A Corpus-based Study on "However" in Chinese Learners' Writing

The use of "however" by Chinese learners' writing is studied through a comparison of its use in CLEC and in BROWN and found that "however" is overused in the front of a sentence,underused in the middle of a sentence and misused as a disjunctive conjunction,as is followed by the analysis of three attributable factors,i.e.the writing style,confusion with "but" and negative L1 transfer.

Association between visual status and mental health status in Thai rural elderly:a community-based study

AIM：To evaluate the association between visual impairment（VI） and mental health or social engagement in older adults living in rural Thailand.METHODS：Data for this cross-sectional study were drawn from a community survey conducted in 2015 in Saraburi Province,Thailand.Participants were 327 adults aged ≥50 y.VI was assessed using presenting distance visual acuity.Mental health and social engagement were evaluated in face-to-face interviews using validated questionnaires.After determining the prevalence of VI and relevant sociodemographic characteristics,multivariate regression analysis was used to evaluate the impact of VI on mental health and social engagement.RESULTS：The prevalence of VI was 18.3%.Major causes were refractive error（58.3%） and cataract（35%）.Factors associated with VI in the crude analysis were：older age [odds ratio（OR） 8.08],unemployment（OR 2.72）,widowhood（OR 2.47）,being divorced/separated（OR 3.27）,smoking（OR 2.09） and disability in activities of daily living（OR 2.35）.Protective factors were undergoing eye screening at least once a year（P=0.029） and obesity（P=0.005）.VI was significantly associated with low social engagement（adjusted OR 4.13） but not with poor mental health（P〉0.05）.CONCLUSION：Although VI older adults reported less participation in social activities,there is no significant association between VI and poor mental health.Annual eye examinations may prevent VI in older adults.Information about employment and anti-smoking should be targeted to older adults with VI.

Factors associated with gastric adenocarcinoma and dysplasia in patients with chronic gastritis:a population-based study

Objective： Gastric cancer （GC） is one of the leading causes of death in China and other Asian countries. Recently, gastric endoscopy has become the main approach for GC screening, but the identification of high-risk individuals remains a challenge in GC screening programs. Methods： There were 7,302 patients with chronic gastritis involved in this study. Endoscopic examinations were performed, and their demographic characteristics and lifestyle data were collected. Each possible associated factor of GC/premalignant and precursor lesions was evaluated by univariate and multivariate logistic regressions. Nomograms were used for visualization of those models, and receiver operating characteristic （ROC） curve analysis was used to present the predictive accuracy. Resu Its： We detected 8 （0.11% ） gastric adenocarcinomas, 17 （0.23 %） dysplasia cases, 14 （0.19%） hyperplasia cases, 52 （0.71%） intestinal metaplasia cases, 217 （2.97%） inflammatory lesions, 141 （1.93%） gastric ulcers, 10 （0.14%） atrophic gastritis cases, 1,365 （18.69%） erosive gastritis cases, and 5,957 （81.58%） superficial gastritis cases in 7,302 patients. The age （P〈0.001）, gender （P=0.086）, labor intensity （P=0.018） and leek food intake （P=0.143） were identified as independent predictive factors of GC/premalignant lesions possibility. The corresponding nomogram exhibited an area under the curve （AUC） [95% confidence interval （95% CI）] of 0.82 （0.74-0.89） for the modeling group and 0.80 （0.75-0.85） for the validation group. The age （P=0.002）, gender （P=0.024）, smoldng （P=0.002） and leek food intake （P=0.039） were independent predictive factors of precursor lesions possibility. The corresponding nomogram exhibited an AUC （95% CI） of 0.62 （0.60-0.65） for the modeling group and 0.61 （0.59-0.63） for the validation group. Conclusions： We identified several potential associated factors and provided a preclinical nomogram with the potential to predict the possibility of GC/premalignant and precursor lesions.

