Effects of PM2.5 Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang, China

Asthma is a common chronic inflammatory disorder that is more prevalent in children than in adults.China has seen an increasing prevalence of childhood asthma in recentdecades[1].Earlier studies have shown that air particulate matter (PM),particularly fine particulate matter(PM2.5)[2],is an important factor triggering childhood asthma. Since nationalPM2.5data were nota vailabl euntil 2013,

Efficacy of Singing Bowls in Childhood Asthma—A Pilot and Feasibility Study

The potential use of sound and vibration for diagnostic and therapeutic purposes remains largely under-explored and under-estimated.Sound and vibrational energy has great positive impact on the mind and body.It could be particularly useful for psychosomatic diseases as a complementary therapy.Singing bowls,the spiritual ancient therapy has been claimed to aid in mind relaxation and painful and inflammatory conditions.Childhood asthma is an inflammatory airway disease and a psychosomatic disorder.The psychological management in it is often neglected leading to under-treatment or a relapse.Hence,we hypothesized that sound therapy with singing bowls might be useful as complementary therapy in management of childhood asthma.We aimed to study the effect of singing bowl session on child’s asthma severity and control and on the psychological well-being.Children<18 years of age and suffering from childhood asthma were recruited after informed written consent of parents.At the baseline,demographic and clinical details were noted.Anthropometric parameters,PEFR readings,asthma severity,parental and child’s subjective feeling of well-being,asthma control score,and pediatric symptom checklist score(based on age)were determined.The child was given 15 min of singing bowl session as per the set protocol.The subjective and objective evaluation of asthma control and psychological assessment was repeated at 1 month and 3 months follow-up and compared with the baseline results for clinical significance.Eighteen children formed the study group with a mean age of 9.13±2.15 years(range 2–15.25 years).4 children had psychological issues on initial screening.There was a significant improvement in asthma severity,subjective feeling of well-being and asthma control score at 3 months(p<0.05).Singing bowl therapy could be a useful,low-cost complementary therapy in childhood asthmatics.

The Pattern of Comorbidities of Childhood Asthma as Seen in the Rivers State University Teaching Hospital, Nigeria

Background: Asthma exits with comorbidities which can affect the quality of life of children with asthma. Objective: To identify the common comorbidities with asthma, identify factors associated with the presence of specific comorbidities and evaluate their impact on asthma severity and control among children attending the respiratory clinic in the Rivers State University Teaching Hospital. Materials & Methods: All asthma cases seen in the paediatric respiratory clinic, from 1st November 2014 to 30th October 2019 were consecutively recruited. Results: Of 264 children with asthma, 190 (72.0%) had other comorbidities with a F:M ratio of 1.56:1. Difficulty in breathing, chest pain, and the degree of asthma control were significantly associated with having other comorbidities while SPO2 at 1st consult was significantly lower in children with comorbidities, P value < 0.05. Allergic rhinitis 116 (43.9%), adenotonsillar hypertrophy 99 (37.5%), atopic dermatitis 54 (20.5%), allergic conjunctivitis 37 (14%), food allergy 27 (10.2) and Gastroesophageal reflux14 (5.3%) were the commonest comorbidities identified. Majority (24, 88.9%) had allergy to one type of food. Children < 3 years and those whose age at diagnosis was <2 years were significantly at lower risk of having atopic dermatitis. Gastroesophageal reflux disease was significantly more likely to be seen in children aged > 11 years, overweight children, and those presenting with chest pain or chest tightness. Presence of various comorbidities increased the odds of having a more severe asthma, and likelihood of which increased with increasing number of coexisting comorbidities. Conclusion: The prevalence of allergic comorbidity is high among asthmatic children with allergic rhinitis being the commonest cause. Most children with asthma have more than one allergic comorbidity. A comprehensive evaluation of these comorbidities is thus essential in the management of asthmatic children for improved outcomes and quality of life.

Easy Breathing—Definition of a Gamification System to Support the Chronic Care of Childhood Asthma

Asthma is the most common noncommunicable disease among children. It leads to substantial problems both in health and economic terms to individuals and families. This paper introduces a technological solution, Easy Breathing, that supports the man-agement of childhood asthma, providing tools for both doctors and patients. Through the establishment of an asthma chronic care model, it combines doctors’ professional guidance and a gamification system to improve the compliance of patients with their treatments and to provide them with tools for the self-management of their disease. The system is in the testing phase, the first mockup has been developed and validated with 270 medical experts and patients, and it will be tested with 540 end-users over the next months.

