Advances in modern Chinese medicine treatment of cervical spondylotic radiculopathy

Objective: On the basis of a brief description of the current research status of modern Chinese medicine on the name, etiology, pathogenesis and classification of cervical spondylotic radiculopathy, this paper summarizes the research progress of modern Chinese medicine treatment of cervical spondylotic radiculopathy from the perspective of modern Chinese medicine treatment. This article mainly summarizes the following aspects: modern Chinese medicine for internal and external use;Chinese medicine acupuncture with filiform needle, electro-acupuncture and warm moxibustion;Chinese medicine massage and acupoint therapy;moxibustion, cupping, scraping and other comprehensive treatment;and Chinese medicine comprehensive therapy. The purpose of this article is to provide references for modern Chinese medicine treatment of cervical spondylotic radiculopathy.

Keyhole Foraminotomy via a Percutaneous Posterior Full-endoscopic Approach for Cervical Radiculopathy:An Advanced Procedure and Clinical Study

Endoscopic cervical foraminotomy is increasingly used for cervical spondylotic radiculopathy(CSR),but there is great concern about radiation exposure because of the heavy dependence of this surgical method on fluoroscopy.The objective of this study was to introduce in detail an advanced surgical technique of keyhole foraminotomy via a percutaneous posterior full-endoscopic approach as a treatment for CSR and investigate its clinical outcomes.We retrospectively reviewed 33 consecutive patients with CSR who underwent keyhole foraminotomy via a percutaneous posterior full-endoscopic approach from October 2015 to April 2017.The patients’general characteristics,including operative time,blood loss,hospital stay,complications,and recurrence,were obtained.Clinical outcomes were evaluated using the visual analogue scale(VAS)for radicular pain,the neck disability index(NDI)for functional assessment,and the modified MacNab criteria for patient satisfaction.All operations were successfully performed(mean operation time,62 min),with no measurable blood loss or severe related complications.The mean follow-up was 25 months.The VAS and NDI scores were significantly improved as compared with those in the preoperative period(preoperative vs.final follow-up:7.6±1.6 vs.3.83±7.34 for VAS,P<0.01;69.5%±10.5%vs.17.54%±13.40%for NDI,P<0.01).Of the 33 patients,32(97.0%)had good-to-excellent global outcomes and all patients obtained symptomatic improvement.In conclusion,keyhole foraminotomy via a percutaneous posterior full-endoscopic approach is an efficient,safe,and feasible procedure for the treatment of CSR.Its simplified single-step blunt incision for localization appears to decrease radiation exposure risks.

Clinical practice guidelines of acupuncture-moxibustion for cervical spondylotic radiculopathy

On the basis of relevant literature and evidence, Clinical Practice Guidelines of Acupuncture-moxibust^on .for Cervical 5pondyloffc Radiculopathy has been formulated according to the quality of evidences and by adopting the method of Grades of Recommendations Assessment, Development and Evaluation （GRADE）, in which the objective of guidelines formulation, the scope of application of the guidelines, the principle of acupuncture-moxibustion treatment of cervical spondylotic radiculopathy, the time for intervention and different acupuncture-moxibustion regimens, etc. were specified.

Treatment of 30 patients with cervical spondylotic radiculopathy by acupuncture plus warming-needle moxibustion:a randomized controlled trial

