Recent advances in hydrothermal modification of calcium phosphorus coating on magnesium alloy

Magnesium(Mg) and its alloys have emerged as a favored candidate for bio-regenerative medical implants due to their superior biocompatibility, biodegradability and the elastic modulus close to that of human bone. Unfortunately, the rapid and uncontrollable degradation rate of Mg alloys in chloride-rich body microenvironments limits their clinical orthopedic applications. Recently, Calcium Phosphate(Ca-P)biomaterials, especially Hydroxyapatite(HA), have been broadly applied in the surface functional modification of metal-based biomaterials attributed to their excellent bioactivity and biocompatibility. Hydrothermal modification of Ca-P coatings on Mg alloys has been extensively exploited by researchers for its significant superiorities in controlling coating structure and improving interfacial bonding strength for better osseointegration and corrosion resistance. This work focuses on the up-to-the-minute advances in Ca-P coatings on the surface of Mg and its alloys via hydrothermal methods, including the strategies and mechanisms of hydrothermal modification. Herein, we are inclined to share some feasible and attractive hydrothermal surface modification strategies. From the perspectives of hydrothermal manufacturing technique innovation and coating structure optimization, we evaluate how to foster the corrosion resistance, coating bonding strength, osseointegration and antibacterial properties of Mg alloys with Ca-P coatings synthesized by hydrothermal method. The challenges and future perspectives on the follow-up exploration of Mg alloys for orthopedic applications are also elaborately proposed.

Correlation between Metroptosis Pathogenesis of Buffalo and Contents of Serum Calcium,Phosphorus and Antioxidation Levels

[Objective] The paper was to study the metroptosis pathogenesis of dairy buffalo.[Method]A total of 53 dairy buffaloes were selected to detect serum calcium,phosphorus,malondialdehyde（MDA） and total antioxidant capacity（TAC） levels.Dairy buffaloes were divided into metroptosis group（M） and healthy control group（UM） according to metroptosis situations of buffalo.The correlation between metroptosis of buffalo and calcium,phosphorus and oxidation/antioxidation levels in plasma was analyzed.[Result] The contents of serum calcium and phosphorus and oxidation/antioxidation level of dairy buffalo at the prenatal week and the calving day in M group were significantly lower than that in UM group.The TAC level of dairy buffalo in M group from the first three weeks to the calving day was significantly lower than that in UM group.The MDA level in M group was significantly higher than that in UM group.[Conclusion] The occurrence of postpartum metroptosis in buffalo was related to insufficient levels of calcium and phosphorus in prepartum buffalo,declined total antioxidation capacity and accumulation of peroxide products.

Long-Term Animal Feeding Trial of the Refined Konjac Meal Ⅰ. Effects of the Refined Konjac Meal on the Calcium and Phosphorus Metabolism and the Bone in Rat

Effects of refined konjac meal (RKM) on the calcium and phosphorus metabolism and bone parameters were observed in rats of both sexes fed with food containing 1% of RKM for 18 months. A comparable group of rats fed on basic diet only was used as a control.Results obtained indicate that all the measured parameters (serum calcium and phosphorus level, femur weight and its calcium and phesphorus content, and the osteometry of the tibia) showed no significant difference between the experimental and the control groups.Thus there is no adverse effect either on the calcium and phosphorus metabolism or on the bone after a long-term intake at a moderate dosage.

乳腺癌放疗对甲状腺功能和钙磷离子水平的影响

目的:通过对比乳腺癌术后锁骨上区放疗前后甲状腺、甲状旁腺功能,甲状腺超声和钙磷离子的变化,探讨放疗对甲状腺损伤的影响因素。方法:选取甘肃省肿瘤医院放疗科2015年1月至2017年1月收治的120例分期为Ⅱ、Ⅲ期,且具有术后放疗适应证的女性乳腺癌患者,分别在放疗前、放疗结束、放疗结束后1个月、6个月、12个月、24个月检查甲状腺、甲状旁腺功能,甲状腺超声和钙磷离子水平。结果:放疗结束、放疗结束后1和6个月三碘甲状腺原氨酸(T3)[(2.01±0.33)nmol/L、(2.05±0.39)nmol/L、(2.05±0.27)nmol/L]与放疗前相比明显减低,差异有统计学意义(P<0.05);放疗结束后1个月血清游离甲状腺激素(FT4)[(13.63±1.67)pmol/L]与放疗前比较明显降低,差异有统计学意义(P<0.05);放疗结束12个月后甲状腺过氧化物酶抗体(A-TPO)[(5.38±0.73)IU/L]与放疗前比较明显降低,差异有统计学意义(P<0.05);放疗结束12个月后患者钙离子检测有下降趋势,磷离子和甲状旁腺激素无明显变化;甲状腺结节与结节附近丰富血流比例在放疗结束6个月后减少较明显。结论:乳腺癌术后锁骨上区放疗对甲状腺、甲状旁腺功能有影响,但影响有限,随时间延长,甲减风险增高;对甲状旁腺和磷离子无明显影响;钙离子放疗结束12个月后有降低趋势;放疗结束6个月后甲状腺结节和血流减少明显。

Component changes of calcium and phosphorus in osteogenesis by lengthening procedures in adult canines

Objective: To explore chemical component changes of dog bone at different lengthening time and in different bone regions of interest, and to evaluate the mineralization during Ilizarov lengthening process. Methods: The ash weight, the concentrations of calcium, phosphorus and the calcium/phosphorus ratio were measured at different intervals (2, 4, 6, 8, 12 weeks) since lengthening and the lengthened part was compared with a control area at each interval. Results: The ash weight, the concentrations of calcium and phosphorus in the lengthened area differed at all development time. The calcium/phosphorus (Ca/P) ratio in the lengthened region remained significantly lower than that in the control region up to 12 weeks after the lengthening. Conclusions: These results suggest that also other inorganic ions play an important role in the mineralization process and that they become relatively more important since 8 weeks after the lengthening.

Research Progresses on Physiological Functions of Vitamin D

Vitamin D is a fat soluble vitamin that is foundin a variety of forms , amongwhich 1,25-（0H） 2D3 is themain active form. It not only exhibits a major physiological function to regulate the metabolism of calcium and phosphorus, but also relates to the prevention and treatment of a variety of diseases such as lung diseases, cancers, diabetes, tuberculosis, lupus erythematosus, autoimmune diseases and liver damage. In this paper, the latest research progresses of the physiological function of vitamin D were summarized and discussed, aiming at providing the solid basis for utilization and application of vitamin D.

Early Diagnosis and Prevention of Osteodystrophy in Perinatal Cow

Hydroxyproline is the main component of collagen,accounting for 20% or so of collagen,and metabolic changes in bone collagen directly affect the level of hydroxyproline in the blood.So inspecting the content of hydroxyproline is very important for pathogenesis and prophylactico-therapeutic measures on osteodystrophy of dairy cows.This experiment monitored and studied the change regularity of serum calcium,serum phosphorus and serum free hydroxyproline of perinatal cow in Hebei Province,and discussed a new and early diagnosis way for osteodystrophy.Thus,effective control measures could be implemented before the bone became deformed without any clinical symptom.The paper provided a theoretical foundation for early diagnosis of perinatal cow.