Comparison of efficacy and safety between late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy for cervical cancer complicated with pelvic lymph node metastasis

Objective This study aimed to compare and analyze the clinical efficacy and safety of late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy(IMRT) for cervical cancer complicated with pelvic lymph node metastasis. Methods Sixty patients with cervical cancer complicated with pelvic lymph node metastasis who were admitted to our hospital from January 2013 to January 2015 were enrolled. The patients were randomly divided into the late-course dose-increasing IMRT group and the simultaneous integrated dose-increasing IMRT group, with 30 cases included in each group, respectively. All patients were concurrently treated with cisplatin. After treatment, the clinical outcomes of the two groups were compared. Results The remission rate of symptoms in the simultaneous integrated dose-increasing IMRT group was significantly higher than that in the late-course dose-increasing IMRT group(P < 0.05). The follow-up results showed that the overall survival time, progression-free survival time, and distant metastasis time of patients in the simultaneous integrated dose-increasing IMRT group were significantly longer than those in the late-course dose-increasing IMRT group(P < 0.05). The recurrent rate of lymph nodes in the radiation field in the simultaneous integrated dose-increasing IMRT group was significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in the incidence of cervical and vaginal recurrence and distant metastasis between the two groups(P > 0.05). The radiation doses of Dmax in the small intestine, D1 cc(the minimum dose to the 1 cc receiving the highest dose) in the bladder, and Dmax in the rectum in the simultaneous integrated dose-increasing IMRT group were significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in intestinal D2 cc(the minimum dose to the 2 cc receiving the highest dose) between the two groups(P > 0.05). The incidence of bone marrow suppression in the simultaneous integrated dose-increasing IMRT group was significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group.Conclusion The application of simultaneous integrated dose-increasing IMRT in the treatment of cervical cancer patients complicated with pelvic lymph node metastasis can significantly control tumor progression, improve the long-term survival time, and postpone distant metastasis time with high safety.

Establishment of Risk Prediction Model and Nomogram for Lymph Node Metastasis of Cervical Cancer: Based on SEER Database

Objective: To predict the risk factors of lymph node metastasis in cervical cancer by using large sample clinical data, and to construct and verify the nomogram for predicting lymph node metastasis. Methods: A total of 5940 patients with cervical cancer from 2004 to 2015 in the National Cancer Institute Surveillance Epidemiology and End Results database were retrospectively screened and randomly assigned to training group (n = 4172) and validation group (n = 1768). Multivariate Logistic regression analysis was used, and the optimal model was selected according to AIC or BIC and likelihood ratio test, and a nomogram was drawn. The accuracy and robustness of the prediction model were evaluated in three aspects: discrimination, calibration and clinical net benefit. Results: The prediction model based on race, tumor tissue differentiation degree, tumor histopathological type, distant metastasis of tumor, tumor diameter and other risk factors was successfully established and a nomogram was constructed. The AUCs of training group and validation group were: 0.736 and 0.714, respectively. And the p-values of the Hosmer-Lemeshow test were 0.28 and 0.11, respectively. The calibration curve was in good agreement with the ideal curve. It had high accuracy and applicability after internal verification. Conclusion: A prediction model is constructed based on the risk factors of lymph node metastasis of cervical cancer. The nomogram has a good effective prediction and can provide a theoretical basis for clinicians to assess the disease quickly before surgery.

Prognostic significance of the number of pelvic lymph nodes removed in patients with early cervical cancer

Objective The aim of this research was to study the prognostic significance of the number of pelvic lymph nodes removed in patients with early cervical cancer.Methods We searched the Pub Med database using the terms "cervical cancer" and "lymph nodes" or "lymphadenectomy". Studies on the association between number of lymph nodes removed and prognosis or survival were identified. We retrospectively studied the relevant research.Results Ten retrospective studies were included. Two studies indicated that the number of lymph nodes had no association with prognosis whereas three studies found a positive relationship. Five studies indicated some factors that could influence the relationship between number of lymph nodes and prognosis.Conclusion The number of lymph nodes removed may positively influence the prognosis of patients with cervical cancer. Some factors may influence the relationship between the extent of lymph nodes removed and patient prognosis. Additional multicenter, prospective studies with large samples are required to confirm the study findings.

