目的探讨应用头孢曲松的患者血浆头孢曲松浓度与血清钙浓度变化的相关性。方法收集2020年11月至2021年8月应用头孢曲松的75例患者临床资料,其中男60例、女15例。根据用药前后血清钙浓度的变化将患者分为降低组(n=57)和非降低组(n=18),应...目的探讨应用头孢曲松的患者血浆头孢曲松浓度与血清钙浓度变化的相关性。方法收集2020年11月至2021年8月应用头孢曲松的75例患者临床资料,其中男60例、女15例。根据用药前后血清钙浓度的变化将患者分为降低组(n=57)和非降低组(n=18),应用HPLC法检测血浆头孢曲松稳态谷浓度。比较各组临床资料并进行Logistic回归分析,以明确头孢曲松血浆浓度对血清钙降低的影响。结果降低组患者血浆头孢曲松浓度水平显著高于非降低组[102.99(85.64,160.20)μg/mL vs 46.69(35.46,56.35)μg/mL,P<0.05]。受试者工作曲线显示,血浆头孢曲松浓度预测血清钙浓度降低的最佳截断值为65.83μg/mL,灵敏度为100%,特异度为83.3%。结论血浆头孢曲松浓度水平与血清钙浓度变化相关,高浓度的头孢曲松是影响血清钙浓度降低的独立风险因素。展开更多
Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associate...Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as microglia, astrocytes and oligodendrocytes, have also been demon- strated to take part in the process of secondary injury. Partial optic nerve transection is a useful model which was established about 13 years ago. The merit of this model compared with other optic nerve injury models used for glaucoma study, including complete optic nerve transection model and optic nerve crush model, is the possibility to separate primary degeneration from secondary degeneration in location. Therefore, it provides a good tool for the study of secondary degeneration. This review will focus on the research progress of the mechanisms of secondary degeneration using partial optic nerve transection model.展开更多
Calcium hexaluminate （ CA6 ） was synthesized by mixing light-weight calcium carbonate and Al2O3 mi- cropowder （calcined α-Al2O3, activated α-Al2O3 or α-Al2O3） according to the stoichimetric ratio of CA6, and ...Calcium hexaluminate （ CA6 ） was synthesized by mixing light-weight calcium carbonate and Al2O3 mi- cropowder （calcined α-Al2O3, activated α-Al2O3 or α-Al2O3） according to the stoichimetric ratio of CA6, and reaction sintering at 1 200, 1 300, 1 400 and 1 500 ℃fin 3 h, respectiely. Efcts of the three alu- mina micropowders on the phase composition, micro- structure and properties of CA were investigated. The re- sults show that ： （ 1 ） for the three Al2O3 micropowders, the reaction to generate CA6 in specimens basically com- plete. at about 1 500 ℃ ; CA6 generated in all specimens is planar, bat the array modes are slightly different; （2） the specimel＇s prepared from, calcined α-Al2O3or ρ-Al2O3 shrink almost, while the specimens prepared from activated α-Al2O3 expand ; （ 3 ） the cold crushing strength of the specimen prepared from activated α-Al2O3 is the highest, reaching 42.5 MPa when only CA6 exists （ after firing at 1 500 ℃ ） ; （ 4 ） the specimen prepared from ρ-Al2O3 has the lowest generation temperature of CA6 and the highest apparent porosity, reaching 70. 1% when only CA exists （after firing at 1 500 ℃）; （5） the specimen prepared from calcined α-Al2O3 has the biggest bulk density.展开更多
文摘目的探讨应用头孢曲松的患者血浆头孢曲松浓度与血清钙浓度变化的相关性。方法收集2020年11月至2021年8月应用头孢曲松的75例患者临床资料,其中男60例、女15例。根据用药前后血清钙浓度的变化将患者分为降低组(n=57)和非降低组(n=18),应用HPLC法检测血浆头孢曲松稳态谷浓度。比较各组临床资料并进行Logistic回归分析,以明确头孢曲松血浆浓度对血清钙降低的影响。结果降低组患者血浆头孢曲松浓度水平显著高于非降低组[102.99(85.64,160.20)μg/mL vs 46.69(35.46,56.35)μg/mL,P<0.05]。受试者工作曲线显示,血浆头孢曲松浓度预测血清钙浓度降低的最佳截断值为65.83μg/mL,灵敏度为100%,特异度为83.3%。结论血浆头孢曲松浓度水平与血清钙浓度变化相关,高浓度的头孢曲松是影响血清钙浓度降低的独立风险因素。
基金supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(HKU 776109M)supported by the Fundamental Research Funds for the Central Universities Grant 21609101
文摘Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as microglia, astrocytes and oligodendrocytes, have also been demon- strated to take part in the process of secondary injury. Partial optic nerve transection is a useful model which was established about 13 years ago. The merit of this model compared with other optic nerve injury models used for glaucoma study, including complete optic nerve transection model and optic nerve crush model, is the possibility to separate primary degeneration from secondary degeneration in location. Therefore, it provides a good tool for the study of secondary degeneration. This review will focus on the research progress of the mechanisms of secondary degeneration using partial optic nerve transection model.
文摘Calcium hexaluminate （ CA6 ） was synthesized by mixing light-weight calcium carbonate and Al2O3 mi- cropowder （calcined α-Al2O3, activated α-Al2O3 or α-Al2O3） according to the stoichimetric ratio of CA6, and reaction sintering at 1 200, 1 300, 1 400 and 1 500 ℃fin 3 h, respectiely. Efcts of the three alu- mina micropowders on the phase composition, micro- structure and properties of CA were investigated. The re- sults show that ： （ 1 ） for the three Al2O3 micropowders, the reaction to generate CA6 in specimens basically com- plete. at about 1 500 ℃ ; CA6 generated in all specimens is planar, bat the array modes are slightly different; （2） the specimel＇s prepared from, calcined α-Al2O3or ρ-Al2O3 shrink almost, while the specimens prepared from activated α-Al2O3 expand ; （ 3 ） the cold crushing strength of the specimen prepared from activated α-Al2O3 is the highest, reaching 42.5 MPa when only CA6 exists （ after firing at 1 500 ℃ ） ; （ 4 ） the specimen prepared from ρ-Al2O3 has the lowest generation temperature of CA6 and the highest apparent porosity, reaching 70. 1% when only CA exists （after firing at 1 500 ℃）; （5） the specimen prepared from calcined α-Al2O3 has the biggest bulk density.