Objective To observe the clinical efficacy of acupuncture plus warming-needle moxibustion for the treatment of cervical spondylotic radiculopathy.Methods Sixty patients with cervical spondylotic radiculopathy were randomly divided into a warming-needle moxibustion group（group A）and an acupuncture group（group B）according to random number table,with thirty cases in each group.For the patients in the group A,Fengchi（风池 GB 20）,Jingjiaji（Jiaji points on the neck）,Dazhui（大椎 GV 14）,Dazhu（大杼 BL 11）,Jugu（巨骨 LI 16）,Tianzong（天宗 SI 11）,Tianliao（天髎 TE 15）,Jianjing（肩井 GB 21） and Hegu（合谷 LI 4） were selected for warming-needle moxibustion.In the group B,Jianliao（肩髎 TE 14）,Jianyu（肩髃 LI 15）,Quchi（曲池 LI 11）,Tianjing（天井 TE 10）,Yangchi（阳池 TE 4）,and Waiguan（外关 TE 5） were selected for acupuncture.Both groups were treated once a day and ten times constituted a course of treatment.Results Compared with the group B,significant differences were observed in the group A after a course of treatment in terms of 20-score scoring for symptoms of cervical spondylotic radiculopathy,VAS scoring and clinical efficacy[16.63±2.31 vs 15.67±2.48,2.36±1.59 vs 3.98±2.32,100%（30/30） vs 86.7%,all P〈0.05].Conclusion Acupuncture plus warming-needle moxibustion can significantly reduce neck pain and improve neck function of patients with cervical spondylotic radiculopathy,which is worthy of clinical application due to its simple manipulation.

Treatment of cervical spondylotic radiculopathy: acupuncture at neck Jiájǐ points and blood-letting puncture with the plum-blossom needle

Objective To observe the therapeutic effect of acupuncture at neck Jiájǐ （EX） points and blood-letting puncture with the plum-blossom needle on cervical spondylotic radiculopathy. Methods Sixty cases of cervical spondylotic radiculopathy were divided into a treatment group and a control group with 30 cases in each group. Acupuncture at neck Jiájǐ （EX） points （Extra） and blood-letting puncture with the plum-blossom needle were adopted for the treatment group. And acupuncture at neck Jiájǐ （EX） points was adopted for the control group. The therapeutic effect, visual analogue scale （VAS） and the numbness score were observed after 2 treatment courses. Results The total effective rate of the treatment group was 86.7% （26/30）, while the rate of the control group was 83.3% （25/30）. Comparison of the differences of the two groups was without statistic significance （P0.05）. The VAS scores of the two groups after treatment were both improved （both P0.01）, but without statistic significance between the two groups （P0.05）. The numbness scores of the two groups after treatment were both better than those before treatment （P0.01）. The therapeutic effect on numbness of the extremities of the treatment group was better than that of the control group （P0.05）. Conclusion Blood-letting puncture with the plum flower needle has a satisfactory effect on treatment of numbness of the extremities of patient with cervical spondylotic radiculopathy.

郑氏手法结合针刺治疗中老年神经根型颈椎病对其颈椎生理曲度影响的临床观察

目的观察郑氏手法结合针刺治疗中老年神经根型颈椎病的临床疗效及对其颈椎生理曲度的影响。方法将该院2021年6月—2022年5月收治的63例符合神经根型颈椎病急性期诊断标准的患者分为治疗组和对照组,其中治疗组在治疗中脱离2例,完成治疗30例,对照组在治疗中脱离1例,完成治疗30例。治疗组采用郑氏手法结合普通针刺治疗,对照组采用普通手法结合针刺治疗。1周治疗5次,两组均治疗2周。比较两组总体疗效,比较两组治疗前后视觉模拟评分法(visual analogue scale,VAS)、颈椎功能障碍指数(neck disability index,NDI)和颈椎病临床评价量表(clinical evaluation scale of cervical spondylosis,CASCS)评分变化;比较两组治疗前后颈椎生理曲度变化。结果治疗组治疗总有效率为86.67%(26/30),对照组治疗总有效率为63.33%(19/30)。治疗组总体疗效优于对照组(P<0.05);治疗组治疗后VAS评分、NDI评分低于对照组,CASCS评分高于对照组(P<0.05);治疗组治疗后颈椎生理弧度高于对照组(P<0.05)。结论郑氏手法结合针刺是治疗神经根型颈椎病的有效方案,值得临床进一步研究。