Favorable clinical outcome of nonalcoholic liver cirrhosis patients with coronary artery disease:A population-based study

AIM To elucidate the prevalence and risk of mortality of nonalcoholic liver cirrhosis(LC) patients with coronary artery disease(CAD).METHODS The study cohort included newly diagnosed nonalcoholic LC patients age ≥ 40 years old without a diagnosis of CAD from 2006 until 2011 from a longitudinal health insurance database. The mean follow-up period for the study cohort was 1152 ± 633 d. The control cohort was matched by sex, age, residence, and index date. Hazard ratios(HRs) were calculated using the Cox proportional hazard model and the Kaplan-Meier method. RESULTS After exclusion, a total of 3409 newly diagnosed nonalcoholic cirrhotic patients were identified from one million samples from the health insurance database. We found that CAD(5.1% vs 17.4%) and hyperlipidemia(20.6% vs 24.1%) were less prevalent in nonalcoholic LC patients than in normal subjects(all P < 0.001), whereas other comorbidities exhibited an increased prevalence. Among the comorbidities, chronic kidney disease exhibited the highest risk for mortality(adjusted HR(AHR) = 1.76; 95%CI: 1.55-2.00, P < 0.001). Ascites or peritonitis exhibited the highest risk of mortality among nonalcoholic cirrhotic patients(AHR = 2.34; 95%CI: 2.06-2.65, P < 0.001). Finally, a total of 170 patients developed CAD after a diagnosis of nonalcoholic LC. The AHR of CAD in nonalcoholic LC patients was 0.56(95%CI: 0.43-0.74, P < 0.001). The six-year survival rates for nonalcoholic LC patients with and without CAD were 52% and 50%, respectively(P = 0.012). CONCLUSION We conclude that CAD was less prevalent and associated with a reduced risk of mortality in nonalcoholic cirrhotic patients.

EVIDENCE-BASED MEDICINE AND THE CLINICAL STUDY ON ACUPUNCTURE AND MOXIBUSTION

In this article, the authors hold that the evidence based medicine(EBM) is a new medical action produced at the historic moment in clinical practice, which is promoting development of the medicine and even the whole life science in a fully new train of thought and method. Further the briefly introduced contents are the effect of EBM, the difficulty of utilizing in the acupuncture clinical practice and how to resolve them. It is highly recommended that the doctors of the acupuncture science field should study EBM and its effect and difficulties in practice as earlier as possible, insistently assimilate new knowledge and keep abreast of the times’ progress to facilitate the further development of acupunctology.

Study on Identification of Inductive-Motors Load Partition Based on Coherence

A new inductive motors load equivalence algorithm based on coherence is proposed in this paper. In order to partite motors load rapidly and accurately, fuzzy c-means clustering along with particle swarm optimization (PSO-FCM) algorithm is proposed to identify coherent motors base on its physical essence of fuzziness. The merits of PSO algorithm are independent to initial value and convergent to optimum value rapidly, and the validity function is constructed to assess clustering validity. The test on IEEE 39-Bus System is presented to evaluate the effectiveness of the new algorithm, the membership matrix definite not only coherence group of motors but also correlation value of coherence between motors. The algorithm can be used to partite motor load based on coherency in dynamic equivalence with power system operating on different modes.

Adaptive Smoothing Method Based on Fuzzy Theory Study and Realization

In this paper, we study about a method to optimize the fused track quality in intelligence network of radar target fusion system, considering the role of people in the fusion system;we start to find ways to optimize the quality of the fused track, and adaptive smoothing method is proposed based on fuzzy theory. Tests show that this method can greatly improve the quality of the fused track system for battlefield reconnaissance provides high-quality, high-reliability battlefield.

Cost-benefit analysis of screening for diabetic retinopathy among Chinese type 2 diabetes: decision from different perspectives of a population-based study

The purpose of this study is to explore whether it is worthwhile to launch a routine diabetic retinopathy (DR) screening for blindness pre-vention among Chinese type 2 diabetes from different perspective based on the popula-tion-based study in Kinmen, Taiwan. A total of 971 community dwelling adults previously di-agnosed with type 2 diabetes in 1991-1993 un-derwent DR screening in 1999-2002 by a panel of ophthalmologists using on-site indirect oph-thalmoscopy and 45-degree color fundus retinal photographs. The cost-benefit analysis is used to evaluate the DR screening. In terms of bene-fit-cost ratio, the different screening programs for DR could save New Taiwan Dollars (NTD) from 14.38 to 36.83 in discounted costs for each dollar incurred in different screening years from the societal viewpoint for Taiwan and save NTD from 0.81 to 1.80 in different screening years from health care payer’s perspective. The av-erage estimate of willingness-to-pay to translate into benefit yields NTD from 937.8 to 4,689 be- nefits per case due to DR screening in different screening years during 10-year follow-up. The net present value of the DR screening were NTD from -167,318 to -307,251.2 in different screening years. In conclusion, it is worthwhile to initial a routine DR screening of Chinese type 2 diabetes for blindness prevention from the societal per-spective but not from consumer decision based on the willingness-to-pay perspective.

