Cancer related depression(CRD)refers to the significant and lasting depression of the patient due to tumor diagnosis,treatment and comorbidities.It can be attributed to the category of“stagnation syndrome”in traditi...Cancer related depression(CRD)refers to the significant and lasting depression of the patient due to tumor diagnosis,treatment and comorbidities.It can be attributed to the category of“stagnation syndrome”in traditional Chinese medicine(TCM).Clinically,cancer-related depression can be divided into three stages,namely primary,middle and final stages by analogy with depression syndrome.The location of the initial disease is in the liver.The main syndrome was excess,while the basic pathogenesis is mainly due to liver-qi stagnation syndrome and the principle of treatment is dispersing stagnated liver qi for relieving qi stagnation by using modified Xiaoyao Powder and Chaihu Shugan Powder.In the middle stage of the disease,the location is in the spleen and stomach.The main syndrome was intermingled deficiency and excess.The principle of treatment is relaxing bowels,dissipating phlegm and eliminating dampness,regulating qi-flowing and promoting blood,invigorating spleen and heart,nourishing qi and blood.Xuefuzhuyu tang,Guipi decotion,Bailongjieyu granules can be used as treatment for this period.At the final stage of the disease,the main syndrome was deficiency,the principle of treatment is replenishing lung and heart,benefiting qi and regulating spleen,nourishing lung and kidney.Baihe formulas,Kai-Xin-San are chosed at this stage.展开更多
目的:系统评价甘麦大枣汤治疗肿瘤相关性抑郁的临床疗效。方法:计算机检索中国知网、万方数据数据库、维普数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science等数据库,收集自建库起至2023年6月30日有关甘麦大...目的:系统评价甘麦大枣汤治疗肿瘤相关性抑郁的临床疗效。方法:计算机检索中国知网、万方数据数据库、维普数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science等数据库,收集自建库起至2023年6月30日有关甘麦大枣汤治疗肿瘤相关性抑郁的随机对照临床试验文献,使用Review Manager 5.4.1软件进行Meta分析。结果:本研究共纳入10篇文献,包含739例患者,观察组370例,对照组369例。Meta分析结果显示,经甘麦大枣汤治疗后,观察组有效率高于对照组[OR=1.91,95%CI(1.07,3.40),P=0.03];观察组汉密尔顿抑郁量表评分低于对照组[MD=-8.17,95%CI(-13.12,-3.22),P=0.001];观察组抑郁自评量表评分低于对照组[MD=-17.45,95%CI(-23.18,-11.72),P<0.0001];观察组CD3^(+)水平高于对照组[MD=9.85,95%CI(8.75,10.94),P<0.00001];观察组CD4^(+)水平高于对照组[MD=5.85,95%CI(3.14,8.56),P<0.0001];观察组CD8^(+)水平低于对照组[MD=-4.82,95%CI(-6.45,-3.18),P<0.00001];观察组与对照组CD4^(+)/CD8^(+)比较,差异无统计学意义[MD=0.31,95%CI(-0.12,0.75),P=0.16];观察组自然杀伤细胞水平高于对照组[MD=34.26,95%CI(20.52,47.99),P<0.00001];观察组生活质量评分高于对照组[MD=12.14,95%CI(10.76,13.51),P<0.00001]。结论:甘麦大枣汤治疗肿瘤相关性抑郁疗效显著,能改善患者的抑郁状态,提高免疫水平及生活质量。展开更多
目的探讨规范化心理护理对鼻咽癌患者的癌因性疲乏(cancer related fatigue,CRF)、焦虑及抑郁状态的干预作用。方法以2019年12月至2021年12月兰州大学第二医院放疗科收治的需进行放射性治疗的148名鼻咽癌患者为研究对象,采取随机数字表...目的探讨规范化心理护理对鼻咽癌患者的癌因性疲乏(cancer related fatigue,CRF)、焦虑及抑郁状态的干预作用。方法以2019年12月至2021年12月兰州大学第二医院放疗科收治的需进行放射性治疗的148名鼻咽癌患者为研究对象,采取随机数字表法分为试验组和对照组,对照组予以常规护理,试验组在常规护理基础上采用规范化心理护理干预。比较两组患者入院后24 h、出院前24 h、出院后3个月时CRF程度、焦虑及抑郁状态。结果放疗前两组CRF程度、焦虑及抑郁状态量表评分比较无统计学意义(P>0.05),出院前24 h试验组患者的焦虑及抑郁量表评分均低于对照组(P<0.05),出院后3个月时试验组患者的CRF程度、焦虑及抑郁量表评分均低于对照组,差异均有统计学意义(P<0.05)。结论全程的规范化心理护理能有效改善鼻咽癌患者的焦虑及抑郁状态与CRF程度,这为临床中鼻咽癌患者的心理护理提供了新的方向。展开更多
基金National natural science foundation of China(No.81673797)。
文摘Cancer related depression(CRD)refers to the significant and lasting depression of the patient due to tumor diagnosis,treatment and comorbidities.It can be attributed to the category of“stagnation syndrome”in traditional Chinese medicine(TCM).Clinically,cancer-related depression can be divided into three stages,namely primary,middle and final stages by analogy with depression syndrome.The location of the initial disease is in the liver.The main syndrome was excess,while the basic pathogenesis is mainly due to liver-qi stagnation syndrome and the principle of treatment is dispersing stagnated liver qi for relieving qi stagnation by using modified Xiaoyao Powder and Chaihu Shugan Powder.In the middle stage of the disease,the location is in the spleen and stomach.The main syndrome was intermingled deficiency and excess.The principle of treatment is relaxing bowels,dissipating phlegm and eliminating dampness,regulating qi-flowing and promoting blood,invigorating spleen and heart,nourishing qi and blood.Xuefuzhuyu tang,Guipi decotion,Bailongjieyu granules can be used as treatment for this period.At the final stage of the disease,the main syndrome was deficiency,the principle of treatment is replenishing lung and heart,benefiting qi and regulating spleen,nourishing lung and kidney.Baihe formulas,Kai-Xin-San are chosed at this stage.
