Carbazole is an irreplaceable basic organic chemical raw material and intermediate in industry.The separation of carbazole from anthracene oil by environmental benign solvents is important but still a challenge in che...Carbazole is an irreplaceable basic organic chemical raw material and intermediate in industry.The separation of carbazole from anthracene oil by environmental benign solvents is important but still a challenge in chemical engineering.Deep eutectic solvents (DESs) as a sustainable green separation solvent have been proposed for the separation of carbazole from model anthracene oil.In this research,three quaternary ammonium-based DESs were prepared using ethylene glycol (EG) as hydrogen bond donor and tetrabutylammonium chloride (TBAC),tetrabutylammonium bromide or choline chloride as hydrogen bond acceptors.To explore their extraction performance of carbazole,the conductor-like screening model for real solvents (COSMO-RS) model was used to predict the activity coefficient at infinite dilution (γ^(∞)) of carbazole in DESs,and the result indicated TBAC:EG (1:2) had the stronger extraction ability for carbazole due to the higher capacity at infinite dilution (C^(∞)) value.Then,the separation performance of these three DESs was evaluated by experiments,and the experimental results were in good agreement with the COSMO-RS prediction results.The TBAC:EG (1:2) was determined as the most promising solvent.Additionally,the extraction conditions of TBAC:EG (1:2) were optimized,and the extraction efficiency,distribution coefficient and selectivity of carbazole could reach up to 85.74%,30.18 and 66.10%,respectively.Moreover,the TBAC:EG (1:2) could be recycled by using environmentally friendly water as antisolvent.In addition,the separation performance of TBAC:EG (1:2) was also evaluated by real crude anthracene,the carbazole was obtained with purity and yield of 85.32%,60.27%,respectively.Lastly,the extraction mechanism was elucidated byσ-profiles and interaction energy analysis.Theoretical calculation results showed that the main driving force for the extraction process was the hydrogen bonding ((N–H...Cl) and van der Waals interactions (C–H...O and C–H...π),which corresponding to the blue and green isosurfaces in IGMH analysis.This work presented a novel method for separating carbazole from crude anthracene oil,and will provide an important reference for the separation of other high value-added products from coal tar.展开更多
New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carb...New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carbazole scaffold have been developed. The markers in complex with Eu<sup>3+</sup> ions possess stability in the aqueous phase, intense and prolonged luminescence (τ 550 - 570 μs) with characteristic emission maxima in the region of 615 nm and excitation wavelengths in the region of 380 - 390 nm, which distinguishes them from most of the analogs used. In the study of marker conjugation with streptavidin, a reagent containing 4 - 5 europium labeling complexes based on spacer-containing carbazole tetraketone was obtained. The marker-doped silicate nanoparticles exhibit intense and long-lived luminescence in the characteristic region.展开更多
Here a fluorescent probe based on a carbazole derivative(CNS)was developed to increase the detection range and reduce the detection limit of brilliant blue.Characteristics of CNS are studied.Due to the quenching abili...Here a fluorescent probe based on a carbazole derivative(CNS)was developed to increase the detection range and reduce the detection limit of brilliant blue.Characteristics of CNS are studied.Due to the quenching ability of colorants,CNS shows an excellent current response to brilliant blue(from 1 to 10μM)with a detection limit of 2.7×10^(-8)mol/L(3σ/k)in the conditions of a 1:1 volume ratio of water to tetrahydrofuran.And the stability and reproducibility of CNS in the detection of actual samples indicate great potential for application.展开更多
Three new metal-organic frameworks [Cd(L)(obba)]·H)2O(1),[Co(L)(obba)]·MeCN(2) and [Cd_2(L)_2(ip)_2]·6H_2O·DMF(3)(H_2obba = 4,4?-oxybisbenzoic acid,H2 ip = m-phthalic acid) have been successfully s...Three new metal-organic frameworks [Cd(L)(obba)]·H)2O(1),[Co(L)(obba)]·MeCN(2) and [Cd_2(L)_2(ip)_2]·6H_2O·DMF(3)(H_2obba = 4,4?-oxybisbenzoic acid,H2 ip = m-phthalic acid) have been successfully synthesized based on the controllable self-assembly of 9-ethyl-3,6-diimidazolyl-carbazole(L),varied carboxylates and different metal ions under solvothermal conditions,which were characterized by single-crystal X-ray diffraction,elemental analysis,IR spectroscopy and thermogravimetry. Furthermore,luminescence and magnetic susceptibility of compound 2 are also investigated in detail. Single-crystal X-ray diffraction and topology analysis reveal that complexes 1~3 exhibit similar two-dimensional(2D) networks.展开更多
Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were se...Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.展开更多
To identify the effect of solvents and anthracene on the purification of carbazole,the solvent crystallization of carbazole was investigated with xylene,chlorobenzene and tetrachloroethylene(TCE)as solvents under two ...To identify the effect of solvents and anthracene on the purification of carbazole,the solvent crystallization of carbazole was investigated with xylene,chlorobenzene and tetrachloroethylene(TCE)as solvents under two forced circulation cooling(FCC)modes.The co-crystalline experimental data were obtained from runs carried out at different anthracene levels between 1%(mass)and 10%(mass).The results showed that a uniform flake carbazole crystal obtained when using xylene and chlorobenzene under the FCC-1 mode with gradual cooling rate.Nevertheless,fine flake crystals grown under shock cooling of FCC-2 mode.It is beneficial to improving the purity of carbazole with chlorobenzene as solvent under cooling mode of FCC-1.Anthracene could promote the growth of carbazole in solution,and it has a significant influence on the purification of carbazole.展开更多
Novel 9-proparylcarbazole monomers containing amino acid moieties,2-N(tert-butoxycarbonyl)-L-alanine- 9-proparylcarbazole ester(1),2-N-(tert-butoxycarbonyl)-L-O-cyclohexyl-L-glutamic acid-9-proparylcarbazole ester(2) ...Novel 9-proparylcarbazole monomers containing amino acid moieties,2-N(tert-butoxycarbonyl)-L-alanine- 9-proparylcarbazole ester(1),2-N-(tert-butoxycarbonyl)-L-O-cyclohexyl-L-glutamic acid-9-proparylcarbazole ester(2) and 2-N-(tert-butoxycarbonyl)-L-phenylalanine-9-proparylcarbazole ester(3) were synthesized and polymerized with (nbd)Rh^+[η~6-C_6H_5B^-(C_6H_5)_3]to give the corresponding polymers with number-average molecular weights ranging from 7050 to 10500 in 70%-86%yields.The polymers were completely...展开更多
The fullerene C60 and phthalocyanine co-grafted poly (epoxy propyl carbazole) (C60-CuPC-PEPC) was synthesized by Friedel-Crafts reaction. It was found that C60-CuPc-PEPC had good UV-Vis absorption property, whose acti...The fullerene C60 and phthalocyanine co-grafted poly (epoxy propyl carbazole) (C60-CuPC-PEPC) was synthesized by Friedel-Crafts reaction. It was found that C60-CuPc-PEPC had good UV-Vis absorption property, whose active spectral range was expanded from UV to visible spectrum region, and exhibited better photoconductivity than CuPc-PEPC and PEPC. These improvements could be attributed to the interaction between C60, phthalocyanine and PEPC.展开更多
A new luminescent and thermally stable platinum(Ⅱ) polyyne polymer trans-[-Pt(PBu_3)_2C=CArC=C-]_n(P1) containing the 2,7-fluorene chromophoric spacer substituted by pendant carbazolyl group via long alkyl bridges. T...A new luminescent and thermally stable platinum(Ⅱ) polyyne polymer trans-[-Pt(PBu_3)_2C=CArC=C-]_n(P1) containing the 2,7-fluorene chromophoric spacer substituted by pendant carbazolyl group via long alkyl bridges. The regiochemical structures of these compounds were studied by various spectroscopic analyses.We report the photophysical properties of this group 10 polymetallayne and a comparison was made to its binuclear model complex trans-[Pt(Ph)(PEt_3)_2C≡CArC≡CPt(Ph)(PEt_3)_2](M1) as well as to those ...展开更多
A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and characterized.The absorption and fluorescence spectra in solvents of different pol...A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and characterized.The absorption and fluorescence spectra in solvents of different polarities prove that the compound has a distinct intramolecular charge transfer character.Compound 5 can be used as a new class of fluorescent probe or biosensor due to its sensitivity to the local microenvironment such as solvent polarity.展开更多
Blue emission from polymer blends composed of poly(2,5-dibutoxyphenyiene)(PPP)in a matrix polymer poly(N-vinylcarbazole)(PVK)is reported.The light-emitting layer can be fabricated by spin-coating of PPP-PVK blend solu...Blue emission from polymer blends composed of poly(2,5-dibutoxyphenyiene)(PPP)in a matrix polymer poly(N-vinylcarbazole)(PVK)is reported.The light-emitting layer can be fabricated by spin-coating of PPP-PVK blend solution without subsequent processing or heat treatment.A cell structure of glass substrate/indium-tin-oxide/PPP-PVK blend/aluminum is employed.Blue light emission with a peak position at 448nm occurs at a bias of about 8V.展开更多
