Abstract Production planning under uncertainty is considered as one of the most important problems in plant-wide optimization. In this article, first, a stochastic programming model with uniform distribution assumptio...Abstract Production planning under uncertainty is considered as one of the most important problems in plant-wide optimization. In this article, first, a stochastic programming model with uniform distribution assumption is developed for refinery production planning under demand uncertainty, and then a hybrid programming model incorporating the linear programming model with the stochastic programming one by a weight factor is proposed. Subsequently, piecewise linear approximation functions are derived and applied to solve the hybrid programming model-under uniform distribution assumption. Case studies show that the linear approximation algorithm is effective to solve.the hybrid programming model, along with an error≤0.5% when the deviatiorgmean≤20%. The simulation results indicate that the hybrid programming model with an appropriate weight factor (0.1-0.2) can effectively improve the optimal operational strategies under demand uncertainty, achieving higher profit than the linear programming model and the stochastic programming one with about 1.3% and 0.4% enhancement, respectavely.展开更多
This paper intends to complete the primary logistics planning of oil products under the imbalance of supply and demand. An integrated mathematical programming model is developed to simultaneously find the balance betw...This paper intends to complete the primary logistics planning of oil products under the imbalance of supply and demand. An integrated mathematical programming model is developed to simultaneously find the balance between supply and demand, and optimize the logistics scheme. The model takes minimum logistics cost and resource adjustment cost as the objective function, and takes supply and demand capacity, transportation capacity, mass balance, and resource adjustment rules as constraints.Three adjustment rules are considered in the model, including resource adjustment within oil suppliers,within oil consumers, and between oil consumers. The model is tested on a large-scale primary logistics of a state-owned petroleum enterprise, involving 37 affiliated refineries, 31 procurement departments,286 market depots and dedicated consumers. After the unified optimization, the supply and demand imbalance is eased by 97% and the total cost is saved by 7%, which proves the effectiveness and applicability of the proposed model.展开更多
A quadratic programming model is established to choose the blocks to be blasted in a given period. The length of this period depends on the production planning requirements. During the given period, the blocks' pa...A quadratic programming model is established to choose the blocks to be blasted in a given period. The length of this period depends on the production planning requirements. During the given period, the blocks' parameters are available from the geological database of the mine. The objective is to minimize the deviation of the average ore grade of blasted blocks from the standard ore grade required by the mill. Transportation ability constraint. production quantity demand constraint. minimum safety bench constraint. block size constraint and block, bench precedence constraints are considered in forming the programming model. This model has more practical objective function and reasonable constraints compared with the existing model for this kind of problems.展开更多
Iron and steel industry is an important sector of Iran's economy.Choghart iron ore mine is an important iron ore producer of Iran steel industry.Phosphorous contained in the iron ore concentrates of Choghart mine ...Iron and steel industry is an important sector of Iran's economy.Choghart iron ore mine is an important iron ore producer of Iran steel industry.Phosphorous contained in the iron ore concentrates of Choghart mine has a detrimental effect on the steel making process,whereby this causes cracks to form in the refractory lining of blast furnaces.In the past,about 1.43 Mt of low-grade and 4.53 Mt of high-phosphorous materials had been transported to low grade and high phosphorous stockpiles,respectively,for future beneficiation.As a result of the progressive depletion of high-grade ore and establishment of beneficiation plant in Choghart,exploitation of these two stockpiles in this mine became an important issue.In this work,a linear goal programming(GP) model was developed in order to determine the optimum iron ore blend in terms of quality from low grade and high phosphorous stockpiles of Choghart mine.The model was solved by the SOLVER V.9 program.Results show that feeding with acceptable quality(w(Fe)≥50% and w(P)≤1.2%,mass fraction) materials can be blended from stockpiles that satisfy the needs of the Choghart processing line.展开更多
