The bromination of paeonol with bromine and copper(Ⅱ)bromide was studied.The target compounds were different because of the different solvents.When paeonol was brominated with reagents like bromine in anhydrous dieth...The bromination of paeonol with bromine and copper(Ⅱ)bromide was studied.The target compounds were different because of the different solvents.When paeonol was brominated with reagents like bromine in anhydrous diethyl ether and anhydrous aluminium trichloride,5bromo4methoxy2hydroxyacetophenone was obtained.The yield was 445%.Like cupric bromide in chloroformethyl acetate and anhydrous ethanol,the yield we obtained ωbromo4methoxy5bromo2hydroxyacetophenone was 475%.Paeonol was selectively brominated by copper(Ⅱ)bromide in anhydrous methanol(or chloroformethyl acetate)to give ωbromo4methoxy2hydroxyacetophenone in yield of 633%(or 487%).The structures of the target compounds were characterized by IR,1H NMR and MS.展开更多
文摘The bromination of paeonol with bromine and copper(Ⅱ)bromide was studied.The target compounds were different because of the different solvents.When paeonol was brominated with reagents like bromine in anhydrous diethyl ether and anhydrous aluminium trichloride,5bromo4methoxy2hydroxyacetophenone was obtained.The yield was 445%.Like cupric bromide in chloroformethyl acetate and anhydrous ethanol,the yield we obtained ωbromo4methoxy5bromo2hydroxyacetophenone was 475%.Paeonol was selectively brominated by copper(Ⅱ)bromide in anhydrous methanol(or chloroformethyl acetate)to give ωbromo4methoxy2hydroxyacetophenone in yield of 633%(or 487%).The structures of the target compounds were characterized by IR,1H NMR and MS.
