the literature,are established in terms of scale functions.With the help of these expressions,we are able to characterize the optimal strategy among the set of admissible double barrier dividend strategies.When the tail of the Lévy measure is log-convex,this optimal double barrier dividend strategy is then verified as the optimal dividend strategy,solving our optimal impulse control problem. 展开更多
关键词 spectrally negative Lévy process Chapter 11 bankruptcy De Finetti's dividend problem double barrier strategy impulse control
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Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls
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作者 Yang Shi Mingjun Wu +14 位作者 Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期98-134,共37页
Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and... Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field. 展开更多
关键词 Biomass materials Electromagnetic interference shielding Micro-nano structure interface control CONDUCTIVITY
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Synthetic analysis of meteorological elements for the sea fogs occurred in northwest the Yellow Sea under low pressure control and comparison with sea fogs occurred under high pressure control in summer
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作者 WANG Kaiyue MA Zheng +3 位作者 MIAO Qingsheng ZHAO Binru ZHANG Zengjian LI Cheng 《Marine Science Bulletin》 2024年第1期1-18,共18页
Based on the principle of transient perturbation analysis,in this paper,a method to objectively determine the weather pattern formed by sea fog is provided.On the basis of the classification results,the circulation si... Based on the principle of transient perturbation analysis,in this paper,a method to objectively determine the weather pattern formed by sea fog is provided.On the basis of the classification results,the circulation situation,divergence and vertical velocity field,and the vertical profile of temperature and humidity are synthesized and analyzed.The basic characteristics of the circulation and physical field of sea fog under low pressure control(L type sea fog)are obtained,and the results are compared with the sea fog under the control of high pressure(H type sea fog):a)L type sea fogs potential height anomaly disturbance is mainly manifested in the low layer,and its average value is-65.66 gpm,gradually weakening upward;b)L type sea fogs inversion structure is weaker than H type sea fogs when it occurs,the fog layer is thicker and the high relative humidity level is high over the fog layer,while the H type sea fogs fog layer has a relatively obvious dry layer;c)L sea fog has three layers of structure at the vertical direction.The first layer 1000-950 hPa is convergence accompanied by weak rise and subsidence,the second layer 950-850 hPa is divergence accompanied by weak subsidence,and the third layer 850 to 500hPa is gradually strengthened.While there are two layer structures of the H type sea fog.1000 hPa is divergence accompanied by weak rising and sinking movement,950-500 hPa is a uniform subsidence movement.d)Probability density statistical analysis further quantified the vertical movement of L and H type sea fog and the distribution of relative humidity in each layer.These conclusions provide an important reference for forecasting the sea fog in the northwest of the Yellow Sea under the condition of low pressure circulation in summer. 展开更多
关键词 sea fog under the low pressure control sea fog under the high pressure control northwest of the Yellow Sea synthetic analysis transient method
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Effect of Jianpi Wenshen Granules on the Nutritional Control Status Score in Elderly Patients Undergoing Maintenance Hemodialysis
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作者 Hailiang Ye Teng Ma +2 位作者 Yan Zhou Taoli Li Hong Zhu 《Proceedings of Anticancer Research》 2024年第5期25-31,共7页
Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maint... Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects.The patients were randomly divided into two groups:the study group and the control group,with 35 patients in each group.Both groups received maintenance hemodialysis,while the control group received only conventional Western medicine treatment,and the study group was additionally treated with Jianpi Wenshen Granules.The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups.The nutritional status of the patients was assessed using the Controlling Nutritional Status(CONUT)score,and detailed statistics were gathered on anemia and albumin levels in both groups.Results:After treatment,the CONUT score in the study group significantly decreased compared to the control group,showing a significant correlation(P<0.05).Albumin and hemoglobin levels significantly increased,with a notable difference(P<0.05).There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment(P>0.05).Conclusion:In elderly patients undergoing maintenance hemodialysis,Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status,demonstrating potential for clinical application and promotion. 展开更多
关键词 Jianpi Wenshen Granules Maintenance hemodialysis controlling Nutritional Status score
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Passive activity enhances residual control ability in patients with complete spinal cord injury