At the first sight it seems that advanced operation research is not used enough in continuous production systems as comparison with mass production, batch production and job shop systems, but really in a comprehensive...At the first sight it seems that advanced operation research is not used enough in continuous production systems as comparison with mass production, batch production and job shop systems, but really in a comprehensive evaluation the advanced operation research techniques can be used in continuous production systems in developing countries very widely, because of initial inadequate plant layout, stage by stage development of production lines, the purchase of second hand machineries from various countries, plurality of customers. A case of production system planning is proposed for a chemical company in which the above mentioned conditions are almost presented. The goals and constraints in this issue are as follows: (1) Minimizing deviation of customer's requirements. (2) Maximizing the profit. (3) Minimizing the frequencies of changes in formula production. (4) Minimizing the inventory of final products. (5) Balancing the production sections with regard to rate in production. (6) Limitation in inventory of raw material. The present situation is in such a way that various techniques such as goal programming, linear programming and dynamic programming can be used. But dynamic production programming issues are divided into two categories, at first one with limitation in production capacity and another with unlimited production capacity. For the first category, a systematic and acceptable solution has not been presented yet. Therefore an innovative method is used to convert the dynamic situation to a zero- one model. At last this issue is changed to a goal programming model with non-linear limitations with the use of GRG algorithm and that's how it is solved.展开更多
In recent years,large numbers of novel cell death types have been reported such as autophagic death,paraptosis,mitosis,oncosis and pyroptosis.As a new type of proinflammatory programmed cell death,pyroptosis has attra...In recent years,large numbers of novel cell death types have been reported such as autophagic death,paraptosis,mitosis,oncosis and pyroptosis.As a new type of proinflammatory programmed cell death,pyroptosis has attracted increasing attentions gradually,and its morphological characteristics and molecular mechanisms are significantly different from other cell death types such as necrosis and apoptosis.Many research groups have demonstrated the association between pyroptosis and various human diseases including immunological disease,cancer,atherosclerosis,infectious disease,and cardiovascular and cerebrovascular disease.Natural products are small molecules synthetized in organisms including primary and secondary metabolites.Natural products are important sources of modern innovative drugs discovery and can be used as key tools to explore the molecular mechanism of cell fate.The aim of this study is to review the molecular mechanisms and pathways of pyroptosis,and to categorize and conclude research results on the correlation between different natural products and pyroptosis in recent years.In this study,a total of 39 papers were enrolled in analyses.The molecular pathways and mechanisms of pyroptosis were clearly described.Fourteen types of natural products,their sources,effects,mechanisms and therapeutic potentials are categorized and illuminated.It is showed that a variety of natural products and pyroptosis have close correlations.They negatively or positively affect or act on different positions of pyroptosis inflammatory pathways,indicating that they may have certain potential therapeutic effects on pyroptosis-related diseases.Pyroptosis,a relatively new way of cell death,is closely associated with a variety of diseases.Natural products can have obvious effects on the process of pyroptosis as potential sources of new drugs.In-depth studies using natural products to investigate pyroptosis will help to enhance our understandings of human diseases and establish effective prevention and treatment strategies.展开更多
Stochastic demand is an important factor that heavily affects production planning.It influences activities such as purchasing,manufacturing,and selling,and quick adaption is required.In production planning,for reasons...Stochastic demand is an important factor that heavily affects production planning.It influences activities such as purchasing,manufacturing,and selling,and quick adaption is required.In production planning,for reasons such as reducing costs and obtaining supplier discounts,many decisions must be made in the initial stage when demand has not been realized.The effects of non-optimal decisions will propagate to later stages,which can lead to losses due to overstocks or out-of-stocks.To find the optimal solutions for the initial and later stage regarding demand realization,this study proposes a stochastic two-stage linear program-ming model for a multi-supplier,multi-material,and multi-product purchasing and production planning process.The objective function is the expected total cost after two stages,and the results include detailed plans for purchasing and production in each demand scenario.Small-scale problems are solved through a deterministic equivalent transformation technique.To solve the problems in the large scale,an algorithm combining metaheuristic and sample average approximation is suggested.This algorithm can be implemented in parallel to utilize the power of the solver.The algorithm based on the observation that if the remaining quantity of materials and number of units of products at the end of the initial stage are given,then the problems of the first and second stages can be decomposed.展开更多
