Objective: To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke. Methods: The patients who were diagnosed with ischemic str...Objective: To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke. Methods: The patients who were diagnosed with ischemic stroke in Zhouzhi County People's Hospital between February 2015 and March 2017 were selected as the stroke group of the study, and healthy subjects who received physical examination during the same period were selected as the control group of the study. Serum was collected to determine the contents of HMGB1, sTLT-1, oxidative stress reaction molecules and endothelial injury molecules. Results: Serum HMGB1, sTLT-1, vWF, vWF-cp, sTM, ET-1, D-D, 8-OHdG, LPO and NOS contents of stroke group were significantly higher than those of control group while T-SOD and GSH-Px contents were significantly lower than those of control group;serum T-SOD and GSH-Px contents of stroke patients with high HMBG-1 content were significantly lower than those of stroke patients with low HMBG-1 content while 8-OHdG, LPO and NOS contents were significantly higher than those of stroke patients with low HMBG-1 content;serum vWF, vWF-cp, sTM, ET-1 and D-D contents of stroke patients with high sTLT-1 content were significantly higher than those of stroke patients with low sTLT-1 content. Conclusion: The abnormally elevated HMGB1 and sTLT-1 in serum of patients with ischemic stroke can induce oxidative stress response and aggravate endothelial injury.展开更多
文摘Objective: To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke. Methods: The patients who were diagnosed with ischemic stroke in Zhouzhi County People's Hospital between February 2015 and March 2017 were selected as the stroke group of the study, and healthy subjects who received physical examination during the same period were selected as the control group of the study. Serum was collected to determine the contents of HMGB1, sTLT-1, oxidative stress reaction molecules and endothelial injury molecules. Results: Serum HMGB1, sTLT-1, vWF, vWF-cp, sTM, ET-1, D-D, 8-OHdG, LPO and NOS contents of stroke group were significantly higher than those of control group while T-SOD and GSH-Px contents were significantly lower than those of control group;serum T-SOD and GSH-Px contents of stroke patients with high HMBG-1 content were significantly lower than those of stroke patients with low HMBG-1 content while 8-OHdG, LPO and NOS contents were significantly higher than those of stroke patients with low HMBG-1 content;serum vWF, vWF-cp, sTM, ET-1 and D-D contents of stroke patients with high sTLT-1 content were significantly higher than those of stroke patients with low sTLT-1 content. Conclusion: The abnormally elevated HMGB1 and sTLT-1 in serum of patients with ischemic stroke can induce oxidative stress response and aggravate endothelial injury.
