Cembrene (1), a cembrene-type hydrocarbon diterpene, is the first discovered natural-ly occurring fourteen-membered macrocyclic diterpenoid, which has been found in manyspecies of plant pines. The total synthesis of l...Cembrene (1), a cembrene-type hydrocarbon diterpene, is the first discovered natural-ly occurring fourteen-membered macrocyclic diterpenoid, which has been found in manyspecies of plant pines. The total synthesis of l has been reported by Dauben, Kato展开更多
p-Tolylsulfenyl chloride adds regioselectively at the C(11)=C(12) bond of cembrene 1 to give 11-(R)-p-tolylthio-1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 2 following a rapid HCl elimination. Two new cembranoids, 1-(S)-...p-Tolylsulfenyl chloride adds regioselectively at the C(11)=C(12) bond of cembrene 1 to give 11-(R)-p-tolylthio-1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 2 following a rapid HCl elimination. Two new cembranoids, 1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 3 and 1-(S)-cembra-2E, 4Z, 7E, 11Z- tetraen-20-o1 4 are prepared from 2.展开更多
基金Project supported by the National Natural Science Foundation of China the Special Research Grant for Doctoral Sites in Universities
文摘Cembrene (1), a cembrene-type hydrocarbon diterpene, is the first discovered natural-ly occurring fourteen-membered macrocyclic diterpenoid, which has been found in manyspecies of plant pines. The total synthesis of l has been reported by Dauben, Kato
文摘p-Tolylsulfenyl chloride adds regioselectively at the C(11)=C(12) bond of cembrene 1 to give 11-(R)-p-tolylthio-1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 2 following a rapid HCl elimination. Two new cembranoids, 1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 3 and 1-(S)-cembra-2E, 4Z, 7E, 11Z- tetraen-20-o1 4 are prepared from 2.