The purpose of this paper was to examine the role of quantitative analysis in production planning decisions. This draws from the observed imperatives of quantitative analysis in business decisions and its capacity for...The purpose of this paper was to examine the role of quantitative analysis in production planning decisions. This draws from the observed imperatives of quantitative analysis in business decisions and its capacity for predictability and enhanced decision making given the increasingly complex nature of the business environment. The paper therefore addressed the historical evolution of quantitative technique as an efficient and effective decision-making tool. The content of the paper addressed commonly applied quantitative technique in manufacturing firms today which is, linear programming and its subsequent impact on production planning decisions. The results based on a congruence of views revealed that the “best-fit” application of quantitative analysis models and tools can untangle the complexities of production and planning decision making process in order to achieve the organizational goal. This is, as literature also showed that there is obviously no consensus or integrated model that is capable of solving all managerial problem, different models such as the linear programming model have however been developed to cater for different problems as they arise. The workability or suitability of quantitative analysis is actually premised on its appropriate application. The paper recommends the application of quantitative analysis using linear programming in solving various resource allocation related issues in the primary production planning function of manufacturing firms.展开更多
This paper proposes an inner product Laplacian embedding algorithm based on semi-definite programming, named as IPLE algorithm. The new algorithm learns a geodesic distance-based kernel matrix by using semi-definite p...This paper proposes an inner product Laplacian embedding algorithm based on semi-definite programming, named as IPLE algorithm. The new algorithm learns a geodesic distance-based kernel matrix by using semi-definite programming under the constraints of local contraction. The criterion function is to make the neighborhood points on manifold as close as possible while the geodesic distances between those distant points are preserved. The IPLE algorithm sufficiently integrates the advantages of LE, ISOMAP and MVU algorithms. The comparison experiments on two image datasets from COIL-20 images and USPS handwritten digit images are performed by applying LE, ISOMAP, MVU and the proposed IPLE. Experimental results show that the intrinsic low-dimensional coordinates obtained by our algorithm preserve more information according to the fraction of the dominant eigenvalues and can obtain the better comprehensive performance in clustering and manifold structure.展开更多
One of the most important responsibilities of a supply chain manager is to decide “how much” (or “many”) of inventory items to order and how to transport them. This paper presents four mixed-integer linear program...One of the most important responsibilities of a supply chain manager is to decide “how much” (or “many”) of inventory items to order and how to transport them. This paper presents four mixed-integer linear programming models to help supply chain managers make these decisions for multiple products subject to multiple constraints when suppliers offer quantity discounts and shippers offer freight discounts. Each model deals with one of the possible combinations of all-units, incremental quantity discounts, all-weight and incremental freight discounts. The models are based on a piecewise linear approximation of the number of orders function. They allow any number of linear constraints and determine if independent or common (fixed) cycle ordering has a lower total cost. Results of computational experiments on an example problem are also presented.展开更多
In this study, Simplex Method, a Linear Programming technique was used to create a mathematical model that optimized the financial portfolio of Golden Guinea Breweries Plc, Nigeria. This work was motivated by the obse...In this study, Simplex Method, a Linear Programming technique was used to create a mathematical model that optimized the financial portfolio of Golden Guinea Breweries Plc, Nigeria. This work was motivated by the observed and anticipated miscalculations which Golden Guinea Breweries was bound to face if appropriate linear programming techniques were not applied in determining the profit level. This study therefore aims at using Simplex Method to create a Mathematical Model that will optimize the production of brewed drinks for Golden Guinea Breweries Plc. The first methodology involved the collection of sample data from the company, analyzed and the relevant coefficients were deployed for the coding of the model. Secondly, the indices collected from the first method were deployed in the software model called PHP simplex, an online software for solving Linear Programming Problem to access the profitability of the organization. The study showed that Linear Programming Model would give a high profit coefficient of N9,190,862,833 when compared with the result obtained from the manual computation which gave a profit coefficient of N7,172,093,375. Also, Bergedoff Lager, Eagle Stout and Bergedoff Malta were found not to contribute to overall profitability of the company and it was therefore recommended that their productions should be discontinued. It also recommends that various quantities of Golden Guinea Lager (1 × 12) and Golden Guinea Lager (1 × 24) should be produced.展开更多
