Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several ye...Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several years,there have been significant advances in the study of digoxin pharmacology and its potential noncardiac clinical applications,including anti-inflammatory,antineoplastic,metabolic,and antimicrobial use.Digoxin holds promise in the treatment of gastrointestinal disease,including nonalcoholic steatohepatitis and alcoholassociated steatohepatitis as well as in obesity,cancer,and treatment of viral infections,among other conditions.In this review,we provide a summary of the clinical uses of digoxin to date and discuss recent research on its emerging applications.展开更多
Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia spec...Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.展开更多
基金Supported by NIH UO1(to Mehal WZ),No.5U01AA026962-02.
文摘Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several years,there have been significant advances in the study of digoxin pharmacology and its potential noncardiac clinical applications,including anti-inflammatory,antineoplastic,metabolic,and antimicrobial use.Digoxin holds promise in the treatment of gastrointestinal disease,including nonalcoholic steatohepatitis and alcoholassociated steatohepatitis as well as in obesity,cancer,and treatment of viral infections,among other conditions.In this review,we provide a summary of the clinical uses of digoxin to date and discuss recent research on its emerging applications.
文摘Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.