A novel carbazole derivative 2-cyano-3-(9-ethyl-9H-carbazol-3-yl)-acrylic acid ethyl ester(L) was designed and synthesized through Vilsmeier and Knoevenagelreactions, which was characterized by FT-IR, ~1H NMR and13 C ...A novel carbazole derivative 2-cyano-3-(9-ethyl-9H-carbazol-3-yl)-acrylic acid ethyl ester(L) was designed and synthesized through Vilsmeier and Knoevenagelreactions, which was characterized by FT-IR, ~1H NMR and13 C NMR spectra. The crystal of L crystallizes in the monoclinic system, space group P21/c with a = 10.8298(15), b = 13.4660(19), c = 15.4358(16) ?, β = 131.214(6)o, V = 1693.4(4) ?~3, Z = 4, Dc = 1.249 g/cm^3, Mr = 318.36, μ = 0.082 mm-1, F(000) = 672, completeness to theta was 99.9% and GOOF = 1.091.Rint = 0.0338, R(I >2σ(I)) = 0.0631, w R(I > 2σ(I)) = 0.1861, R(all data) = 0.1027 andw R(all data) = 0.2105. There were three types of weak intermolecular interactions(C(8)–H(8)···N(2), C(14)–H(14)···O(2) and C(20B)– H(20B)···π)among the adjacent molecules to construct a three-dimensional single crystal. The UV-Vis spectra, fluorescence emission and time-dependent density functional theory(TD-DFT) calculation of L were studied and the results revealedthe existence of intramolecular charge transfer(ICT) process of L molecule. The optical properties indicated that it can be used as a potential candidate in the application oforganic light emitting diodes(OLEDs).展开更多
The photorefractive effect was observed in poly(N-vinylcarbazole)composite films doped with electro-optic chromophore 2,5-dimetly-4(p-nitrophenylazo)anisole,plasticizer N-ethylcarbazole and different content fullerene...The photorefractive effect was observed in poly(N-vinylcarbazole)composite films doped with electro-optic chromophore 2,5-dimetly-4(p-nitrophenylazo)anisole,plasticizer N-ethylcarbazole and different content fullerene C60.Their two-beam coupling experiment was performed by using a cw He-Ne laser at 632.8nm.The two-beam-coupling gain coefficient as higher as 140cm^(-1) was measured at poling dc electric field of 76V/μm and it was also found to be relied on the content of photosensitizer C60.展开更多
The key issues concerning the design and synthesis of high fluorescent efficiency, good thermal stability of organic blue materials should be solved urgently in organic light emitting diodes. In this article, three D-...The key issues concerning the design and synthesis of high fluorescent efficiency, good thermal stability of organic blue materials should be solved urgently in organic light emitting diodes. In this article, three D-A type blue emitters based on carbazole and phenylquinoline with flexible chains were prepared through Friedlander condensation reaction in relatively high yield. The photoelectric properties of all compounds were studied by UV-vis absorption, emission spectra and cyclic voltammograms. Density functional theory calculations(DFT) were performed to obtain a better understanding of the electronic structures. Interestingly, compound a3 with the highest fluorescence quantum yield of 0.53 can be applied into blue light emission materials on account of good thermal performance. Furthermore, a1~a3 with narrow band gap make them become potential candidates in the fields of OLED, solar cells and OFET.展开更多
Alternating copolymerization of 9,9-dihexyl-2,7-dibromofluorene, N-hexyl-2,7-dibromocarbazole (HCz) with diethynyldimethylsilane, diethynyldiphenylsilane, has been investigated using Sonogashira coupling reaction. Pho...Alternating copolymerization of 9,9-dihexyl-2,7-dibromofluorene, N-hexyl-2,7-dibromocarbazole (HCz) with diethynyldimethylsilane, diethynyldiphenylsilane, has been investigated using Sonogashira coupling reaction. Photophysical properties of the resulting copolymers were investigated with UV-Vis absorption and photoluminescence spectroscopy. All the copolymers in chloro-form solution showed absorption peaks at 270 - 280 nm with shoulder peaks at around 380 nm derived from π-π* transition or intra-molecular charge transfer through σ-π moiety, respectively. The chloroform solutions of the copolymers showed broad emission peaks at 415 - 425 nm. The emission wave lengths of the copolymers in the solid state (cast film) detected at 360 - 385 nm were remarkably blue-shifted in comparison with those in the chloroform solutions. Hydrosilylation reaction of the copolymers with 1,4-bis(dimethylsilyl)benzene yielded networked copolymers soluble in chloroform, indicating formation of branching polymers. The chloroform solutions of the HCz-based networked copolymers showed bimodal emission derived from new highly energy states in the σ-π conjugation.展开更多
The optical properties of the fullerenated poly(epoxy propyl carbazole) (PEPC) havebeen investigated. Compared with pure PEPC, fullerenated PEPC has the same structure inthe UV region of the absorption spectrum, and e...The optical properties of the fullerenated poly(epoxy propyl carbazole) (PEPC) havebeen investigated. Compared with pure PEPC, fullerenated PEPC has the same structure inthe UV region of the absorption spectrum, and extends the active range to a longerwavelength. The apparent quenching of PEPC fluorescence was observed in thefullerenated polymer and it can be attributed to intramolecular excited state energytransfer.展开更多
Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-B...Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this work.Pure powders of BCz and its derivatives merely exhibit blue fluorescence at ambient condition.However,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room temperature.Moreover,the UORTP color can be tuned between green and yellow depending on the matrix.The ultralong phosphorescence originates from the generation of charge-separated states via radicals.The matrixes play a key role in both stabilizing charge-separated states and controlling UORTP color.More interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room temperature.Comparedwith Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical applications.This work gains a deeper insight into the mechanism of UORTP and paves a new approach to applying organic phosphorescent materials to underwater coating and imaging.展开更多
Conjugated microporous polymers (CMPs) featuring extended π-structures, large specific surface area and tailor-made functionalities are a class of promising organic photocatalysts for hydrogen evolution reaction (HER...Conjugated microporous polymers (CMPs) featuring extended π-structures, large specific surface area and tailor-made functionalities are a class of promising organic photocatalysts for hydrogen evolution reaction (HER) from water. However, the photocatalytic activities of most CMPs are severely hindered by slow charge transfer rate and fast charge recombination process. Herein, we develop a strategy for the synthesis of donor-acceptor CMPs through nickel(0)-catalyzed Yamamoto cross-coupling of 3,6-dibromo-9-(4-bromophenyl)carbazole (CZ) with 5,5'-dibromo-2,2'-bipyridine (DBPy) for efficient HER from water. The PCZN-4 prepared with a 2 : 3 stoichiometric ratio of CZ to DBPy exhibited the highest photocatalytic hydrogen evolution rate of 7160 μmol·g^(–1)·h^(–1), which was nearly equal to 179 times and 143 times that of PCZN-1 (40 μmol·g^(–1)·h^(–1)) and PCZN-6 (50 μmol·g^(–1)·h^(–1)) obtained by Yamamoto homocoupling of CZ and DBPy, respectively. Compared to the homocoupling counterparts, the enhanced photocatalytic activity of PCZN-4 results from improved separation efficiency of charge carriers. Interestingly, the photocatalytic H2 evolution performance of PCZN-4 could be further improved up to 17080 μmol·g^(–1)·h^(–1) by adjusting pH of the aqueous solution. This work offers a novel approach for improving photocatalytic efficiency by tuning the chemical structures and surrounding microenvironment of the polymer backbone.展开更多
Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and te...Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and tetrahydro-carboline derivatives were reported as D_(3)R selective ligands.Through a structure-based virtual screen,ZLG-25(D_(3)R K_i=685 nmol/L;D_2R K_i>10,000 nmol/L)was identified as a novel D_(3)R selective bitopic ligand with a carbazole scaffold.Scaffolds hopping led to the discovery of novel D_(3)R-selective analogs with tetrahydro-β-carboline or tetrahydro-γ-carboline core.Further functional studies showed that most derivatives acted as h D_(3)R-selective antagonists.Several lead compounds could dose-dependently inhibit the MK-801-induced hyperactivity.Additional investigation revealed that 23j and 36b could decrease the apomorphine-induced climbing without cataleptic reaction.Furthermore,36b demonstrated unusual antidepressant-like activity in the forced swimming tests and the tail suspension tests,and alleviated the MK-801-induced disruption of novel object recognition in mice.Additionally,preliminary studies confirmed the favorable PK/PD profiles,no weight gain and limited serum prolactin levels in mice.These results revealed that 36b provided potential opportunities to new antipsychotic drugs with the multiple antipsychotic-like properties.展开更多
Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain uncertain.Herein,female and male Sprague-Dawley(SD)mice were treated with four typical...Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain uncertain.Herein,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate underlyingmechanisms.In female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose level.The only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,6-DCCZ.We also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic disorders.Our findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic activities.Overall,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.展开更多
基金financially supported by Shanxi Province Natural Science Foundation of China(20210302123167)NSFC-Shanxi joint fund for coal-based low carbon(U1610223)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SX-TD006).
