AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODS: Forma...AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 urn thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117. RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells, were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine. CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected.展开更多
Objective： The purpose of this study was to assess the features of bronchial alveolar carcinoma in fluorine-18 fluorodeoxyglucose （FDG） uptake by Positron emission tomography（PET）. Methods： From December 1998 to...Objective： The purpose of this study was to assess the features of bronchial alveolar carcinoma in fluorine-18 fluorodeoxyglucose （FDG） uptake by Positron emission tomography（PET）. Methods： From December 1998 to October 2004, 35 patients with bronchial alveolar carcinoma （BAC） were imaged with FDG-PET before surgery. The PET results were interpreted using visual and semiquantitative assessment. For semiquantitative analysis, standardized uptake value （SUV） was calculated. Results： All tumors of the patients could be detected by FDG-PET and identified by visual method. By semiquantitative analysis, FDG uptake of the tumor （SUVmax and SUVmean） was higher than that of normal lung （SUVlung） （P〈0.001）, SUVmax, SUVmean of the tumor and SUVlung were 3.14±1.65, 2.40±1.34 and 0.38±0.08 respectively. Correlations were found between FDG uptake and tumor size （P〈0.05）. SUVmean in 21 tumors （21/35, 60.0%） and SUVmax in 15 tumors （15/35, 42.9%） were lower than 2.5. These 21 tumors were all considered as benign by visual method and semiquantitative analysis. Conclusion： （1） FDG uptake was higher in bronchial alveolar carcinoma than that in normal lung tissue. （2） FDG uptake and tumor size appear to be correlated with each other. （3） Bronchial alveolar carcinomas lead to many false negative cases in FDG-PET.展开更多
Bronchial artery infusion(BAI)with chemical agents was performed in 41 patients with lung carcinoma up to 61times,included 33 cases(51 times)primary lung carcinoma(PLC)and 8cases(10 times)lung metastatic carcinoma (LM...Bronchial artery infusion(BAI)with chemical agents was performed in 41 patients with lung carcinoma up to 61times,included 33 cases(51 times)primary lung carcinoma(PLC)and 8cases(10 times)lung metastatic carcinoma (LMC). Short-time effects were valuable in 31 cases with PLC and 7 cases with LMC.Complete remission(CR)plus partial rimission(PR)ocurred in 14 cases(45.16%)among 31 patients with PLC and 1 case(14.28%)among 14 patients with LMC(P<0 .01).CR plus PR was 10cases(52.63%)among 19 patients with central type cancer (CTC)and 4 cases (33.33%) among 12 patients with perprephal type cancer(PTC) of PLC(P<0.05). CR plus PR in 15 squamous carcinomas(SC),6 adenocarcinomas (AC)2 small cell undifferentiated carcinomas(SCLC)and 8 histologically unclassfied carcinomas(HUC)were 8(53.33%),1(50%),and 3(37.5%), respectively.The rate of CR plus PR in squamous carcinoma was higher than that in adenocarcinoma and histologically unclassified carcinoma(P<0.05).There was no remarkable difference in CR plus PR among stage Ⅱ-Ⅲand Ⅳpatients with PLC, CAP and FMP protocol treatment.This study also investigated and analysed the side effects of 41 patients by BAI treatment.展开更多
文摘AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 urn thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117. RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells, were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine. CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected.
文摘Objective： The purpose of this study was to assess the features of bronchial alveolar carcinoma in fluorine-18 fluorodeoxyglucose （FDG） uptake by Positron emission tomography（PET）. Methods： From December 1998 to October 2004, 35 patients with bronchial alveolar carcinoma （BAC） were imaged with FDG-PET before surgery. The PET results were interpreted using visual and semiquantitative assessment. For semiquantitative analysis, standardized uptake value （SUV） was calculated. Results： All tumors of the patients could be detected by FDG-PET and identified by visual method. By semiquantitative analysis, FDG uptake of the tumor （SUVmax and SUVmean） was higher than that of normal lung （SUVlung） （P〈0.001）, SUVmax, SUVmean of the tumor and SUVlung were 3.14±1.65, 2.40±1.34 and 0.38±0.08 respectively. Correlations were found between FDG uptake and tumor size （P〈0.05）. SUVmean in 21 tumors （21/35, 60.0%） and SUVmax in 15 tumors （15/35, 42.9%） were lower than 2.5. These 21 tumors were all considered as benign by visual method and semiquantitative analysis. Conclusion： （1） FDG uptake was higher in bronchial alveolar carcinoma than that in normal lung tissue. （2） FDG uptake and tumor size appear to be correlated with each other. （3） Bronchial alveolar carcinomas lead to many false negative cases in FDG-PET.
文摘Bronchial artery infusion(BAI)with chemical agents was performed in 41 patients with lung carcinoma up to 61times,included 33 cases(51 times)primary lung carcinoma(PLC)and 8cases(10 times)lung metastatic carcinoma (LMC). Short-time effects were valuable in 31 cases with PLC and 7 cases with LMC.Complete remission(CR)plus partial rimission(PR)ocurred in 14 cases(45.16%)among 31 patients with PLC and 1 case(14.28%)among 14 patients with LMC(P<0 .01).CR plus PR was 10cases(52.63%)among 19 patients with central type cancer (CTC)and 4 cases (33.33%) among 12 patients with perprephal type cancer(PTC) of PLC(P<0.05). CR plus PR in 15 squamous carcinomas(SC),6 adenocarcinomas (AC)2 small cell undifferentiated carcinomas(SCLC)and 8 histologically unclassfied carcinomas(HUC)were 8(53.33%),1(50%),and 3(37.5%), respectively.The rate of CR plus PR in squamous carcinoma was higher than that in adenocarcinoma and histologically unclassified carcinoma(P<0.05).There was no remarkable difference in CR plus PR among stage Ⅱ-Ⅲand Ⅳpatients with PLC, CAP and FMP protocol treatment.This study also investigated and analysed the side effects of 41 patients by BAI treatment.
