BACKGROUND The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not clear.AIM To explore the role of epinephrine in the treatment of pulp capping in patients with reversible...BACKGROUND The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not clear.AIM To explore the role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis.METHODS A total of 100 patients with reversible pulpitis who were treated in Anhui Jieshou People's Hospital from January 2020 to December 2021 were included in the study.They were categorized into an observation group(n=50;treatment with adrenaline)and a control group(n=50;treatment with zinc oxide eugenol paste).The 24-h postoperative pain,regression time of gingival congestion and redness,clinical efficacy,and incidence of adverse reactions were compared between the groups.Patients were further categorized into the ineffective and effective treatment groups based on clinical efficacy.Logistic multiple regression analysis explored factors affecting the efficacy of pulp capping treatment.RESULTS A significant difference in 24-h postoperative pain was observed between the groups(P<0.05),with a higher proportion of grade I pain noted in the observation group than in the control group(P<0.01).The regression time of gingival congestion and swelling was lower in the observation group(2.61±1.44 d and 2.73±1.36 d,respectively)than in the control group(3.85±1.47 d and 4.28±1.61 d,respectively)(P<0.05).The 2-wk postoperative total effective rate was lower in the control group(80.00%)than in the observation group(94.00%)(P<0.05).The incidence of adverse reactions was not significantly different between the control(14.00%)and observation(12.00%)groups(P>0.05).The proportion of adrenaline usage was lower(P<0.05)and that of anaerobic digestion by Streptococcus and Fusobacterium nucleatum was higher in the ineffective treatment group than in the effective treatment group(P<0.05).Logistic multiple regression analysis revealed adrenaline as a protective factor(P<0.05)and anaerobic digestion by Streptococcus and F.nucleatum as risk factors for pulp capping in reversible pulpitis(P<0.05).CONCLUSION Adrenaline demonstrated therapeutic efficacy in pulp capping treatment for reversible pulpitis,reducing pain and improving clinical symptoms safely.It is a protective factor for pulp capping,whereas Streptococcus and F.nucleatum are risk factors.Targeted measures can be implemented to improve clinical efficacy.展开更多
Based on seismic,drilling,and source rock analysis data,the petroleum geological characteristics and future exploration direction of the oil-rich sags in the Central and West African Rift System(CWARS)are discussed.Th...Based on seismic,drilling,and source rock analysis data,the petroleum geological characteristics and future exploration direction of the oil-rich sags in the Central and West African Rift System(CWARS)are discussed.The study shows that the Central African Rift System mainly develops high-quality lacustrine source rocks in the Lower Cretaceous,and the West African Rift System mainly develops high-quality terrigenous organic matter-rich marine source rocks in the Upper Cretaceous,and the two types of source rocks provide a material basis for the enrichment of oil and gas in the CWARS.Multiple sets of reservoir rocks including fractured basement and three sets of regional cap rocks in the Lower Cretaceous,the Upper Cretaceous,and the Paleogene are developed in the CWARS.Since the Late Mesozoic,due to the geodynamic factors including the dextral strike-slip movement of the Central African Shear Zone,the basins in different directions of the CWARS differ in terms of rifting stages,intervals of regional cap rocks,trap types and accumulation models.The NE-SW trending basins have mainly preserved one stage of rifting in the Early Cretaceous,with regional cap rocks developed in the Lower Cretaceous strata,forming traps of reverse anticlines,flower-shaped structures and basement buried hill,and two types of hydrocarbon accumulation models of"source and reservoir in the same formation,and accumulation inside source rocks"and"up-source and down-reservoir,and accumulation below source rocks".The NW–SE basins are characterized by multiple rifting stages superimposition,with the development of regional cap rocks in the Upper Cretaceous and Paleogene,forming traps of draping anticlines,faulted anticlines,antithetic fault blocks and the accumulation model of"down-source and up-reservoir,and accumulation above source rocks".The combination of reservoir and cap rocks inside source rocks of basins with multiple superimposed rifting stages,as well as the lithologic reservoirs and the shale oil inside source rocks of strong inversion basins are important fields for future exploration in basins of the CWARS.展开更多