Pathway-based analysis of genome-wide association study of circadian phenotypes

Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single nucleotide polymorphisms（SNPs） which may cause circadian phenotypes, elucidate the potential mechanisms, and generate corresponding SNP-gene-pathways. A genome-wide association studies（GWAS） dataset of circadian phenotypes was utilized in the study. Then, the Identify Candidate Causal SNPs and Pathways analysis was employed to the GWAS dataset after quality control filters. Furthermore, genotype-phenotype association analysis was performed with HapMap database. Four SNPs in three different genes were determined to correlate with usual weekday bedtime,totally providing seven hypothetical mechanisms. Eleven SNPs in six genes were identified to correlate with usual weekday sleep duration, which provided six hypothetical pathways. Our results demonstrated that fifteen candidate SNPs in eight genes played vital roles in six hypothetical pathways implicated in usual weekday bedtime and six potential pathways involved in usual weekday sleep duration.

THE XPS STUDY OF Cu-Co BASED CATALYSTS FOR SYNGAS CONVERSION TO ALCOHOLS

The copper-cobalt based catalysts were effective for higher alcohol synthesis, the surface state of the catalysts and the nature of the active sites were investigated by using XPS and XAES spectra, and some strong interactions were also observed, in each of the three cases, (after calcination, after reduction, and during the syngas reaction).

STUDY OF CALCIUM ION-SELECTIVE ELECTRODE BASED ON A NEW NEUTRAL CARRIER

A calcium ion-setective eletrode based on a new neutral carrier was studied.The electrode gives a Nernstian response in the rang 5.9-1 Pa and the response is stable in a wide pH range.Logarithms of setectivity coefficents are -2.3 Li(+),-3.5 Na(+),-4.0 K(+),-3.7NH_4(+),-4.5 Mg(2+) and -4.4Zn(2+).

THE STUDY OF PHOTOELECTROCHEHICAL CELLS BASED ON CHLOROPHYLL AND ORGANIC DYES

Tetraiodofluorescein(TIF)and safranine T(ST)had great effects on the photovoltaic parameters of the cells.The Voc of the cells was about 3-5 times higher than that of the cells without TIK and ST,Isc increased 1 to 2 orders of magnitude.The Voc and Isc could be increased greatly only when Voc and Isc of the cell with Pt as WE properly combined with the Voc and Isc produced by chla in the original cell.According to absorption spectra and output characters,the results were elucidated.

The memristive conductance studying of an Au/Ti_nO_(2n-1) memristor device based on oxygen vacancy drifting

With the insight of memristor researsh growing continuously,many semiconductor material has been manufactured to various kinds of memristive device.Yet the stabilization of memristive performance haven’t been fulfilled,the fathom of memristive-acting mechanism still not being generalized.To put a futher move on low-consuming and high-stable memristive conductance device,we built a high stable double-pair-electrode device,based on the fabrication of TiO_(2-x),which has been generally applied as a n-type semiconductor.Under the constant-repeating cyclic voltammerty;we nailed the memristive quality of our mental/semiconductor thin film device.Moreover,through multifarious analytical processes based on our doping,filming growing path,we build a rational model for our memristor‘s memristive conductance mechanism,which indicated the carrier motion and electron tunnel following the biasing voltage.Our work exhibited a new type of TiO_(2-x)-based memristor,and emerged a new way to explicate the single-stage-switching memristive feature,which might initiate a new guiding ideology in semiconductor memristor’s studying.

Genetic Dissection of Grain Size Traits Through Genome-Wide Association Study Based on Genic Markers in Rice

