BACKGROUND Esophageal cancer is a common cause of cancer-related death worldwide.Cutaneous metastasis of esophageal squamous cell carcinoma is rare,particularly in diffuse skin metastasis.CASE SUMMARY In this case rep...BACKGROUND Esophageal cancer is a common cause of cancer-related death worldwide.Cutaneous metastasis of esophageal squamous cell carcinoma is rare,particularly in diffuse skin metastasis.CASE SUMMARY In this case report,we describe an 82-year-old male who was diagnosed with esophageal squamous cell carcinoma.The tumor was staged as T4N3M1(Stage IVB).The pathological findings revealed poorly differentiated squamous cell carcinoma of the esophagus.Four months after diagnosis,the patient began chemotherapy,and symptoms were relieved after four cycles of chemotherapy.After that,the patient returned home without a systematic physical examination.One year after diagnosis,the patient realized that the skin of the abdominal wall was hard and rough without pain,and the color became darker than normal skin.Thirteen months after diagnosis,a biopsy of the patient’s abdominal lesion revealed that the skin metastasis was derived from the esophagus.Then the patient received two cycles of apatinib combined with docetaxel,but the abdominal lesion worsened.Two cycles of nivolumab were administered,but the patient eventually died of multiple organ failure.CONCLUSION This report highlights cutaneous metastasis as a late and untreatable metastasis of esophageal cancer.展开更多
目的：探讨鳞状上皮细胞癌抗原（SCC-Ag）联合液基薄层细胞检测（TCT）在宫颈病变筛查中的应用价值。方法TCT检测提示异常的58例患者，行病理活检，同时进行血清SCC-Ag检测，以病理活检为诊断标准，计算TCT与SCC-Ag联合检测筛查宫颈病...目的：探讨鳞状上皮细胞癌抗原（SCC-Ag）联合液基薄层细胞检测（TCT）在宫颈病变筛查中的应用价值。方法TCT检测提示异常的58例患者，行病理活检，同时进行血清SCC-Ag检测，以病理活检为诊断标准，计算TCT与SCC-Ag联合检测筛查宫颈病变的敏感度、特异度，评价两者联合检测的诊断价值。结果 TCT检测的敏感度和特异度分别为75％和65.8％；SCC-Ag检测的敏感度和特异度分别为60％和86.9％；两者联合检测的敏感度和特异度分别为55％和89.4％。 TCT检测与SCC-Ag检测差异有统计学意义（ P ＜0.05），两者联合检测与单一TCT检测差异有统计学意义（ P ＜0.05）。结论TCT与SCC-Ag联合检测可提高宫颈检测的特异度，在宫颈病变筛查中具有一定的临床应用价值。展开更多
文摘BACKGROUND Esophageal cancer is a common cause of cancer-related death worldwide.Cutaneous metastasis of esophageal squamous cell carcinoma is rare,particularly in diffuse skin metastasis.CASE SUMMARY In this case report,we describe an 82-year-old male who was diagnosed with esophageal squamous cell carcinoma.The tumor was staged as T4N3M1(Stage IVB).The pathological findings revealed poorly differentiated squamous cell carcinoma of the esophagus.Four months after diagnosis,the patient began chemotherapy,and symptoms were relieved after four cycles of chemotherapy.After that,the patient returned home without a systematic physical examination.One year after diagnosis,the patient realized that the skin of the abdominal wall was hard and rough without pain,and the color became darker than normal skin.Thirteen months after diagnosis,a biopsy of the patient’s abdominal lesion revealed that the skin metastasis was derived from the esophagus.Then the patient received two cycles of apatinib combined with docetaxel,but the abdominal lesion worsened.Two cycles of nivolumab were administered,but the patient eventually died of multiple organ failure.CONCLUSION This report highlights cutaneous metastasis as a late and untreatable metastasis of esophageal cancer.
文摘目的：探讨鳞状上皮细胞癌抗原（SCC-Ag）联合液基薄层细胞检测（TCT）在宫颈病变筛查中的应用价值。方法TCT检测提示异常的58例患者，行病理活检，同时进行血清SCC-Ag检测，以病理活检为诊断标准，计算TCT与SCC-Ag联合检测筛查宫颈病变的敏感度、特异度，评价两者联合检测的诊断价值。结果 TCT检测的敏感度和特异度分别为75％和65.8％；SCC-Ag检测的敏感度和特异度分别为60％和86.9％；两者联合检测的敏感度和特异度分别为55％和89.4％。 TCT检测与SCC-Ag检测差异有统计学意义（ P ＜0.05），两者联合检测与单一TCT检测差异有统计学意义（ P ＜0.05）。结论TCT与SCC-Ag联合检测可提高宫颈检测的特异度，在宫颈病变筛查中具有一定的临床应用价值。
