Charles C.Fries一般被认为是美国结构主义语言学家,当代理论语言学往往也往往将Fries的贡献集中在结构主义语言学领域,对他在功能语言学领域的影响较少提及。本文从Fries的语言交际观、信号语法、语言意义研究、语料收集和语境研究等...Charles C.Fries一般被认为是美国结构主义语言学家,当代理论语言学往往也往往将Fries的贡献集中在结构主义语言学领域,对他在功能语言学领域的影响较少提及。本文从Fries的语言交际观、信号语法、语言意义研究、语料收集和语境研究等方面入手,对比结构主义语言学并参照功能语言学进行梳理分析,认为Fries的语言研究在很多方面都蕴含功能主义思想,具有功能主义特色。通过对Fries的语言观的分析,对其语言研究所属的理论流派重新定位,旨在使人们对Fries的语言学思想及美国语言学发展史有深入全面的认识。展开更多
In recent years great progress has been made in developing refractories to replace som imported ones for C.C. in Baogang.Mean-while,many new products have also bee devel-oped to meet the demand of C.C. production in ...In recent years great progress has been made in developing refractories to replace som imported ones for C.C. in Baogang.Mean-while,many new products have also bee devel-oped to meet the demand of C.C. production in Baogang on the basis of Chinese conditions ,This paper presents the refractories products and their quality,application for C.C. steel ladles,refining devices,tundish and compares them with those imported ones.展开更多
Objective: To conduct clinical, genetic, and molecular diagnostics of two sisters with typical symptoms of complete androgen insensitivity syndrome. Design: Case report. Setting: Research laboratory at a university of...Objective: To conduct clinical, genetic, and molecular diagnostics of two sisters with typical symptoms of complete androgen insensitivity syndrome. Design: Case report. Setting: Research laboratory at a university of medical science. Patient(s): Two patients with 46,XY karyotype and a female phenotype were diagnosed because of primary amenorrhea. Their sister with 46,XX karyotype, her daughter, and five other family members including their mother also were examined. Intervention(s): Orchiectomy, estrogen substitution therapy. Main Outcome Measure(s): Cancer prophylaxis. Result(s): Multiple-temperature single-stranded conformation polymorphism and sequence analyses of the androgen receptor gene(AR) revealed a c.C2812T transition in exon 7 in the two sisters. Their mother and the third sister(46,XX) were carriers of the same mutation. This mutation, which previously had never been reported, resulted in Pro817Leu substitution in the ligand-binding domain of the androgen. Computer simulation of structural changes generated by Pro817Leu substitution revealed appreciable conformational changes in the region responsible for dimerization of the receptor. Conclusion(s): The novel c.C2812T transition that might impair dimerization of the receptor is responsible for the clinical symptoms of complete androgen insensitivity syndrome in the affected individuals. Molecular analysis of AR proved to be very useful for genetic counseling of the unaffected sister, who was a carrier of the same mutation.展开更多
文摘In recent years great progress has been made in developing refractories to replace som imported ones for C.C. in Baogang.Mean-while,many new products have also bee devel-oped to meet the demand of C.C. production in Baogang on the basis of Chinese conditions ,This paper presents the refractories products and their quality,application for C.C. steel ladles,refining devices,tundish and compares them with those imported ones.
文摘Objective: To conduct clinical, genetic, and molecular diagnostics of two sisters with typical symptoms of complete androgen insensitivity syndrome. Design: Case report. Setting: Research laboratory at a university of medical science. Patient(s): Two patients with 46,XY karyotype and a female phenotype were diagnosed because of primary amenorrhea. Their sister with 46,XX karyotype, her daughter, and five other family members including their mother also were examined. Intervention(s): Orchiectomy, estrogen substitution therapy. Main Outcome Measure(s): Cancer prophylaxis. Result(s): Multiple-temperature single-stranded conformation polymorphism and sequence analyses of the androgen receptor gene(AR) revealed a c.C2812T transition in exon 7 in the two sisters. Their mother and the third sister(46,XX) were carriers of the same mutation. This mutation, which previously had never been reported, resulted in Pro817Leu substitution in the ligand-binding domain of the androgen. Computer simulation of structural changes generated by Pro817Leu substitution revealed appreciable conformational changes in the region responsible for dimerization of the receptor. Conclusion(s): The novel c.C2812T transition that might impair dimerization of the receptor is responsible for the clinical symptoms of complete androgen insensitivity syndrome in the affected individuals. Molecular analysis of AR proved to be very useful for genetic counseling of the unaffected sister, who was a carrier of the same mutation.