文摘Carbazole is an irreplaceable basic organic chemical raw material and intermediate in industry.The separation of carbazole from anthracene oil by environmental benign solvents is important but still a challenge in chemical engineering.Deep eutectic solvents (DESs) as a sustainable green separation solvent have been proposed for the separation of carbazole from model anthracene oil.In this research,three quaternary ammonium-based DESs were prepared using ethylene glycol (EG) as hydrogen bond donor and tetrabutylammonium chloride (TBAC),tetrabutylammonium bromide or choline chloride as hydrogen bond acceptors.To explore their extraction performance of carbazole,the conductor-like screening model for real solvents (COSMO-RS) model was used to predict the activity coefficient at infinite dilution (γ^(∞)) of carbazole in DESs,and the result indicated TBAC:EG (1:2) had the stronger extraction ability for carbazole due to the higher capacity at infinite dilution (C^(∞)) value.Then,the separation performance of these three DESs was evaluated by experiments,and the experimental results were in good agreement with the COSMO-RS prediction results.The TBAC:EG (1:2) was determined as the most promising solvent.Additionally,the extraction conditions of TBAC:EG (1:2) were optimized,and the extraction efficiency,distribution coefficient and selectivity of carbazole could reach up to 85.74%,30.18 and 66.10%,respectively.Moreover,the TBAC:EG (1:2) could be recycled by using environmentally friendly water as antisolvent.In addition,the separation performance of TBAC:EG (1:2) was also evaluated by real crude anthracene,the carbazole was obtained with purity and yield of 85.32%,60.27%,respectively.Lastly,the extraction mechanism was elucidated byσ-profiles and interaction energy analysis.Theoretical calculation results showed that the main driving force for the extraction process was the hydrogen bonding ((N–H...Cl) and van der Waals interactions (C–H...O and C–H...π),which corresponding to the blue and green isosurfaces in IGMH analysis.This work presented a novel method for separating carbazole from crude anthracene oil,and will provide an important reference for the separation of other high value-added products from coal tar.
文摘New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carbazole scaffold have been developed. The markers in complex with Eu<sup>3+</sup> ions possess stability in the aqueous phase, intense and prolonged luminescence (τ 550 - 570 μs) with characteristic emission maxima in the region of 615 nm and excitation wavelengths in the region of 380 - 390 nm, which distinguishes them from most of the analogs used. In the study of marker conjugation with streptavidin, a reagent containing 4 - 5 europium labeling complexes based on spacer-containing carbazole tetraketone was obtained. The marker-doped silicate nanoparticles exhibit intense and long-lived luminescence in the characteristic region.
基金Funded by the Open Subject from Jiangsu Marine Resources Development Research Institute (JSIMR202117)the Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Ocean University。
文摘Here a fluorescent probe based on a carbazole derivative(CNS)was developed to increase the detection range and reduce the detection limit of brilliant blue.Characteristics of CNS are studied.Due to the quenching ability of colorants,CNS shows an excellent current response to brilliant blue(from 1 to 10μM)with a detection limit of 2.7×10^(-8)mol/L(3σ/k)in the conditions of a 1:1 volume ratio of water to tetrahydrofuran.And the stability and reproducibility of CNS in the detection of actual samples indicate great potential for application.
基金supported by the National Natural Science Foundation of China(21102117)Key Laboratory of Chemical Synthesis and Pollution Control of Sichuan Province(CSPC2014-4-1)
文摘Three new metal-organic frameworks [Cd(L)(obba)]·H)2O(1),[Co(L)(obba)]·MeCN(2) and [Cd_2(L)_2(ip)_2]·6H_2O·DMF(3)(H_2obba = 4,4?-oxybisbenzoic acid,H2 ip = m-phthalic acid) have been successfully synthesized based on the controllable self-assembly of 9-ethyl-3,6-diimidazolyl-carbazole(L),varied carboxylates and different metal ions under solvothermal conditions,which were characterized by single-crystal X-ray diffraction,elemental analysis,IR spectroscopy and thermogravimetry. Furthermore,luminescence and magnetic susceptibility of compound 2 are also investigated in detail. Single-crystal X-ray diffraction and topology analysis reveal that complexes 1~3 exhibit similar two-dimensional(2D) networks.