归芪活血胶囊对神经根型颈椎病大鼠炎性损伤和微循环血流的影响

目的:探究归芪活血胶囊(GQ)对神经根型颈椎病(CSR)大鼠的治疗效应及机制。方法:观察CSR大鼠自发痛、热痛阈、步态评分、前肢和颈部体表微循环状态、脊髓病理结构及超微结构变化、脊髓p38磷酸化情况以及血清白细胞介素-1β(IL-1β)、IL-6以及肿瘤坏死因子-α(TNF-α)。结果:GQ高、中剂量在干预第14天时可显著升高CSR模型大鼠的热痛阈(P<0.05),降低其步态评分和自发痛评分(P<0.05,P<0.01);GQ各剂量均可改善CSR大鼠脊髓炎症水肿变化,显著增加尼氏(Nissl)染色阳性细胞数目(P<0.05),恢复髓鞘和线粒体正常形态,且GQ中剂量效果较明显;GQ高、中剂量可显著升高CSR大鼠颈部和前肢皮肤血流灌注量(P<0.05),对前肢远端血流灌注量的改善程度优于芬必得组(P<0.01);与模型组比较,GQ中剂量可降低CSR大鼠脊髓p38磷酸化比率。结论:GQ可以缓解CSR大鼠热痛觉过敏和步态不稳的程度,改善脊髓炎症病理变化,恢复前肢和颈部体表血流灌注量,且GQ中剂量在改善CSR大鼠炎症损伤方面更有优势。

臭氧联合低温等离子射频消融术对神经根型颈椎病的疗效

目的探讨臭氧联合低温等离子射频消融术对神经根型颈椎病的疗效及炎性反应的影响。方法对2022年5月至2023年5月在首都医科大学附属北京安贞医院疼痛科治疗的75例神经根型颈椎病患者行臭氧联合低温等离子射频消融术。采用视觉模拟评分(VAS)和颈椎功能障碍指数(NDI)评估治疗前及治疗后2周的疼痛程度。酶联免疫吸附试验(ELISA)分析治疗前及治疗2周后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和干扰素-γ(IFN-γ)的水平。结果臭氧联合低温等离子射频术后VAS及NDI评分较术前显著降低[VAS:5.36(4,7)vs.1.32(1,2),P<0.0001;NDI:32.72(24,70)vs.7.62(3.55,8.9),P<0.0001]。手术治疗两周后可有效降低炎性细胞因子IL-6、TNF-α和IFN-γ的水平,减轻炎性反应[IL-6:4.33(2.51,5.04)vs.3.49(2.08,4.43),P<0.05;TNF-α:1.95(1.41,2.21)vs.1.61(1.02,2.03),P<0.05;IFN-γ:1.84(1.18,2.47)vs.1.55(0.76,2.09),P<0.05]。结论臭氧联合低温等离子射频术是治疗神经根型颈椎病的一种有效的方法。

循经按摩治疗神经根型颈椎病

目的:观察循经按摩治疗神经根型颈椎病的临床疗效。方法:选择2020年3月至2023年6月就诊的神经根型颈椎病患者64例,分为观察组和治疗组各32例。观察组采用常规治疗,男14例,女18例,年龄32~55(41.34±7.23)岁;病程9~17(14.23±3.56)个月;C5、C6神经根受压12例,C7神经根受压17例,C8神经根受压3例。治疗组在常规治疗的基础上加以循经按摩治疗,男17例,女15例,年龄30~54(40.86±6.97)岁;病程8~18(15.43±3.48)个月;C5、C6神经根受压14例,C7神经根受压16例,C8神经根受压2例。分别在治疗前和治疗2周后采用疼痛视觉模拟评分(visual analogue scale,VAS)、颈椎功能障碍指数评分(neck disability index,NDI)、颈椎病临床评价量表(clinical assessment scale for cervical spondylosis,CASCS)评价临床疗效,并比较治疗前后颈椎功能活动度。结果:治疗2周后,治疗组和观察组的VAS、NDI评分均降低,CASCS评分均升高(P<0.001)。治疗2周后,治疗组VAS、NDI评分低于观察组,CASCS评分高与观察组(P<0.001)。与治疗前相比,两组治疗2周后前屈、后伸、左侧屈、右侧屈、左旋转、右旋转活动度均增加(P<0.05)。与观察组相比,治疗组前屈、后伸、左侧屈、右侧屈、左旋转、右旋转活动度增加更明显(P<0.05)。结论:循经按摩治疗神经根型颈椎病疗效显著,能有效缓解颈项部疼痛,改善临床症状,患者满意度更高。

