AIM:To define the possible beneficial impact of probiotics oral supplementation on patients affected by chalazion.METHODS:Prospective comparative pilot study on 20 adults suffering from chalazion randomly divided into...AIM:To define the possible beneficial impact of probiotics oral supplementation on patients affected by chalazion.METHODS:Prospective comparative pilot study on 20 adults suffering from chalazion randomly divided into two groups.The first group(n=10)received conservative treatment with lid hygiene,warm compression,and dexamethasone/tobramycin ointment for at least 20 d.The second group(n=10),in addition to the conservative treatment,received a mixture of probiotic microorganisms of Streptococcus thermophilus ST10(DSM 25246),Lactococcus lactis LLC02(DSM 29536)and Lactobacillus delbrueckii(DSM 16606)once a day up to 3 mo.Chalazia were classified according to their size into three groups:small(<2 mm),medium(≥2 to<4 mm),or large(≥4 mm).When conservative treatment with and without probiotics supplementation failed to resolve the lesion,invasive methods were used,intralesional steroid injection in medium size chalazion and surgical incision and curettage for the largest ones.RESULTS:Medical treatment with or without probiotics supplementation was effective only on the small size chalazia.There was a significant difference in the time taken for complete resolution of small size chalazia between the two groups in favor of the patients receiving probiotics(38.50±9.04 d vs 21.00±7.00 d,P=0.039).Medium and large size chalazia did not respond to medical treatment with or without probiotics supplementation over the follow-up period(3 mo).The treatment did not induce any complications in both groups and no recurrence of chalaziosis was recorded in both groups.CONCLUSION:The considerable difference in time taken for complete resolution of small chalazia between the two groups in favor of the experimental one confirms the presence of a gut-eye axis.展开更多
文摘AIM:To define the possible beneficial impact of probiotics oral supplementation on patients affected by chalazion.METHODS:Prospective comparative pilot study on 20 adults suffering from chalazion randomly divided into two groups.The first group(n=10)received conservative treatment with lid hygiene,warm compression,and dexamethasone/tobramycin ointment for at least 20 d.The second group(n=10),in addition to the conservative treatment,received a mixture of probiotic microorganisms of Streptococcus thermophilus ST10(DSM 25246),Lactococcus lactis LLC02(DSM 29536)and Lactobacillus delbrueckii(DSM 16606)once a day up to 3 mo.Chalazia were classified according to their size into three groups:small(<2 mm),medium(≥2 to<4 mm),or large(≥4 mm).When conservative treatment with and without probiotics supplementation failed to resolve the lesion,invasive methods were used,intralesional steroid injection in medium size chalazion and surgical incision and curettage for the largest ones.RESULTS:Medical treatment with or without probiotics supplementation was effective only on the small size chalazia.There was a significant difference in the time taken for complete resolution of small size chalazia between the two groups in favor of the patients receiving probiotics(38.50±9.04 d vs 21.00±7.00 d,P=0.039).Medium and large size chalazia did not respond to medical treatment with or without probiotics supplementation over the follow-up period(3 mo).The treatment did not induce any complications in both groups and no recurrence of chalaziosis was recorded in both groups.CONCLUSION:The considerable difference in time taken for complete resolution of small chalazia between the two groups in favor of the experimental one confirms the presence of a gut-eye axis.