Association of Polymorphisms of STAT6 and SO_2 with Chinese Childhood Asthma: a Case-control Study

Objective To investigate the association of polymorphisms of STAT6 gene and air pollutants of PM10, NO2, and SO2, with asthma in Chinese children. Methods 418 subjects aged 14 years and under were recruited in a case-control study. The association between STAT6 polymorphisms and childhood asthma were tested by allele frequency, genotype analysis, and MDR analysis. Exposure to outdoor air pollutants was estimated by a 5-day moving average level. Statistical analyses were performed with SAS 9.1 software. Results Only 3 alleles of GT repeats at exon 1 of STAT6 were found in Chinese children. C258T and T710C were 2 new SNPs of STAT6 at 3＇-UTR. Children who carried T allele of C258T were more common in asthma children than in control subjects （P〈0.05）. The MDR analysis showed that GT repeats, C258T and T710C of STAT6 polymorphisms interacted together in leading to susceptibility to childhood asthma among Chinese people. After confounding factors were controlled, such as SNP C258T, family history of asthma, frequency of influenza within a year, the 5-day average of SO2 was tested to be a key risk factor of asthma in Chinese children （P〈0.05）. Conclusion Chinese children differed in polymorphisms of STAT6 and in its relation with childhood asthma.

Integrating multi-omics data of childhood asthma using a deep association model

Childhood asthma is one of the most common respiratory diseases with rising mortality and morbidity.The multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding diagnostic models of childhood asthma.To capture the nonlinear association of multi-omics data and improve interpretability of diagnostic model,we proposed a novel deep association model(DAM)and corresponding efficient analysis framework.First,the Deep Subspace Reconstruction was used to fuse the omics data and diagnostic information,thereby correcting the distribution of the original omics data and reducing the influence of unnecessary data noises.Second,the Joint Deep Semi-Negative Matrix Factorization was applied to identify different latent sample patterns and extract biomarkers from different omics data levels.Third,our newly proposed Deep Orthogonal Canonical Correlation Analysis can rank features in the collaborative module,which are able to construct the diagnostic model considering nonlinear correlation between different omics data levels.Using DAM,we deeply analyzed the transcriptome and methylation data of childhood asthma.The effectiveness of DAM is verified from the perspectives of algorithm performance and biological significance on the independent test dataset,by ablation experiment and comparison with many baseline methods from clinical and biological studies.The DAM-induced diagnostic model can achieve a prediction AUC of o.912,which is higher than that of many other alternative methods.Meanwhile,relevant pathways and biomarkers of childhood asthma are also recognized to be collectively altered on the gene expression and methylation levels.As an interpretable machine learning approach,DAM simultaneously considers the non-linear associations among samples and those among biological features,which should help explore interpretative biomarker candidates and efficient diagnostic models from multi-omics data analysis for human complexdiseases.

Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the disease.We have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)children.Eight PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,respectively.Moreover,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as control.Thirty-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and TNBP.These results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

Research on the intelligent internet nursing model based on the child respiratory and asthma control test scale for asthma management of preschool children

BACKGROUND Childhood asthma is a common respiratory ailment that significantly affects preschool children.Effective asthma management in this population is particularly challenging due to limited communication skills in children and the necessity for consistent involvement of a caregiver.With the rise of digital healthcare and the need for innovative interventions,Internet-based models can potentially offer relatively more efficient and patient-tailored care,especially in children.AIM To explore the impact of an intelligent Internet care model based on the child respiratory and asthma control test(TRACK)on asthma management in preschool children.METHODS The study group comprised preschoolers,aged 5 years or younger,that visited the hospital's pediatric outpatient and emergency departments between January 2021 and January 2022.Total of 200 children were evenly and randomly divided into the observation and control groups.The control group received standard treatment in accordance with the 2016 Guidelines for Pediatric Bronchial Asthma and the Global Initiative on Asthma.In addition to above treatment,the observation group was introduced to an intelligent internet nursing model,emphasizing the TRACK scale.Key measures monitored over a six-month period included the frequency of asthma attack,emergency visits,pulmonary function parameters(FEV1,FEV1/FVC,and PEF),monthly TRACK scores,and the SF-12 quality of life assessment.Post-intervention asthma control rates were assessed at six-month follow-up.RESULTS The observation group had fewer asthma attacks and emergency room visits than the control group(P<0.05).After six months of treatment,the children in both groups had higher FEV1,FEV1/FVC,and PEF(P<0.05).Statistically significant differences were observed between the two groups(P<0.05).For six months,children in the observation group had a higher monthly TRACK score than those in the control group(P<0.05).The PCS and MCSSF-12 quality of life scores were relatively higher than those before the nursing period(P<0.05).Furthermore,the groups showed statistically significant differences(P<0.05).The asthma control rate was higher in the observation group than in the control group(P<0.05).CONCLUSION TRACK based Intelligent Internet nursing model may reduce asthma attacks and emergency visits in asthmatic children,improve lung function,quality of life,and the TRACK score and asthma control rate.The effect of nursing was significant,allowing for development of an asthma management model.

