Clinical features of multiple myeloma invasion of the central nervous system in Chinese patients

Background Although neurologic manifestations often complicate the course of patients with multiple myeloma, direct central nervous system invasion is rare. This study explored the neurologic symptoms, signs, clinical features, therapy and prognosis of Chinese patients with central nervous system myeloma invasion. Methods The diagnosis, therapy and prognosis were analyzed retrospectively in 11 Chinese multiple myeloma patients with central nervous system infiltration from a total of 625 patients who have been treated at Changzheng Hospital （Shanghai, China） between January 1993 and May 2009. Survival curve was constructed with the use of Kaplan-Meier estimates. Results There were 11 patients with central nervous system involvement from 625 multiple myeloma patients. The occurrence rate was 1.8%. Ten of the 11 patients had other extramedullary diseases. Symptoms included cerebral symptoms, cranial nerve palsies, and spinal cord or spinal nerve roots symptoms. Cerebrospinal fluid was abnormal in 7 patients, usually exhibiting pleocytosis and elevated protein content, plus positive cytologic findings. Specific magnetic resonance imaging findings suggestive of central nervous system invasion were found in 9 patients. After a median follow-up of 19 months, 3 patients were alive. The median overall survival for all patients was 23 months, while the median overall survival for patients after central nervous system invasion was merely 6 months. Conclusions It is exceedingly rare for there to be central nervous system infiltration in multiple myeloma patients. When it occurs, the prognosis is extremely poor despite the use of aggressive local and systemic treatment including stem cell transplantation.

FEATURES OF GRAVITY AND MAGNETIC ANOMALIES IN CENTRAL AND NORTHERN PARTS OF THE SOUTH CHINA SEA AND THEIR GEOLOGICAL INTERPRETATION

The gravity and magnetic survey lines of about 13,500 km were carried out in the centraland northern parts of the South China Sea from 1977 to 1978. The results obtained showthat the Bouguer gravity and magnetic anomalies have a tendency to increase gradually theirvalues from the northern continental shelf, through the slope, to the central abyssal basin of theSouth China Sea. The change in free-air gravity anomaly values coincides to a certain degreewith the undulation of the sea-bottom topography. The primary factor determining regionalvariation of the Bouguer gravity anomayl values is the Moho depth. The main factor deter-mining the magnetic anomly values is the nature of the basement rock. The high magnetieand Bouguer gravity anomaly values observed in some fault basin areas are inferred to becaused by draping the basic and ultrabasic magma extruding along the faults on the basementof the metamorphic rock,or by intrusion of the same magma into the basement.

Sustainability policy considerations for ecosystem management in Central and Eastern Europe

Here I discuss Central and Eastern European(CEE)countries as a region undergoing rapid change,resulting from the collapse of the Soviet Union and admission of some of the states into the European Union.These events brought changes in governance and ecosystem management,triggering impacts on land use and biodiversity.What are some of the policy options toward sustainability in the face of these political,governance,and socioeconomic changes?Some policy considerations for ecosystem management and sustainability include taking a social-ecological systems approach to integrate biophysical subsystems and social subsystems;paying attention to institutions relevant to shared resources(commons)management;and using resilience theory to study change and guidance for governance.Documented experience in CEE seems to indicate shortcomings for both the centralized state management option and the purely market-driven option for ecosystem management.If so,a“smart mix”of state regulations,market incentives,and self-governance using local commons institutions may be the most promising policy option to foster ecosystem stewardship at multiple levels from local to international.

Assessing impact of land use and climate change on regulating ecosystem services in the Czech Republic

Ecosystem services,defined as benefits provided by ecosystem functioning to society,are essential to human well-being.Due to global environmental change and related anthropogenic drivers,ecosystems are often degraded,which hinders the delivery of ecosystem services.This study aims to quantify the impacts of land use and climate change on two regulating ecosystem services-carbon sequestration and water purification in terms of nitrogen retention in the Czech Republic.While employing approaches of scenarios and modeling,we illustrate current and potential future status of these ecosystem services.Our results show that among the ecosystem change drivers,one of the dominant domestic land-use change of ALARM BAMBU(Business-As Might Be Usual)scenario is change of arable land and grassland to forest area that increases by 4.5%in 2080 compared to 2000.The results of ecosystem service modeling based on BAMBU scenario for the years 2050 and 2080 indicate that the highest yearly carbon sequestration rate occurred in 2000-2050,reaching 640 GgC·yr^(−1),2000-2080 shows decline in this regulating service by 16%.Average nitro-gen leaching to water streams reached 0.75 kgN·ha^(−1)·yr^(−1)for BAMBU in 2050 scenario and 0.80 kgN·ha^(−1)·yr^(−1)for BAMBU in 2080 scenario as a result of decreasing nitrogen load,which suggested a decrease in nitrogen pollution compared to 2000.Since ecosystem services have not been extensively mainstreamed into research and policies in eastern European countries,we aim to contribute to improvement of knowledge on current status and potential future pathways of the provision of regulating ecosystem services in the Czech Republic.