Progress in the Study of Lymph Node Metastasis in Early-stage Cervical Cancer

Spread into regional lymph node is the major route of metastasis in cervical cancer. Although lymph node status is not involved in the International Federation of Gynecology and Obstetrics staging system of uterine cervical cancer, the presence or absence of lymph node metastasis provides important information for prognosis and treatment. In this review, we have attempted to focus on the incidence and patterns of lymph node metastasis, and the issues surrounding surgical assessment of lymph nodes. In addition, the preoperative prediction of lymph node status, as well as the intraoperative assessment by sentinel nodes will be reviewed. Finally, lymph node micrometastasis also will be discussed.

Value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in papillary thyroid carcinoma

BACKGROUND Cervical lymph node metastasis in papillary thyroid carcinoma(PTC) affects the treatment and prognosis of patients. Ultrasound is a common imaging method for detecting cervical lymph nodes in PTC patients; however, it is not accurate in determining lymph node metastasis.AIM To evaluate the value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in PTC.METHODS A total of 94 patients with PTC were recruited. According to pathological results,lymph nodes were divided into two groups: metastatic group(n = 50) and reactive group(n = 63). The routine ultrasound findings, contrast-enhanced ultrasound and elastography data were recorded and compared. Logistic regression was used to generate predictive probability distributions for the diagnosis of lymph node metastasis with different indicators. Receiver operating characteristic curve analysis was used to test the efficacy of contrast-enhanced ultrasound combined with elastography based on routine ultrasound in evaluating PTC cervical lymph node metastasis.RESULTS The ratio of long diameter/short diameter(L/S) ≤ 2, irregular marginal morphology, missing lymphatic portal, peripheral or mixed blood flow distribution, peak intensity(PI), non-uniform contrast distribution and elasticity score in the metastatic group were significantly higher than those in the reactive group(P < 0.05). L/S ratio, missing lymphatic portal, PI and elasticity score had a significant influence on the occurrence of PTC cervical lymph node metastasis(P< 0.05). Furthermore, the area under the curve(AUC) for lymph node metastasis diagnosed using the combination of PI ratio, elasticity score, missing lymphatic portal and LS was 0.936, which was significantly higher than the AUC for PI ratio alone. The difference was statistically significant(P < 0.05). The fitting equation for the combined diagnosis was logit(P) =-12.341 + 1.482 × L/S ratio + 3.529 ×missing lymphatic portal + 0.392 × PI + 3.288 × elasticity score.CONCLUSION Based on the gray-scale ultrasound, the combination of contrast-enhanced ultrasound and elastography can accurately assess PTC cervical lymph node metastasis.

Relationship between Expression of Vascular Endothelial Growth Factor and Cervical Lymph Node Metastasis in Papillary Thyroid Cancer: A Meta-analysis

The aim of the present study was to examine the relationship between the protein expression of vascular endothelial growth factor（VEGF） and lymph node metastasis（LNM） in papillary thyroid cancer（PTC）. VEGF-related articles that had been published until August 2016 were searched from the Pub Med, EMBASE, and MEDLINE to identify the risk factors of LNM in PTC. Rev Man 5.3 software was used for the meta-analysis. Finally, 9 articles met the inclusion criteria and were included in our meta-analysis. LNM was found to be present in 176 of 318 patients（57.8%） with high VEGF expression and in 71 of 159 patients（47.0%） with low VEGF expression. The overall OR was 2.81（95% confidence interval, 1.49–5.29）. LNM occurred more frequently in patients with high VEGF expression than in those with low VEGF expression（P=0.001）. Heterogeneity was markedly decreased in the subgroup analyses of LNM in terms of the patients＇ country of origin and the detection methods. Our meta-analysis concluded that the VEGF protein expression is associated with LNM in PTC.

DETECTION OF SENTINEL LYMPH NODE IN EARLY CERVICAL CANCER

Objective: To assess the value of sentinel lymph node (SLN) localization by lymphoscintigraphy and gamma probe detection in early cervical cancer. Methods: A total of 27 patients with operable invasive early cervical cancer and clinically proved negative pelvic lymph nodes were included in this study. The 99Tcm-dextran of 74 MBq (2 mCi) was injected around the cervix at 2 and 10. Lymphoscintigraphy and gamma probe detection were used to find the SLN. Results: The SLN was identified in 27 patients. The sensitivity and specificity of the SLN detection to predict the metastasis of the pelvic lymph node were 100% and 100% respectively. Conclusion: Identification of the SLN using radionuclide is feasible and possible in women with early cervical cancer.

