Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness.Anterior cervical surgery can eliminate not only chronic neck pain,cervical radiculopathy or myelopathy,...Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness.Anterior cervical surgery can eliminate not only chronic neck pain,cervical radiculopathy or myelopathy,but also dizziness.Immunohistochemical studies show that a large number of mechanoreceptors,especially Ruffini corpuscles,are present in degenerated cervical discs.The available evidence suggests a key role of Ruffini corpuscles in the pathogenesis of dizziness caused by cervical degenerative disease(i.e.cervical discogenic dizziness).Disc degeneration is characterized by an elevation of inflammatory cytokines,which stimulates the mechanoreceptors in degenerated discs and results in peripheral sensitization.Abnormal cervical proprioceptive inputs from the mechanoreceptors are transmitted to the central nervous system,resulting in sensory mismatches with vestibular and visual information and leads to dizziness.In addition,neck pain caused by cervical disc degeneration can play a key role in cervical discogenic dizziness by increasing the sensitivity of muscle spindles.Like cervical discogenic pain,the diagnosis of cervical discogenic dizziness can be challenging and can be made only after other potential causes of dizziness have been ruled out.Conservative treatment is effective for the majority of patients.Existing basic and clinical studies have shown that cervical intervertebral disc degeneration can lead to dizziness.展开更多
目的:探讨Pfirrmann腰椎间盘突出症分级法对胶原蛋白酶介入治疗颈椎间盘源性痛的临床意义。方法:将60例颈椎间盘突出导致颈椎间盘源性痛患者按照Pfirrmann颈椎间盘突出症MRI分级法分组,在C型臂X线透视引导下经椎旁后外入路穿刺行胶原酶...目的:探讨Pfirrmann腰椎间盘突出症分级法对胶原蛋白酶介入治疗颈椎间盘源性痛的临床意义。方法:将60例颈椎间盘突出导致颈椎间盘源性痛患者按照Pfirrmann颈椎间盘突出症MRI分级法分组,在C型臂X线透视引导下经椎旁后外入路穿刺行胶原酶溶解术。观察术前及术后1天、3天、7天、90天、180天的视觉模拟疼痛评分(visual analogue scale,VAS),并应用健康调查简表(Short Form 36 Health Survey Questionnaire,SF-36)中的"生理机能、躯体疼痛、总体健康"3个维度对疗效进行研究分析。结果:4组介入治疗后五个时间点的VAS评分均低于术前VAS评分,差异均有统计学意义(P<0.01),说明4组病例介入治疗后疼痛均有缓解;其中PfirrmannⅡ级及PfirrmannⅢ级组介入术后180天VAS评分低于术后90天VAS评分,差异均有统计学意义(P<0.05),说明PfirrmannⅡ级及PfirrmannⅢ级组介入治疗的远期疗效更佳。SF-36量表的调查,4组病例治疗6个月后生理功能、躯体疼痛、总体健康3个维度的得分均高于术前,差异均有统计学意义(P<0.05),说明患者的生活质量改善。结论:应用Pfirrmann腰椎间盘突出症分级法对颈椎间盘突症进行MRI分级,对胶原蛋白酶介入治疗颈椎间盘源性痛的远期疗效评估具有临床意义。展开更多
文摘Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness.Anterior cervical surgery can eliminate not only chronic neck pain,cervical radiculopathy or myelopathy,but also dizziness.Immunohistochemical studies show that a large number of mechanoreceptors,especially Ruffini corpuscles,are present in degenerated cervical discs.The available evidence suggests a key role of Ruffini corpuscles in the pathogenesis of dizziness caused by cervical degenerative disease(i.e.cervical discogenic dizziness).Disc degeneration is characterized by an elevation of inflammatory cytokines,which stimulates the mechanoreceptors in degenerated discs and results in peripheral sensitization.Abnormal cervical proprioceptive inputs from the mechanoreceptors are transmitted to the central nervous system,resulting in sensory mismatches with vestibular and visual information and leads to dizziness.In addition,neck pain caused by cervical disc degeneration can play a key role in cervical discogenic dizziness by increasing the sensitivity of muscle spindles.Like cervical discogenic pain,the diagnosis of cervical discogenic dizziness can be challenging and can be made only after other potential causes of dizziness have been ruled out.Conservative treatment is effective for the majority of patients.Existing basic and clinical studies have shown that cervical intervertebral disc degeneration can lead to dizziness.
文摘目的:探讨Pfirrmann腰椎间盘突出症分级法对胶原蛋白酶介入治疗颈椎间盘源性痛的临床意义。方法:将60例颈椎间盘突出导致颈椎间盘源性痛患者按照Pfirrmann颈椎间盘突出症MRI分级法分组,在C型臂X线透视引导下经椎旁后外入路穿刺行胶原酶溶解术。观察术前及术后1天、3天、7天、90天、180天的视觉模拟疼痛评分(visual analogue scale,VAS),并应用健康调查简表(Short Form 36 Health Survey Questionnaire,SF-36)中的"生理机能、躯体疼痛、总体健康"3个维度对疗效进行研究分析。结果:4组介入治疗后五个时间点的VAS评分均低于术前VAS评分,差异均有统计学意义(P<0.01),说明4组病例介入治疗后疼痛均有缓解;其中PfirrmannⅡ级及PfirrmannⅢ级组介入术后180天VAS评分低于术后90天VAS评分,差异均有统计学意义(P<0.05),说明PfirrmannⅡ级及PfirrmannⅢ级组介入治疗的远期疗效更佳。SF-36量表的调查,4组病例治疗6个月后生理功能、躯体疼痛、总体健康3个维度的得分均高于术前,差异均有统计学意义(P<0.05),说明患者的生活质量改善。结论:应用Pfirrmann腰椎间盘突出症分级法对颈椎间盘突症进行MRI分级,对胶原蛋白酶介入治疗颈椎间盘源性痛的远期疗效评估具有临床意义。
