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Aging effect and test-retest reliability of the sinusoidal harmonic acceleration test and velocity step test using nanotorque rotatory chair 被引量:1
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作者 Nourhan Ghoraba Samir Assal Doaa Elmoazen 《Journal of Otology》 CAS CSCD 2023年第3期125-131,共7页
Introduction:Rotatory chair testing has been used to evaluate horizontal canal function.Frequently used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age... Introduction:Rotatory chair testing has been used to evaluate horizontal canal function.Frequently used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age effect on the SHAT and VST and assessment of test-retest reliability of the parameters of those two tests.Methods:A prospective study was performed on 100 subjects with no ear or vestibular complaints and normal vestibular evaluation.They were divided into two groups;Group A:below 50 years of age and Group B:50 years of age or above.SHAT was presented at frequencies 0.02,0.04,0.08,0.16,0.32,0.64 Hz with a peak velocity of 60°/s.VST was performed using a maximum velocity of 100°/s with acceleration and deceleration of 200°/s2.Thirty subjects were tested twice to assess reliability.Results:Study participants ranged in age from 20 to 67 years.Regarding group A,the mean age was30.92±7.31 and 55.36±4.61 for group B.No significant differences were found in SHAT parameters between the two groups.As well,there was no significant difference in VST per-rotatory time constant,however,post-rotatory time constant was significantly longer for Group B(P value<0.05).Intraclass correlation coefficient(ICC)values showed moderate to good reliability(ICC 0.5800.818)for SHAT parameters for the lower frequencies and indicated moderate reliability for VST time constant(ICC 0.5090.652).Conclusions:Age has no significant effect on the parameters of SHAT and VST.Test-retest reliability is generally good for both tests. 展开更多
关键词 Rotatory chair testing Sinusoidal harmonic acceleration test Velocity step test Age effect Test-retest reliability
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Sn-doped BiOCl nanosheet with synergistic H^(+)/Zn^(2+)co-insertion for“rocking chair”zinc-ion battery
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作者 Yuzhu Qian Hongrui Wang +6 位作者 Xinni Li Ting Song Yong Pei Li Liu Bei Long Xiongwei Wu Xianyou Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第6期623-632,I0014,共11页
The development of insertion-type anodes is the key to designing“rocking chair”zinc-ion batteries.However,there is rare report on high mass loading anode with high performances.Here,{001}-oriented Bi OCl nanosheets ... The development of insertion-type anodes is the key to designing“rocking chair”zinc-ion batteries.However,there is rare report on high mass loading anode with high performances.Here,{001}-oriented Bi OCl nanosheets with Sn doping are proposed as a promising insertion-type anode.The designs of cross-linked CNTs conductive network,{001}-oriented nanosheet,and Sn doping significantly enhance ion/electron transport,proved via experimental tests and theoretical calculations(density of states and diffusion barrier).The H^(+)/Zn^(2+)synergistic co-insertion mechanism is proved via ex situ XRD,Raman,XPS,and SEM tests.Accordingly,this optimized electrode delivers a high reversible capacity of 194 m A h g^(-1)at 0.1 A g^(-1)with a voltage of≈0.37 V and an impressive cyclability with 128 m A h g^(-1)over 2500 cycles at 1 A g^(-1).It also shows satisfactory performances at an ultrahigh mass loading of 10 mg cm^(-2).Moreover,the Sn-Bi OCl//MnO_(2)full cell displays a reversible capacity of 85 m A h g^(-1)at 0.2 A g^(-1)during cyclic test. 展开更多
关键词 Sn-doped BiOCl nanosheet High mass loading anode Synergistic H^(+)/Zn^(2+)co-insertion Fast ionic/electronic diffusion “Rocking chair”zinc-ion battery