文摘Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.
基金supported by the National Natural Science Foundation of China(21776192,22038008)。
文摘To identify the effect of solvents and anthracene on the purification of carbazole,the solvent crystallization of carbazole was investigated with xylene,chlorobenzene and tetrachloroethylene(TCE)as solvents under two forced circulation cooling(FCC)modes.The co-crystalline experimental data were obtained from runs carried out at different anthracene levels between 1%(mass)and 10%(mass).The results showed that a uniform flake carbazole crystal obtained when using xylene and chlorobenzene under the FCC-1 mode with gradual cooling rate.Nevertheless,fine flake crystals grown under shock cooling of FCC-2 mode.It is beneficial to improving the purity of carbazole with chlorobenzene as solvent under cooling mode of FCC-1.Anthracene could promote the growth of carbazole in solution,and it has a significant influence on the purification of carbazole.
基金supported by the"Program for New Century Excellent Talents in University"(NCET-08-0204)"The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(China)"
文摘Novel 9-proparylcarbazole monomers containing amino acid moieties,2-N(tert-butoxycarbonyl)-L-alanine- 9-proparylcarbazole ester(1),2-N-(tert-butoxycarbonyl)-L-O-cyclohexyl-L-glutamic acid-9-proparylcarbazole ester(2) and 2-N-(tert-butoxycarbonyl)-L-phenylalanine-9-proparylcarbazole ester(3) were synthesized and polymerized with (nbd)Rh^+[η~6-C_6H_5B^-(C_6H_5)_3]to give the corresponding polymers with number-average molecular weights ranging from 7050 to 10500 in 70%-86%yields.The polymers were completely...
文摘The fullerene C60 and phthalocyanine co-grafted poly (epoxy propyl carbazole) (C60-CuPC-PEPC) was synthesized by Friedel-Crafts reaction. It was found that C60-CuPc-PEPC had good UV-Vis absorption property, whose active spectral range was expanded from UV to visible spectrum region, and exhibited better photoconductivity than CuPc-PEPC and PEPC. These improvements could be attributed to the interaction between C60, phthalocyanine and PEPC.
基金supported by the Hong Kong Research Grants Council(No.HKBU202607)Hong KongBaptist University(FRG/06-07/Ⅱ-63).
文摘A new luminescent and thermally stable platinum(Ⅱ) polyyne polymer trans-[-Pt(PBu_3)_2C=CArC=C-]_n(P1) containing the 2,7-fluorene chromophoric spacer substituted by pendant carbazolyl group via long alkyl bridges. The regiochemical structures of these compounds were studied by various spectroscopic analyses.We report the photophysical properties of this group 10 polymetallayne and a comparison was made to its binuclear model complex trans-[Pt(Ph)(PEt_3)_2C≡CArC≡CPt(Ph)(PEt_3)_2](M1) as well as to those ...
基金supported by the National Science Foundation of China(No.20875059)the Youth Science Foundation of Shanxi Province(No.20051005).
文摘A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and characterized.The absorption and fluorescence spectra in solvents of different polarities prove that the compound has a distinct intramolecular charge transfer character.Compound 5 can be used as a new class of fluorescent probe or biosensor due to its sensitivity to the local microenvironment such as solvent polarity.
基金Supported by the National Natural Science Foundation of Chinathe Polymer Physics Laboratory of Changchun Institute of Applied Chemistry,Chinese Academy of Sciences.
文摘Blue emission from polymer blends composed of poly(2,5-dibutoxyphenyiene)(PPP)in a matrix polymer poly(N-vinylcarbazole)(PVK)is reported.The light-emitting layer can be fabricated by spin-coating of PPP-PVK blend solution without subsequent processing or heat treatment.A cell structure of glass substrate/indium-tin-oxide/PPP-PVK blend/aluminum is employed.Blue light emission with a peak position at 448nm occurs at a bias of about 8V.
