Two polymorphic forms （forms I and IV） of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. ...Two polymorphic forms （forms I and IV） of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. Form I crystallizes in the triclinic system, space group P1^- with Z= 2, a = 7.6943（8）, b = 7.9347（9）, c = 13.8558（15） A, a = 85.971（3）, β = 85.619（2）, γ = 65.974（3）°, V = 769.66（14） A^3, Dc= 1.384 g/cm^3, formula C13H19C1NOBr, F（000） = 328, p = 2.83 mm^-1, the final R = 0.0579 and wR = 0.1282 for 1756 observed reflections with I 〉 2σ（I）. Another polymorphic form, IV, belongs to the orthorhombic system, space group Pbca with a = 8.6365（3）, b = 12.4167（4）, c = 27.7299（9） A, Z = 8, V= 2973.67（17） A^3, Dc= 1.432 g/cm^3, formula C13H19CINOBr, F（000） = 1312,μ = 2.93 mm^-1, the final R = 0.044 and wR = 0.1093 for 2018 observed reflections with I 〉 2σ（I）. In the crystal structure of the two polymorphic forms, expected proton transfer from HBr to amino group of bupropion molecule occurs and intramolecular and intermolecular hydrogen bonds N-H…Br are formed. These interactions result in hydrogen-bond dimers in these two forms. The bupropion molecule adopts different conformations in the two investigated solid state modifications.展开更多
Dear editor,We report a case of a 47-year-old female who presented with a toxic bupropion ingestion leading to cardiac arrest.She initially exhibited a loss of brainstem reflexes in conjunction with burst-suppression ...Dear editor,We report a case of a 47-year-old female who presented with a toxic bupropion ingestion leading to cardiac arrest.She initially exhibited a loss of brainstem reflexes in conjunction with burst-suppression pattern on EEG.Burst suppression is an EEG waveform pattern of alternating isoelectric suppressions and high voltage bursts.^([1])展开更多
目的:系统评价盐酸安非他酮缓释片和盐酸氟西汀片治疗抑郁症的有效性及安全性,为其临床应用提供依据。方法:计算机检索Cochrane图书馆临床对照试验资料库、Ovid-medline全文数据库、PubMed、Embase、中国期刊全文数据库、万方数字化期...目的:系统评价盐酸安非他酮缓释片和盐酸氟西汀片治疗抑郁症的有效性及安全性,为其临床应用提供依据。方法:计算机检索Cochrane图书馆临床对照试验资料库、Ovid-medline全文数据库、PubMed、Embase、中国期刊全文数据库、万方数字化期刊库、维普数据库和中国生物医学文献数据库中盐酸安非他酮缓释片对比盐酸氟西汀片治疗抑郁症的有效性与安全性的随机对照试验(RCT),提取资料后采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入9项RCT,合计1 106例患者。Meta分析,盐酸安非他酮缓释片与盐酸氟西汀片治疗抑郁症的有效性无明显差异[OR=1.13,95%CI(0.87,1.48),P>0.05];不良反应发生率与盐酸氟西汀片治疗抑郁症比较也无明显差异[OR=1.13,95%CI(0.91,1.41),P>0.05]。结论:盐酸安非他酮缓释片和盐酸氟西汀片治疗抑郁症具有相似的疗效及不良反应。展开更多
基金supported by the Natural Science Foundation of Zhejiang Province (J200801)
文摘Two polymorphic forms （forms I and IV） of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. Form I crystallizes in the triclinic system, space group P1^- with Z= 2, a = 7.6943（8）, b = 7.9347（9）, c = 13.8558（15） A, a = 85.971（3）, β = 85.619（2）, γ = 65.974（3）°, V = 769.66（14） A^3, Dc= 1.384 g/cm^3, formula C13H19C1NOBr, F（000） = 328, p = 2.83 mm^-1, the final R = 0.0579 and wR = 0.1282 for 1756 observed reflections with I 〉 2σ（I）. Another polymorphic form, IV, belongs to the orthorhombic system, space group Pbca with a = 8.6365（3）, b = 12.4167（4）, c = 27.7299（9） A, Z = 8, V= 2973.67（17） A^3, Dc= 1.432 g/cm^3, formula C13H19CINOBr, F（000） = 1312,μ = 2.93 mm^-1, the final R = 0.044 and wR = 0.1093 for 2018 observed reflections with I 〉 2σ（I）. In the crystal structure of the two polymorphic forms, expected proton transfer from HBr to amino group of bupropion molecule occurs and intramolecular and intermolecular hydrogen bonds N-H…Br are formed. These interactions result in hydrogen-bond dimers in these two forms. The bupropion molecule adopts different conformations in the two investigated solid state modifications.
文摘Dear editor,We report a case of a 47-year-old female who presented with a toxic bupropion ingestion leading to cardiac arrest.She initially exhibited a loss of brainstem reflexes in conjunction with burst-suppression pattern on EEG.Burst suppression is an EEG waveform pattern of alternating isoelectric suppressions and high voltage bursts.^([1])
文摘目的:系统评价盐酸安非他酮缓释片和盐酸氟西汀片治疗抑郁症的有效性及安全性,为其临床应用提供依据。方法:计算机检索Cochrane图书馆临床对照试验资料库、Ovid-medline全文数据库、PubMed、Embase、中国期刊全文数据库、万方数字化期刊库、维普数据库和中国生物医学文献数据库中盐酸安非他酮缓释片对比盐酸氟西汀片治疗抑郁症的有效性与安全性的随机对照试验(RCT),提取资料后采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入9项RCT,合计1 106例患者。Meta分析,盐酸安非他酮缓释片与盐酸氟西汀片治疗抑郁症的有效性无明显差异[OR=1.13,95%CI(0.87,1.48),P>0.05];不良反应发生率与盐酸氟西汀片治疗抑郁症比较也无明显差异[OR=1.13,95%CI(0.91,1.41),P>0.05]。结论:盐酸安非他酮缓释片和盐酸氟西汀片治疗抑郁症具有相似的疗效及不良反应。