基于“筋、节、骨、髓”分型探讨神经根型颈椎病的手法治疗

神经根型颈椎病(CSR)是一种由于颈椎间盘和椎间关节退变引起的疾病,主要表现为颈部、肩部及上肢神经支配区域的疼痛、感觉异常和运动障碍。传统中医的筋骨辨证在治疗该病时存在概念不清、辨证分型不一等问题。岐黄学者林定坤教授在筋骨辨证的基础上,结合现代解剖学提出了颈椎“筋”“节”“骨”“髓”4大分型。该文通过总结林定坤教授对CSR筋骨辨证学术思想,总结手法治疗该病的作用靶点,提出基于筋劳、节错、骨变和髓损等4种病损分型,采用理筋、调节、护髓和治骨4种手法治疗,以期完善骨伤科手法治疗CSR的辨证施治体系,为临床提供参考。

System evaluation and Meta analysis on clinical effi cacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy

Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medical（CBM） database, Chinese Science and Technology Periodical Database（VIP）, Wan Fang Data, Pubmed and Cochrane Library were retrieved to search the randomized controlled trials（RCT） on heat-sensitive moxibustion in treatment of CSR, and Meta analysis was conducted by applying Rev Man 5.3 software. Results Eventually, 10 papers were included in this study, including 1008 subjects. Meta analysis result showed： the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.13, 95%CI（1.06, 1.21）, Z=3.54, P=0.000 4]; the cure rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.80, 95%CI（1.52, 2.13）, Z=6.82, P〈0.000 01]; the improvement of short-form Mc Gill pain questionnaire（SF-MPQ） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–4.44, 95%CI（–6.38,-2.50）, Z=4.49, P〈0.000 01]; visual analogue scale（VAS） of treatment group was lower than that of control group, and the difference was statistically significant [MD=-0.36, 95%CI（-0.50, –0.23）, Z=5.42, P〈0.00001]; and the improvement of interleukin-6（IL-6） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–7.32, 95%CI（-11.49, –3.14）, Z=3.44, P=0.000 6]. Conclusion It is indicated from the Meta analysis result that the clinical efficacy of heat-sensitive moxibustion or acupuncture combined with heat-sensitive moxibustion in treatment of CSR is superior to that of simple acupuncture or traditional suspended moxibustion, providing a new therapeutic method for treatment of CSR. However, the abovementioned conclusion still needs to be confirmed through randomized blind controlled trials with high quality and large sample size since the sample size of included studies was small, and the quality was low.

阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症的随机对照研究

目的:探究阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症的临床疗效。方法:本研究纳入2021年6月至2023年12月于四川省中西医结合医院、四川省第二中医医院门诊就诊且符合纳入标准的神经根型颈椎病患者,共计370例。采用随机对照研究方法,将患者随机分为对照组和治疗组,每组185例。治疗组接受阿是穴四花刺法治疗,对照组接受常规针刺法治疗,分别在治疗前、治疗后第1、2、3、7、14天进行评定,并观察其疼痛强度、疼痛频度、疼痛持续时间、压痛、生活质量评分的变化,以判断疗效。结果:治疗后,两组患者在VAS评分、SF-MPQ评分、疼痛频度评分、疼痛持续时间评分、压痛评分、生活质量评分方面都有显著改善。与对照组相比,治疗组的疼痛频度更早得到改善,其余各项指标在相同时间节点改善程度更高(P<0.05)。结论:阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症具有肯定疗效,相比常规针刺法治疗其起效更快,疗效更好,在提高患者生活质量方面也表现出优势,是治疗神经根型颈椎病颈肩肢痛症的理想方法。