基金Supported by the Natural Science Foundation of Anhui Province(1508085SMB208)the Educational Commission of Anhui Province(KJ2016A788)
文摘A novel carbazole derivative 2-cyano-3-(9-ethyl-9H-carbazol-3-yl)-acrylic acid ethyl ester(L) was designed and synthesized through Vilsmeier and Knoevenagelreactions, which was characterized by FT-IR, ~1H NMR and13 C NMR spectra. The crystal of L crystallizes in the monoclinic system, space group P21/c with a = 10.8298(15), b = 13.4660(19), c = 15.4358(16) ?, β = 131.214(6)o, V = 1693.4(4) ?~3, Z = 4, Dc = 1.249 g/cm^3, Mr = 318.36, μ = 0.082 mm-1, F(000) = 672, completeness to theta was 99.9% and GOOF = 1.091.Rint = 0.0338, R(I >2σ(I)) = 0.0631, w R(I > 2σ(I)) = 0.1861, R(all data) = 0.1027 andw R(all data) = 0.2105. There were three types of weak intermolecular interactions(C(8)–H(8)···N(2), C(14)–H(14)···O(2) and C(20B)– H(20B)···π)among the adjacent molecules to construct a three-dimensional single crystal. The UV-Vis spectra, fluorescence emission and time-dependent density functional theory(TD-DFT) calculation of L were studied and the results revealedthe existence of intramolecular charge transfer(ICT) process of L molecule. The optical properties indicated that it can be used as a potential candidate in the application oforganic light emitting diodes(OLEDs).
基金Supported by the National Natural Science Foundation of China under Grant 19525412National Education Commission,and National Science and Technology Commission of China.
文摘The photorefractive effect was observed in poly(N-vinylcarbazole)composite films doped with electro-optic chromophore 2,5-dimetly-4(p-nitrophenylazo)anisole,plasticizer N-ethylcarbazole and different content fullerene C60.Their two-beam coupling experiment was performed by using a cw He-Ne laser at 632.8nm.The two-beam-coupling gain coefficient as higher as 140cm^(-1) was measured at poling dc electric field of 76V/μm and it was also found to be relied on the content of photosensitizer C60.
基金Supported by the sponsorship of Jiangsu Overseas Research&Training Program for University Prominent Young&Middle-aged Teachers and Presidents and the found of Nanjing Polytechnic Institute(NHKY-2015-02)Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(TAPP,PPZY2015B179)
文摘The key issues concerning the design and synthesis of high fluorescent efficiency, good thermal stability of organic blue materials should be solved urgently in organic light emitting diodes. In this article, three D-A type blue emitters based on carbazole and phenylquinoline with flexible chains were prepared through Friedlander condensation reaction in relatively high yield. The photoelectric properties of all compounds were studied by UV-vis absorption, emission spectra and cyclic voltammograms. Density functional theory calculations(DFT) were performed to obtain a better understanding of the electronic structures. Interestingly, compound a3 with the highest fluorescence quantum yield of 0.53 can be applied into blue light emission materials on account of good thermal performance. Furthermore, a1~a3 with narrow band gap make them become potential candidates in the fields of OLED, solar cells and OFET.
文摘Alternating copolymerization of 9,9-dihexyl-2,7-dibromofluorene, N-hexyl-2,7-dibromocarbazole (HCz) with diethynyldimethylsilane, diethynyldiphenylsilane, has been investigated using Sonogashira coupling reaction. Photophysical properties of the resulting copolymers were investigated with UV-Vis absorption and photoluminescence spectroscopy. All the copolymers in chloro-form solution showed absorption peaks at 270 - 280 nm with shoulder peaks at around 380 nm derived from π-π* transition or intra-molecular charge transfer through σ-π moiety, respectively. The chloroform solutions of the copolymers showed broad emission peaks at 415 - 425 nm. The emission wave lengths of the copolymers in the solid state (cast film) detected at 360 - 385 nm were remarkably blue-shifted in comparison with those in the chloroform solutions. Hydrosilylation reaction of the copolymers with 1,4-bis(dimethylsilyl)benzene yielded networked copolymers soluble in chloroform, indicating formation of branching polymers. The chloroform solutions of the HCz-based networked copolymers showed bimodal emission derived from new highly energy states in the σ-π conjugation.
文摘The optical properties of the fullerenated poly(epoxy propyl carbazole) (PEPC) havebeen investigated. Compared with pure PEPC, fullerenated PEPC has the same structure inthe UV region of the absorption spectrum, and extends the active range to a longerwavelength. The apparent quenching of PEPC fluorescence was observed in thefullerenated polymer and it can be attributed to intramolecular excited state energytransfer.
基金supported by the National Natural Science Foundation of China(grant nos.22175015 and 21704002)the Beijing Natural Science Foundation(grant no.2182054)+1 种基金the Big Science Project from BUCT(grant no.XK180301)the Fundamental Research Funds for the Central Universities to Z.Y.Ma.