Lateral pelvic lymph nodes for rectal cancer:A review of diagnosis and management

The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node(LPLN)metastasis of rectal cancer are described in this review.Magnetic resonance imaging(MRI)is recommended for the diagnosis of LPLN metastasis.A LPLN-positive status on MRI is a strong risk factor for metastasis,and evaluation by MRI is important for deciding treatment strategy.LPLN dissection(LPLD)has an advantage of reducing recurrence in the lateral pelvis but also has a disadvantage of complications;therefore,LPLD may not be appropriate for cases that are less likely to have LPLN metastasis.Radiation therapy(RT)and chemoradiation therapy(CRT)have limited effects in cases with suspected LPLN metastasis,but a combination of preoperative CRT and LPLD may improve the treatment outcome.Thus,RT and CRT plus selective LPLD may be a rational strategy to omit unnecessary LPLD and produce a favorable treatment outcome.

Sentinel lymph node identification in patients with early stage cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy

Background In general,sentinel lymph node (SLN) can reflect the whole state of the entire drainage area. The present study evaluated the clinical significance of sentinel lymph node identification in the treatment of early stage cervical cancer.Methods Twenty-eight patients with early stage (Ia-IIa) cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy were included in this study. At two locations 8 hours before operation,0.4 ml 37 Mbq technicium-99 labeled dextran was injected intracervically. After that,preoperative lymphoscintigraphy was performed to detect SLNs. During the operation,lymph nodes were detected ex vivo by a γ-counter to identify SLNs. The samples of SLNs and non-SLNs were used for pathological examination separately and compared with the final results. Results SLNs were identified in 27 of 28 (96.4%) patients. A total of 123 SLNs were identified from 814 nodes. Six patients had altogether 11 positive lymph nodes,which were all SLNs. No patient had false-negative sentinel node. Conclusion SLNs can successfully predict the lymphatic metastasis in patients with cervical cancer. The clinical validity of this technique should be evaluated prospectively.

基于深度学习的宫颈癌淋巴结转移预测

目的:基于深度学习,利用T_(2)加权成像(T_(2)WI)序列的高分辨特性获得宫颈癌淋巴结的结构信息,并预测淋巴结是否转移;利用弥散加权成像(DWI)序列的功能特性,获取淋巴结区域,并预测淋巴结是否转移;综合多模态MRI数据,预测淋巴结是否转移。方法:收集2021年6月至2022年5月年新疆维吾尔自治区人民医院收治的52例宫颈癌患者的多参数MRI影像数据以及病理检查数据作为训练集,另收集2022年6月至2023年5月新疆维吾尔自治区人民医院收治的150例宫颈癌患者多参数MRI影像数据以及病理检查数据作为验证集。训练集52例宫颈癌患者均接受MRI扫描,扫描序列包括T_(2)WI和DWI序列。对训练集52例宫颈癌患者的多参数MRI影像学图像进行非均匀性校正和标准化的预处理后,通过渐进演化空洞卷积对T_(2)WI图像进行分割,在扩大感受野的同时,有效降低空洞对图像丢失的影响;通过基于注意力网络机制的深度学习模型引导网络在预测时更关注淋巴结区域,并为预测结果提供一定程度的解释性;通过多模态协同学习模型实现T_(2)WI和DWI序列在淋巴结性质预测任务之间的经验共享。采用验证集患者的图像资料对基于多模态协同学习模型的淋巴结转移预测模型进行验证。结果:验证集150例患者中良性淋巴结585枚,恶性淋巴结65枚,其良恶性淋巴结在大小(长径、短径)和边界上存在差异,差异有统计学意义(x^(2)=8.437、143.100、104.608,P<0.05)。验证集150例患者中48例患者出现淋巴结转移,基于多模态协同学习模型的淋巴结性质预测模型准确预测出46例患者出现淋巴结转移,准确预测出99例患者未发生淋巴结转移,预测准确率为96.67%。结论:渐进演化空洞卷积结合U-Net框架完成了对T_(2)WI宫颈癌影像的多目标自动分割任务,基于注意力网络机制的深度学习模型完成了动态关注淋巴结区域的任务,多模态协同学习模型有效地避免了特征层融合之后特征空间分布的改变。