Correlation between the Childhood-Asthma Control Test and the Criterion for Clinical Asthma Control

Setting: Three pediatric pneumatologist offices in Bucaramanga, Colombia. Objective: To establish the concordance between medical criteria and the Childhood-Asthma Control Test (cACT). Design: Study of the assessment of diagnostic technology using transverse sampling. 127 asthma patients aged between 4 and 11 years and their parents filled before clinical evaluation made by a pediatric pneumologist. Patients were classified as controlled or not controlled. Criteria validity was established comparing this classification using Cohen’s kappa and performance indicators according to ROC analysis. Results: 78% of the patients were controlled;patients who are not controlled have a higher score in cACT (mean difference: 3.25 points). Concordance among cACT subscales is acceptable (ρ = 0.554). cACT’s sensitivity was 53.6%, specificity 78.8%, positive likelihood ratio (LR+) 2.53, and negative likelihood ratio (LR-) 0.59. The best cut-off point is 15, with 98% sensitivity, a specificity of 14.3%, LR+ in 1.14, and LR- in 0.14. Conclusions: cACT is a valid tool to determine asthma control in children without replacing medical criteria or other clinical tests. In populations with difficult access to high complexity services, it is useful to decide whether urgent referral to the specialist is necessary.

应用ECHO模型评价药物治疗管理服务在儿童支气管哮喘治疗中的效果

目的探究药物治疗管理(MTM)服务对儿童哮喘治疗的应用效果。方法选取2022年7—12月在河北省人民医院咳喘药学门诊就诊的5~11岁哮喘患儿107例,随机分成对照组(50例)和干预组(52例)。对照组患儿首诊时给予单次吸入制剂教育服务;干预组患儿给予全程规范化MTM服务。应用经济、临床与人文结果(ECHO)模型,分别于干预前、干预3个月及干预6个月后,统计2组患儿在经济(药物成本、成本-效用比),临床(ACT评分、吸入制剂使用正确率、哮喘发作次数)和人文(EQ-5D-5L效用值、Morisky用药依从性、患者满意度)结果中的差异,评价MTM服务在哮喘患儿中的应用效果。结果干预前2组各项评分指标差异无统计学意义;干预后干预组患儿经济结果、临床结果、人文结果3方面均优于对照组,差异有统计学意义(P<0.05)。结论药师主导的MTM服务可使哮喘患儿在经济、临床、人文多维度获益,既使哮喘患儿疾病得到长期有效控制,又提升药师药学专科服务能力。