毫针速刺法松解肌筋膜改善神经根型颈椎病患者上肢功能障碍的疗效观察

目的观察毫针速刺法松解肌筋膜改善神经根型颈椎病患者上肢功能障碍的治疗效果。方法本研究为随机对照试验,纳入2021年1月至2022年12月南京中医药大学连云港附属医院收治的72例神经根型颈椎病患者,以区组随机方法进行分组。试验组36例中男20例,女16例,年龄(47.94±6.16)岁,病程(27.25±9.49)个月;对照组36例中男18例,女18例,年龄(46.73±5.14)岁,病程(26.02±7.58)个月。试验组采用毫针速刺法治疗,针对颈项部软组织损伤部位予以穿透性松解刺激,隔日1次,并与推拿治疗交替进行,各治疗6次;对照组予传统针刺治疗,每日1次,6次为1个疗程,每隔1个疗程休息1 d,共治疗2个疗程。分别于治疗前1 d、治疗结束后第1天比较两组患者的田中靖久颈椎症状评分、颈椎功能障碍指数(NDI),并评定两组临床疗效。采用t检验、χ^(2)检验。结果与治疗前1 d比较,治疗结束后第1天两组患者的田中靖久颈椎症状评分均升高[试验组(14.93±2.74)分比(9.70±2.45)分,对照组(12.70±2.93)分比(9.40±2.01)分],NDI评分均降低[试验组(15.92±4.21)分比(38.19±5.86)分,对照组(25.46±3.84)分比(36.76±7.25)分],差异均有统计学意义(均P<0.05);且试验组各评分改善程度均优于对照组[田中靖久颈椎症状评分(5.23±1.89)分比(3.30±1.25)分,NDI评分(22.27±4.67)分比(11.30±3.97)分,均P<0.05]。试验组患者的治疗总有效率高于对照组[91.7%(33/36)比72.2%(26/36)],差异有统计学意义(χ^(2)=4.560,P=0.032)。结论毫针速刺法松解肌筋膜治疗能够缓解神经根型颈椎病患者的临床症状,减轻患者痛苦,并实现对上肢功能的良性调节,降低疾病对生活能力的影响,相对传统针刺治疗方案具有一定优势,值得在临床上进一步推广应用。

超声引导下针刀神经触激术治疗神经根型颈椎病的临床观察

目的:观察在超声引导下针刀神经触激术治疗神经根型颈椎病的临床疗效。方法:按照随机数字表法将纳入的60例神经根型颈椎病患者分为观察组和对照组,各30例。观察组采取针刀神经触激术治疗,每周1次,治疗3周;对照组采取针刺治疗,每日1次,治疗3周。分别于治疗前、治疗1周和3周后观察2组患者视觉模拟评分(VAS)、颈椎功能障碍指数(NDI)评分、田中靖久评分、尺神经与正中神经的F波出现率及传导速度变化。结果:与对照组比较,观察组在治疗1周后、3周后,VAS评分、NDI评分、颈部田中靖久评分、尺神经与正中神经F波出现率、尺神经与正中神经神经传导速度均明显优于对照组(P<0.05)。观察组总有效率为93.33%,对照组总有效率为86.66%,观察组总有效率优于对照组(P<0.05)。结论:超声引导下针刀神经触激术治疗神经根型颈椎病安全有效,优于针刺治疗。

推拿结合针灸治疗神经根型颈椎病患者的疗效观察

目的探讨CSR的治疗方法。方法回顾性收集80例CSR患者的临床资料,根据治疗方法的不同将其分为两组,各40例。对照组予以中医针灸治疗,观察组加用中医推拿治疗。比较两组疗效以及主要症状积分、疼痛程度、颈椎功能的改善情况。结果观察组有效率为95%,高于对照组的77.5%(χ^(2)=5.17,P=0.023);观察组治疗后主要症状积分、疼痛程度、颈椎功能改善程度均优于对照组(t=8.45~18.55,P<0.05)。结论中医推拿结合针灸治疗CSR患者疗效更优。