高分辨率MRI扫描对结直肠癌盆腔淋巴结转移的诊断价值

目的:探讨高分辨率磁共振成像(MRI)扫描对结直肠癌盆腔淋巴结转移的诊断价值。方法:选取2021年10月至2022年10月聊城市人民医院收治的结直肠癌患者80例,均行高分辨率MRI扫描,以病理检查结果为金标准,分析高分辨率MRI扫描诊断结直肠癌盆腔淋巴结转移的灵敏度、特异度、准确度,并分析MRI图像特征与结直肠癌盆腔淋巴结转移的相关性。结果:以病理检查结果作为金标准,纳入的80例结直肠癌患者共出现盆腔淋巴结转移53例,占比66.25%;高分辨率MRI诊断结直肠癌盆腔淋巴结转移的灵敏度、特异度、准确度分别为86.79%、85.19%、86.25%。结直肠癌盆腔淋巴结转移患者MRI图像中边缘模糊、内部信号不均匀比例高于无淋巴结转移患者,淋巴结短径长于无淋巴结转移患者(P<0.05)。ROC曲线分析显示,MRI图像特征中短径诊断结直肠癌盆腔淋巴结转移的临界值为3.08mm,预测灵敏度为81.1%,特异度为92.6%,均高于边缘、内部信号预测的71.7%、67.9%和74.1%、77.8%。结论:结直肠癌患者采用高分辨率MRI扫描可有效诊断盆腔淋巴结转移情况,尤其是MRI图像特征中短径对盆腔淋巴结转移的预测价值更高。

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage ⅠA-ⅡB Cervical Squamous Cell Carcinoma

Background：Pelvic lymph node metastasis （LNM） is an important prognostic factor in cervical cancer.Cervical squamous cell carcinoma accounts for approximately 75-80% of all cervical cancers.Analyses of the effects of the number of positive lymph nodes （LNs）,unilateral vcrsus bilateral pelvic LNM and a single group versus multiple groups of pelvic LNM on survival and recurrence of cervical squamous cell carcinoma are still lacking.The study aimed to analyze the effects of the number of positive pelvic LNs and a single group versus multiple groups of pelvic LNM on survival and recurrence.Methods：We performed a retrospective review of 296 patients diagnosed with Stage ⅠA-ⅡB cervical squamous cell carcinoma who received extensive/sub-extensive hysterectomy with pelvic lymphadenectomy/pelvic LN sampling at Peking University People＇s Hospital from November 2004 to July 2013.Ten clinicopathological variables were evaluated as risk factors for pelvic LNM：Age at diagnosis,gravidity,clinical stage,histological grade,tumor diameter,lymph-vascular space involvement （LVSI）,depth of cervical stromal invasion,uterine invasion,parametrial invasion,and neoadjuvant chemotherapy.Results：The incidence of pelvic LNM was 20.27% （60/296 cases）.Pelvic LNM （P =0.00） was significantly correlated with recurrence.Pelvic LNM （P =0.00）,the number of positive pelvic LNs （P =0.04） and a single group versus multiple groups of pelvic LNM （P =0.03）had a significant influence on survival.Multivariate analysis revealed that LVSI （P =0.00）,depth of cervical stromal invasion （P =0.00）and parametrial invasion （P =0.03） were independently associated with pelvic LNM.Conclusions：Patients with pelvic LNM had a higher recurrence rate and poor survival outcomes.Furthermore,more than 2 positive pelvic LNs and multiple groups of pelvic LNM appeared to identify patients with worse survival outcomes in node-positive ⅠA-ⅡB cervical squamous cell carcinoma.LVSI,parametrial invasion,and depth of cervical stromal invasion were identified as independent clinicopathological risk factors for pelvic LNM.

