[ Objective ] The paper was to ascertain the insects on the stored traditional Chinese medicinal （TCM） materials in Anhui Province of China, so as to control pests on stored TCM materials effectually. [ Method] The ...[ Objective ] The paper was to ascertain the insects on the stored traditional Chinese medicinal （TCM） materials in Anhui Province of China, so as to control pests on stored TCM materials effectually. [ Method] The insects on stored TCM materials in 17 regions of Anhui Province were investigated from 2009 to 2012 and 873 kinds of insect samples on TCM materials were collected. [ Result] Investigation showed that a total of 94 species of insects on stored TCM materials belonging to 38 families, 9 orders in Anhui Province had been identified, among which 81 species of pests belonged to 31 families, 5 orders, and 13 species of natu- ral enemies belonged to 7 families, 4 orders ; additionally, 24 species of insects were newly recorded in Anhui Province. The distribution and hosts of 94 species of insects were also described. [ Conclusion] The results could provide scientific basis for controlling pests of the stored traditional Chinese medicinal materials in An- hui Province.展开更多
从20种天然氨基酸的41个分子轮廓指数（randic molecular profiles,R）、44个分子特征值指数（eigenvalue based indices,E）和47个分子运转路径数目（walk and path counts,W）分别进行主成分分析,得出1种新的氨基酸描述符（scores vec...从20种天然氨基酸的41个分子轮廓指数（randic molecular profiles,R）、44个分子特征值指数（eigenvalue based indices,E）和47个分子运转路径数目（walk and path counts,W）分别进行主成分分析,得出1种新的氨基酸描述符（scores vector of R,E,W-SVREW）。将其应用于血管紧张素转化酶（ACE）抑制二肽、三肽、四肽、九肽结构表征,应用多元线性回归建立定量构效关系模型,同时采用内部与外部双重验证的方法验证模型的稳定性。所建ACE抑制二肽、三肽、四肽、九肽的模型复相关系数（Rcum^2）、留一法（LOO）交互校验复相关系数（Rcv^2）和外部样本校验相关系数（Qext^2）分别为：0.907、0.791、0.633;0.831、0.603、0.723;0.834、0.668、0.718;0.964、0.853、0.948。经研究表明：SVREW描述符应用于ACE抑制肽结构表征所建模型稳定性与预测能力均较好。展开更多
Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory d...Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol（0.1, 1.0, 10.0 mg/kg） was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.展开更多
基金Supported by Priority Project of Natural Science Foundation of Education Department of Anhui Province ( KJ2010A210 )Natural Science Foundation of Anhui Province( 1308085MC39)
文摘[ Objective ] The paper was to ascertain the insects on the stored traditional Chinese medicinal （TCM） materials in Anhui Province of China, so as to control pests on stored TCM materials effectually. [ Method] The insects on stored TCM materials in 17 regions of Anhui Province were investigated from 2009 to 2012 and 873 kinds of insect samples on TCM materials were collected. [ Result] Investigation showed that a total of 94 species of insects on stored TCM materials belonging to 38 families, 9 orders in Anhui Province had been identified, among which 81 species of pests belonged to 31 families, 5 orders, and 13 species of natu- ral enemies belonged to 7 families, 4 orders ; additionally, 24 species of insects were newly recorded in Anhui Province. The distribution and hosts of 94 species of insects were also described. [ Conclusion] The results could provide scientific basis for controlling pests of the stored traditional Chinese medicinal materials in An- hui Province.
文摘从20种天然氨基酸的41个分子轮廓指数（randic molecular profiles,R）、44个分子特征值指数（eigenvalue based indices,E）和47个分子运转路径数目（walk and path counts,W）分别进行主成分分析,得出1种新的氨基酸描述符（scores vector of R,E,W-SVREW）。将其应用于血管紧张素转化酶（ACE）抑制二肽、三肽、四肽、九肽结构表征,应用多元线性回归建立定量构效关系模型,同时采用内部与外部双重验证的方法验证模型的稳定性。所建ACE抑制二肽、三肽、四肽、九肽的模型复相关系数（Rcum^2）、留一法（LOO）交互校验复相关系数（Rcv^2）和外部样本校验相关系数（Qext^2）分别为：0.907、0.791、0.633;0.831、0.603、0.723;0.834、0.668、0.718;0.964、0.853、0.948。经研究表明：SVREW描述符应用于ACE抑制肽结构表征所建模型稳定性与预测能力均较好。
基金financially supported by the Science and Technology Commission Foundation of Zhangjiakou City,No.1021098Dthe Medical Scientific Research Project of Health Bureau of Hebei Province,No.20100144+2 种基金the Natural Science Foundation of Hebei Province,No.H2012405016the Innovative Talents Project of Hebei North University,No.CXRC1325the Major Projects of Hebei North University,No.ZD201310
文摘Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol（0.1, 1.0, 10.0 mg/kg） was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.
