Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control.

Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep wells.This paper aims to predict the casing burst strength with considerations of both wear and corrosion.Firstly,the crescent wear shape is simplified into three categories according to common mathematical models.Then,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are obtained.Secondly,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are obtained.At last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is obtained.The results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth growth.The accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded casing.The burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

The GECAM Real-time Burst Alert System

Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM),consisting of two microsatellites,is designed to detect gamma-ray bursts associated with gravitational-wave events.Here,we introduce the real-time burst alert system of GECAM,with the adoption of the BeiDou-3 short message communication service.We present the post-trigger operations,the detailed ground-based analysis,and the performance of the system.In the first year of the in-flight operation,GECAM was triggered by 42 gamma-ray bursts.The GECAM real-time burst alert system has the ability to distribute the alert within~1 minute after being triggered,which enables timely follow-up observations.

Numerical study of plasmas start-up by electron cyclotron waves in NCST spherical tokamak and CN-H1 stellarator

According to the physics of tokamak start-up,this study constructs a zero-dimensional(0D)model applicable to electron cyclotron(EC)wave assisted start-up in NCST spherical torus(spherical tokamak)and CN-H1 stellarators.Using the constructed 0D model,the results obtained in this study under the same conditions are compared and validated against reference results for pure hydrogen plasma start-up in tokamak.The results are in good agreement,especially regarding electron temperature,ion temperature and plasma current.In the presence of finite Ohmic electric field in the spherical tokamak,a study on the EC wave assisted start-up of the NCST plasma at frequency of 28 GHz is conducted.The impact of the vertical magnetic field B_(v)on EC wave assisted start-up,the relationship between EC wave injection power P_(inj),Ohmic electric field E,and initial hydrogen atom density n_(H0)are explored separately.It is found that under conditions of Ohmic electric field lower than ITER(~0.3 V m^(-1)),EC wave can expand the operational space to achieve better plasma parameters.Simulating the process of28 GHz EC wave start-up in the CN-H1 stellarator plasma,the plasma current in the zerodimensional model is replaced with the current in the poloidal coil of the stellarator.Plasma startup can be successfully achieved at injection powers in the hundreds of kilowatts range,resulting in electron densities on the order of 10^(17)-10^(18)m^(-3).

GRB 200612A:An Ultralong Gamma-Ray Burst Powered by Magnetar Spinning Down

GRB 200612A could be classified as an ultralong gamma-ray burst due to its prompt emission lasting up to~1020 s and the true timescale of the central engine activity t_(burst)≥4×10^(4) s.The late X-ray light curve with a decay index ofα=7.53 is steeper than the steepest possible decay from an external shock model.We propose that this X-ray afterglow can be driven by dipolar radiation from the magnetar spindown during its early stage,while the magnetar collapsed into the black hole before its spindown,resulting in a very steep decay of the late X-ray light curve.The optical data show that the light curve is still rising after 1.1 ks,suggesting a late onset.We show that GRB 200612A’s optical afterglow light curve is fitted with the forward shock model by Gaussian structured off-axis jet.This is a special case among GRBs,as it may be an ultralong gamma-ray burst powered by a magnetar in an off-axis observation scenario.

First Digit Distributions of Gamma-Ray Bursts

The occurrence of the first significant digits from real world sources is usually not equally distributed,but is consistent with a logarithmic distribution instead,known as Benford’s law.In this work,we perform a comprehensive investigation on the first digit distributions of the duration,fluence,and energy flux of gamma-ray bursts (GRBs) for the first time.For a complete GRB sample detected by the Fermi satellite,we find that the first digits of the duration and fluence adhere to Benford’s law.However,the energy flux shows a significant departure from this law,which may be due to the fact that a considerable part of the energy flux measurements is restricted by lack of spectral information.Based on the conventional duration classification scheme,we also check if the durations and fluences of long and short GRBs (with duration T_(90)>2 s and T_(90)≤2 s,respectively) obey Benford’s law.We find that the fluences of both long and short GRBs still agree with the Benford distribution,but their durations do not follow Benford’s law.Our results hint that the long–short GRB classification scheme does not directly represent the intrinsic physical classification scheme.

A Comparative Study of the Power-law Relationship between the Pulse width and Energy of Precursor and Main Burst

In gamma-ray burst prompt emission,there is still no consistent conclusion if the precursor and main burst share the same origin.In this paper,we try to study this issue based on the relationship between pulse width and energy of the precursor and main burst.We systematically search the light curve data observed by Swift/BAT and Fermi/GBM,and find 13 long bursts with well-structured precursors and main bursts.After fitting the precursor light curve of each different energy channel with the Norris function,we find that there is not only a power-law relationship between precursor width and energy,but also a power-law relationship between the ratio of the rising width to the decaying width and energy.By comparing the relationship between the precursors and the main burst pulses,we find that the distribution of the precursors and the relationship between the power-law indices are roughly the same as those of the main burst.In addition,it is found that the precursor width distribution as well as the upper limit of the pulse width ratio does not exceed 1 and both are asymmetric,which are also consistent with the main burst.These indicate that the precursor and the main burst are indistinguishable,and the precursor and the main burst may have the same physical origin.

