A new Staudinger strategy entails a unique C-P bond cleavage,instead of N-P bond cleavage,during the construction of N-acyl phosphinamidites by using acyl-phosphine substrates.The reaction is performed under very mild...A new Staudinger strategy entails a unique C-P bond cleavage,instead of N-P bond cleavage,during the construction of N-acyl phosphinamidites by using acyl-phosphine substrates.The reaction is performed under very mild conditions,with no need for additional catalysts or additives,and thus preserves stereogenic centers that are sensitive to epimerization.A range of novel N-acyl phosphinamidites,including those bearing a chiral amino acid skeleton and axial chirality as well as complex natural product scaffolds,were produced with N_(2) gas as the only byproduct.These N-acyl phosphinamidites are potential novel P-O ligands,and preliminary screening results have demonstrated their application as chiral organic catalysts.展开更多
文摘A new Staudinger strategy entails a unique C-P bond cleavage,instead of N-P bond cleavage,during the construction of N-acyl phosphinamidites by using acyl-phosphine substrates.The reaction is performed under very mild conditions,with no need for additional catalysts or additives,and thus preserves stereogenic centers that are sensitive to epimerization.A range of novel N-acyl phosphinamidites,including those bearing a chiral amino acid skeleton and axial chirality as well as complex natural product scaffolds,were produced with N_(2) gas as the only byproduct.These N-acyl phosphinamidites are potential novel P-O ligands,and preliminary screening results have demonstrated their application as chiral organic catalysts.
