Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses

Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,

Seasonal linkage of the Southern Hemisphere extratropical climate variability to two types of ENSO

This study uses the Climate Forecast System Reanalysis(CFSR) to investigate the responses of the Southern Hemisphere(SH) extratropical climate to two types of El Nino–Southern Oscillation(ENSO)-the eastern Pacific(EP) type and the central Pacific(CP) type in different seasons. The responses are denoted by the anomalies of climate variables associated with one-standard-deviation increase in the Nino3 or Nino4 index. The results show that in austral spring the differences in the ENSO-related anomaly(ERA) patterns of atmospheric circulation between the EP ENSO period(1979–1998) and CP ENSO period(1999–2010) are mainly associated with the change in the ENSO-PSA2 relationship. Such differences affect the ERA fields of surface air temperature and mixed layer temperature, and finally result in significant differences in sea-ice concentration anomalies in the Atlantic sector. In austral summer, significant correlation exists between the variations of SAM and both of the variations of Nino3 and Nino4 in 1979–1998, while the correlation between SAM and Nino4 disappears in 1999–2010. For all seasons, the strength of the climate ERAs depend on if there are close relationship between ENSO and the major climate variation modes of the SH extratropics. For the climate variables, the ERA patterns of surface air temperature are generally controlled by surface wind anomalies and mirrored by the mixed layer temperature anomalies. The mixed layer depth anomalies are primarily modulated by surface heat flux anomalies and occasionally by anomalous wind. There are strikingly strong anomalies of surface heat flux in the autumn of 1979–1998 related to the Nino3 variation, the period when there is only significant correlation between ENSO and PSA2. There are no evidence that the SH extratropical climate variability induced by Nino3 variations are stronger in the EP-ENSO period, and that variability induced by Nino4 variations are stronger in the CP-ENSO period.

Manifestations of type 2 diabetes in corneal endothelial cell density,corneal thickness and intraocular pressure

We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for age.In the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.

Prediabetes and type 2 diabetes implication in central proliferation and neurogenesis

Type 2 diabetes （T2D） is an important risk factor for developing dementias, including Alzheimer＇s disease （AD）. Hyperinsulin- emia and glucose intolerance, as features of T2D, might increase the neurodegeneration process, synaptic loss and brain atrophy, leading to cognitive impairment observed in AD. Also, adult neurogenesis seems to be impaired in AD models. Therefore, we have studied morphological alterations, cell proliferation and neurogenesis in the central nervous system （CNS） from a classical model of T2D, the db/db mouse, and in a prediabetes insulin-resistant model, obtained after long-term high fat diet （HFD） administration to C57B1/6 mice. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. Neurogen- esis and cell proliferation were increased in young db/db mice, when compared with control mice, whereas no differences were detected in the prediabetic model. We also detected significant correlations between metabolic parameters and central atrophy, altered proliferation and neurogenesis in the central nervous system. Altogether these data support that glycaemia control in elderly patients, could help to control central alterations and improve dementia prognosis.

Value of autofluorescence bronchoscope in diagnosis of central type lung cancer

Objective To evaluate the value of autofluorescence bronchoscope (AFB) in airway examination in central type lung cancer. Methods From Sep 2009 to Mar 2010,29 patients (23 men,6 women,median age 62. 2 years,range from 34 to 81 years) underwent AFB procedure. There were 3 lesions located at trachea,1 at

Mantle cell lymphoma with endobronchial involvement:A case report

BACKGROUND Mantle cell lymphoma(MCL)is a subtype of Non-Hodgkin’s lymphoma(NHL).MCL frequently affects extranodal sites while endobronchial involvement is uncommon.Only 5 cases of MCL with endobronchial involvement have been previously reported.CASE SUMMARY A 56-year-old male patient arrived at the hospital complaining of a dry cough.A mass in the right upper lobe of the lung was revealed in Chest computed tomography(CT).Right lung hilar and mediastinal lymphadenopathies were also found by CT scan.The patient was diagnosed with central-type lung cancer with multiple lymph node metastases after positron emission tomography(PET)CT scan examination.The fiber optic bronchoscope examination revealed diffuse neoplasm infiltration in the inlet of the right up lobar bronchus.The patient was finally diagnosed with MCL based on the bronchoscopy and mediastinoscopy biopsy results.CONCLUSION MCL could masquerade as central type lung cancer.An endobronchial biopsy examination is necessary for the early diagnosis of MCL.