Time-resolved Spectral Properties of Fermi-GBM Bright Long Gamma-Ray Bursts

The prompt emission mechanism of gamma-ray bursts(GRBs)is still unclear,and the time-resolved spectral analysis of GRBs is a powerful tool for studying their underlying physical processes.We performed a detailed time-resolved spectral analysis of 78 bright long GRB samples detected by Fermi/Gamma-ray Burst Monitor.A total of 1490 spectra were obtained and their properties were studied using a typical Band-shape model.First,the parameter distributions of the time-resolved spectrum are given as follows:the low-energy spectral indexα~-0.72,high-energy spectral indexβ~2.42,the peak energy E_(p)~221.69 keV,and the energy flux F~7.49×10^(-6)erg cm^(-2)s^(-1).More than 80%of the bursts exhibit the hardest low-energy spectral indexα_(max),exceeding the synchrotron limit(-2/3).Second,the evolution patterns of a and E_(p)were statistically analyzed.The results show that for multi-pulse GRBs the intensity-tracking pattern is more common than the hard-to-soft pattern in the evolution of both E_(p)andα.The hard-to-soft pattern is generally shown in single-pulse GRBs or in the initial pulse of multi-pulse GRBs.Finally,we found a significant positive correlation between F and E_(p),with half of the samples exhibiting a positive correlation between F andα.We discussed the spectral evolution of different radiation models.The diversity of spectral evolution patterns indicates that there may be more than one radiation mechanism occurring in the GRB radiation process,including photo spheric radiation and synchrotron radiation.However,it may also involve only one radiation mechanism,but more complicated physical details need to be considered.

Simulation Study on Constraining Gravitational Wave Propagation Speed by Gravitational Wave and Gamma-ray Burst Joint Observation on Binary Neutron Star Mergers

Theories of modified gravity suggest that the propagation speed of gravitational waves(GW)v_gmay deviate from the speed of light c.A constraint can be placed on the difference between c and v_gwith a simple method that uses the arrival time delay between GW and electromagnetic wave simultaneously emitted from a burst event.We simulated the joint observation of GW and short gamma-ray burst signals from binary neutron star merger events in different observation campaigns,involving advanced LIGO(aLIGO)in design sensitivity and Einstein Telescope(ET)joint-detected with Fermi/GBM.As a result,the relative precision of constraint on v_gcan reach~10~(-17)(aLIGO)and~10^(-18)(ET),which are one and two orders of magnitude better than that from GW170817,respectively.We continue to obtain the bound of graviton mass m_g≤7.1(3.2)×10~(-20)eV with aLIGO(ET).Applying the Standard-Model Extension test framework,the constraint on v_gallows us to study the Lorentz violation in the nondispersive,nonbirefringent limit of the gravitational sector.We obtain the constraints of the dimensionless isotropic coefficients S_(00)^(4)at mass dimension d=4,which are-1×10^(-15)<S_(00)^(4)<9×10^(-17)for aLIGO and-4×10^(-16)<s_(00)^(4<8<10^(-18))for ET.

Effects of pressure relief holes on coal burst:Insights from true-triaxial unloading tests

Drilling pressure relief is one of the methods to reduce the risk of coal bursts in deep mines.However,the effect of the drill hole orientations has not been studied well enough to understand their impact on the burst failure mechanism.In this study,we investigated two designs of drill hole orientations.The first design includes drill holes located on the upper free face of the rectangular samples and labelled as upper hole(UH)and centre hole(CH)e the long axes of the drill holes are aligned with minor principal stress,s3,direction.The second design includes drill holes at the top(TH)and the side(SH)of the rectangular samples in which the long axes of the drill holes are aligned with the maximum,s1,and intermediate principal stress,s2,directions,respectively.The coal samples with the proposed drill hole orientations were subjected to the true-triaxial unloading coal burst tests.The results show that the drill holes reduce the risk of coal bursts.However,we found that the intensity of coal burst was significantly reduced with the SH-type,followed by the CH-types.We also observed that the coal burst intensity is reduced better for the CH,UH,TH,and SH-type drilling patterns.However,it was found that the orientations of drill holes have little influence on the failure mode(splitting).The acoustic emission(AE)activities for coal with drill holes noticeably decreased,especially for the UH and CH layouts.The drill holes reduced the upper limit of the AE entropy(chaos of microcracks generation).However,regarding reducing the coal burst risk,the TH and SH are less effective than UH and CH.