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Cementing Ties Uganda’s chairing of G77+China to heighten relationship with China
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作者 GODFREY OLUKYA 《ChinAfrica》 2023年第11期38-39,共2页
For the past six decades,Uganda and China have enjoyed remarkable bilateral relations and Uganda being recently elected to chair G77+China mechanism is set to drive the relationship to even greater heights.That’s acc... For the past six decades,Uganda and China have enjoyed remarkable bilateral relations and Uganda being recently elected to chair G77+China mechanism is set to drive the relationship to even greater heights.That’s according to Uganda’s First Deputy Prime Minister Rebecca Kadaga,who made the remarks recently while speaking at an event to mark the 74th anniversary of the founding of the People’s Republic of China.In response,the charge d’affaires at the Chinese Embassy in Uganda,Fan Xuecheng,toasted the long-standing friendship between the peoples of China and Uganda. 展开更多
关键词 FOUNDING chair SPEAKING
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Chair Tilings非周期艺术图案的生成 被引量:10
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作者 邹玉茹 李文侠 鲁坚 《计算机辅助设计与图形学学报》 EI CSCD 北大核心 2006年第4期498-501,共4页
在Chairtilings结构的基础上构造出新的函数来生成彩色非周期图案,其原胞具有丰富的图形结构,为计算机实现非周期拼砌提供了新方法·
关键词 chair TILINGS 替换法 不变映射 非周期艺术图案
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不同手术方案对Chair畸形Ⅰ型患者术后临床疗效的观察 被引量:1
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作者 牛海涛 杨明 +1 位作者 张艳艳 于金然 《河北医药》 CAS 2019年第5期695-698,702,共5页
目的探讨不同手术方案对Chair畸形Ⅰ型患者术后的临床疗效,为Chair畸形Ⅰ型患者的治疗提供更优越的手术方案。方法选取2015年5月至2018年4月就诊的128例诊断为Chair畸形Ⅰ型的患者,依据随机数字表法患者随机分为2组,每组64例。2组患者... 目的探讨不同手术方案对Chair畸形Ⅰ型患者术后的临床疗效,为Chair畸形Ⅰ型患者的治疗提供更优越的手术方案。方法选取2015年5月至2018年4月就诊的128例诊断为Chair畸形Ⅰ型的患者,依据随机数字表法患者随机分为2组,每组64例。2组患者给予术前相关检查,其中对照组给予改良后颅窝减压术治疗,研究组给予后颅窝减压术联合硬膜成形术及小脑扁桃体切除术治疗,2组患者随访12个月,评价2组患者的住院时间、短期临床症状改善情况、并发症发生率、脊髓空洞缓解率及肢体感觉障碍缓解率。结果治疗后2组患者的短期临床症状、脊髓空洞缓解率及肢体感觉障碍缓解率均较前明显改善(P<0.05);研究组患者的住院时间、短期临床症状改善情况和并发症发生率均明显优于对照组(P<0.05),2组患者术后1年的肢体感觉障碍缓解率及脊髓空洞缓解率与对照组比较差异无统计学意义(P>0.05)。结论后颅窝减压术联合硬膜成形术及小脑扁桃体切除术与改良后颅窝减压术比较,临床疗效较为显著,可有效改善患者的相关临床症状,减少并发症的发生率,并且有效缩短患者的住院时间,减少患者及其家庭的经济负担,但是两种术式对于患者的肢体感觉障碍的缓解率及脊髓空洞缓解率未见明显异常,说明对于临床症状及体征不同的患者应采取不同的治疗方案,因人而异与个体化的手段相结合。 展开更多
关键词 chair畸形Ⅰ型 不同手术方案 治疗结果
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单纯后颅窝减压术与后颅窝减压硬膜扩大成形术治疗chair畸形的疗效比较 被引量:1
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作者 孙卫 习斌 刘健民 《现代医院》 2015年第10期45-46,共2页
目的分析单纯后颅窝减压术与后颅窝减压硬膜扩大成形术治疗chair畸形的疗效。方法将60例chair畸形患者按照术式的不同分为观察组和对照组各30例,分别采取后颅窝减压硬膜扩大成形术、单纯后颅窝减压术治疗,对比两组患者术后效果。结果观... 目的分析单纯后颅窝减压术与后颅窝减压硬膜扩大成形术治疗chair畸形的疗效。方法将60例chair畸形患者按照术式的不同分为观察组和对照组各30例,分别采取后颅窝减压硬膜扩大成形术、单纯后颅窝减压术治疗,对比两组患者术后效果。结果观察组总有效率96.7%较对照组总有效率60%高,其症状消失率明显高于对照组,p<0.05;术后未发生脑脊液漏、颅内感染等并发症,恢复良好。结论颅窝减压硬膜扩大成形术治疗chair畸形疗效优于单纯后颅窝减压术,效果更为显著。 展开更多
关键词 单纯后颅窝减压术 后颅窝减压硬膜扩大成形术 chair 畸形
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Wireless Head Gesture Controlled Robotic Wheel Chair for Physically Disable Persons 被引量:3
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作者 Shadman Mahmood Khan Pathan Wasif Ahmed +3 位作者 Md. Masud Rana Md. Shahjalal Tasin Faisul Islam Anika Sultana 《Journal of Sensor Technology》 2020年第4期47-59,共13页
A robotic wheelchair is assumed to be capable of doing tasks like navigation, obstacle detection, etc. using sensors and intelligence. The initial part of the work was development of a cap controlled wheelchair to tes... A robotic wheelchair is assumed to be capable of doing tasks like navigation, obstacle detection, etc. using sensors and intelligence. The initial part of the work was development of a cap controlled wheelchair to test and verify the gesture operation. Following that, a real time operating wheelchair was developed consisting of mode changing option between joystick control mode and head gesture control mode as per as the user’s requirement. The wheelchair consists of MPU6050 sensor, joystick module, RF module, battery, dc motor, toggle switch and Arduino. The movement of the head is detected by MPU6050 and the signal is transmitted to the microcontroller. Then the signal is processed by controller and motion of wheelchair is enabled for navigation. The wheelchair was capable of moving left, right, forward and backward direction. The speed of the wheelchair was 4.8 km/h when tested. Design objective of the wheelchair included cost effectiveness without compromising safety, flexibility and mobility for the users. 展开更多