雷火炙结合大活络胶囊对神经根型颈椎病患者炎症因子、血液流变学指标和T淋巴细胞亚群的影响

目的探究雷火灸结合大活络胶囊对神经根型颈椎病(CSR)患者炎症因子、血液流变学指标和T淋巴细胞亚群的影响。方法前瞻性选取2021年10月至2023年10月广州市中西医结合医院收治的120例CSR患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组各60例。对照组给予大活络胶囊(口服,3次/d,每次服用4粒)治疗,观察组给予雷火灸结合大活络胶囊治疗,雷火灸每次30 min,1次/d,每周5次,两组均持续治疗2周。比较两组患者的临床疗效,治疗前和治疗2周的疼痛程度[视觉模拟评分法(VAS)评分]、症状积分、炎症因子[白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)]、血液流变学指标[全血高切黏度、全血低切黏度、血浆黏度、红细胞比容(HCT)]及T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化。结果观察组临床总有效率为91.67%,高于对照组(76.67%),差异有统计学意义(P<0.05)。治疗2周后,两组VAS均较治疗前降低,症状积分均较治疗前升高,且观察组的VAS评分为(1.74±0.55)分,低于对照组[(2.82±0.83)分],症状积分为(16.20±3.26)分,高于对照组[(14.85±3.47)分],差异均有统计学意义(P<0.05)。治疗2周后,两组血清IL-6、IL-8、TNF-α水平均较治疗前降低,且观察组的血清IL-6、IL-8、TNF-α水平分别为(27.37±3.47)ng/L、(56.54±15.21)g/L、(8.61±2.13)ng/L,均低于对照组[(38.34±4.64)ng/L、(81.91±16.78)g/L、(13.57±2.42)ng/L],差异均有统计学意义(P<0.05)。治疗2周后,两组全血高切黏度、全血低切黏度、血浆黏度及HCT水平均较治疗前降低,且观察组的全血高切黏度、全血低切黏度、血浆黏度及HCT分别为(3.11±0.45)mPa/s、(6.62±2.17)mPa/s、(1.35±0.1)mPa/s、(38.95±3.08)%,均低于对照组[(3.62±0.68)mPa/s、(8.35±2.36)mPa/s、(1.78±0.26)mPa/s、(42.97±2.85)%],差异均有统计学意义(P<0.05)。治疗2周后,CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均较治疗前升高,CD8^(+)水平均较治疗前降低,且观察组的CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)分别为(75.32±7.23)%、(47.58±6.33)%、2.17±0.77,均高于对照组[(68.04±8.01)%、(42.49±7.47)%、1.79±0.72],CD8^(+)水平为(20.15±4.45)%,低于对照组[(23.75±4.54)%],差异均有统计学意义(P<0.05)。结论雷火灸结合大活络胶囊治疗CSR疗效显著,可有效减轻患者疼痛,缓解临床症状,抑制炎症反应、改善血液流变学指标、增强免疫力可能是其疗效的作用机制。

循经温和灸联合局部药物注射治疗神经根型颈椎病的效果

目的探讨循经温和灸联合局部药物注射治疗神经根型颈椎病(CSR)的临床效果。方法按随机数字表法将河南科技大学第二附属医院2021年1月至2022年9月收治的82例CSR患者分为对照组(41例,局部药物注射治疗)和观察组(41例,局部药物注射治疗+循经温和灸治疗),均持续治疗2周。比较两组临床疗效、疼痛程度[简化McGill疼痛问卷(SF-MPQ)]、颈动脉血流速度及颈椎功能[颈椎病临床评价量表(CASCS)、颈椎功能障碍指数(NDI)],统计两组治疗期间不良反应发生情况。结果观察组临床总有效率、颈动脉血流速度、CASCS评分高于对照组,SF-MPQ问卷评分、NDI评分均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论循经温和灸联合局部药物注射可提高CSR患者的治疗效果,减轻疼痛程度,改善颈动脉血流速度及颈椎功能,且不会增加不良反应。