A Feature Selection Method for Prediction Essential Protein

Essential proteins are vital to the survival of a cell. There are various features related to the essentiality of proteins, such as biological and topological features. Many computational methods have been developed to identify essential proteins by using these features. However, it is still a big challenge to design an effective method that is able to select suitable features and integrate them to predict essential proteins. In this work, we first collect 26 features, and use SVM-RFE to select some of them to create a feature space for predicting essential proteins, and then remove the features that share the biological meaning with other features in the feature space according to their Pearson Correlation Coefficients（PCC）. The experiments are carried out on S. cerevisiae data. Six features are determined as the best subset of features. To assess the prediction performance of our method, we further compare it with some machine learning methods, such as SVM, Naive Bayes, Bayes Network, and NBTree when inputting the different number of features. The results show that those methods using the 6 features outperform that using other features, which confirms the effectiveness of our feature selection method for essential protein prediction.

Socioecological drivers facilitating biodiversity conservation in traditional farming landscapes

Traditional farming landscapes have evolved as tightly coupled socioecological systems that support high biodiversity.However,land-use change severely threatens the high biodiversity of these landscapes.Navigating nature conservation in such landscapes requires a thorough understanding of the key drivers underpinning biodiversity.Through empirical research on mammals,birds,butterflies,and plants in a traditional cultural landscape in Romania,we revealed seven hypothesized drivers facilitating biodiversity conservation.Similar proportions of three main land-use types support the landscape species pool,most likely through habitat connectivity and frequent spillover between land-use types.Landscape complementation and supplementation provide additional habitat for species outside their core habitats.Gradients of woody vegetation cover and gradients in land-cover heterogeneity provide mosaic landscapes with wide ranges of resources.Traditional land-use practices underpin landscape heterogeneity,traditional land-use elements such as wood pastures,and human-carnivore coexistence.Top-down predator control may limit herbivore populations.Lastly,cultural ties between humans and nature have a central influence on people’s values and sustainable use of natural resources.Conservation approaches should aim to maintain or restore these socioecological drivers by targeting the heterogeneous character of the forest-farmland mosaic at large scales through"broad and shallow"conservation measures.These large-scale measures should be complemented with"deep and narrow"conservation measures addressing specific land-use types,threats,or species.In both cases,conservation measures should integrate the entire socioecological system,by recognizing and strengthening important links between people and the environment.

Rural social-ecological systems navigating institutional transitions: case study from Transylvania (Romania)

Traditional rural social-ecological systems(SES)share many features which are crucial for sus-tainable development.Eastern European countries such as Romania,are still rich in traditional cultural landscapes.However,these landscapes are increasingly under internal(e.g.,people’s aspirations toward western socioeconomic ideals)and external(institutional changes,globalization of the commodity market,connectivity with other cultures)pressures.Therefore,understanding the ways how traditional SES navi-gated past and more recent changes is of crucial importance in getting insights about the future trajectory of these systems.Here,we present the rural SES from the Saxon region of Transylvania through the lens of institutional transitions which happened in the past century in this region.We show that the rural SES went through episodic collapses and renewals,their cyclic dynamic being related to the episodic chang-es of the higher level formal institutions.These episodic collapses and renewals created a social-ecolog-ical momentum for the sustainability of these SES.While we recognize that policy effectiveness depends on institutional stability(and institutions are unstable and prone to collapses),maintaining those social-ecological system properties which can assure navigation of societies through the challenges imposed by global changes should be in the heart of every governance system.Such properties includes wide extent of native vegetation,fertile soils,wide range of provisioning ecosystem services,genuine links between people and landscapes and knowledge about the social-ecological systems.These features could provide important capitals and memory elements for the(re)emergence of social-ecological systems(old or new).

