Carcass weight is an economically important trait for beef cattle breeding and markets. The previous studies detected two single nucleotide polymorphisms (SNPs) associated with carcass weight of Japanese Black: c.1326...Carcass weight is an economically important trait for beef cattle breeding and markets. The previous studies detected two single nucleotide polymorphisms (SNPs) associated with carcass weight of Japanese Black: c.1326T>G in NCAPG gene and FJX_250879 in PLAG1 gene. Here, I carried out multiple marker association analysis for the two SNPs in Japanese Black population of 218 animals. The multiple marker analysis with the model including the main effects of the two SNPs and their interaction detected significant main effects of c.1326T>G and FJX_250879 and a significant interaction between the two SNPs, for carcass weight. These findings suggest the presence of inter-allelic interactions among genes affecting the variation of carcass weight. For effective marker-assisted selection for beef production, interaction between the two markers needs to be considered.展开更多
Porcine carcass traits and organ weights have important economic roles in the swine industry. A total of 576 animals from a Large White×Minzhu intercross population were genotyped using the Illumina PorcineSNP60K...Porcine carcass traits and organ weights have important economic roles in the swine industry. A total of 576 animals from a Large White×Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip and were phenotyped for 10 traits, speciifcally, backfat thickness （6-7 libs）, carcass length, carcass weight, foot weight, head weight, heart weight, leaf fat weight, liver weight, lung weight and slaughter body weight. The genome-wide association study （GWAS） was assessed by Genome Wide Rapid Association using the mixed model and regression-genomic control approach. A total of 31 single nucleotide polymorphisms （SNPs） （with the most signiifcant SNP being MARC0033464, P value=6.80×10-13） were located in a 9.76-Mb （31.24-41.00 Mb） region on SSC7 and were found to be signiifcantly associated with one or more carcass traits and organ weights. High percentage of phenotypic variance explanation was observed for each trait ranging from 31.21 to 67.42%. Linkage analysis revealed one haplotype block of 495 kb, in which the most signiifcant SNP being MARC0033464 was contained, on SSC7 at complete linkage disequilibrium. Annotation of the pig reference genome suggested 6 genes （GRM4, HMGA1, NUDT3, RPS10, SPDEF and PACSIN1） in this candidate linkage disequilibrium （LD） interval. Functional analysis indicated that the HMGA1 gene presents the prime biological candidate for carcass traits and organ weights in pig, with potential application in breeding programs.展开更多
Background: The aim of this study was to determine how maternal undernutrition during pregnancy and offspring birth-weight can affect the postnatal development of offspring under farm conditions, which may lead to con...Background: The aim of this study was to determine how maternal undernutrition during pregnancy and offspring birth-weight can affect the postnatal development of offspring under farm conditions, which may lead to consequences in its meat and carcass quality. The current study involved a total of 80 litters from Iberian sows fed a diet fulfilling daily requirements(n = 47; control) or providing 70% daily requirements(n = 33; underfed) from d 38 to d 90 of gestation when fetal tissue development begins. After birth, piglets born live were classified as low birthweight(LBW; < 1 kg) and normal birth-weight(NBW; ≥1 kg). During the growing phase, 240 control and 230 underfed pigs(50% males and females) distributed by BW category and sex were studied until the slaughter.Results: At birth and weaning, there were significant differences in all morphological measures and weight between NBW and LBW piglets as expected(P < 0.0005), but few effects of the gestational feed restriction. During the growing phase, NBW pigs continued with higher weight than LBW pigs on all the days of evaluation(P < 0.05),even though control-LBW-females and LBW-males showed a catch-up growth. However, underfed pigs showed slower growth and higher feed conversion ratio than control pigs(P < 0.0001) at 215 days old. Moreover, the average daily weight gain(ADWG) for the overall period was greater for NBW, male and control pigs than for their LBW, female and underfed pigs(P < 0.0001, P< 0.0005 and P< 0.05, respectively) and NBW pigs were slaughtered at a younger age than LBW pigs(P < 0.0001). After slaughtering, control pigs also had higher carcass yield and backfat depth than underfed pigs(P < 0.0005) and the maternal nutritional effect caused main changes in the polar lipid fraction of liver and loin. The fatty acid composition of loin in control pigs had higher C18:1 n-9 and n-3 FA concentrations, as well as lower ∑n-6/∑n-3 ratio, than in underfed pigs(P < 0.005).Conclusions: In brief, results showed that the effects of maternal nutritional restriction appeared and increased with offspring age, causing worse developmental patterns for underfed pigs than for control pigs.展开更多
文摘Carcass weight is an economically important trait for beef cattle breeding and markets. The previous studies detected two single nucleotide polymorphisms (SNPs) associated with carcass weight of Japanese Black: c.1326T>G in NCAPG gene and FJX_250879 in PLAG1 gene. Here, I carried out multiple marker association analysis for the two SNPs in Japanese Black population of 218 animals. The multiple marker analysis with the model including the main effects of the two SNPs and their interaction detected significant main effects of c.1326T>G and FJX_250879 and a significant interaction between the two SNPs, for carcass weight. These findings suggest the presence of inter-allelic interactions among genes affecting the variation of carcass weight. For effective marker-assisted selection for beef production, interaction between the two markers needs to be considered.