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作者 Yanqing Xiao Mingming Gao +6 位作者 Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS 2025年第8期2337-2347,共11页
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these... Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury. 展开更多
关键词 complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task
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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury
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作者 Qi Liu Jianye Xie +5 位作者 Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi 《Neural Regeneration Research》 SCIE CAS 2025年第2期503-517,共15页
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv... Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury. 展开更多
关键词 angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 NEUROPROTECTION self-assembling nanofiber hydrogel
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Camptothecin and 10-Hydroxycamptothecin Accumulate Differentially Under Specific Developmental Control in Camptotheca acuminata 被引量:11
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作者 祖元刚 唐中华 +1 位作者 于景华 赵春建 《Acta Botanica Sinica》 CSCD 2003年第4期494-499,共6页
Camptotheca acuminata Decaisne is a tree unique to China, producing terpenoid indole alkaloid (TIA), camptothecin (CPT), and 10-hydroxycamptothecin (HCPT), which possesses strong anti-cancer bioactivity. The dynamics ... Camptotheca acuminata Decaisne is a tree unique to China, producing terpenoid indole alkaloid (TIA), camptothecin (CPT), and 10-hydroxycamptothecin (HCPT), which possesses strong anti-cancer bioactivity. The dynamics of HCPT and CPT during seed maturation, seed germination, postgerminative development and daily growth were measured by High Performance Liquid Chromatography (HPLC). This article provides some evidence for presenting the theory that each characteristic of HCPT and CPT accumulation is under developmental regulation and then attempt to elucidate the metabolic relationships between them. HCPT accumulates particularly in young tissues and organs and is relatively unstable, while the distribution of CPT is more ubiquitous and stable. Their different distribution properties suggest that HCPT and CPT are differentially regulated and play distinct roles:during development. 展开更多
关键词 Camptotheca acuminata CAMPTOTHECIN 10-HYDROXYCAMPTOTHECIN control DEVELOPMENT
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Migration and Transformation of Coated Controlled Release Nitrogen in Soil under Co-situs Application Mode 被引量:11
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作者 肖强 王甲辰 +4 位作者 左强 张琳 刘宝存 赵同科 邹国元 《Agricultural Science & Technology》 CAS 2009年第6期144-149,共6页
By using field trials, the migration and transformation of coated controlled release nitrogen (YZS80) in soil under the co-situs application mode were studied. The results indicated that YZS80 nitrogen dissolved out... By using field trials, the migration and transformation of coated controlled release nitrogen (YZS80) in soil under the co-situs application mode were studied. The results indicated that YZS80 nitrogen dissolved out in average speed of about 0.4%/d and 32% totally in 80 d compared with common compound fertUizer. For YZS80, in the vertical downward direction of application points, urea nitrogen content increased significantly (P 〈0.05) in the 45 -80 d and the 30 -60 cm soil layers; nitrate nitrogen content was little change range and in moderate (10 -100 mg/kg) in 0 -80 d and 10 -60 cm soil layers, but increased significantly ( P 〈0.05) 45 -80 d compared to 0 -45 d; ammonium nitrogen content was significant lower (P〈0.05) before 45 d in 10 -30 cm soil layers, but significant higher(P〈0.05) after 45 d in 10 -60 cm soil layers; NO3^- -N/NH4^+ -N meets gradually the needs of the crop with the extension of time. Under the co-situs application mode, the possibility of burning root and salt injury and loss dsk of nitrate leaching is a significant reduction. 展开更多
关键词 Co-situs application Slow/controlled release fertilizer MIGRATION TRANSFORMATION
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Control of Wheat Stripe Rust and Ensuring High Yield of Crops under Planting of Wheat Variety Mixtures 被引量:3
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作者 沈丽 叶香萍 +4 位作者 廖华明 何华健 王胜 刘如东 罗林明 《Agricultural Science & Technology》 CAS 2008年第1期134-138,共5页
Wheat stripe rust has become the most dangerous disease which threaten safe yield of wheat in Sichuan Province. It is meaningful to provide technique support for integrated disease control by exploring the effective c... Wheat stripe rust has become the most dangerous disease which threaten safe yield of wheat in Sichuan Province. It is meaningful to provide technique support for integrated disease control by exploring the effective control measures of wheat stripe rust. Wheat stripe rust dynamic developments of all-planting and mixed-planting have been systematically investigated in this study by taking different mixed-planting combinations among 6 wheat varieties with different resistance levels. The results of this experiment show that the mixed-plantings of 4 and 6 wheat varieties can delay the occurance of wheat stripe rust,slow the speed of disease and decline the damage of disease as well as stabilize yield of wheats. 展开更多
关键词 Mixed-planting Wheat stripe rust control Stable yield
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