TRACK与C-ACT评分在儿童哮喘管理中的价值评估

目的:通过研究儿童呼吸和哮喘控制测试(test for respiratory and asthma control in kids,TRACK)和儿童哮喘控制测试(childhood asthma control test,C-ACT)与全球哮喘防治创议(global initiative for asthma,GINA)标准哮喘控制水平评估的一致性、与哮喘儿童肺功能指标的相关性,探讨2种评分方法在儿童哮喘管理中的价值。方法:选择2020年8月至2022年3月重庆市妇幼保健院儿科门诊就诊的哮喘患儿135例为研究对象,用TRACK评分表和C-ACT评分表对相应年龄的患儿及其家长进行问卷调查,分析2种评分方法与GINA标准哮喘控制水平评估分级的一致性、与肺功能指标的相关性,并比较不同评分结果组肺功能指标差异。结果:TRACK评分、C-ACT评分与GINA哮喘控制水平分级一致性检验Kappa值分别为0.517和0.531,均显示一致性一般;TRACK评分与TPF%TE和VPF%VE存在显著的正相关,但TRACK评分、C-ACT评分与FEV1%均没有显著性相关;不同TRACK评分组哮喘患儿的FEV1%差异无统计学意义(F=2.054,P=0.134),但多重比较发现≥80分组与<60分组FEV1%的差异有统计学意义(P=0.048);不同TRACK评分组哮喘患儿的TPTEF/TE(%)(F=3.171,P=0.044)和VPEF/VE(%)(F=3.919,P=0.022)差异有统计学意义,进一步多重比较发现其差异主要来自于≥80分组与60~80分组,其中VPEF/VE(%)(P=0.017)的组间差异较TPTEF/TE(%)(P=0.030)更为明显;比较不同C-ACT评分组哮喘患儿的FEV1%差异无统计学意义(F=1.756,P=0.182)。结论:TRACK评分能更好反映儿童肺功能的差异,可作为5岁以下儿童哮喘管理的一个有效评估工具。

应用大语言模型解答儿童哮喘问题的效果研究

目的评估大语言模型解答儿童哮喘问题的表现,全面了解其提供儿童健康相关信息的质量,并识别其局限以促进模型的改进。方法制订出60个儿童哮喘相关的常见问题,分别向2种在国内向公众开放使用的文心一言、智谱清言大语言模型提问。由3名儿科哮喘专业医师采用盲法评估大语言模型的回答质量。结果在准确性、理解力、可靠性和逻辑性维度方面,文心一言得分较高;在安全性维度方面,智谱清言的得分较高。对比5个不同的维度的得分发现,大语言模型在理解力、可靠性、逻辑性方面得分较高,而在准确性与安全性方面相对不足。结论大语言模型在儿童哮喘患者教育中的应用能够为儿童哮喘患者及其家长提供有益的参考。然而,当前大语言模型技术在准确性、安全性等方面仍存在一定的局限性,需要进一步改进和优化。

基于两样本孟德尔随机化分析妊娠期糖尿病与子代儿童期哮喘风险的因果关系

背景在传统流行病学队列研究中,母体在妊娠期间发生的高血糖可能会影响胎儿的免疫系统和肺部发育,导致儿童更容易发生哮喘。然而,这一研究结果可能受到混杂因素的影响,有必要进一步探讨GDM与儿童哮喘之间的因果关联。目的 采用两样本孟德尔随机化(TSMR)的方法来探究GDM与子代儿童期哮喘之间的因果关联,为临床防治提供建议。设计病例对照研究。方法 通过全基因关联研究(GWAS)汇总数据库中选择一项年份最近、样本量最大的GDM和子代儿童期哮喘密切相关的遗传位点,以单核苷酸多态性(SNPs)作为工具变量,GDM作为暴露因素,儿童期哮喘为结局变量,分析GDM与子代儿童期哮喘的因果关系。在工具变量的筛选上设置P值(P<5.0×10~(-7)),为避免连锁不平衡(LD)偏倚,与GDM相关的显著SNP的LD须满足条件:r~2<0.001和遗传距离为10 000 kb,剔除统计量F<10的SNP。使用最常用及较公认的逆方差加权法(IVW)的同时,也参考使用加权中位数法、MR-Egger回归法进行TSMR分析推断因果关系。并采用MR-Egger回归、Cochran Q检验和逐个剔除检验“留一法”行敏感性分析。统计分析采用R 4.3.1软件包TwoSampleMR进行,检验水准α取0.05。主要结局指标GDM与子代儿童期哮喘关联性。结果 在GWAS汇总数据库的芬兰人种数据集的GDM数据集中,病例组6 033例,对照组110 330例,SNPs总计16 379 684个;哮喘数据集,病例组3 025例,对照组135 449例,SNPs总计16 379 865个。根据研究工具变量的筛选标准进行筛选,最终确定10个SNPs作为工具变量,所有的SNP位点对应的F统计量均>10。IVW结果表明GDM和子代儿童期哮喘风险增加存在因果关系(OR=1.15,95%CI:1.01~1.32,P=0.039),Cochran Q检验表明纳入的SNPs不存在异质性(P均>0.05);MR-Egger回归分析,截距项为-0.013(P=0.68),差异无统计学意义,表明基因多效性影响的可能性较小;“留一法”对因果效应进行敏感性分析,逐步剔除各SNP后,未发现工具变量中具有对结果有强影响性的SNP位点,这表明因果关系具有一定的稳定性;漏斗图发现以单个SNP作为工具变量时,GDM与子代儿童期哮喘的因果效应基本呈对称分布。结论 GDM与子代儿童期哮喘之间存在正向因果关联。