Multistage hydraulic fracturing of a horizontal well for hard roof related coal burst control:Insights from numerical modelling to field application

Multistage hydraulic fracturing of horizontal wells(MFHW)is a promising technology for controlling coal burst caused by thick and hard roofs in China.However,challenges remain regarding the MFHW control mechanism of coal burst and assessment of the associated fracturing effects.In this study,these challenges were investigated through numerical modelling and field applications,based on the actual operating parameters of MFHW for hard roofs in a Chinese coal mine.A damage parameter(D)is proposed to assess the degree of hydraulic fracturing in the roof.The mechanisms and effects of MFHW for controlling coal burst are analyzed using microseismic(MS)data and front-abutment stress distribution.Results show that the degree of fracturing can be categorized into lightly-fractured(D≤0.3),moderately fractured(0.3<D≤0.6),well-fractured(0.6<D≤0.9),and over-fractured(0.9<D≤0.95).A response stage in the fracturing process,characterized by a slowdown in crack development,indicates the transition to a wellfractured condition.After MFHW,the zone range and peak value of the front-abutment stress decrease.Additionally,MS events shift from near the coal seam to the fractured roof layers,with the number of MS events increases while the average MS energy decreases.The MFHW control mechanisms of coal bursts involve mitigating mining-induced stress and reducing seismic activity during longwall retreat,ensuring stresses remain below the ultimate stress level.These findings provide a reference for evaluating MFHW fracturing effects and controlling coal burst disasters in engineering.

Predicting Rock Burst in Underground Engineering Leveraging a Novel Metaheuristic-Based LightGBM Model

Rock bursts represent a formidable challenge in underground engineering,posing substantial risks to both infrastructure and human safety.These sudden and violent failures of rock masses are characterized by the rapid release of accumulated stress within the rock,leading to severe seismic events and structural damage.Therefore,the development of reliable prediction models for rock bursts is paramount to mitigating these hazards.This study aims to propose a tree-based model—a Light Gradient Boosting Machine(LightGBM)—to predict the intensity of rock bursts in underground engineering.322 actual rock burst cases are collected to constitute an exhaustive rock burst dataset,which serves to train the LightGBMmodel.Two population-basedmetaheuristic algorithms are used to optimize the hyperparameters of the LightGBM model.Finally,the sensitivity analysis is used to identify the predominant factors that may incur the occurrence of rock bursts.The results show that the population-based metaheuristic algorithms have a good ability to search out the optimal hyperparameters of the LightGBM model.The developed LightGBM model yields promising performance in predicting the intensity of rock bursts,with which accuracy on training and testing sets are 0.972 and 0.944,respectively.The sensitivity analysis discloses that the risk of occurring rock burst is significantly sensitive to three factors:uniaxial compressive strength(σc),stress concentration factor(SCF),and elastic strain energy index(Wet).Moreover,this study clarifies the particular impact of these three factors on the intensity of rock bursts through the partial dependence plot.

Turbo Message Passing Based Burst Interference Cancellation for Data Detection in Massive MIMO-OFDM Systems

This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.

High performance micromachining of sapphire by laser induced plasma assisted ablation(LIPAA)using GHz burst mode femtosecond pulses

GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the conventional irradiation scheme of fs laser(single-pulse mode).In this paper,we take advantage of the moderate pulse interval of 205 ps(4.88 GHz)in the burst pulse for high-quality and high-efficiency micromachining of single crystalline sapphire by laser induced plasma assisted ablation(LIPAA).Specifically,the preceding pulses in the burst generate plasma by ablation of copper placed behind the sapphire substrate,which interacts with the subsequent pulses to induce ablation at the rear surface of sapphire substrates.As a result,not only the ablation quality but also the ablation efficiency and the fabrication resolution are greatly improved compared to the other schemes including single-pulse mode fs laser direct ablation,single-pulse mode fs-LIPAA,and nanosecond-LIPAA.

Refinement of the Proposed Gamma-Ray Burst Time Delay Model

This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause of these pondersome time delays is that they are a result of the photon being endowed with a non-zero mass. While we do not rule out the possibility of a non-zero mass for the photon, our working assumption is that the major cause of these time delays may very well be that these photons are travelling in a rarefied cosmic plasma in which the medium’s electrons interact with the electric component of the Photon, thus generating tiny currents that lead to dispersion, hence, a frequency-dependent speed of Light (FDSL). In the present instalment, we “improve” on the model presented in the first instalment by dropping the assumption that the resultant pairs of these radio photons leave the shock front simultaneously. The new assumption of a non-simultaneous— albeit systematic—emission of these photon pairs allows us to obtain a much more convincing and stronger correlation in the time delay. This new correlation allows us to build a unified model for the four GRBs in our sample using a relative distance correction mechanism. The new unified model allows us to obtain as our most significant result a value for the frequency equivalence of the interstellar medium (ISM)’s conductance ν* ~ 1.500 ± 0.009 Hzand also an independent distance measure to the GRBs where we obtain for our four GRB samples an average distance of: ~69.40 ± 0.10, 40.00 ± 0.00, 58.40 ± 0.40, and 86.00 ± 1.00 Mpc, for GRB 030329, 980425, 000418 and 021004 respectively.