Orthomyxo- and bunyaviruses steal the 5' cap portion of host RNAs to prime their own transcription in a process called "capsnatching." We report that RNA modification of the cap portion by host 2'-O-...Orthomyxo- and bunyaviruses steal the 5' cap portion of host RNAs to prime their own transcription in a process called "capsnatching." We report that RNA modification of the cap portion by host 2'-O-ribose methyltransferase 1 (MTr1) is essential for theinitiation of influenza A and B virus replication, but not for other cap-snatching viruses. We identified with in silico compoundscreening and functional analysis a derivative of a natural product from Streptomyces, called trifluoromethyl-tubercidin (TFMT),that inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication.Mechanistically, TFMT impairs the association of host cap RNAs with the viral polymerase basic protein 2 subunit in human lungexplants and in vivo in mice. TFMT acts synergistically with approved anti-influenza drugs.展开更多
目的:通过计算环切缘的最佳截断值,分析食管鳞状细胞癌患者环周切缘情况与术后生存预后的相关性。方法:本研究回顾性纳入2012年04月至2018年01月期间在我院接受手术治疗的200例食管鳞状细胞癌患者。所有患者术后病理结果均显示为pT_(3)N...目的:通过计算环切缘的最佳截断值,分析食管鳞状细胞癌患者环周切缘情况与术后生存预后的相关性。方法:本研究回顾性纳入2012年04月至2018年01月期间在我院接受手术治疗的200例食管鳞状细胞癌患者。所有患者术后病理结果均显示为pT_(3)N_(0)M_(0)期。通过测量肿瘤细胞距离垂直切缘的最小距离,并使用X-tile软件计算影响肿瘤预后的环切缘最佳截断值。我们根据最佳截断值自定义了改进型环切缘标准,并将其与传统的美国病理学家学院(College of American Pathologists,CAP)和英国皇家病理学家学院(Royal College of Physicians,RCP)标准进行卡方检验和对比分析。与此同时,利用单因素和多因素COX回归分析研究影响食管鳞状细胞癌预后的因素。结果:通过使用X-tile软件计算得出的结果显示,环切缘的最佳截断值为0.65 mm。根据此值,我们自定义改进型环切缘标准,并能够区分不同组别之间的生存差异(P<0.05)。卡方检验分析结果显示,对患者年龄、性别、肿瘤位置、肿瘤长度、肿瘤分化程度和术后辅助治疗等临床病理参数进行校正后,三种环切缘分型之间没有显著差异;单因素和多因素COX回归分析结果显示,本研究自定义的改进型环切缘标准在不同手术分组中均是影响食管鳞状细胞癌预后的独立危险因素。结论:环切缘状态是影响食管鳞状细胞癌患者预后的独立影响因素,本研究所得出的改进型环切缘标准相比传统标准能够更好地评估食管鳞状细胞癌术后患者的预后。展开更多
Rock fall accidents in mountainous cliff areas have significant consequences for human life and transportation.This study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast...Rock fall accidents in mountainous cliff areas have significant consequences for human life and transportation.This study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast coast of Algeria by identifying the key factors contributing to rockfall occurrence.We employed a combination of kinematic analysis,Matterocking method,and 3D trajectory simulations to determine zones that are susceptible to rockfall mobilization.By using a probabilistic and structural approach in conjunction with photogrammetry,we identified the controlling factors.The kinematic analysis revealed the presence of five discontinuity families,which indicated both plane and wedge failure modes.The 3D trajectory simulations demonstrated that the falling blocks followed the stream direction.We then validated the susceptibility maps generated from the analysis using aerial photos and historical rockfall events.The findings of this study enhance our understanding of rockfall phenomena and provide valuable insights for the development of effective strategies to mitigate rockfall hazards.展开更多
The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent years.However,the Cryogenian-Ediac...The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent years.However,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic pattern.This study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern Sichuan.The results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied area.The Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb dating.Regional stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three Gorges.Typically,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast sandstones.The proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing strata.During the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early Ediacaran.Overall,the early Ediacaran of northeastern Sichuan succeeded the paleogeographic features of the late Cryogenian.展开更多
基金The study was reviewed and approved by Anhui Jieshou People's Hospital Institutional Review Board,No.2019-11-001.