关键词 Head Gesture Wheel chair Arduino Motor Driver Joystick Module
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The Cardiac Function in the Beach Chair Position under General Anesthesia 被引量:1
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作者 Kumiko Tanabe Yuko Yamada +2 位作者 Kiyoshi Nagase Nobuo Terabayashi Hiroki Iida 《Open Journal of Anesthesiology》 2018年第1期27-34,共8页
Background: Shoulder surgery is performed in the beach chair position (BCP). The systemic arterial blood pressure (BP) must be increased to prevent cerebral hypoperfusion. However, it is not clear how the cardiac func... Background: Shoulder surgery is performed in the beach chair position (BCP). The systemic arterial blood pressure (BP) must be increased to prevent cerebral hypoperfusion. However, it is not clear how the cardiac function is affected when BP increase to maintain cerebral perfusion pressure in anesthetized patients. Methods: An analysis was performed using the data from 13 patients. We prepared a parallel circuit using a FloTrac Sensor transducer and an arterial BP transducer. Following the transfer of the patient to the BCP under general anesthesia, the FloTrac Sensor transducer was placed at the level of the fourth intercostal space, the arterial BP transducer was placed at the external auditory meatus level. We selected two points before surgery (120 s apart), during which the mean arterial BP (mABP) at the level of the brain was stable and at which the values in the supine position and the BCP were within 5 mmHg. Results: While the patients were in the supine position, the mean mABP at the mid-axillary level was 65.7 mmHg. In the BCP, the mean mABP was 66.5 mmHg at the external auditory meatus and 80.7 mmHg at the fourth intercostal space. The cardiac index changed from 2.2 (supine position) to 2.5 l/min/m2 (BCP). The stroke volume index was significantly increased from 35.8 to 42.3 ml/m2 (P = 0.003). The heart rate changed from 63.0 to 58.6 beats/min. The stroke volume variation was significantly decreased from 12.4% to 8.8% (P = 0.024). Conclusion: In order to ensure patient safety, close attention should be paid to the systemic cardiovascular changes that occur when the BP is increased. 展开更多
关键词 BEACH chair POSITION CARDIAC Function CEREBRAL PERFUSION
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Design and Structural Analysis of Flexible Wearable Chair Using Finite Element Method 被引量:1
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作者 Ashutosh Bijalwan Anadi Misra 《Open Journal of Applied Sciences》 2016年第7期465-477,共14页
The flexible wearable chair is like a light weight mobile exoskeleton that allows people to sit any-where in any working position. The traditional chair is difficult to move to different working locations due to its l... The flexible wearable chair is like a light weight mobile exoskeleton that allows people to sit any-where in any working position. The traditional chair is difficult to move to different working locations due to its large size, heavy weight (~5 - 7 kg) and rigid structure and thus, they are inappropriate for workplaces where enough space is not available. Flexible wearable chair has a gross weight of 3 kg as it utilizes light-weight aluminium alloy members. Unlike the traditional chair, it consists of kinematic pairs which enable taking halts between continuous movements at any working position and thus, it is capable of reducing the risk of the physical musculoskeletal disorder substantially among workers. The objective of this paper is to focus on the mechanical design and finite element analysis (FEA) of the mechanism using ANSYS<sup>®</sup> software. In the present work, all the parts of the mechanism are designed under static load condition. The results of the analysis indicate that flexible wearable chair satisfies equilibrium and stability criterion and is capable of reducing fatigue during working in an assembly line/factory. 展开更多
