In this paper we first determine three phases of cell images： background, cytoplasm and nucleolus according to the general physical characteristics of cell images, and then develop a variational model, based on these...In this paper we first determine three phases of cell images： background, cytoplasm and nucleolus according to the general physical characteristics of cell images, and then develop a variational model, based on these characteristics, to segment nucleolus and cytoplasm from their relatively complicated backgrounds. In the meantime, the preprocessing obtained information of cell images using the OTSU algorithm is used to initialize the level set function in the model, which can speed up the segmentation and present satisfactory results in cell image processing.展开更多
基金supported by the National Basic Research Program of China (Grant No. 2011CB707701)the National Natural Science Foundation of China (Grant No. 60873124)+2 种基金the Joint Research Foundation of Beijing Education Committee (GrantNo. JD100010607)the International Science and Technology Supporting Programme (Grant No. 2008BAH26B00)the Zhejiang Service Robot Key Laboratory (Grant No. 2008E10004)
文摘In this paper we first determine three phases of cell images： background, cytoplasm and nucleolus according to the general physical characteristics of cell images, and then develop a variational model, based on these characteristics, to segment nucleolus and cytoplasm from their relatively complicated backgrounds. In the meantime, the preprocessing obtained information of cell images using the OTSU algorithm is used to initialize the level set function in the model, which can speed up the segmentation and present satisfactory results in cell image processing.
