Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital...Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital from April 2019 to February 2020 were selected.Those in the same period were randomly selected by SPSS19.0 software machine according to the ratio of 1:1,and divided into the treatment group(BBT-RF-A radiofrequency group)and the observation group(recombinant human interferon suppository group)with 50 cases in each group.The negative conversion rate of high risk-HPV between the 2 groups was compared at the 6th and 12th months after treatment,and the types of persistent HR-HPV infection in Changle were studied.Results:The negative conversion rates of HR-HPV in the treatment group were 60%(35/50)and 82%(41/50)at 6 and 12 months after treatment,respectively,while the negative conversion rates of high risk-HPV in the observation group were 30%(15/50)and 44%(22/50)at 6 and 12 months after treatment,respectively.The negative conversion rates in the treatment group were significantly higher than those in the observation group(P<0.05).Studying the main types of high risk-HPV persistent infection has guiding value for HPV vaccine injection in Changle.Conclusion:Self-clotting cutter radiofrequency ablation has a good effect on the negative conversion rate of high risk-HPV persistent infection.These results suggest that the main types of single persistent cervical HR-HPV infection are 16,52 and 58,not including the 18 types.展开更多
Cervical lesions have been regarded as the common and frequently occurring diseases in China.Recently,the morbidity and youth tendency of cervical cancer have gradually increased.Cervical cancer,related with human pap...Cervical lesions have been regarded as the common and frequently occurring diseases in China.Recently,the morbidity and youth tendency of cervical cancer have gradually increased.Cervical cancer,related with human papilloma virus(HPV)infection,has been one of the severest diseases threatening health and life of women,and is an infectious disease.The universality of HPV infection in the reproductive tract should not be ignored.The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors,immunosuppression,age,contraceptive methods,the concurrent infection of other sexually transmitted diseases,etc.The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process,including the subclinical,latent,and persistent infection of high risk(HR)-HPV,chronic cervicitis with abnormal results of cytological examination,cervical intraepithelial neoplasia(CIN),and cervical cancer.The outcome of patients with HPV infection is influenced by many factors,such as HPV subtype dominance,persistent HPV infection,HPV loading dose,and multiple HPV infection.Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.展开更多
目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗...目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗时间为3个月;治疗组患者在此基础上给予膦甲酸钠氯化钠注射液250 m L,ivgtt,qd,治疗时间为14 d。观察两组患者根据HPV病毒载量判定的疗效、HPV转阴率、宫颈炎评分、根据宫颈炎评分改善率判定的疗效及不良反应发生情况。结果:治疗组患者根据HPV病毒载量判定的总有效率(94.29%)明显高于对照组(76.67%),差异有统计学意义(P<0.05);治疗组患者HPV转阴率(77.14%)明显高于对照组(36.67%),差异有统计学意义(P<0.05)。两组患者宫颈炎评分均较治疗前明显降低,且治疗组[(1.49±0.70)分]明显低于对照组[(1.97±0.89)分],差异均有统计学意义(P<0.05);治疗组患者根据宫颈炎评分改善率判定的总有效率(88.57%)明显高于对照组(73.33%),差异有统计学意义(P<0.05)。两组患者治疗过程中均未见不良反应发生。结论:膦甲酸钠联合重组人干扰素α2b能有效抑制HPV病毒复制、提高HPV转阴率、缓解宫颈炎症状,且安全性较高。展开更多
文摘Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital from April 2019 to February 2020 were selected.Those in the same period were randomly selected by SPSS19.0 software machine according to the ratio of 1:1,and divided into the treatment group(BBT-RF-A radiofrequency group)and the observation group(recombinant human interferon suppository group)with 50 cases in each group.The negative conversion rate of high risk-HPV between the 2 groups was compared at the 6th and 12th months after treatment,and the types of persistent HR-HPV infection in Changle were studied.Results:The negative conversion rates of HR-HPV in the treatment group were 60%(35/50)and 82%(41/50)at 6 and 12 months after treatment,respectively,while the negative conversion rates of high risk-HPV in the observation group were 30%(15/50)and 44%(22/50)at 6 and 12 months after treatment,respectively.The negative conversion rates in the treatment group were significantly higher than those in the observation group(P<0.05).Studying the main types of high risk-HPV persistent infection has guiding value for HPV vaccine injection in Changle.Conclusion:Self-clotting cutter radiofrequency ablation has a good effect on the negative conversion rate of high risk-HPV persistent infection.These results suggest that the main types of single persistent cervical HR-HPV infection are 16,52 and 58,not including the 18 types.
基金supported by the Special Funds for State Key Development Program for Basic Research of China(973 Program)(No.2009CB521800)the National Natural Science Foundation of China(Grant Nos.30672227,30770913,30628029,30500596 and 30600667).
文摘Cervical lesions have been regarded as the common and frequently occurring diseases in China.Recently,the morbidity and youth tendency of cervical cancer have gradually increased.Cervical cancer,related with human papilloma virus(HPV)infection,has been one of the severest diseases threatening health and life of women,and is an infectious disease.The universality of HPV infection in the reproductive tract should not be ignored.The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors,immunosuppression,age,contraceptive methods,the concurrent infection of other sexually transmitted diseases,etc.The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process,including the subclinical,latent,and persistent infection of high risk(HR)-HPV,chronic cervicitis with abnormal results of cytological examination,cervical intraepithelial neoplasia(CIN),and cervical cancer.The outcome of patients with HPV infection is influenced by many factors,such as HPV subtype dominance,persistent HPV infection,HPV loading dose,and multiple HPV infection.Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.
文摘目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗时间为3个月;治疗组患者在此基础上给予膦甲酸钠氯化钠注射液250 m L,ivgtt,qd,治疗时间为14 d。观察两组患者根据HPV病毒载量判定的疗效、HPV转阴率、宫颈炎评分、根据宫颈炎评分改善率判定的疗效及不良反应发生情况。结果:治疗组患者根据HPV病毒载量判定的总有效率(94.29%)明显高于对照组(76.67%),差异有统计学意义(P<0.05);治疗组患者HPV转阴率(77.14%)明显高于对照组(36.67%),差异有统计学意义(P<0.05)。两组患者宫颈炎评分均较治疗前明显降低,且治疗组[(1.49±0.70)分]明显低于对照组[(1.97±0.89)分],差异均有统计学意义(P<0.05);治疗组患者根据宫颈炎评分改善率判定的总有效率(88.57%)明显高于对照组(73.33%),差异有统计学意义(P<0.05)。两组患者治疗过程中均未见不良反应发生。结论:膦甲酸钠联合重组人干扰素α2b能有效抑制HPV病毒复制、提高HPV转阴率、缓解宫颈炎症状,且安全性较高。
