Objective The aim of the present study mas to compare the gender difference for cadmium-induced renal tubular dysfunction between the male and female inhabitants. Methods Urinary β2-microglobulin was measured in 299 ...Objective The aim of the present study mas to compare the gender difference for cadmium-induced renal tubular dysfunction between the male and female inhabitants. Methods Urinary β2-microglobulin was measured in 299 male (94%) and 342 female (92%) inhabitants aged 54-72 years,and the development of renal tubular dysfunction for 11 years was studied in the 62 married couples from them. Results A significantly higher cumulative incidence was found in both men and women in cadmium-polluted area,showing 68. 4% in men and 64. 8% in women compared to 15. 3% in men and 5. 9% in women in the reference areas. Relative risk of renal tubular dysfunction in females (11. 0) was higher than males (4. 5). The ratios of urinary β2-microglobulin and glucose were higher in women than those in men in both the cadmium-polluted areas and the reference areas. Conclusion Although almost identical incidences were detected between men and women, the changes in excretion of β2-microglobulin and glucose was greater in women than those in men. These findings suggest that renal tubular dysfunction might be more progressive in women than that in men.展开更多
基金Supported by Grant-in-Aid for Scientific Research from the Ministry of Education,Japan(B.09480121)
文摘Objective The aim of the present study mas to compare the gender difference for cadmium-induced renal tubular dysfunction between the male and female inhabitants. Methods Urinary β2-microglobulin was measured in 299 male (94%) and 342 female (92%) inhabitants aged 54-72 years,and the development of renal tubular dysfunction for 11 years was studied in the 62 married couples from them. Results A significantly higher cumulative incidence was found in both men and women in cadmium-polluted area,showing 68. 4% in men and 64. 8% in women compared to 15. 3% in men and 5. 9% in women in the reference areas. Relative risk of renal tubular dysfunction in females (11. 0) was higher than males (4. 5). The ratios of urinary β2-microglobulin and glucose were higher in women than those in men in both the cadmium-polluted areas and the reference areas. Conclusion Although almost identical incidences were detected between men and women, the changes in excretion of β2-microglobulin and glucose was greater in women than those in men. These findings suggest that renal tubular dysfunction might be more progressive in women than that in men.