Most products have the potential to negatively impact the environment during all life-cycle stages.However,most environmental impact assessment methods focus on a single product life-cycle and on a specific life-cycle ...Most products have the potential to negatively impact the environment during all life-cycle stages.However,most environmental impact assessment methods focus on a single product life-cycle and on a specific life-cycle stage.Product design plays a significant role by determining traditional environmental impacts,such as embodied energy of materials,but also by influencing market adoption and production volumes.The main objective of this work is to develop a design optimization framework that estimates the environmental impact of design decisions(e.g.materials choice,etc.)across all life-cycle stages in consumer products.The methodology relies on quality function deployment(QFD),multi-attribute utility theory,non-linear mathematical programming,and life-cycle assess-ment tools to estimate the utility of the design options to the customer,the producer,and the environment.The proposed framework allows designers and other decision makers to select options that are environmentally sound and also aligned with the business objectives.展开更多
基金the Specialized Research Fund for Doctoral Program of Higher Education of China(20060003087)
文摘Abstract Production planning under uncertainty is considered as one of the most important problems in plant-wide optimization. In this article, first, a stochastic programming model with uniform distribution assumption is developed for refinery production planning under demand uncertainty, and then a hybrid programming model incorporating the linear programming model with the stochastic programming one by a weight factor is proposed. Subsequently, piecewise linear approximation functions are derived and applied to solve the hybrid programming model-under uniform distribution assumption. Case studies show that the linear approximation algorithm is effective to solve.the hybrid programming model, along with an error≤0.5% when the deviatiorgmean≤20%. The simulation results indicate that the hybrid programming model with an appropriate weight factor (0.1-0.2) can effectively improve the optimal operational strategies under demand uncertainty, achieving higher profit than the linear programming model and the stochastic programming one with about 1.3% and 0.4% enhancement, respectavely.
基金partially supported by the National Natural Science Foundation of China (51874325)the Science Foundation of China University of PetroleumBeijing (2462021BJRC009)。
文摘This paper intends to complete the primary logistics planning of oil products under the imbalance of supply and demand. An integrated mathematical programming model is developed to simultaneously find the balance between supply and demand, and optimize the logistics scheme. The model takes minimum logistics cost and resource adjustment cost as the objective function, and takes supply and demand capacity, transportation capacity, mass balance, and resource adjustment rules as constraints.Three adjustment rules are considered in the model, including resource adjustment within oil suppliers,within oil consumers, and between oil consumers. The model is tested on a large-scale primary logistics of a state-owned petroleum enterprise, involving 37 affiliated refineries, 31 procurement departments,286 market depots and dedicated consumers. After the unified optimization, the supply and demand imbalance is eased by 97% and the total cost is saved by 7%, which proves the effectiveness and applicability of the proposed model.
文摘A quadratic programming model is established to choose the blocks to be blasted in a given period. The length of this period depends on the production planning requirements. During the given period, the blocks' parameters are available from the geological database of the mine. The objective is to minimize the deviation of the average ore grade of blasted blocks from the standard ore grade required by the mill. Transportation ability constraint. production quantity demand constraint. minimum safety bench constraint. block size constraint and block, bench precedence constraints are considered in forming the programming model. This model has more practical objective function and reasonable constraints compared with the existing model for this kind of problems.
文摘Iron and steel industry is an important sector of Iran's economy.Choghart iron ore mine is an important iron ore producer of Iran steel industry.Phosphorous contained in the iron ore concentrates of Choghart mine has a detrimental effect on the steel making process,whereby this causes cracks to form in the refractory lining of blast furnaces.In the past,about 1.43 Mt of low-grade and 4.53 Mt of high-phosphorous materials had been transported to low grade and high phosphorous stockpiles,respectively,for future beneficiation.As a result of the progressive depletion of high-grade ore and establishment of beneficiation plant in Choghart,exploitation of these two stockpiles in this mine became an important issue.In this work,a linear goal programming(GP) model was developed in order to determine the optimum iron ore blend in terms of quality from low grade and high phosphorous stockpiles of Choghart mine.The model was solved by the SOLVER V.9 program.Results show that feeding with acceptable quality(w(Fe)≥50% and w(P)≤1.2%,mass fraction) materials can be blended from stockpiles that satisfy the needs of the Choghart processing line.
