New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individua...New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.展开更多
Background Healthcare is a complex and divergent system with uncertainty,unpredictability,and multi-layered stakeholders.The relationships among the stakeholders are multifaceted and dynamic,requiring continual interp...Background Healthcare is a complex and divergent system with uncertainty,unpredictability,and multi-layered stakeholders.The relationships among the stakeholders are multifaceted and dynamic,requiring continual interpersonal connections,networks,and co-evolution.It is pivotal to have an evidence-informed theory to explain the phenomenon,uniting the multifaceted stakeholders’efforts.Purpose To describe the development of an evidence-informed theory,the Convergent Care Theory,assembling healthcare stakeholders to work together and achieve optimal health outcomes.Methods The Convergent Care Theory was developed using a theory synthesis approach based on empirical research and literature reviews published by the theory-proposing author.The empirical evidence was categorized into:patients and families,healthcare providers,healthcare organizations,and patients’and healthcare providers’self-care.Results The Convergent Care Theory includes four concepts:all-inclusive organizational care,healthcare professional collaborative care,person-centered precision care,and patients’and healthcare providers’self-care.Achieving convergent care is a process requiring all stakeholders to work together.Six major facilitators emerged from the research evidence:competence,compassion,accountability,trusting,sharing,and engaging.Conclusion This article introduced the development process of the evidence-informed Convergent Care Theory.Healthcare systems are complex,with multiple stakeholders’needs to meet.The Convergent Care Theory strives to unite healthcare stakeholders,bond resources,and join forces to achieve optimal healthcare outcomes.The underpinning of the theory is a caring culture,which is an underlying code for organizational and team behaviors and the foundation of optimal health outcomes.展开更多
文摘New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.
文摘Background Healthcare is a complex and divergent system with uncertainty,unpredictability,and multi-layered stakeholders.The relationships among the stakeholders are multifaceted and dynamic,requiring continual interpersonal connections,networks,and co-evolution.It is pivotal to have an evidence-informed theory to explain the phenomenon,uniting the multifaceted stakeholders’efforts.Purpose To describe the development of an evidence-informed theory,the Convergent Care Theory,assembling healthcare stakeholders to work together and achieve optimal health outcomes.Methods The Convergent Care Theory was developed using a theory synthesis approach based on empirical research and literature reviews published by the theory-proposing author.The empirical evidence was categorized into:patients and families,healthcare providers,healthcare organizations,and patients’and healthcare providers’self-care.Results The Convergent Care Theory includes four concepts:all-inclusive organizational care,healthcare professional collaborative care,person-centered precision care,and patients’and healthcare providers’self-care.Achieving convergent care is a process requiring all stakeholders to work together.Six major facilitators emerged from the research evidence:competence,compassion,accountability,trusting,sharing,and engaging.Conclusion This article introduced the development process of the evidence-informed Convergent Care Theory.Healthcare systems are complex,with multiple stakeholders’needs to meet.The Convergent Care Theory strives to unite healthcare stakeholders,bond resources,and join forces to achieve optimal healthcare outcomes.The underpinning of the theory is a caring culture,which is an underlying code for organizational and team behaviors and the foundation of optimal health outcomes.