文摘BACKGROUND The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not clear.AIM To explore the role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis.METHODS A total of 100 patients with reversible pulpitis who were treated in Anhui Jieshou People's Hospital from January 2020 to December 2021 were included in the study.They were categorized into an observation group(n=50;treatment with adrenaline)and a control group(n=50;treatment with zinc oxide eugenol paste).The 24-h postoperative pain,regression time of gingival congestion and redness,clinical efficacy,and incidence of adverse reactions were compared between the groups.Patients were further categorized into the ineffective and effective treatment groups based on clinical efficacy.Logistic multiple regression analysis explored factors affecting the efficacy of pulp capping treatment.RESULTS A significant difference in 24-h postoperative pain was observed between the groups(P<0.05),with a higher proportion of grade I pain noted in the observation group than in the control group(P<0.01).The regression time of gingival congestion and swelling was lower in the observation group(2.61±1.44 d and 2.73±1.36 d,respectively)than in the control group(3.85±1.47 d and 4.28±1.61 d,respectively)(P<0.05).The 2-wk postoperative total effective rate was lower in the control group(80.00%)than in the observation group(94.00%)(P<0.05).The incidence of adverse reactions was not significantly different between the control(14.00%)and observation(12.00%)groups(P>0.05).The proportion of adrenaline usage was lower(P<0.05)and that of anaerobic digestion by Streptococcus and Fusobacterium nucleatum was higher in the ineffective treatment group than in the effective treatment group(P<0.05).Logistic multiple regression analysis revealed adrenaline as a protective factor(P<0.05)and anaerobic digestion by Streptococcus and F.nucleatum as risk factors for pulp capping in reversible pulpitis(P<0.05).CONCLUSION Adrenaline demonstrated therapeutic efficacy in pulp capping treatment for reversible pulpitis,reducing pain and improving clinical symptoms safely.It is a protective factor for pulp capping,whereas Streptococcus and F.nucleatum are risk factors.Targeted measures can be implemented to improve clinical efficacy.
基金Supported by the National Natural Science Foundation Project(92255302)National Science and Technology Major Project(2016ZX05029005)Scientific Research and Technological Development Project of PetroChina(2021DJ31).
文摘Based on seismic,drilling,and source rock analysis data,the petroleum geological characteristics and future exploration direction of the oil-rich sags in the Central and West African Rift System(CWARS)are discussed.The study shows that the Central African Rift System mainly develops high-quality lacustrine source rocks in the Lower Cretaceous,and the West African Rift System mainly develops high-quality terrigenous organic matter-rich marine source rocks in the Upper Cretaceous,and the two types of source rocks provide a material basis for the enrichment of oil and gas in the CWARS.Multiple sets of reservoir rocks including fractured basement and three sets of regional cap rocks in the Lower Cretaceous,the Upper Cretaceous,and the Paleogene are developed in the CWARS.Since the Late Mesozoic,due to the geodynamic factors including the dextral strike-slip movement of the Central African Shear Zone,the basins in different directions of the CWARS differ in terms of rifting stages,intervals of regional cap rocks,trap types and accumulation models.The NE-SW trending basins have mainly preserved one stage of rifting in the Early Cretaceous,with regional cap rocks developed in the Lower Cretaceous strata,forming traps of reverse anticlines,flower-shaped structures and basement buried hill,and two types of hydrocarbon accumulation models of"source and reservoir in the same formation,and accumulation inside source rocks"and"up-source and down-reservoir,and accumulation below source rocks".The NW–SE basins are characterized by multiple rifting stages superimposition,with the development of regional cap rocks in the Upper Cretaceous and Paleogene,forming traps of draping anticlines,faulted anticlines,antithetic fault blocks and the accumulation model of"down-source and up-reservoir,and accumulation above source rocks".The combination of reservoir and cap rocks inside source rocks of basins with multiple superimposed rifting stages,as well as the lithologic reservoirs and the shale oil inside source rocks of strong inversion basins are important fields for future exploration in basins of the CWARS.