磁共振成像对直肠癌盆腔侧方淋巴结转移的诊断价值分析

目的:分析磁共振成像(MRI)对直肠癌盆腔侧方淋巴结转移(PLLNM)的诊断价值。方法:选取2020年3月—2022年2月新乡医学院第三附属医院收治的80例直肠癌患者作为研究对象,所有患者术前均接受MRI检查及病理活检确诊,均行直肠癌切除及盆腔淋巴结清扫术。以病理结果为金标准,计算MRI对直肠癌PLLNM的准确度、敏感度、特异度及一致性,比较不同性质淋巴结的MRI图像特征。采用Pearson检验分析MRI图像特征与直肠癌PLLNM的相关性,采用多因素logistic回归分析模型分析影响PLLNM的独立危险因素。结果:80例直肠癌患者经病理诊断共检出PLLNM 29例,未转移51例;MRI诊断共检出PLLNM 35例,未转移45例,两者的诊断一致性良好(Kappa=0.845)。PLLNM患者的边缘模糊及型号不均匀占比显著高于未转移者,淋巴结短径显著长于未转移者,差异有统计学意义(χ^(2)=12.342、8.136;t=13.857,P<0.01)。Pearson相关性分析结果显示,直肠癌PLLNM检出率与淋巴结短径、边缘模糊及信号不均匀具有正相关性(r>0,P<0.001)。多因素logistic回归分析结果显示,淋巴结信号是影响直肠癌PLLNM的独立危险因素。结论:MRI对直肠癌PLLNM的诊断效能较高,不同性质淋巴结的MRI图像特征存在明显差异,其中淋巴结短径、边缘模糊及信号不均匀与PLL-NM密切相关,淋巴结信号是影响直肠癌PLLNM的独立危险因素。用MRI测量淋巴结短径是诊断直肠癌PLLNM的可靠参数,对PLLNM的早期预测具有积极作用。

DCE-MRI联合IVIM-DWI预测早期宫颈癌盆腔淋巴结转移的价值

目的探讨动态对比增强MRI(dynamic contrast-enhanced MRI,DCE-MRI)联合体素内不相干运动扩散加权成像(intravoxel incoherent motion diffusion-weighted imaging,IVIM-DWI)预测早期宫颈癌盆腔淋巴结转移(pelvic lymph node metastasis,PLNM)的价值。材料与方法回顾性分析124例经病理证实为国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)ⅠB~ⅡA期宫颈癌患者的临床及影像资料,比较PLNM组与无PLNM组原发肿瘤DCE-MRI及IVIM-DWI定量参数的差异,采用多因素logistic回归分析确定独立危险因素,绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估各参数诊断效能。结果PLNM组容积转运常数(volume transfer constant,K^(trans);t=6.203,P<0.001)、灌注分数(perfusion fraction,f;t=3.944,P<0.001)、表观扩散系数(apparent diffusion coefficient,ADC;Z=4.393,P<0.001)、细胞外血管外间隙容积比(extravascular extracellular volume fraction,V_(e);Z=2.312,P=0.021)低于无PLNM组,差异均有统计学意义,多因素logistic回归分析示K^(trans)(P<0.001)、f(P=0.003)、ADC(P=0.031)是宫颈癌PLNM的独立危险因素,ROC曲线示K^(trans)、f、ADC预测PLNM的曲线下面积(area under the curve,AUC)分别为0.808、0.707、0.745;与单一参数相比,三者联合预测PLNM的诊断效能最高,AUC为0.893,敏感度和特异度分别为82.4%、86.8%。结论早期宫颈癌原发肿瘤DCE-MRI的K^(trans)、V_(e)及IVIM-DWI的f、ADC有助于鉴别PLNM。独立危险因素K^(trans)、f、ADC具有较高的预测价值,三者联合应用可进一步提高诊断效能。

甲状腺癌术后患者行超声引导下射频消融侧颈区和中央区转移性淋巴结的有效性及安全性比较

背景超声引导下射频消融(radiofrequency ablation,RFA)对甲状腺癌术后患者侧颈区与中央区的转移性淋巴结(cervical lymph nodes metastasis,CLNM)疗效的对比研究较少。目的评估RFA对甲状腺癌全切术后侧颈区和中央区CLNM的治疗效果和并发症发生情况。方法回顾性分析2020年1月—2021年1月在解放军总医院第一医学中心超声诊断科行RFA治疗甲状腺癌全切术后发生侧颈区和中央区CLNM的患者,随访截至2023年1月1日,对比两组患者消融前后的CLNM体积和消融后体积缩小率(volume reduction rate,VRR)以及消融时和随访中的并发症发生情况。结果共52例患者(96枚CLNM)纳入研究。侧颈区38例(74枚CLNM),男性10例,女性28例,平均年龄(43.1±8.3)岁;中央区14例(22枚CLNM),男性4例,女性10例,平均年龄(34.4±16.3)岁。两组年龄和性别无统计学差异(P>0.05)。侧颈区和中央区的CLNM在消融后1个月、3个月、6个月、12个月和24个月体积逐渐减小且VRR逐渐增加,随访2年内CLNM完全消失,且各随访节点两组间的CLNM体积和VRR差异均无统计学意义(P>0.05)。消融时6例有颈部疼痛(侧颈区2例,中央区4例),无其他轻微不良反应和严重并发症发生。随访期间8例(15.4%)出现消融区域外的复发(侧颈区3例,中央区5例),均成功完成二次RFA。结论RFA对甲状腺癌全切术后颈部侧颈区和中央区的CLNM均有良好的有效性和安全性。