抗免疫球蛋白E药物在儿童哮喘中的合理应用

儿童哮喘作为一种常见的慢性呼吸道疾病,对患儿的生活质量及家庭负担造成了严重影响。近年来,抗免疫球蛋白E(IgE)药物作为治疗儿童哮喘的新型生物制剂,其疗效和安全性得到了广泛关注。本文综述了抗IgE药物在儿童哮喘治疗中的研究进展,包括作用机制、药物特性、临床应用及与其他治疗药物的联合应用等,旨在探讨抗IgE药物在儿童哮喘中的合理应用策略及治疗展望,以期为临床实践提供参考。

基于《证治汇补·哮病》探析儿童哮喘防治思路

儿童哮喘是儿科常见疾病之一,明末清初医家李用粹所著《证治汇补·哮病》总结前人医家的观点,指出“非时之感”为本病的外在诱因,“胶固之痰”为内在根本,“壅塞之气”则是病机所在。儿童哮喘急性发作期以肺气壅塞为主,治疗应当以宣肺理气为主,兼顾疏风散邪和化痰祛饮;缓解期的治疗则当以祛除“伏痰”为主要目标,化痰祛饮和补虚扶正双管齐下,其中补虚尤当注重补脾胃,且补脾胃当重健运而非进补之法;而对“非时之感”的防范和治疗则应当贯彻疾病的全过程,尤其在缓解期和迁延期,需意识到其仍有未尽之风痰,邪不去则正难复,此外也要将患儿精神心理因素纳入防治的范畴;愈后当防复发,日常饮食生活调摄当尤为重视,家长应积极引导患儿养成健康的生活习惯。

基于孟德尔随机化探讨炎症因子与儿童哮喘的因果关联

目的:通过孟德尔随机化(MR)方法来探究炎症因子与儿童哮喘之间的因果关系。方法:将从3个芬兰队列(n=8 293)研究中测量到的41种炎性细胞因子的循环水平用作暴露因素,筛选出与暴露因素强相关且相互独立的单核苷酸多态性作为有效工具变量。从GWAS数据库中获取包含3 025名儿童哮喘患者和135 449名对照个体的数据集(finn-b-ASTHMA_CHILD)以用作研究的结局变量。通过“TwoSampleMR”R软件包进行两样本MR分析,以风险值(OR)来评估炎症因子与儿童哮喘之间的因果关联。通过留一法对所得结果进行敏感性分析,利用MR-Egger intercept和MR-PRESSO global test来检验水平多效性,Cochran’s Q检测异质性。结果:IVW方法分析所得结果表明IL-2 (OR=0.835,95%CI:0.717~0.973,P=0.021)与儿童哮喘存在显著负相关。利用留一法进行敏感性分析发现因果关系的结果表现稳定,MR-Egger intercept和MR-PRESSO global test检验无水平多效性,Cochran’s Q检验不存在异质性。结论:炎症因子IL-2和儿童哮喘之间存在因果关系,IL-2可降低儿童哮喘的发病风险。

