“Burnt-Out” Endomyocardial Fibrosis—An Overview

Tropical endomyocardial fibrosis (EMF) is a public health problem affecting the children, young adults and elderly individuals in an epidemic fashion in the coastal districts of south India. Due to lack of resources for research in these endemic areas, its etiology remains elusive and hypotheses ranging from infections and allergic causes to malnutrition and toxins have not been tested rigorously. The disease is characterized by endocardial fibrosis and the right ventricle is the cardiac chamber most frequently affected. Patients may present clinically with heart failure and an associated AV (atrioventricular) valve regurgitation is common. Several features of the advanced disease called as “burnt-out” stage of endomyocardial fibrosis (EMF) are not fully understood. Background of these case studies described the clinical presentation, echocardiographic features and management of this late stage of the disease.

小容量注射剂生产中如何减少“焦头”的产生

目的寻找在小容量注射剂生产中减少"焦头"废品产生的方法。方法将灌封机上的直筒药液灌注针头,改为"三孔"针头。结果使用三孔针头灌注药液,使最终产品中因"焦头"而被剔除的废品率大大降低。结论该设备的选择可提高小容量注射剂的合格率。

某船主机连续机损事故分析

某船主机SULZER 6RLB56仅3个月时间连续发生多起拉缸、活塞头烧损、活塞环卡死等事故。文章参照轮机日志和船员口述,对该船频发事故的原因进行了逐一排查分析,特别是对气口处横向裂纹产生的机理进行了剖析,得出在更换缸套后没有进行必要的磨合以及缺少日常管理的结论。由事故的教训,引发科学管理的的必要性,提出如何预防类似事故发生的具体措施。