卡波姆基质口腔溃疡乳化型凝胶的研制

介绍了以新型药用辅料卡波姆（Ｃａｒｂｏｍｅｒ）为基质的口腔溃疡凝胶的研制。卡波姆为基质的口腔溃疡凝胶在保证了原有药效的基础上，具有与粘膜粘合性好，作用持久，使用方便等优点，是一种较为理想的口腔溃疡治疗药物。

Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.