In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable challenge.DNA is an excellent candidate for building molecular robots because it is ...In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable challenge.DNA is an excellent candidate for building molecular robots because it is highly programmable.Here,we present an artificial nanorobot,in which a DNA cube serves as the inert‘body’,and nucleic acid catalysts based on an enzymatic nicking reaction act as the‘legs’for walking.The nanorobot can execute a series of actions,such as‘start’,‘turn’,and‘stop’when it walks along a predefined track.Its performance could be confirmed and monitored by using an atomic force microscope(AFM)and fluorescence spectroscopy.Inspired by biological machines,we artificially designed a series of specialized tasks that combined walking with control of cargo transport and catalysis.Real-time fluorescence kinetics curves provide monitoring signals for cargo transport and catalytic processes.Our work can enrich the toolbox of DNA machinery and has great potential for engineering molecular nanofactories.展开更多
Evacuated Tube Transport Technologies （ET3） offers the potential for more than an order of magnitude improvement in transportation efficiency, speed, cost, and effectiveness. An ET3 network may be optimized to susta...Evacuated Tube Transport Technologies （ET3） offers the potential for more than an order of magnitude improvement in transportation efficiency, speed, cost, and effectiveness. An ET3 network may be optimized to sustainably displace most global transportation by car, ship, truck, train, and jet aircraft. To do this, ET3 standards should adhere to certain key principals： maximum value through efficiency, reliability, and simplicity; equal consideration for passenger and cargo loads; optimum size; high speed/high frequency operation; demand oriented; random accessibility; scalability; high granularity; automated control; full speed passive switching; open standards of implementation; and maximum use of existing capacities, materials, and processes.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21991080,22374042)the Science and Technology Major Project of Hunan Province,China(No.2021SK1020).
文摘In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable challenge.DNA is an excellent candidate for building molecular robots because it is highly programmable.Here,we present an artificial nanorobot,in which a DNA cube serves as the inert‘body’,and nucleic acid catalysts based on an enzymatic nicking reaction act as the‘legs’for walking.The nanorobot can execute a series of actions,such as‘start’,‘turn’,and‘stop’when it walks along a predefined track.Its performance could be confirmed and monitored by using an atomic force microscope(AFM)and fluorescence spectroscopy.Inspired by biological machines,we artificially designed a series of specialized tasks that combined walking with control of cargo transport and catalysis.Real-time fluorescence kinetics curves provide monitoring signals for cargo transport and catalytic processes.Our work can enrich the toolbox of DNA machinery and has great potential for engineering molecular nanofactories.
文摘Evacuated Tube Transport Technologies （ET3） offers the potential for more than an order of magnitude improvement in transportation efficiency, speed, cost, and effectiveness. An ET3 network may be optimized to sustainably displace most global transportation by car, ship, truck, train, and jet aircraft. To do this, ET3 standards should adhere to certain key principals： maximum value through efficiency, reliability, and simplicity; equal consideration for passenger and cargo loads; optimum size; high speed/high frequency operation; demand oriented; random accessibility; scalability; high granularity; automated control; full speed passive switching; open standards of implementation; and maximum use of existing capacities, materials, and processes.
