[Objectives] To optimize the extraction process of total flavonoids in stems of Mallotus apelta. [Methods]On the basis of singlefactor test,with volume fraction of ethanol,extraction time and ratio of solvent as indep...[Objectives] To optimize the extraction process of total flavonoids in stems of Mallotus apelta. [Methods]On the basis of singlefactor test,with volume fraction of ethanol,extraction time and ratio of solvent as independent variables,the content of total flavonoids as dependent variables,the completely secondary response surface regression fitting was conducted on the independent and dependent variables,and the Response Surface Method was used to optimize the optimum extraction process of total flavonoids in Mallotus apelta stems and predict the optimum process. [Results] The optimum extraction process of total flavonoids in Mallotus apelta was determined as follows: ethanol concentration of 71. 5%; extraction time of 154. 6 min; solid-liquid ratio of 1∶19. 2; total flavonoids content of 7. 060 mg/g; fitted binomial squared correlation coefficient R^2= 0. 8751.[Conclusions]Composite Design/Response Surface Method could be used in the extraction process optimization of total flavonoids in Mallotus apelta stems,the mathematical model established had high prediction accuracy,the method was simple and operability was good.展开更多
The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was use...The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was used for the optimization.Independent variables were extraction temperature,extraction pressure and entrainer flow rate.Dependent variable was yield ratio of icariin from Herba Epimedii.A two-order polynomial equation was fitted to the data.The results showed that the optimum extraction conditions were as follows:extraction temperature 46.5℃,extraction pressure 30.6 MPa,entrainer flow rate 3.3 mL/min.CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.展开更多
基金Supported by Chinese Medicine Science and Technology Project of Guangxi Administration of Traditional Chinese Medicine(GZLC14-31)Science and Technology Research and Development Program of Guilin Bureau of Technology(20130403-4)+1 种基金Guangxi"2011 Collaborative Innovation Center"-Zhuang and Yao Medicine Collaborative Innovation Center(Gui201320)the Autonomous Region-Level College Students’ Innovation and Entrepreneurship Training Program(201710601082)
文摘[Objectives] To optimize the extraction process of total flavonoids in stems of Mallotus apelta. [Methods]On the basis of singlefactor test,with volume fraction of ethanol,extraction time and ratio of solvent as independent variables,the content of total flavonoids as dependent variables,the completely secondary response surface regression fitting was conducted on the independent and dependent variables,and the Response Surface Method was used to optimize the optimum extraction process of total flavonoids in Mallotus apelta stems and predict the optimum process. [Results] The optimum extraction process of total flavonoids in Mallotus apelta was determined as follows: ethanol concentration of 71. 5%; extraction time of 154. 6 min; solid-liquid ratio of 1∶19. 2; total flavonoids content of 7. 060 mg/g; fitted binomial squared correlation coefficient R^2= 0. 8751.[Conclusions]Composite Design/Response Surface Method could be used in the extraction process optimization of total flavonoids in Mallotus apelta stems,the mathematical model established had high prediction accuracy,the method was simple and operability was good.
文摘The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was used for the optimization.Independent variables were extraction temperature,extraction pressure and entrainer flow rate.Dependent variable was yield ratio of icariin from Herba Epimedii.A two-order polynomial equation was fitted to the data.The results showed that the optimum extraction conditions were as follows:extraction temperature 46.5℃,extraction pressure 30.6 MPa,entrainer flow rate 3.3 mL/min.CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.