基金supported by the Agricultural Science and Technology Innovation Program, China (ASTIPIAS02)the National Key Technology R&D Program of China (2011BAD28B01)+2 种基金the National Natural Science Foundation of China (31201781)the Earmarked Fund for Modern Agroindustry Technology Research System, National Technology Program of China (2011ZX08006-003)the Chinese Academy of Agricultural Sciences Foundation (2011cj-5, 2012ZL069 and 2014ywf-yb-8)
文摘Porcine carcass traits and organ weights have important economic roles in the swine industry. A total of 576 animals from a Large White×Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip and were phenotyped for 10 traits, speciifcally, backfat thickness （6-7 libs）, carcass length, carcass weight, foot weight, head weight, heart weight, leaf fat weight, liver weight, lung weight and slaughter body weight. The genome-wide association study （GWAS） was assessed by Genome Wide Rapid Association using the mixed model and regression-genomic control approach. A total of 31 single nucleotide polymorphisms （SNPs） （with the most signiifcant SNP being MARC0033464, P value=6.80×10-13） were located in a 9.76-Mb （31.24-41.00 Mb） region on SSC7 and were found to be signiifcantly associated with one or more carcass traits and organ weights. High percentage of phenotypic variance explanation was observed for each trait ranging from 31.21 to 67.42%. Linkage analysis revealed one haplotype block of 495 kb, in which the most signiifcant SNP being MARC0033464 was contained, on SSC7 at complete linkage disequilibrium. Annotation of the pig reference genome suggested 6 genes （GRM4, HMGA1, NUDT3, RPS10, SPDEF and PACSIN1） in this candidate linkage disequilibrium （LD） interval. Functional analysis indicated that the HMGA1 gene presents the prime biological candidate for carcass traits and organ weights in pig, with potential application in breeding programs.
基金supported by funds from the Ministry of Economy and competitiveness(project AGL2013–48121-C3-R and AGL2016–79321-C2–2-R)co-funded by FEDER.More funds were obtained from MEDGAN-REDLAB(project S2013/ABI-2913)CAM,co-funded by FEDER.MVG and CGC are backed by the Spanish Government(MVG:FPU National Program Grant Number FPU014/01285.CGC:FPI National Program Grant Number BES-2014-070464)
文摘Background: The aim of this study was to determine how maternal undernutrition during pregnancy and offspring birth-weight can affect the postnatal development of offspring under farm conditions, which may lead to consequences in its meat and carcass quality. The current study involved a total of 80 litters from Iberian sows fed a diet fulfilling daily requirements(n = 47; control) or providing 70% daily requirements(n = 33; underfed) from d 38 to d 90 of gestation when fetal tissue development begins. After birth, piglets born live were classified as low birthweight(LBW; < 1 kg) and normal birth-weight(NBW; ≥1 kg). During the growing phase, 240 control and 230 underfed pigs(50% males and females) distributed by BW category and sex were studied until the slaughter.Results: At birth and weaning, there were significant differences in all morphological measures and weight between NBW and LBW piglets as expected(P < 0.0005), but few effects of the gestational feed restriction. During the growing phase, NBW pigs continued with higher weight than LBW pigs on all the days of evaluation(P < 0.05),even though control-LBW-females and LBW-males showed a catch-up growth. However, underfed pigs showed slower growth and higher feed conversion ratio than control pigs(P < 0.0001) at 215 days old. Moreover, the average daily weight gain(ADWG) for the overall period was greater for NBW, male and control pigs than for their LBW, female and underfed pigs(P < 0.0001, P< 0.0005 and P< 0.05, respectively) and NBW pigs were slaughtered at a younger age than LBW pigs(P < 0.0001). After slaughtering, control pigs also had higher carcass yield and backfat depth than underfed pigs(P < 0.0005) and the maternal nutritional effect caused main changes in the polar lipid fraction of liver and loin. The fatty acid composition of loin in control pigs had higher C18:1 n-9 and n-3 FA concentrations, as well as lower ∑n-6/∑n-3 ratio, than in underfed pigs(P < 0.005).Conclusions: In brief, results showed that the effects of maternal nutritional restriction appeared and increased with offspring age, causing worse developmental patterns for underfed pigs than for control pigs.