关键词 Assembly Line Musculoskeletal Disorder (MSD) Flexible Wearable chair Equilibrium and Constraint Equations Finite Element Analysis (FEA)
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Randomized Trial of the Use of Dexmedetomidine vs. Propofol after Regional Blockade in Shoulder Surgery Patients in Beach Chair Position
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作者 Piyush Gupta Ofer Wellisch +5 位作者 Mark Kronenfeld Jack Choueka Kenneth D. Eichenbaum Murali Pagala Peter Homel Dennis E. Feierman 《Open Journal of Anesthesiology》 2015年第8期187-191,共5页
Background: Propofol is often the drug of choice for ambulatory orthopedic cases. However, propofol can be associated with apnea or other events requiring airway interventions. Dexmedetomidine (Dex) has the unique pha... Background: Propofol is often the drug of choice for ambulatory orthopedic cases. However, propofol can be associated with apnea or other events requiring airway interventions. Dexmedetomidine (Dex) has the unique pharmacologic profile of providing sedation without respiratory depression. This is particularly relevant in patients with morbid obesity and/or challenging airways. The hypotheses were: 1) Propofol would cause more apnea or require more airway manipulations than dexmedetomidine;2) Propofol would have shorter post anesthesia unit recovery times;and 3) Dexmedetomidine would be associated with more bradycardia and hypotension. Methods: After IRB approval, 50 patients were randomized to receive either propofol or Dex for Total Intravenous anesthesia (TIVA) after interscalene brachial plexus block was performed preoperatively under ultrasound guidance. The main end points that we measured where: airway interventions, intra-operative bradycardia, hypotension, and PACU length of stay. Results: There were more airway interventions in the propofol group compared to the Dex group. Additionally, the Dex group had significantly longer PACU stays. Conclusion: We would recommend that Dex should be preferentially considered for patients predisposed to airway obstruction;however, the standard use of Dex over Propofol needed to reconsider since the use of Dex as the agent for TIVA was associated with longer PACU stays. 展开更多
关键词 DEXMEDETOMIDINE PROPOFOL BEACH chair REGIONAL Block
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Paraplegia by Acute Cervical Disc Herniation after Shoulder Arthroscopic Surgery in Beach-Chair Position
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作者 Hye Young Kim Gang Han Jung 《Open Journal of Anesthesiology》 2018年第11期280-283,共4页
Paraplegia after non-cervical spine surgery under general anesthesia is a rare devastating postoperative complication [1]. A patient with shoulder pain was scheduled for shoulder arthroscopy due to rotator cuff repair... Paraplegia after non-cervical spine surgery under general anesthesia is a rare devastating postoperative complication [1]. A patient with shoulder pain was scheduled for shoulder arthroscopy due to rotator cuff repair. Arthroscopic shoulder surgery was performed with the patient in the beach-chair. Postoperatively, patients complained the weakness of both lower leg and marked numbness and tingling in the both arms. MRI showed a herniated intervertebral disc between C6 and C7 with spinal cord compression. Despite urgent discectomy, the patient remained dysesthesia of both upper extremities for 6 months. The purpose of this report is to introduce our case with a paraplegia observed after arthroscopic shoulder surgery in beach-chair position because of acute cervical herniation. 展开更多
