Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid (4)and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate)adenine (11),were synthesiz...Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid (4)and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate)adenine (11),were synthesized.The formation of lactone of 5'-deoxy-adenosineacetic acid(AAA,3)was investigated by using different reagents for lactonization from AAA,but all of the efforts failed, and sone unexpected compounds were obtained.展开更多
In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance,a series of pleuromutilin derivatives with novel C（14） side chain were synthesized and evaluated f...In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance,a series of pleuromutilin derivatives with novel C（14） side chain were synthesized and evaluated for their in vitro antibacterial activities.The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive organisms.In particular,compound lOd exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid,emerged as potential molecule for further investigation.展开更多
基金The project was supported by the National Natural Science Foundation of China.
文摘Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid (4)and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate)adenine (11),were synthesized.The formation of lactone of 5'-deoxy-adenosineacetic acid(AAA,3)was investigated by using different reagents for lactonization from AAA,but all of the efforts failed, and sone unexpected compounds were obtained.
基金National Science and Technology Major Project for the support of this researchsupported by Key New Drug Creation and Manufacturing Program,China(No:2009ZX09301-001)
文摘In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance,a series of pleuromutilin derivatives with novel C（14） side chain were synthesized and evaluated for their in vitro antibacterial activities.The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive organisms.In particular,compound lOd exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid,emerged as potential molecule for further investigation.