Grain size plays a significant role in rice,starting from affecting yield to consumer preference,which is the driving force for deep investigation and improvement of grain size characters.Quantitative inheritance makes these traits complex to breed on account of several alleles contributing to the complete trait expression.We employed genome-wide association study in an association panel of 88 rice genotypes using 142 new candidate gene based SSR(cgSSR)markers,derived from yield-related candidate genes,with the efficient mixed-model association coupled mixed linear model for dissecting complete genetic control of grain size traits.A total of 10 significant associations were identified for four grain size-related characters(grain weight,grain length,grain width,and length-width ratio).Among the identified associations,seven marker trait associations explain more than 10%of the phenotypic variation,indicating major putative QTLs for respective traits.The allelic variations at genes OsBC1L4,SHO1 and OsD2 showed association between 1000-grain weight and grain width,1000-grain weight and grain length,and grain width and length-width ratio,respectively.The cgSSR markers,associated with corresponding traits,can be utilized for direct allelic selection,while other significantly associated cgSSRs may be utilized for allelic accumulation in the breeding programs or grain size improvement.The new cgSSR markers associated with grain size related characters have a significant impact on practical plant breeding to increase the number of causative alleles for these traits through marker aided rice breeding programs.

STUDY ON AB-CROSSLINKED POLYMERS Ⅰ. THE SYNTHESIS AND MECHANICAL PROPERTIES OF AB-CROSSLINKED POLYMERS BASED. ON PU/PS

The AB-crosslinked polymers (i.e. ABCP) with polystyrene as chain A and vinyl group blocked prepolymers of polyurethanes (PU) as chain B were synthesized and studied. The results of dynamic mechanical spectrometry (DMS) show that the compatibility between the components A and B can be improved greatly through chemical crosslinking during the formation of ABCPs. This effect is especially pronounced when short chain prepolymers is chosen as one of the components. It is apparent that the degree of crosslinking between the two components plays a major role in determining their compatibility. Copolymerizafion of styrene with maleic anhydride in chain A can improve the compatibility and broaden the damping temperature range. Mechanical properties of the sythesized ABCPs were also studied.

Global Statistical Study of Ionospheric Waves Based on COSMIC GPS Radio Occultation Data

Extracting and parameterizing ionospheric waves globally and statistically is a longstanding problem. Based on the multichannel maximum entropy method（MMEM） used for studying ionospheric waves by previous work, we calculate the parameters of ionospheric waves by applying the MMEM to numerously temporally approximate and spatially close global-positioning-system radio occultation total electron content profile triples provided by the unique clustered satellites flight between years 2006 and 2007 right after the constellation observing system for meteorology, ionosphere, and climate（COSMIC） mission launch. The results show that the amplitude of ionospheric waves increases at the low and high latitudes（~0.15 TECU） and decreases in the mid-latitudes（~0.05 TECU）. The vertical wavelength of the ionospheric waves increases in the mid-latitudes（e.g., ~50 km at altitudes of 200–250 km） and decreases at the low and high latitudes（e.g., ~35 km at altitudes of 200–250 km）.The horizontal wavelength shows a similar result（e.g., ~1400 km in the mid-latitudes and ~800 km at the low and high latitudes）.

Studies on Zeolite Modified Electrode(Ⅰ)─Ascorbic Acid Sensor Based on Carbon Paste Electrode Containing Fe(Ⅲ)Y Zeolite

A new ascorbic acid sensor constituted of carbon paste and Fe(Ⅲ)Y zeolite was studied.The characters of the sensor such as linear range. potential window、apparen Michaelis constant、response time、stability and accuracy wee investigated. The experimental results indicate that the analytical performance of the sensor is satisfactory.

Study on  Chart Based on Short Production Run

High intellectual, high flexible automatic manufacturing system based on low volume production is the trend in the future, but the traditional control charts whose control limits are based on at least 20～25 subgroups of five observations each are not suitable in this environment. The paper presents variance control chart used in small batch production in which there are not sufficient observations. The control limits are set reliably without restriction of the number of samples.

Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares

With recent advances in biotechnology, genome-wide association study （GWAS） has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression （LR） based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression （PC-LR）, partial least squares-based logistic regression （PLS-LR）, have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor- mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism （SNP） set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis. On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data.

A STUDY OF SOIL CONSERVATION MONITORING INFORMATION SYSTEM BASED ON REMOTELY SENSED DATA FOR A CATCHMENT ON THE LOESS PLATEAU

The Soil Conservation Monitorins Information System (SCMIS) presented in this paper is oriented to soil erosion control, resources exploitation, utilization, planning and management for a small watershed (about 10 sq. km.) on the Loess Plateau. It sums up Remote sensing (RS), Geographical Information System (GIS) and Expert System (ES) and consists of a integrated system. As a basic level information system of Loess Plateau, its perfection and psreading will bring about a great advance in resources exploitation and management of Loess Plateau.