耳穴贴压治疗神经根型颈椎病疗效的Meta分析

目的:总结评价耳穴贴压对神经根型颈椎病(CSR)的护理疗效,以便为中医护理提供参考。方法:计算机检索PubMed、EMbase、Cochrane Library、Web of Science、中国生物医学文献服务系统、万方数据库、维普数据库和中国知网,搜集有关耳穴贴压治疗CSR的随机对照试验(RCT),检索时限为建库至2022年7月。参考Cochrane风险偏倚评估工具对文献质量进行评价,并进行Meta分析。结果:共纳入16项研究,1391例患者。结果显示,耳穴贴压可以提高CSR治疗效果,差异具有统计学意义[OR=3.59,95%CI(2.41,5.33),Z=6.32,P<0.00001];降低CSR患者的疼痛[MD=–1.39,95%CI(–1.81,–0.98),Z=6.57,P<0.00001];提高CSR患者的颈椎功能[MD=5.12,95%CI(4.25,5.98),Z=11.58,P<0.00001];减轻CSR患者颈浅部肌肉疼痛[MD=–1.24,95%CI(–1.30,–1.18),Z=42.68,P<0.00001]。结论:现有证据表明,耳穴贴压对CSR治疗有效,可降低颈椎疼痛,提高颈椎功能,减轻颈浅部肌肉疼痛感,但由于本研究文献质量普遍不高,未来仍需要高质量的RCT研究进一步验证。

桃红四物汤联合针刺、洛芬待因缓释片治疗营血虚滞型神经根型颈椎病的效果分析

目的:分析桃红四物汤联合针刺、洛芬待因缓释片治疗营血虚滞型神经根型颈椎病的效果。方法:选取2021年10月—2022年10月北京市昌平区中西医结合医院收治的营血虚滞型神经根型颈椎病患者60例作为研究对象,随机分为观察组与对照组,各30例。对照组给予针刺联合洛芬待因缓释片治疗,观察组在对照组基础上给予桃红四物汤治疗。比较两组治疗效果。结果:观察组肢体麻木、颈椎疼痛、头晕头痛改善时间早于对照组,差异有统计学意义(P<0.05)。观察组复发率低于对照组,差异有统计学意义(P=0.044)。治疗后,两组疼痛评分低于治疗前,且观察组低于对照组,两组颈椎功能评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.023)。治疗后,两组生理功能、社会功能、躯体疼痛、情感职能评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:桃红四物汤联合针刺、洛芬待因缓释片治疗营血虚滞型神经根型颈椎病的效果显著,可快速改善患者临床症状,减轻疼痛,恢复颈椎功能,降低复发率,提高生活质量。

急性期神经根型颈椎病患者的血清差异蛋白组学分析

背景:正常健康人向急性期神经根型颈椎病转化的具体分子机制尚未完全明确,需进一步深入研究。目的:探讨正常健康人群与急性期神经根型颈椎病患者的血清蛋白组学差异表达,并寻找及鉴定两者之间的潜在特异性血清标志物。方法:收集急性期神经根型颈椎病患者、正常健康人群血清各8例,应用绝对定量技术联合液相色谱-串联质谱技术进行蛋白组学筛选与分析,以期探寻与鉴定急性期神经根型颈椎病患者差异表达的血清蛋白质。结果与结论:①绝对定量技术筛查出有意义差异蛋白183种,鉴定出11种显著性差异蛋白质(P<0.05),其中与正常健康人组相比,急性期神经根型颈椎病组中人类白细胞抗原A、分泌珠蛋白家族1a成员1、蛋白4-羟基苯丙酮酸双加氧酶等3种差异蛋白显著上调,免疫球蛋白IgG3恒定区、皮肤因子、肌球蛋白轻链3等7种差异蛋白显著下调;②基因本体富集分析结果表明,这些差异蛋白参与了抗原结合、免疫球蛋白受体结合等分子功能;③蛋白相互作用网络分析表明,正常健康人群与急性期神经根型颈椎病之间的共同差异蛋白中HLA-A、HPD、PSMA3、DMKN、SCGB1A1、MYL3等6种位于功能网络节点,且与机体免疫、细胞炎症反应、能量代谢、机械压力等系统关系密切;④采用免疫印迹实验对显著性差异蛋白HLA-A、HPD、MYL3进行验证,其验证结果与蛋白组学结果相一致;⑤提示通过绝对定量技术联合液相色谱-串联质谱技术发现正常健康人群与急性期神经根型颈椎病患者之间的血清差异表达蛋白质,并初步认为HLA-A、HPD、MYL3可能是急性期神经根型颈椎病的特异性血清标志物,为进一步研究其发病机制提供了新方向。