Osteoarthritis(OA)is a multifaceted bone and joint disease with degenerative changes of articular cartilage.Therefore,the current research on the etiology of OA mainly focuses on the etiology of articular cartilage de...Osteoarthritis(OA)is a multifaceted bone and joint disease with degenerative changes of articular cartilage.Therefore,the current research on the etiology of OA mainly focuses on the etiology of articular cartilage degeneration.Clarifying the pathogenesis of OA from the molecular level has become an important research topic in the field of orthopedics.Its main pathological features are the decrease of chondrocyte metabolic activity,cartilage matrix degradation,and osteophyte formation.Icariin(ICA)is the main active monomer of epimedium,a traditional Chinese medicine,and the pharmacological research has revealed favorable effects of ICA on the bone system.ICA can promote the proliferation of chondrocytes and inhibit the apoptosis of chondrocytes,alleviate the degradation rate of cartilage matrix,and effectively protect articular cartilage.This review also expounds the mechanism of promoting cartilage repair.展开更多
Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and...Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations（〉 15 wt%）. The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEGPLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.展开更多
In an effort to develop a method for cartilage tissue engineering,researchers successfully used cartilage cells from cow knee joints.By creating a successful method with conditions conducive to growing healthy cartila...In an effort to develop a method for cartilage tissue engineering,researchers successfully used cartilage cells from cow knee joints.By creating a successful method with conditions conducive to growing healthy cartilage tissue,the findings could help lead to a new treatment cure for osteoarthritis using stem cell-based tissue engineering.Articular cartilage is tissue that is found on all the joint surfaces in the body.Since the tissue展开更多
基金This work is supported by Foundation for Basic Research of Central University(xjj2016107)Natural Science Foundation of China(No.81001225)Shaanxi International Cooperation Plan(fys20163).
文摘Osteoarthritis(OA)is a multifaceted bone and joint disease with degenerative changes of articular cartilage.Therefore,the current research on the etiology of OA mainly focuses on the etiology of articular cartilage degeneration.Clarifying the pathogenesis of OA from the molecular level has become an important research topic in the field of orthopedics.Its main pathological features are the decrease of chondrocyte metabolic activity,cartilage matrix degradation,and osteophyte formation.Icariin(ICA)is the main active monomer of epimedium,a traditional Chinese medicine,and the pharmacological research has revealed favorable effects of ICA on the bone system.ICA can promote the proliferation of chondrocytes and inhibit the apoptosis of chondrocytes,alleviate the degradation rate of cartilage matrix,and effectively protect articular cartilage.This review also expounds the mechanism of promoting cartilage repair.
基金financially supported by the National Natural Science Foundation of China(Nos.81171681,51233004,51273196,51203153 and 51303174)the Scientific Development Program of Jilin Province(No.20140520050JH)
文摘Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations（〉 15 wt%）. The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEGPLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.
文摘In an effort to develop a method for cartilage tissue engineering,researchers successfully used cartilage cells from cow knee joints.By creating a successful method with conditions conducive to growing healthy cartilage tissue,the findings could help lead to a new treatment cure for osteoarthritis using stem cell-based tissue engineering.Articular cartilage is tissue that is found on all the joint surfaces in the body.Since the tissue
