This paper presents finite element modeling （FEM） to simulate the present-day stress field and crustal deformation using NE-SW structural section in the central Seismic Gap region of the Garhwal Himalaya. Our study ...This paper presents finite element modeling （FEM） to simulate the present-day stress field and crustal deformation using NE-SW structural section in the central Seismic Gap region of the Garhwal Himalaya. Our study deals with the effect of geometrical characteristics and rock layer parameters on the upper crust. Modeling results show that two types of tectonic regimes developed in the central Seismic Gap region： the geotectonics of the northern part has been controlled by regional compression, whereas southern part is characterized by regional extension. Correspondingly, thrust faults are induced in the northern part and normal faults are extensively developed in the southern front. Those evidences noticeably indicate that the compressive tectonic environment of the Himalaya becomes change into the extensional tectonic regime in its front. The computed shear stress accumulation along the northern fiat of Main Himalayan Thrust （MHT） implies that considerable amount of interseismic stress is building up along the MHT system in the Himalaya, which ultimately release through the possible future great Himalayan earthquake （M 〉 8）. The comparison between our modeled stress field, faulting pattern and horizontal shortening rate with the distribution of the microseismic events, focal mechanism solutions, active faulting and GPS data in the central Seismic Gap region shows good agreement.展开更多
Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions un...Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.展开更多
The land-atmosphere energy and turbulence exchange is key to understanding land surface processes on the Tibetan Plateau(TP). Using observed data for Aug. 4 to Dec. 3, 2012 from the Bujiao observation point(BJ) of the...The land-atmosphere energy and turbulence exchange is key to understanding land surface processes on the Tibetan Plateau(TP). Using observed data for Aug. 4 to Dec. 3, 2012 from the Bujiao observation point(BJ) of the Nagqu Plateau Climate and Environment Station(NPCE-BJ), different characteristics of the energy flux during the Asian summer monsoon(ASM) season and post-monsoon period were analyzed. This study outlines the impact of the ASM on energy fluxes in the central TP. It also demonstrates that the surface energy closure rate during the ASM season is higher than that of the post-monsoon period. Footprint modeling shows the distribution of data quality assessments(QA) and quality controls(QC) surrounding the observation point. The measured turbulent flux data at the NPCE-BJ site were highly representative of the target land-use type. The target surface contributed more to the fluxes under unstable conditions than under stable conditions. The main wind directions(180° and 210°) with the highest data density showed flux contributions reaching 100%, even under stable conditions. The lowest flux contributions were found in sectors with low data density, e.g., 90.4% in the 360° sector under stable conditions during the ASM season. Lastly, a surface energy water balance(SEWAB) model was used to gap-fill any absent or corrected turbulence data. The potential simulation error was also explored in this study. The Nash-Sutcliffe model efficiency coefficients(NSEs) of the observed fluxes with the SEWAB model runs were 0.78 for sensible heat flux and 0.63 for latent heat flux during the ASM season, but unrealistic values of-0.9 for latent heat flux during the post-monsoon period.展开更多
文摘This paper presents finite element modeling （FEM） to simulate the present-day stress field and crustal deformation using NE-SW structural section in the central Seismic Gap region of the Garhwal Himalaya. Our study deals with the effect of geometrical characteristics and rock layer parameters on the upper crust. Modeling results show that two types of tectonic regimes developed in the central Seismic Gap region： the geotectonics of the northern part has been controlled by regional compression, whereas southern part is characterized by regional extension. Correspondingly, thrust faults are induced in the northern part and normal faults are extensively developed in the southern front. Those evidences noticeably indicate that the compressive tectonic environment of the Himalaya becomes change into the extensional tectonic regime in its front. The computed shear stress accumulation along the northern fiat of Main Himalayan Thrust （MHT） implies that considerable amount of interseismic stress is building up along the MHT system in the Himalaya, which ultimately release through the possible future great Himalayan earthquake （M 〉 8）. The comparison between our modeled stress field, faulting pattern and horizontal shortening rate with the distribution of the microseismic events, focal mechanism solutions, active faulting and GPS data in the central Seismic Gap region shows good agreement.
基金supported by the National Natural Science Foundation of China(General Program),No.81271293the National Science Foundation for Young Scientists of China,No.81000490
文摘Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.
基金supported by the National Natural Science Foundation of China (Grant Nos. 91337212, 41175008)Cold and Arid Regions Environmental and Engineering Research Institute Youth Science Technology Service Network initiative (STS)+1 种基金the China Exchange Project (Grant No. 13CDP007)the National Natural Science Foundation of China (Grant Nos. 40825015 and 40675012)
文摘The land-atmosphere energy and turbulence exchange is key to understanding land surface processes on the Tibetan Plateau(TP). Using observed data for Aug. 4 to Dec. 3, 2012 from the Bujiao observation point(BJ) of the Nagqu Plateau Climate and Environment Station(NPCE-BJ), different characteristics of the energy flux during the Asian summer monsoon(ASM) season and post-monsoon period were analyzed. This study outlines the impact of the ASM on energy fluxes in the central TP. It also demonstrates that the surface energy closure rate during the ASM season is higher than that of the post-monsoon period. Footprint modeling shows the distribution of data quality assessments(QA) and quality controls(QC) surrounding the observation point. The measured turbulent flux data at the NPCE-BJ site were highly representative of the target land-use type. The target surface contributed more to the fluxes under unstable conditions than under stable conditions. The main wind directions(180° and 210°) with the highest data density showed flux contributions reaching 100%, even under stable conditions. The lowest flux contributions were found in sectors with low data density, e.g., 90.4% in the 360° sector under stable conditions during the ASM season. Lastly, a surface energy water balance(SEWAB) model was used to gap-fill any absent or corrected turbulence data. The potential simulation error was also explored in this study. The Nash-Sutcliffe model efficiency coefficients(NSEs) of the observed fluxes with the SEWAB model runs were 0.78 for sensible heat flux and 0.63 for latent heat flux during the ASM season, but unrealistic values of-0.9 for latent heat flux during the post-monsoon period.