Abandonment of croplands: problem or chance for grassland restoration? Case studies from Hungary

In Central-and Eastern Europe,the collapse of socialist regimes resulted in a transformation of state-owned agricultural cooperatives to privately owned lands from the early 1990s onwards.These socioeconomic processes resulted in landscape-scale changes in biodiversity,ecosystem services and agricultural production.In parallel,large-scale abandonment of croplands,especially on sandy,salty or fre-quently inundated areas,became common.Abandoned croplands are usually sensitive to species invasions,and are hotspots of noxious weeds,posing threats both to agriculture and nature conservation.Grassland restoration on former croplands can be an effective strategy for suppressing these species.Thus,a common goal of nature conservation and agriculture can be the restoration of grasslands on former croplands to(1)suppress weed and/or invasive species in line with the EU policy“Good Farming Practices”,(2)support animal husbandry by creating meadows or pastures,and to(3)recover biodiversity and ecosystem services.In the present paper we report“best practices”of grassland restoration projects from Hungary.Our aim was to compare the effectiveness of spontaneous grassland recovery vs.active grassland restoration by seed sowing in terms of the recovery of biodiversity and ecosystem services,such as weed control and biomass production.Our results showed that grassland restoration on abandoned fields offers a viable solution for restoring biodiversity and ecosystem services.Seed sowing ensures higher weed control and biomass pro-duction,but results in lower biodiversity compared to spontaneous recovery.Both restoration methods can be cost-effective,or even profitable even within a relatively short period of a nature conservation project.

Common and conflicting objectives and practices of herders and conservation managers:the need for a conservation herder

The mutual dependence of extensive land-use and conservation management has become appar-ent in Europe in the last 20-30 yr.Extensive land-use often survives in protected areas only,in the form of conservation management.Knowledge of extensive herding and that of conservation management are parts of two knowledge systems(traditional and scientific)which often leads to conflicts between locals and con-servationists.We studied two herding/conservation systems(salt steppes and wood-pastures),and devel-oped an inventory on the common/similar and conflicting/different objectives and pasture management practices of herders and conservationists.Data were collected by participatory knowledge co-production in teamwork of the co-authors(herders,conservation managers,and scientists).Data were analyzed and discussed in teamwork too.Herders and conservationists identified 23 objectives and 29 management prac-tices.We found a number of common interests with respect to herding,the ideal state of pastures,legal provisions,and communication.Conflict resolution recommendations(e.g.,on time and place of grazing,pasture improvements)were also developed.We argue that by co-production of knowledge,and establish-ment of a herder“school”the mitigation of the existing conflicts would be more effective.Our conclusion is that a new profession is needed:that of the conservation herder.The conservation herder shall be an indi-vidual knowledgeable about herding and pasture management,trained in conservation and ecology,able to design management experiments,and develop novel but tradition-based management practices.As such,he/she could facilitate adaptation of extensive herding in the changing socio-economic environment.

It is time to change land use and landscape management in the Czech Republic

The identity of man-made landscapes is based on the balance among their ecological,cultural,and economic dimensions.Since the 1950s,short-term economic benefits have globally often outweighed long-term interests.This results in decreased landscape quality manifested as increased erosion of agricultural land,decreased water retention capacity,increased landscape uniformity,and loss of biodiversity.A new phenomenon influencing the condition of man-made landscapes is climate change.Extreme fluctuations of temperature and precipitation have been causing repeated floods and also periods of drought in Europe.Landscapes damaged by inappropriate management are unable to offset these impacts.It is necessary to stop this development by changing land use and management methods to restore the balance among landscape functions.For the Czech Republic,we propose to develop a long-term landscape vision and to formulate a responsible landscape policy with regional strategic goals,including subsidies and penalties(carrots and sticks),based on the principles of the European Landscape Convention.To promote ecological stability,we recommend allocating funds from the Common Agricultural Policy to both the restoration and maintenance of valuable habitats.Landscape research and management(based on habitat/species monitoring in cooperation with stakeholders)must be strengthened in order to play a proper role in the transformation.It is time for clear communication with the public and the training of state officials and land users in spatial and landscape planning.To fill this gap in interdisciplinary cooperation,we call for the establishment of a platform on sustainable landscape management in the Czech Republic.