高频超声对甲状腺乳头状癌颈部淋巴结转移的预测价值

目的探讨甲状腺乳头状癌(papillary thyroid carcinoma,PTC)颈部淋巴结转移的危险因素,评估独立危险因素对转移淋巴结的预测效能。方法收集279例PTC患者的临床及超声声像图资料,以术后病理为依据,根据患者是否存在颈部淋巴结转移分为两组,分析两组患者的相关特征,探寻PTC颈部淋巴结转移的危险因素,通过受试者工作特征(receiver operating characteristic,ROC)曲线比较独立危险因素对颈部转移淋巴结的预测效能。结果两组患者的年龄、性别以及癌结节最大径、边界、形态、微钙化、距被膜的距离等特征是PTC颈部淋巴结转移的危险因素(P均<0.05);男性、癌结节最大径≥10mm、微钙化、距被膜的距离≤2mm是PTC颈部淋巴结转移的独立危险因素(P均<0.05);4种独立危险因素联合预测PTC颈部淋巴结转移效能最高,其AUC为0.785(95%CI:0.721~0.849,P<0.05)。结论男性、癌结节最大径≥10mm、微钙化、距被膜的距离≤2mm是PTC颈部淋巴结转移的独立危险因素,4种独立危险因素联合可辅助评估PTC颈部淋巴结转移风险,改善患者预后。

食管癌伴巨大颈部淋巴结转移1例

多种良恶性肿瘤均可能出现颈部肿物,在既没有其他系统症状又没有病理活组织检查的情况下难以做出正确诊断,容易贻误最佳治疗时机。以巨大颈部淋巴结转移伴疼痛为首发症状的食管癌患者较为少见。该文报道1例以巨大颈部淋巴结转移为首发表现的食管癌患者,患者接受多线治疗方案,病情虽反复进展,但仍达到了33个月的较长生存期。该文对食管癌伴巨大颈部淋巴结转移患者的临床表现、诊疗过程及预后进行报道,以期提高临床医师对食管癌淋巴结转移的认识水平,提高该病首诊率并及早治疗,使患者获得较高生活质量及更长生存期。

ⅢC期宫颈癌根治性放疗后预后相关因素分析

目的探讨ⅢC期宫颈癌根治性放疗疗效及预后的影响因素分析。方法回顾性分析2017年1月—2021年1月于吉林省肿瘤医院放疗四科进行根治性放疗的宫颈癌ⅢC期患者的临床资料,ⅢC1r期患者98例,ⅢC2r期患者19例,观察近、远期疗效和相关预后因素。结果3年OS、DFS分别为75.2%、65.8%。单因素分析显示,总生存率与盆腔淋巴结转移部位、病理类型、分期明显相关;无病生存率则与盆腔淋巴结转移数量、分期有关(OS:χ^(2)=4.542、8.678、4.155;DFS:χ^(2)=5.975、9.047,P<0.05)。多因素分析显示病理类型是影响OS的独立预后因素(HR=0.280,P<0.05),DFS则受盆腔淋巴结转移数量和分期影响(HR=0.498、0.472,P均<0.05)。Logistics回归分析显示,影响ⅢC2r期腹主动脉旁淋巴结转移主要因素为同步放化疗周期数及髂总淋巴结转移(P<0.05)。结论腺癌、盆腔淋巴结转移数量≥3个及发生腹主动脉旁淋巴结转移的ⅢC期宫颈癌患者根治性放疗后的预后较差,需采取更加积极的治疗策略。同步放化疗周期数<4及髂总淋巴结转移的患者发生腹主动脉旁淋巴结转移的风险更大,需预防性扩大照射野范围。