Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-t...Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-to-frequent explosive diarrhea.Methods:In a field surveyconducted by the Faculty of Tropical Medicine.Mahidol Lniversity.as part of the existing parasite-control program,a total of 2 540 faecal samples from villagers in Nan Province,Thailand,were collected and examined to determine the prevalence and clinical characteristics of parasitic infections.Results:Twelve cases of C.cayetanensis infection were found duritig faecal examination of schoolchildren aged 5-12 years.None exhibited obvious clinical symptoms,especially evidence of diarrhea:5 of 12 had loose faeces,one reported frequent symptoms of abdominal discomfort,and another had pale conjunctiva with low hematocrit.The children were generally asymptomatic.Conclusions:This finding confirms a public-health issue with potentially serious consequences whereby children can be exposed to an environment contaminated with food-und water-borne transmitted oocysts,anil can hence become infected with C.cayetunensis.展开更多
Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted...Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens （1.72%, 5/291） were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group （mean age 27.8 years; 2.94%, 5/170） with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.展开更多
基金partially supported by a grant from the Faculty of Tropical Medicine,Mahidol University
文摘Objective:To obtain the prevalence with clinical symptoms of Cyclospora cayetanensis(C.cayetanensis),a coceidian protozoan parasite,in Thailand which is the cause of an intestinal infection characterized by sporadic-to-frequent explosive diarrhea.Methods:In a field surveyconducted by the Faculty of Tropical Medicine.Mahidol Lniversity.as part of the existing parasite-control program,a total of 2 540 faecal samples from villagers in Nan Province,Thailand,were collected and examined to determine the prevalence and clinical characteristics of parasitic infections.Results:Twelve cases of C.cayetanensis infection were found duritig faecal examination of schoolchildren aged 5-12 years.None exhibited obvious clinical symptoms,especially evidence of diarrhea:5 of 12 had loose faeces,one reported frequent symptoms of abdominal discomfort,and another had pale conjunctiva with low hematocrit.The children were generally asymptomatic.Conclusions:This finding confirms a public-health issue with potentially serious consequences whereby children can be exposed to an environment contaminated with food-und water-borne transmitted oocysts,anil can hence become infected with C.cayetunensis.
文摘Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens （1.72%, 5/291） were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group （mean age 27.8 years; 2.94%, 5/170） with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.