文摘Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this work.Pure powders of BCz and its derivatives merely exhibit blue fluorescence at ambient condition.However,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room temperature.Moreover,the UORTP color can be tuned between green and yellow depending on the matrix.The ultralong phosphorescence originates from the generation of charge-separated states via radicals.The matrixes play a key role in both stabilizing charge-separated states and controlling UORTP color.More interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room temperature.Comparedwith Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical applications.This work gains a deeper insight into the mechanism of UORTP and paves a new approach to applying organic phosphorescent materials to underwater coating and imaging.
基金support from the National Natu-ral Science Foundation of China(52073046,52203006)the Na-tional Key Research and Development Program of China(2022YFB3807100,2022YFB3807102,2022YFB3807103)+4 种基金the Pro-gram of Shanghai Academic Research Leader(21XD1420200)the Chang Jiang Scholar Program(Q2019152)the Natural Science Foundation of Shanghai(23ZR1401100)the Shanghai Pujiang Program(21PJ1400300)the Fundamental Research Funds for the Central Universities(2232022D-06).
文摘Conjugated microporous polymers (CMPs) featuring extended π-structures, large specific surface area and tailor-made functionalities are a class of promising organic photocatalysts for hydrogen evolution reaction (HER) from water. However, the photocatalytic activities of most CMPs are severely hindered by slow charge transfer rate and fast charge recombination process. Herein, we develop a strategy for the synthesis of donor-acceptor CMPs through nickel(0)-catalyzed Yamamoto cross-coupling of 3,6-dibromo-9-(4-bromophenyl)carbazole (CZ) with 5,5'-dibromo-2,2'-bipyridine (DBPy) for efficient HER from water. The PCZN-4 prepared with a 2 : 3 stoichiometric ratio of CZ to DBPy exhibited the highest photocatalytic hydrogen evolution rate of 7160 μmol·g^(–1)·h^(–1), which was nearly equal to 179 times and 143 times that of PCZN-1 (40 μmol·g^(–1)·h^(–1)) and PCZN-6 (50 μmol·g^(–1)·h^(–1)) obtained by Yamamoto homocoupling of CZ and DBPy, respectively. Compared to the homocoupling counterparts, the enhanced photocatalytic activity of PCZN-4 results from improved separation efficiency of charge carriers. Interestingly, the photocatalytic H2 evolution performance of PCZN-4 could be further improved up to 17080 μmol·g^(–1)·h^(–1) by adjusting pH of the aqueous solution. This work offers a novel approach for improving photocatalytic efficiency by tuning the chemical structures and surrounding microenvironment of the polymer backbone.
基金supported by The National Key R&D Program (2022YFC2303700,China)the Ningxia Hui Autonomous Region Key Research and Development Project (2022BEG02042,China)+3 种基金the National Natural Science Foundation of China (82030108,81803351)Open Fund of State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University (KF-202304,China)the China Postdoctoral Science Foundation (2018M641122,China)the National Major Scientific and Technological Special Project for Significant New Drugs Development (2018ZX09711002-013-004,2018ZX09735-001,China)。
文摘Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and tetrahydro-carboline derivatives were reported as D_(3)R selective ligands.Through a structure-based virtual screen,ZLG-25(D_(3)R K_i=685 nmol/L;D_2R K_i>10,000 nmol/L)was identified as a novel D_(3)R selective bitopic ligand with a carbazole scaffold.Scaffolds hopping led to the discovery of novel D_(3)R-selective analogs with tetrahydro-β-carboline or tetrahydro-γ-carboline core.Further functional studies showed that most derivatives acted as h D_(3)R-selective antagonists.Several lead compounds could dose-dependently inhibit the MK-801-induced hyperactivity.Additional investigation revealed that 23j and 36b could decrease the apomorphine-induced climbing without cataleptic reaction.Furthermore,36b demonstrated unusual antidepressant-like activity in the forced swimming tests and the tail suspension tests,and alleviated the MK-801-induced disruption of novel object recognition in mice.Additionally,preliminary studies confirmed the favorable PK/PD profiles,no weight gain and limited serum prolactin levels in mice.These results revealed that 36b provided potential opportunities to new antipsychotic drugs with the multiple antipsychotic-like properties.
基金supported by Joint Innovation Fund for Regional Development of National Natural Science Foundation of China(No.U20A20134)Leading Talent of Technological Innovation of Ten-Thousands Talents Program of Zhejiang Province(No.2020R52012).
文摘Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain uncertain.Herein,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate underlyingmechanisms.In female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose level.The only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,6-DCCZ.We also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic disorders.Our findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic activities.Overall,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.