基于中医传承辅助平台分析王孟清教授治疗儿童哮喘缓解期用药规律

目的:采用中医传承辅助平台分析了王孟清教授治疗儿童哮喘缓解期处方,归纳总结了王孟清教授治疗儿童哮喘缓解期用药规律,以期为临床提供参考。方法:收集2022年6月-2023年6月王孟清教授于湖南中医药大学第一附属医院儿科门诊诊疗的哮喘缓解期有效病历。采用中医传承辅助平台统计分析药物的使用频次、常用药物组合、性味、核心药物组合及新处方。结果:共纳入处方149首,涉及中药97味,前10位的依次为白术、茯苓、山药、太子参、黄芪、黄芩、防风、麦冬、甘草、鸡内金、五味子,有22味使用频次大于30的药物;药性使用频率最高的为温,其次为平、寒;药味使用频率最高的为甘,其次为苦、辛;药物归经前4位为肺经、脾经、胃经、肾经。常用药物组合40对,其中包含麦冬、太子参、白术、山药、茯苓、黄芪、黄芩、防风8味中药,出现频次最高的是黄芪、白术。得到3首新处方:(1)黄精、法半夏、甘草、陈皮、熟地黄;(2)法半夏、当归、甘草、陈皮、熟地黄;(3)茯苓、生地黄、太子参、麻黄根、浮小麦。结论:王教授治疗儿童哮喘缓解期组方符合肺、脾、肾同治,全面兼顾,扶正固本的原则。

儿童哮喘健康交流平台的设计与实现

为了能对儿童哮喘进行有效、方便的健康管理,建立一个高质量的健康交流平台来管理哮喘儿童的健康是十分必要的。本文设计了一个哮喘儿童健康管理服务的健康沟通平台,通过对患者所在区域的致敏因素监测、患者呼吸状态采集和医疗资源对接进行建设和规划,帮助哮喘儿童预防和治疗哮喘。测试的结果表明,该系统基本达到了设计功能的要求。

LncRNA TINCR和FGF-1与儿童肥胖型支气管哮喘的相关性研究

目的探讨终末分化诱导的长链非编码RNA(lncRNA TINCR)和成纤维细胞生长因子-1(FGF-1)与肥胖型支气管哮喘患儿病情严重程度及肺功能的关系。方法采用随机抽样法选取我院2021年12月—2023年1月收治的120例支气管哮喘患儿为研究对象,其中肥胖型支气管哮喘患儿60例,非肥胖型支气管哮喘患儿60例;另选取同期于我院进行健康体检的健康儿童120例作为对照组研究对象。又根据肥胖型哮喘患儿的病情严重程度分为轻度组(29例)、中度组(24例)、重度组(7例)。检测所有研究对象的LncRNA TINCR和FGF-1 RNA相对表达水平、嗜酸性粒细胞百分比、第一秒用力呼气容积(FEV1)、最大呼气中段流量(MMEF)等,并分组进行比较分析。结果与非肥胖型支气管哮喘组和对照组相比,肥胖型支气管哮喘组患儿的LncRNA TINCR和FGF-1 RNA相对表达值明显升高(P<0.05);同时,非肥胖型支气管哮喘组患儿的LncRNA TINCR和FGF-1 RNA相对表达值也高于对照组(P<0.05)。肥胖型支气管哮喘组患儿的FEV1%和MMEF显著低于其他2组(P<0.05);另外,非肥胖型支气管哮喘组患儿的FEV1%和MMEF也低于对照组(P<0.05)。在肥胖型支气管哮喘患儿中,重度组的LncRNA TINCR与FGF-1 RNA相对表达水平高于轻度组及中度组(P<0.05)。重度组和中度组的肥胖型支气管哮喘患儿的FEV1%和MMEF都显著低于轻度组(P<0.05)。肥胖型支气管哮喘患儿的LncRNA TINCR、FGF-1与病情严重程度呈正相关(P<0.05),与FEV1%和MMEF呈负相关(P<0.05)。另外,LncRNA TINCR与嗜酸性粒细胞百分比呈正相关(P<0.05)。结论肥胖型支气管哮喘患儿的LncRNA TINCR和FGF-1水平较高,且与病情严重程度及肺功能密切相关。

孟鲁司特钠联合布地奈德治疗儿童哮喘的临床效果

目的探讨孟鲁司特钠联合布地奈德治疗儿童哮喘的临床效果。方法选取2022年5月至2023年5月眉县人民医院收治的60例哮喘患儿作为研究对象,按照随机数字表法分为对照组(30例)与观察组(30例)。对照组采用布地奈德治疗,观察组采用孟鲁司特钠联合布地奈德治疗,比较两组肺功能、临床症状消失时间和临床疗效。结果治疗后,观察组用力肺活量、第1秒用力呼气容积水平高于对照组(P<0.05);观察组咳嗽、憋喘消失时间短于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05)。结论孟鲁司特钠联合布地奈德治疗儿童哮喘可提高治疗效果,降低不良反应发生率,值得在临床实践中应用。