文摘At the first sight it seems that advanced operation research is not used enough in continuous production systems as comparison with mass production, batch production and job shop systems, but really in a comprehensive evaluation the advanced operation research techniques can be used in continuous production systems in developing countries very widely, because of initial inadequate plant layout, stage by stage development of production lines, the purchase of second hand machineries from various countries, plurality of customers. A case of production system planning is proposed for a chemical company in which the above mentioned conditions are almost presented. The goals and constraints in this issue are as follows: (1) Minimizing deviation of customer's requirements. (2) Maximizing the profit. (3) Minimizing the frequencies of changes in formula production. (4) Minimizing the inventory of final products. (5) Balancing the production sections with regard to rate in production. (6) Limitation in inventory of raw material. The present situation is in such a way that various techniques such as goal programming, linear programming and dynamic programming can be used. But dynamic production programming issues are divided into two categories, at first one with limitation in production capacity and another with unlimited production capacity. For the first category, a systematic and acceptable solution has not been presented yet. Therefore an innovative method is used to convert the dynamic situation to a zero- one model. At last this issue is changed to a goal programming model with non-linear limitations with the use of GRG algorithm and that's how it is solved.
基金This study was supported by the National Natural Science Foundation of China[Nos.81773932,30873072 and 81530097]the National Key Technology R&D Program“New Drug Innovation”of China[No.2018ZX09711001-008-003]。
文摘In recent years,large numbers of novel cell death types have been reported such as autophagic death,paraptosis,mitosis,oncosis and pyroptosis.As a new type of proinflammatory programmed cell death,pyroptosis has attracted increasing attentions gradually,and its morphological characteristics and molecular mechanisms are significantly different from other cell death types such as necrosis and apoptosis.Many research groups have demonstrated the association between pyroptosis and various human diseases including immunological disease,cancer,atherosclerosis,infectious disease,and cardiovascular and cerebrovascular disease.Natural products are small molecules synthetized in organisms including primary and secondary metabolites.Natural products are important sources of modern innovative drugs discovery and can be used as key tools to explore the molecular mechanism of cell fate.The aim of this study is to review the molecular mechanisms and pathways of pyroptosis,and to categorize and conclude research results on the correlation between different natural products and pyroptosis in recent years.In this study,a total of 39 papers were enrolled in analyses.The molecular pathways and mechanisms of pyroptosis were clearly described.Fourteen types of natural products,their sources,effects,mechanisms and therapeutic potentials are categorized and illuminated.It is showed that a variety of natural products and pyroptosis have close correlations.They negatively or positively affect or act on different positions of pyroptosis inflammatory pathways,indicating that they may have certain potential therapeutic effects on pyroptosis-related diseases.Pyroptosis,a relatively new way of cell death,is closely associated with a variety of diseases.Natural products can have obvious effects on the process of pyroptosis as potential sources of new drugs.In-depth studies using natural products to investigate pyroptosis will help to enhance our understandings of human diseases and establish effective prevention and treatment strategies.
基金This research is funded by Vietnam National University Ho Chi Minh City(VNU-HCM)under Grant No.C2020-28-10.
文摘Stochastic demand is an important factor that heavily affects production planning.It influences activities such as purchasing,manufacturing,and selling,and quick adaption is required.In production planning,for reasons such as reducing costs and obtaining supplier discounts,many decisions must be made in the initial stage when demand has not been realized.The effects of non-optimal decisions will propagate to later stages,which can lead to losses due to overstocks or out-of-stocks.To find the optimal solutions for the initial and later stage regarding demand realization,this study proposes a stochastic two-stage linear program-ming model for a multi-supplier,multi-material,and multi-product purchasing and production planning process.The objective function is the expected total cost after two stages,and the results include detailed plans for purchasing and production in each demand scenario.Small-scale problems are solved through a deterministic equivalent transformation technique.To solve the problems in the large scale,an algorithm combining metaheuristic and sample average approximation is suggested.This algorithm can be implemented in parallel to utilize the power of the solver.The algorithm based on the observation that if the remaining quantity of materials and number of units of products at the end of the initial stage are given,then the problems of the first and second stages can be decomposed.
