This study used Topological Weighted Centroid (TWC) to analyze the Coronavirus outbreak in Brazil. This analysis only uses latitude and longitude in formation of the capitals with the confirmed cases on May 24, 2020 t...This study used Topological Weighted Centroid (TWC) to analyze the Coronavirus outbreak in Brazil. This analysis only uses latitude and longitude in formation of the capitals with the confirmed cases on May 24, 2020 to illustrate the usefulness of TWC though any date could have been used. There are three types of TWC analyses, each type having five associated algorithms that produce fifteen maps, TWC-Original, TWC-Frequency and TWC-Windowing. We focus on TWC-Original to illustrate our approach. The TWC method without using the transportation information predicts the network for COVID-19 outbreak that matches very well with the main radial transportation routes network in Brazil.展开更多
Wellbore instability is reported frequently as one of the most significant incidents during drilling operations.Analysis of wellbore instability includes estimation of formation mechanical properties and the state of ...Wellbore instability is reported frequently as one of the most significant incidents during drilling operations.Analysis of wellbore instability includes estimation of formation mechanical properties and the state of in situ stresses.In this analysis,the only controllable parameter during drilling operation is the mud weight.If the mud weight is larger than anticipated,the mud will invade into the formation,causing tensile failure of the formation.On the other hand,a lower mud weight can result in shear failures of rock,which is known as borehole breakouts.To predict the potential for failures around the wellbore during drilling,one should use a failure criterion to compare the rock strength against induced tangential stresses around the wellbore at a given mud pressure.The Mohr–Coulomb failure criterion is one of the commonly accepted criteria for estimation of rock strength at a given state of stress.However,the use of other criteria has been debated in the literature.In this paper,Mohr–Coulomb,Hoek–Brown and Mogi–Coulomb failure criteria were used to estimate the potential rock failure around a wellbore located in an onshorefield of Iran.The log based analysis was used to estimate rock mechanical properties of formations and state of stresses.The results indicated that amongst different failure criteria,the Mohr–Coulomb criterion underestimates the highest mud pressure required to avoid breakouts around the wellbore.It also predicts a lower fracture gradient pressure.In addition,it was found that the results obtained from Mogi–Coulomb criterion yield a better comparison with breakouts observed from the caliper logs than that of Hoek–Brown criterion.It was concluded that the Mogi–Coulomb criterion is a better failure criterion as it considers the effect of the intermediate principal stress component in the failure analysis.展开更多
The wellbore stability of a vertical well through the sandstone reservoir layers of the Asmari oil-bearing formation in south-west Iran is investigated.The safe drilling-fluid density range for maintaining wellbore st...The wellbore stability of a vertical well through the sandstone reservoir layers of the Asmari oil-bearing formation in south-west Iran is investigated.The safe drilling-fluid density range for maintaining wellbore stability is determined and simulated using FLAC3 D software and a finite volume model established with drilled strata geomechanical features.The initiation of plastic condition is used to determine the safe mud weight window(SMWW)in specific sandstone layers.The effects of rock strength parameters,major stresses around the wellbore and pore pressure on the SMWW are investigated for this wellbore.Sensitivity analysis reveals that a reduction in cohesion and internal friction angle values leads to a significant narrowing of the SMWW.On the other hand,the reduction of pore pressure and the ratio between maximum and minimum horizontal stresses causes the SMWW to widen significantly.The ability to readily quantify changes in SMWW indicates that the developed model is suitable as a well planning and monitoring tool.展开更多
In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes （T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]） follow...In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes （T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]） following cerebral infarction. The pathological changes were divided into three phases： early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase （less than 2 hours post-infarction）, there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase （2-4 hours post-infarction）, a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase （4-6 hours post-infarction）, significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients （10/51） had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients （8/35） had an onset time less than 6 hours. These data suggest that defining the ＂therapeutic time window＂ as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the ＂therapeutic time window＂.展开更多
文摘This study used Topological Weighted Centroid (TWC) to analyze the Coronavirus outbreak in Brazil. This analysis only uses latitude and longitude in formation of the capitals with the confirmed cases on May 24, 2020 to illustrate the usefulness of TWC though any date could have been used. There are three types of TWC analyses, each type having five associated algorithms that produce fifteen maps, TWC-Original, TWC-Frequency and TWC-Windowing. We focus on TWC-Original to illustrate our approach. The TWC method without using the transportation information predicts the network for COVID-19 outbreak that matches very well with the main radial transportation routes network in Brazil.
文摘Wellbore instability is reported frequently as one of the most significant incidents during drilling operations.Analysis of wellbore instability includes estimation of formation mechanical properties and the state of in situ stresses.In this analysis,the only controllable parameter during drilling operation is the mud weight.If the mud weight is larger than anticipated,the mud will invade into the formation,causing tensile failure of the formation.On the other hand,a lower mud weight can result in shear failures of rock,which is known as borehole breakouts.To predict the potential for failures around the wellbore during drilling,one should use a failure criterion to compare the rock strength against induced tangential stresses around the wellbore at a given mud pressure.The Mohr–Coulomb failure criterion is one of the commonly accepted criteria for estimation of rock strength at a given state of stress.However,the use of other criteria has been debated in the literature.In this paper,Mohr–Coulomb,Hoek–Brown and Mogi–Coulomb failure criteria were used to estimate the potential rock failure around a wellbore located in an onshorefield of Iran.The log based analysis was used to estimate rock mechanical properties of formations and state of stresses.The results indicated that amongst different failure criteria,the Mohr–Coulomb criterion underestimates the highest mud pressure required to avoid breakouts around the wellbore.It also predicts a lower fracture gradient pressure.In addition,it was found that the results obtained from Mogi–Coulomb criterion yield a better comparison with breakouts observed from the caliper logs than that of Hoek–Brown criterion.It was concluded that the Mogi–Coulomb criterion is a better failure criterion as it considers the effect of the intermediate principal stress component in the failure analysis.
文摘The wellbore stability of a vertical well through the sandstone reservoir layers of the Asmari oil-bearing formation in south-west Iran is investigated.The safe drilling-fluid density range for maintaining wellbore stability is determined and simulated using FLAC3 D software and a finite volume model established with drilled strata geomechanical features.The initiation of plastic condition is used to determine the safe mud weight window(SMWW)in specific sandstone layers.The effects of rock strength parameters,major stresses around the wellbore and pore pressure on the SMWW are investigated for this wellbore.Sensitivity analysis reveals that a reduction in cohesion and internal friction angle values leads to a significant narrowing of the SMWW.On the other hand,the reduction of pore pressure and the ratio between maximum and minimum horizontal stresses causes the SMWW to widen significantly.The ability to readily quantify changes in SMWW indicates that the developed model is suitable as a well planning and monitoring tool.
基金supported by the National Natural Science Foundation of China,No.30960399,and No.81160181
文摘In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes （T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]） following cerebral infarction. The pathological changes were divided into three phases： early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase （less than 2 hours post-infarction）, there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase （2-4 hours post-infarction）, a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase （4-6 hours post-infarction）, significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients （10/51） had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients （8/35） had an onset time less than 6 hours. These data suggest that defining the ＂therapeutic time window＂ as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the ＂therapeutic time window＂.