关键词 BEACH chair POSITION PARAPLEGIA SHOULDER ARTHROSCOPY
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Chair Professors and Visiting Professors of "Chang Jiang Scholars Program"
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《Journal of Pharmaceutical Analysis》 SCIE CAS 2011年第4期319-319,共1页
In responding to the ongoing development needs of the university, we are seeking to recruit Chair Professors and Visiting Professors of "Chang Jiang Scholars Program" at home and abroad. School of Medicine, Tsinghua... In responding to the ongoing development needs of the university, we are seeking to recruit Chair Professors and Visiting Professors of "Chang Jiang Scholars Program" at home and abroad. School of Medicine, Tsinghua University 展开更多
关键词 chair Professors and Visiting Professors of Chang Jiang Scholars Program
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Chair Professors and Visiting Professors of "Chang Jiang Scholars Program"
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《Journal of Pharmaceutical Analysis》 SCIE CAS 2011年第2期158-158,共1页
In responding to the ongoing development needs of the university, we are seeking to recruit Chair Professors and Visiting Professors of "Chang Jiang Scholars Program" at home and abroad.
关键词 chair Professors and Visiting Professors of Chang Jiang Scholars Program
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Catalytic Oxidative Coupling of 1-Phenyl-lH-tetrazole-5-thiol(HL)and Complex[Cu(I)6L6]with a Chair Configuration
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作者 TAN Di YANG Jun-wei +1 位作者 TONG Shan-ling YAN Yan 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第1期8-10,共3页
Both a persulfide crystal of L-L(1), the oxidative coupling product of l-phenyl-lH-tetrazole-5-thiol(HL), and a neutral copper(1) complex of Cu6L6(2) were self-assembled and their crystal architectures were ch... Both a persulfide crystal of L-L(1), the oxidative coupling product of l-phenyl-lH-tetrazole-5-thiol(HL), and a neutral copper(1) complex of Cu6L6(2) were self-assembled and their crystal architectures were characterized by CCD method. HL was converted into the persulfide L-L(1) over a metalloporphyrin catalyst with enzymatic characters under ambient conditions. Whlie in the crystal architecture of Cu6L6(2), 6 copper(1) ions were ligated by 6L anions to construct a Cu6 ring, which just resembled the chair configuration of cyclohexane. Notably, both compounds 1 and 2 exhibit strong photoluminescence in solid state. 展开更多
关键词 chair-shape copper complex Oxidative coupling Crystal architecture
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Exploring the Gap:the Influence of Chair-CEO Age Dissimilarity on CEO Monitoring and Incentives
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作者 朱佳俊 高静 谭红平 《Journal of Donghua University(English Edition)》 EI CAS 2019年第3期315-324,共10页
This paper investigates how the chair-CEO age dissimilarity and CEO power affect the dispersion and change of chair-CEO pay gap from both static and dynamic perspectives.The substantial age dissimilarity between the c... This paper investigates how the chair-CEO age dissimilarity and CEO power affect the dispersion and change of chair-CEO pay gap from both static and dynamic perspectives.The substantial age dissimilarity between the chairman and the CEO gives rise to cognitive conflict,thereby increasing board monitoring for firms with greater monitoring needs.Using data of China s listed firms from 2009 to 2017,we find a significant negative effect of CEO power on pay gap between the chairman and the CEO.In addition,when CEO is a member of the board or compensation committee,the power of CEO has different influences on the compensation,but the cognitive conflicts caused by chair-CEO age dissimilarity always inhibit the CEO s power.Thus,age dissimilarity has become an important complement to the board s regulatory mechanisms. 展开更多
