BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)199.Therefore,tumor ...BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)199.Therefore,tumor markers in T2DM are important.AIM To evaluate the expression of serum tumor markers[CA199,CA242,and carcinoembryonic antigen(CEA)]and the clinical implications of the expression in T2DM.METHODS For this observational study conducted at Hefei BOE Hospital,China,we enrolled 82 patients with first-onset T2DM and 51 controls between April 2019 and December 2020.Levels of fasting blood glucose(FBG),tumor markers(CA199,CEA,and CA242),glycosylated hemoglobin(HbA1c),etc.were measured and group index levels were compared.Moreover,FBG and HbA1c levels were correlated with tumor marker levels.Tumor markers were tested for diagnostic accuracy in patients with>9%HbA1c using the receiver operating curve(ROC)curve.RESULTS The T2DM group had high serum FBG,HbA1c,CA199,and CEA levels(P<0.05).A comparative analysis of the two groups based on HbA1c levels(Group A:HbA1c≤9%;Group B:HbA1c>9%)revealed significant differences in CEA and CA199 levels(P<0.05).The areas under the ROC curve for CEA and CA199 were 0.853 and 0.809,respectively.CA199,CEA,and CA242 levels positively correlated with HbA1c(r=0.308,0.426,and 0.551,respectively)and FBG levels(r=0.236,0.231,and 0.298,respectively).CONCLUSION As compared to controls,serum CEA and CA199 levels were higher in patients with T2DM.HbA1c and FBG levels correlated with CA199,CEA,and CA242 levels.Patients with poorly controlled blood sugar must be screened for tumor markers.展开更多
目的探讨甲状腺癌患者血清糖类抗原242(CA242)在甲状腺癌中的临床应用价值,为甲状腺癌的诊疗提供参考。方法筛选141例分化型甲状腺癌患者(甲状腺癌组)、82例甲状腺结节患者(甲状腺结节组)作为研究对象,24例健康查体者作为对照组,应用康...目的探讨甲状腺癌患者血清糖类抗原242(CA242)在甲状腺癌中的临床应用价值,为甲状腺癌的诊疗提供参考。方法筛选141例分化型甲状腺癌患者(甲状腺癌组)、82例甲状腺结节患者(甲状腺结节组)作为研究对象,24例健康查体者作为对照组,应用康乃格试剂采用ELISA方法检测各组CA242,比较各组受试者间的血清CA242水平,分析血清CA242对甲状腺癌诊断的特异性、灵敏度、阳性预测值、阴性预测值,并绘制受试者工作特征曲线(receiver operating characteristic curve,ROC),分析CA242的临床价值。结果甲状腺癌组血清CA242水平高于甲状腺结节组和健康对照组,差异具有统计学意义(P<0.05)。CA242对甲状腺癌诊断的灵敏度为29.8%、特异性为92.7%、阳性预测值87.5%、阴性预测值为43.4%,ROC曲线结果显示,曲线下面积(area under the curve,AUC)为0.626,差异具有统计学意义(P<0.05)。随访中,2例CA242升高的甲状腺结节患者经组织细胞学检查确诊为甲状腺癌。结论对于甲状腺结节患者,B超检查为主要手段,同时结合血CA242检测作为补充,可助于甲状腺癌的诊断。展开更多
文摘BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)199.Therefore,tumor markers in T2DM are important.AIM To evaluate the expression of serum tumor markers[CA199,CA242,and carcinoembryonic antigen(CEA)]and the clinical implications of the expression in T2DM.METHODS For this observational study conducted at Hefei BOE Hospital,China,we enrolled 82 patients with first-onset T2DM and 51 controls between April 2019 and December 2020.Levels of fasting blood glucose(FBG),tumor markers(CA199,CEA,and CA242),glycosylated hemoglobin(HbA1c),etc.were measured and group index levels were compared.Moreover,FBG and HbA1c levels were correlated with tumor marker levels.Tumor markers were tested for diagnostic accuracy in patients with>9%HbA1c using the receiver operating curve(ROC)curve.RESULTS The T2DM group had high serum FBG,HbA1c,CA199,and CEA levels(P<0.05).A comparative analysis of the two groups based on HbA1c levels(Group A:HbA1c≤9%;Group B:HbA1c>9%)revealed significant differences in CEA and CA199 levels(P<0.05).The areas under the ROC curve for CEA and CA199 were 0.853 and 0.809,respectively.CA199,CEA,and CA242 levels positively correlated with HbA1c(r=0.308,0.426,and 0.551,respectively)and FBG levels(r=0.236,0.231,and 0.298,respectively).CONCLUSION As compared to controls,serum CEA and CA199 levels were higher in patients with T2DM.HbA1c and FBG levels correlated with CA199,CEA,and CA242 levels.Patients with poorly controlled blood sugar must be screened for tumor markers.
文摘目的探讨甲状腺癌患者血清糖类抗原242(CA242)在甲状腺癌中的临床应用价值,为甲状腺癌的诊疗提供参考。方法筛选141例分化型甲状腺癌患者(甲状腺癌组)、82例甲状腺结节患者(甲状腺结节组)作为研究对象,24例健康查体者作为对照组,应用康乃格试剂采用ELISA方法检测各组CA242,比较各组受试者间的血清CA242水平,分析血清CA242对甲状腺癌诊断的特异性、灵敏度、阳性预测值、阴性预测值,并绘制受试者工作特征曲线(receiver operating characteristic curve,ROC),分析CA242的临床价值。结果甲状腺癌组血清CA242水平高于甲状腺结节组和健康对照组,差异具有统计学意义(P<0.05)。CA242对甲状腺癌诊断的灵敏度为29.8%、特异性为92.7%、阳性预测值87.5%、阴性预测值为43.4%,ROC曲线结果显示,曲线下面积(area under the curve,AUC)为0.626,差异具有统计学意义(P<0.05)。随访中,2例CA242升高的甲状腺结节患者经组织细胞学检查确诊为甲状腺癌。结论对于甲状腺结节患者,B超检查为主要手段,同时结合血CA242检测作为补充,可助于甲状腺癌的诊断。