文摘Orthomyxo- and bunyaviruses steal the 5' cap portion of host RNAs to prime their own transcription in a process called "capsnatching." We report that RNA modification of the cap portion by host 2'-O-ribose methyltransferase 1 (MTr1) is essential for theinitiation of influenza A and B virus replication, but not for other cap-snatching viruses. We identified with in silico compoundscreening and functional analysis a derivative of a natural product from Streptomyces, called trifluoromethyl-tubercidin (TFMT),that inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication.Mechanistically, TFMT impairs the association of host cap RNAs with the viral polymerase basic protein 2 subunit in human lungexplants and in vivo in mice. TFMT acts synergistically with approved anti-influenza drugs.
文摘目的:通过计算环切缘的最佳截断值,分析食管鳞状细胞癌患者环周切缘情况与术后生存预后的相关性。方法:本研究回顾性纳入2012年04月至2018年01月期间在我院接受手术治疗的200例食管鳞状细胞癌患者。所有患者术后病理结果均显示为pT_(3)N_(0)M_(0)期。通过测量肿瘤细胞距离垂直切缘的最小距离,并使用X-tile软件计算影响肿瘤预后的环切缘最佳截断值。我们根据最佳截断值自定义了改进型环切缘标准,并将其与传统的美国病理学家学院(College of American Pathologists,CAP)和英国皇家病理学家学院(Royal College of Physicians,RCP)标准进行卡方检验和对比分析。与此同时,利用单因素和多因素COX回归分析研究影响食管鳞状细胞癌预后的因素。结果:通过使用X-tile软件计算得出的结果显示,环切缘的最佳截断值为0.65 mm。根据此值,我们自定义改进型环切缘标准,并能够区分不同组别之间的生存差异(P<0.05)。卡方检验分析结果显示,对患者年龄、性别、肿瘤位置、肿瘤长度、肿瘤分化程度和术后辅助治疗等临床病理参数进行校正后,三种环切缘分型之间没有显著差异;单因素和多因素COX回归分析结果显示,本研究自定义的改进型环切缘标准在不同手术分组中均是影响食管鳞状细胞癌预后的独立危险因素。结论:环切缘状态是影响食管鳞状细胞癌患者预后的独立影响因素,本研究所得出的改进型环切缘标准相比传统标准能够更好地评估食管鳞状细胞癌术后患者的预后。
基金the support provided by the Laboratory of Applied Research in Engineering Geology, Geotechnics, Water Sciences, and Environment, Setif 1 University, Algeria
文摘Rock fall accidents in mountainous cliff areas have significant consequences for human life and transportation.This study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast coast of Algeria by identifying the key factors contributing to rockfall occurrence.We employed a combination of kinematic analysis,Matterocking method,and 3D trajectory simulations to determine zones that are susceptible to rockfall mobilization.By using a probabilistic and structural approach in conjunction with photogrammetry,we identified the controlling factors.The kinematic analysis revealed the presence of five discontinuity families,which indicated both plane and wedge failure modes.The 3D trajectory simulations demonstrated that the falling blocks followed the stream direction.We then validated the susceptibility maps generated from the analysis using aerial photos and historical rockfall events.The findings of this study enhance our understanding of rockfall phenomena and provide valuable insights for the development of effective strategies to mitigate rockfall hazards.
基金supported by the China Geological Survey project(DD20221649)the National Natural Science Foundation of China(Nos.U19B6003,42072135,and 42172119)+1 种基金Chongqing Research Program of Basic Research and Frontier Technology(Grant No.cstc2021jcyj-msxm X0023)Open Fund(DGERA 20211105)of Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources,Chengdu University of Technology。
文摘The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent years.However,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic pattern.This study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern Sichuan.The results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied area.The Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb dating.Regional stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three Gorges.Typically,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast sandstones.The proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing strata.During the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early Ediacaran.Overall,the early Ediacaran of northeastern Sichuan succeeded the paleogeographic features of the late Cryogenian.