关键词 age DISSIMILARITY pay GAP CEO power chair-CEO relation MONITORING
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The Case of the Broken Chair
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作者 Edward Hornby 单祝堂 《语言教育》 1998年第12期43-44,共2页
Some time ago I discovered that one of the chairs in myfront hall had a broken leg.I didn’t foresee any great difficultyin getting it mended,as there are a whole lot of antique shopsin the Pimlico Road which is three... Some time ago I discovered that one of the chairs in myfront hall had a broken leg.I didn’t foresee any great difficultyin getting it mended,as there are a whole lot of antique shopsin the Pimlico Road which is three minutes’walk from myflat,so I set forth one morning carrying the chair with me.Iwent into the first shop confidently expecting a friendly recep- 展开更多
关键词 MORNING GETTING minutes chair broken carrying friendly NOTHING LOOKING suddenly
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Using a Simple Chair-Side Copy Denture Technique in the AvaDent Digital Denture Process: A Case Report and Review
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作者 Amit Paryag Reisha Rafeek Ashley Meighan 《Open Journal of Stomatology》 2018年第7期241-249,共9页
Introduction: Several techniques have been described by which a pair of dentures may be replicated. Case Report: The method described in this paper used materials readily available in a private practice to generate a ... Introduction: Several techniques have been described by which a pair of dentures may be replicated. Case Report: The method described in this paper used materials readily available in a private practice to generate a pair of duplicate dentures for a 74-year-old Black male, which captured all of the features of the patients’ existing pair. These were modified chair-side and used to capture vital information on fit, occlusion and aesthetics, forming a template which was transferred to the laboratory and used to generate new dentures via the traditional laboratory process. The same template was also used to generate a pair of “AvaDent Digital Dentures” by digital scanning and production of a digital denture template for try and then fabrication of the digital denture. Conclusion: The results of this pilot study show that this simple chair-side method of fabricating duplicate dentures can be incorporated successfully into the AvaDent Digital Denture fabrication process to generate a pair of dentures with comparability if not superior fit and aesthetics to a pair fabricated from the same template via the traditional laboratory process. 展开更多
关键词 DIGITAL DENTURES DUPLICATE chair-Side Complete DENTURES
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Chair-rising and 3-min walk: A simple screening test for functional mobility
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作者 Tae-Woong Oh Izumi Tabata +2 位作者 Jin-Hwan Kim Tae-Hyun Lee Tatsuki Naka 《Open Journal of Preventive Medicine》 2012年第1期93-97,共5页
Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobil... Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobility tests are usually based on a maximal exercise stress test;however, this test is often difficult and sometimes frightening to older persons. Therefore, the objective of this study was to examine age and gender differences in 3-min walk distance test (3WDT), and time of chair-rising test (CRT) of functional mobility. 