文摘The purpose of this paper was to examine the role of quantitative analysis in production planning decisions. This draws from the observed imperatives of quantitative analysis in business decisions and its capacity for predictability and enhanced decision making given the increasingly complex nature of the business environment. The paper therefore addressed the historical evolution of quantitative technique as an efficient and effective decision-making tool. The content of the paper addressed commonly applied quantitative technique in manufacturing firms today which is, linear programming and its subsequent impact on production planning decisions. The results based on a congruence of views revealed that the “best-fit” application of quantitative analysis models and tools can untangle the complexities of production and planning decision making process in order to achieve the organizational goal. This is, as literature also showed that there is obviously no consensus or integrated model that is capable of solving all managerial problem, different models such as the linear programming model have however been developed to cater for different problems as they arise. The workability or suitability of quantitative analysis is actually premised on its appropriate application. The paper recommends the application of quantitative analysis using linear programming in solving various resource allocation related issues in the primary production planning function of manufacturing firms.
文摘This paper proposes an inner product Laplacian embedding algorithm based on semi-definite programming, named as IPLE algorithm. The new algorithm learns a geodesic distance-based kernel matrix by using semi-definite programming under the constraints of local contraction. The criterion function is to make the neighborhood points on manifold as close as possible while the geodesic distances between those distant points are preserved. The IPLE algorithm sufficiently integrates the advantages of LE, ISOMAP and MVU algorithms. The comparison experiments on two image datasets from COIL-20 images and USPS handwritten digit images are performed by applying LE, ISOMAP, MVU and the proposed IPLE. Experimental results show that the intrinsic low-dimensional coordinates obtained by our algorithm preserve more information according to the fraction of the dominant eigenvalues and can obtain the better comprehensive performance in clustering and manifold structure.
文摘One of the most important responsibilities of a supply chain manager is to decide “how much” (or “many”) of inventory items to order and how to transport them. This paper presents four mixed-integer linear programming models to help supply chain managers make these decisions for multiple products subject to multiple constraints when suppliers offer quantity discounts and shippers offer freight discounts. Each model deals with one of the possible combinations of all-units, incremental quantity discounts, all-weight and incremental freight discounts. The models are based on a piecewise linear approximation of the number of orders function. They allow any number of linear constraints and determine if independent or common (fixed) cycle ordering has a lower total cost. Results of computational experiments on an example problem are also presented.
文摘In this study, Simplex Method, a Linear Programming technique was used to create a mathematical model that optimized the financial portfolio of Golden Guinea Breweries Plc, Nigeria. This work was motivated by the observed and anticipated miscalculations which Golden Guinea Breweries was bound to face if appropriate linear programming techniques were not applied in determining the profit level. This study therefore aims at using Simplex Method to create a Mathematical Model that will optimize the production of brewed drinks for Golden Guinea Breweries Plc. The first methodology involved the collection of sample data from the company, analyzed and the relevant coefficients were deployed for the coding of the model. Secondly, the indices collected from the first method were deployed in the software model called PHP simplex, an online software for solving Linear Programming Problem to access the profitability of the organization. The study showed that Linear Programming Model would give a high profit coefficient of N9,190,862,833 when compared with the result obtained from the manual computation which gave a profit coefficient of N7,172,093,375. Also, Bergedoff Lager, Eagle Stout and Bergedoff Malta were found not to contribute to overall profitability of the company and it was therefore recommended that their productions should be discontinued. It also recommends that various quantities of Golden Guinea Lager (1 × 12) and Golden Guinea Lager (1 × 24) should be produced.
文摘Most products have the potential to negatively impact the environment during all life-cycle stages.However,most environmental impact assessment methods focus on a single product life-cycle and on a specific life-cycle stage.Product design plays a significant role by determining traditional environmental impacts,such as embodied energy of materials,but also by influencing market adoption and production volumes.The main objective of this work is to develop a design optimization framework that estimates the environmental impact of design decisions(e.g.materials choice,etc.)across all life-cycle stages in consumer products.The methodology relies on quality function deployment(QFD),multi-attribute utility theory,non-linear mathematical programming,and life-cycle assess-ment tools to estimate the utility of the design options to the customer,the producer,and the environment.The proposed framework allows designers and other decision makers to select options that are environmentally sound and also aligned with the business objectives.