一种基于Burst-PWM混合控制的LLC谐振变换器宽电压范围输出策略

LLC谐振变换器一般采用脉冲频率调节(PFM)方式控制输出电压,因此在最大开关频率受限的情况下输出电压范围同样会受到限制。该文提出一种基于突发控制-变占空比控制(Burst-PWM)的混合控制模式以实现LLC变换器的宽电压范围输出。首先分析Burst控制与PWM控制应用在LLC变换器中的特性及其不足之处。采用Burst-PWM混合控制时,PWM控制能够减小Burst开通(Burst-on)时段内谐振腔电流峰值,而Burst控制能够在Burst-on时段内为PWM控制下的开关管提供足够的零电压开通(ZVS)电流。这种方式能够保证变换器在宽电压范围内的特性和稳定性。然后采用状态空间轨迹法给出了谐振腔参数优化设计方法以及确定PWM控制下的最小占空比。最终实验证明了分析的正确性以及所述方法的有效性。

Prediction of rock burst classification using cloud model with entropy weight

The method of cloud model with entropy weight was adopted for the prediction of rock burst classification. Some main factors of rock burst including the uniaxial compressive strength （σc）, the tensile strength （σt）, the tangential stress （σθ）, the rock brittleness coefficient （σc/σt）, the stress coefficient （σθ /σc） and the elastic energy index （Wet） are chosen to establish evaluation index system. The entropy？cloud model and criterion are obtained through 209 sets of rock burst samples from underground rock projects. The sensitivity of indicators is analyzed and 209 sets of rock burst samples are discriminated by this model. The discriminant results of the entropy-cloud model are compared with those of Bayes, KNN and RF methods. The results show that the sensitivity order of those factors from high to low is σ_θ /σ_c, σ_θ, W_（ct）, σ_c/σ_t, σ_t, σ_c, and the entropy-cloud model has higher accuracy than Bayes, K-Nearest Neighbor algorithm （KNN） and Random Forest （RF） methods.

大型时态数据库中的Burst模式挖掘

首先分析了挖掘整个大型时态数据库时可能存在的两个问题,提出了解决的一种新方法。该方法采用“先分后合”的思想:先将大型数据库划分成多个小型数据集,接着对这些数据集进行四次裁剪后再进行综合评价,最后挖掘出潜在的Burst模式。实验结果表明,该方法准确有效。挖掘出的Burst模式给公司决策者在制定决策的时候提供参考帮助和支持。

Mechanism of Oxidative Burst in Tobacco Leaves and Cells Induced by Palmin from Phytophthora palmi

In order to reveal the signaling pathways triggered by elicitor in plant-microbe interactions, the mechanisms of hypersensitive necrosis responses in Nicotiana tabacum L. cv. Gexin III induced by palmin were studied at molecular and cellular level. The burst of superoxide, intercellular diffusion of hydrogen peroxide and process of cell death induced by palmin were investigated in tobacco plants by biochemical methods and Confocal microscopy. The results showed that a large amount of O-2(.-) was rapidly generated in tobacco cell elicited by palmin as a result of activation of NADPH oxidase, and the O-2(.-) was dismutated into H2O2 immediately by superoxide dismutase (SOD). Accumulation and intercellular diffusion of H2O2 were shown to be a trigger for hypersensitive cell death; and Ca2+ and some specific protein kinase were also shown to be involved in the activation of oxidative burst in tobacco cell induced by palmin.

用Burst技术改善CINRAD/SA天气雷达相位噪声

为了改善系统相位噪声及地物杂波抑制能力,对国内部分CINRAD/SA天气雷达实施了Burst技术改造,以减少和消除发射信号相位抖动的影响。为了检验CINRAD/SA天气雷达在Burst技术改造后相位噪声及地物杂波抑制能力的改善效果,采用理论分析、性能测试和回波数据分析等方法对性能进行了测试。检验结果表明,Burst技术改造后CINRAD/SA天气雷达系统的相位噪声降低约0.05°,地物杂波抑制能力提高到55dB以上,相位噪声及地物杂波抑制能力改善较明显,可作为其他型号天气雷达技术改造的良好借鉴。