153 men and 159 women aged from 20 to 78 years were recruited as subjects of the present study. The body composition measured the height, body mass (BM), body mass index (BMI), lean tissue mass (LTM), and waist circumference (WC). The Functional mobility tests measured the peak oxygen uptake (VO2peak), 3WDT, leg extension strength (LES), and times of CRT. Both in men and women, height and BMI, WC decreased and increased, respectively, with age. Height, BM, LTM, WC in men are higher than in women. We found no correlation between ages and 3WDT in women and a significant, negative correlation in men. All parameters of fitness performance were negatively correlated with age. Both in men and women, all parameters of fitness performance were positively correlated with sex. Both in men and women, VO2peak, 3WDT, and LES decreased with age. All parameters of fitness performance in men are higher than in women. Both in men and women were observed for the correlation between 3WDT and VO2peak, LES and CRT respectively. Although as the correlation coefficient between 3WTD and VO2peak, LES and CRT were low (r = 0.28 - 0.38), an error may occur, this study shows that 3WDT and CRT test can be a feasible method of providing the information for muscle power and aerobic fitness, possibly avoiding the need for a maximal stress test. 展开更多
关键词 Peak Oxygen UPTAKE 3-Min WALK Distance TEST LEG Extension Strength chair-Rising TEST Mobility
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Where is my chair?
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作者 廖晓熙 《重庆教育》 2002年第F05期242-242,共1页
关键词 “Where is my chair?” 小学 英语教学 教学活动化 英语句型 教学设计
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MMP-8 analysis in gingival crevicular fluid using ELISA and novel chair-side test
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作者 Ghousia Akbari MLV Prabhuji +1 位作者 Bangalore Varadhan Karthikeyan Sandip G Chorghade 《World Journal of Stomatology》 2013年第1期24-29,共6页
AIM: To validate accuracy of a novel chair-side test for matrix metalloproteinase(MMP)-8 as compared to enzyme-linked immunosorbent assay(ELISA) in Periodontal health and disease.METHODS: Gingival crevicular fluid was... AIM: To validate accuracy of a novel chair-side test for matrix metalloproteinase(MMP)-8 as compared to enzyme-linked immunosorbent assay(ELISA) in Periodontal health and disease.METHODS: Gingival crevicular fluid was collected from 150 subjects, Group 1(healthy)- 50 subjects, Group 2(gingivitis)- 50 subjects and Group 3(chronic periodontitis)- 50 subjects. A chair-side test strip was indigenously prepared using polyclonal antibodies(principle of immunochromatography) to detect the MMP-8 levels. The detection accuracy(sensitivity and specificity) of the MMP-8 levels by chair-side test kit were compared with ELISA at baseline and 3 mo after scaling and root planing among the study population.RESULTS: The novel chair side test detected MMP-8 levels in accordance with ELISA which at baseline were higher in Group 2 and Group 3 as compared to controls(P < 0.05), and these enzyme levels decreased after therapy(P < 0.05). The chair-side test could differentiate healthy, gingivitis and periodontitis. The detection accuracy of the chair-side test strip were on par with ELISA(sensitivity 92.9% and specificity of 100%) which were statistically significant(P < 0.05). A desire to arouse interest about periodontal health and maintenance in the Indian population provided a strong rationale for us to develop our chair-side test strips to suit our economy. Moreover, this was the first ever effort to develop and validate a chair-side test strip to detect MMP-8 levels in the Indian population. This test can be used on a large scale in private dental practice for the early detection of disease, tapping the sites at risk for disease, alongside helps in patient education and motivation for maintenance.CONCLUSION: This study shows that the novel chair side test kit detects MMP-8 levels a biomarker of periodontal disease progression accurately making it a good chair side diagnostic tool. Further, it is cost effective and time saving which can make it applicable in private dental practice on a large scale for the early detection of periodontal disease. 展开更多
关键词 chair-side test Chronic PERIODONTITIS GINGIVAL crevicular fluid Matrix metalloproteinase-8 PERIODONTAL health
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