AIM:To compare central corneal thickness(CCT) and anterior chamber depth(ACD) measurements using rotating Scheimpflug imaging and partial coherence interferometry.·METHODS:As part of the first phase of Shahroud E...AIM:To compare central corneal thickness(CCT) and anterior chamber depth(ACD) measurements using rotating Scheimpflug imaging and partial coherence interferometry.·METHODS:As part of the first phase of Shahroud Eye Cohort Study with 5 190 subjects of 40 to 64 years of age,CCT and ACD were measured using Scheimpflug imaging with the Pentacam(Oculus,Inc.,Lynnwood,WA,USA) and partial coherence interferometry with the Allegro BioGraph(Wavelight,Erlangen,Germany).·RESULTS:After applying exclusion criteria,we had data of 4 387 subjects with a mean age of 50.7±6.2 years.Mean CCT with Pentacam and BioGraph were 528.6 ±33.2μm and 525.6 ±32μm respectively;the difference was statistically significant(P 【0.001),but the correlation was high(R=0.920).Mean ACD measurements using Pentacam and BioGraph were 2.68 ±0.35mm and 2.62 ±0.33mm respectively;the inter-device difference was significant(P 【0.001) with high correlation(R=0.944).The 95% limits of agreements between devices were-22.65μm to28.61μm and-0.16mm to 0.29mm for CCT and ACD measurements,respectively.·CONCLUSION:For both CCT and ACD,the BioGraph gave significantly lower values than the Pentacam(P 【0.05).Despite the high inter-device correlation,the 95%limits of agreements were wide,and this may limit their interchangeability in measuring the CCT and ACD.展开更多
AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult population.METHODS:This study was a cross-sectional populationbased investigation includ...AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult population.METHODS:This study was a cross-sectional populationbased investigation including employees and retirees of a coal mining company in Kailuan City,Hebei Province.All the study participants underwent a comprehensive systemic and ophthalmic examination.RNFLD was diagnosed on fundus photographs.Binary logistic regression was used to investigate the risk and protective factors associated with the RNFLD.RESULTS:The community-based study included 14440 participants.There were 10473 participants in our study,including 7120 males(68.0%)and 3353 females(32.0%).The age range was 45-108y,averaging 59.56±8.66y.Totally 568 participants had RNFLD and the prevalence rate was 5.42%.A higher prevalence of RNFLD was associated with older age[P<0.001,odds ratio(OR):1.032;95%confidence interval(CI):1.018-1.046],longer axial length(P=0.010,OR:1.190;95%CI:1.042-1.359),hypertension(P=0.007,OR:0.639;95%CI:0.460-0.887),and diabetes mellitus(P=0.019,OR:0.684;95%CI:0.499-0.939).The protective factors of RNFLD were visual acuity(P=0.038,OR:0.617;95%CI:0.391-0.975),and central anterior chamber depth(P=0.046,OR:0.595;95%CI:0.358-0.990).CONCLUSION:In our cross-sectional community-based study,with an age range of 45-108y,RNFLD is associated with older age,longer axial length,hypertension,and diabetes mellitus.The protective factors of RNFLD are visual acuity and central anterior chamber depth.These can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.展开更多
基金Noor Ophthalmology Research CenterShahroud University of Medical Sciences
文摘AIM:To compare central corneal thickness(CCT) and anterior chamber depth(ACD) measurements using rotating Scheimpflug imaging and partial coherence interferometry.·METHODS:As part of the first phase of Shahroud Eye Cohort Study with 5 190 subjects of 40 to 64 years of age,CCT and ACD were measured using Scheimpflug imaging with the Pentacam(Oculus,Inc.,Lynnwood,WA,USA) and partial coherence interferometry with the Allegro BioGraph(Wavelight,Erlangen,Germany).·RESULTS:After applying exclusion criteria,we had data of 4 387 subjects with a mean age of 50.7±6.2 years.Mean CCT with Pentacam and BioGraph were 528.6 ±33.2μm and 525.6 ±32μm respectively;the difference was statistically significant(P 【0.001),but the correlation was high(R=0.920).Mean ACD measurements using Pentacam and BioGraph were 2.68 ±0.35mm and 2.62 ±0.33mm respectively;the inter-device difference was significant(P 【0.001) with high correlation(R=0.944).The 95% limits of agreements between devices were-22.65μm to28.61μm and-0.16mm to 0.29mm for CCT and ACD measurements,respectively.·CONCLUSION:For both CCT and ACD,the BioGraph gave significantly lower values than the Pentacam(P 【0.05).Despite the high inter-device correlation,the 95%limits of agreements were wide,and this may limit their interchangeability in measuring the CCT and ACD.
基金Supported by the National Natural Science Foundation of China(No.82220108017,No.82141128)The Capital Health Research and Development of Special(No.2020-1-2052)Science&Technology Project of Beijing Municipal Science&Technology Commission(No.Z201100005520045,No.Z181100001818003)。
文摘AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult population.METHODS:This study was a cross-sectional populationbased investigation including employees and retirees of a coal mining company in Kailuan City,Hebei Province.All the study participants underwent a comprehensive systemic and ophthalmic examination.RNFLD was diagnosed on fundus photographs.Binary logistic regression was used to investigate the risk and protective factors associated with the RNFLD.RESULTS:The community-based study included 14440 participants.There were 10473 participants in our study,including 7120 males(68.0%)and 3353 females(32.0%).The age range was 45-108y,averaging 59.56±8.66y.Totally 568 participants had RNFLD and the prevalence rate was 5.42%.A higher prevalence of RNFLD was associated with older age[P<0.001,odds ratio(OR):1.032;95%confidence interval(CI):1.018-1.046],longer axial length(P=0.010,OR:1.190;95%CI:1.042-1.359),hypertension(P=0.007,OR:0.639;95%CI:0.460-0.887),and diabetes mellitus(P=0.019,OR:0.684;95%CI:0.499-0.939).The protective factors of RNFLD were visual acuity(P=0.038,OR:0.617;95%CI:0.391-0.975),and central anterior chamber depth(P=0.046,OR:0.595;95%CI:0.358-0.990).CONCLUSION:In our cross-sectional community-based study,with an age range of 45-108y,RNFLD is associated with older age,longer axial length,hypertension,and diabetes mellitus.The protective factors of RNFLD are visual acuity and central anterior chamber depth.These can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.
