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Audits of Death in HIV-Infected Children and Adolescents Followed up in the Pediatric Department of the Regional Teaching Hospital of Borgou/Alibori from 2005 to 2020
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作者 Alphonse Noudamadjo Mohamed Falilatou Agbeille +6 位作者 Dénagan Kévin Amoussou Médétinmè Gérard Kpanidja Lahanatou Séidou Chantal Chabi Réckya Kilaya Julien Didier Adédémy Agossou Joseph 《Open Journal of Pediatrics》 2024年第2期285-296,共12页
Introduction: Human immunodeficiency virus (HIV) is a major public health problem with high morbidity and mortality among children. The objective of this work was to audit the deaths of children and adolescents with H... Introduction: Human immunodeficiency virus (HIV) is a major public health problem with high morbidity and mortality among children. The objective of this work was to audit the deaths of children and adolescents with HIV infection followed up in the pediatric department of the Regional Teaching Hospital of Borgou/Alibori (CHUDB/A) the from 2005 to 2020. Patients and Method: This was a retrospective and descriptive study conducted in the pediatric department of CHUD/B-A in Parakou. All children with HIV infection who died from January 1, 2005 to August 31, 2020 were included. Data collection was carried out in three stages: a phase of medical records processing, a phase of community survey and a phase of death audits. The variables studied were sociodemographic, clinical, biological, therapeutic and evolutionary. Results: Over the study period, the data of 464 infected children were recorded, including 92 deaths, representing a case fatality rate of 19.83%. Severe acute malnutrition (69.23%), gastro-intestinal tract infections (43.58%) and serious opportunistic pulmonary infections (24.36% pulmonary tuberculosis and 19.23% pneumocystis) were the main causes of death. The main dysfunctions found were: the delayed diagnosis of HIV infection (79.35%), the absence or delay in consultation when the child’s clinical condition deteriorates (32.61% and 47.83%), delayed initiation of antiretroviral treatment (42.39%) and non-adherence to treatment (38.04%). Non-adherence to treatment was predominant in adolescents (90.49%). Conclusion: Specific interventions for early detection, adequate nutritional care, psychosocial support for adolescents and mothers of children are necessary to reduce mortality due to HIV among children and adolescents. 展开更多
关键词 HIV death children Adolescents Dysfunctions BENIN
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Effects of Maternal Death on Children Living in the Sagnarigu Municipality
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作者 David Z. Kolbila Abdul-Razak Doat +2 位作者 David S. Nigarim Wilfred Kwose Sylvanus Kampo 《Open Journal of Obstetrics and Gynecology》 2024年第3期334-347,共14页
Introduction: The greatest effect of maternal mortality is renowned in children aged 2 - 5 months whose mothers had died. Children whose mothers died due to maternal complications were likely to record a higher mortal... Introduction: The greatest effect of maternal mortality is renowned in children aged 2 - 5 months whose mothers had died. Children whose mothers died due to maternal complications were likely to record a higher mortality in infancy compared to children of surviving mothers. Motherless children mostly suffer a lot due to lack of day-to-day care, isolation, lack of motivation as well as economic cost associated with mother’s death. Thus, the purpose of this study was to ascertain the lives of children whose mothers passed away during childbirth at the Sagnarigu Municipality. Methods: This quantitative cross-sectional study was carried out at the Sagnarigu Municipal. The study recruited 297 respondents. To assess the effects of maternal death on the lives of children, families that experienced maternal death were assessed. The number of pregnancies experienced by the deceased woman, pregnancy-related complaints experienced, determinants of maternal death, number of children alive, and their standard of living were assessed with the aid of a structured questionnaire. Results: The data showed that negligence, illiteracy, poor road access, poverty, ignorance, delays in recognizing the problem, delays in making appropriate decisions, delays in the health facility, delays in giving the appropriate treatments, and traditional beliefs were some of the factors that led to maternal death in the Sagnarigu Municipality. Conclusion: The study concluded that determinants of maternal death in the Sagnarigu Municipal included the following;negligence, illiteracy, poverty, and delays in recognizing the problem. The study findings also demonstrated that the effects of maternal death on children are diverse and cut across different areas of a child’s life including livelihood sustenance, healthcare, education, and emotional and psychological development. 展开更多
关键词 Maternal death EFFECTS Orphans children PREGNANCY CHILDBIRTH
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Characteristics of Deaths of Children in the Pediatrics Department of Hôpital Spécialisé Mère-Enfant Blanche Gomes (Republic of the Congo) from 2019 to 2021
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作者 Pascal Diogène Bingui Outman Nelly Sandrine Guembo Pandzou +9 位作者 Rolyne Vanissia Madzou Nganie Verlem Bomelefa-Bomel Benoite Diatewa Kadidja Grace Nkounkou Milandou Jean Brice Mouendenguia Luopou Lamah Audrey Niangui-Bakala Dorthéa Banga Massalat Rel Gérald Boukaka Kala Jean Robert Mabiala Babela 《Open Journal of Pediatrics》 2023年第4期581-593,共13页
Introduction: The United Nations Sustainable Development Goals (SDGs) aim to decrease the global maternal mortality ratio to below 70 per 100,000 live births and eliminate preventable deaths of newborns and children u... Introduction: The United Nations Sustainable Development Goals (SDGs) aim to decrease the global maternal mortality ratio to below 70 per 100,000 live births and eliminate preventable deaths of newborns and children under the age of five in all countries by 2030. The pediatric department at Spécialisé Mère-Enfant Blanche Gomes Hospital (HSMEBG) is divided into two sectors, one catering to children aged one month to four years and the other dedicated to children aged five to 17 years. According to department records, over the past three years, there has been an average of 1050 hospitalizations per year, with an average duration of five days. Objectives: This study aims to describe the socio-demographic characteristics of children who died while in the pediatrics department of the HSMEBG and analyze the factors associated with their deaths. Methodology: A retrospective analytical cross-sectional study was conducted, collecting data over a three-year period, covering the years 2019, 2020 and 2021. Data were collected from medical records of deceased children using Excel software version 2016, and statistical calculations and logistic regression were performed using Epi info software version 7.2.5.0. Results: During the three years of operation, the pediatric department at HSMEBG recorded 3060 new admissions, of which 271 resulted in death, representing an overall frequency of 8.8%. December and January had the highest mortality rates, accounting for 15.5% and 12.5%, respectively. Out of the 271 recorded deaths, 143 (52.77%) occurred in children under the age of one, and 230 (84.87%) occurred in children under the age of five. The average age at death was 2.4 years, ranging from one month to 17 years. The sex ratio was 1. More than half of the deaths (51.66%) occurred during the night, and 165 (60.89%) sought medical help more than three days after the onset of symptoms. Weekend deaths accounted for nearly half (45.7%) of the cases. Upon admission, slightly over half of the children (55.72%) had impaired consciousness, 219 (80.81%) presented with respiratory distress, and 194 (71.59%) had a fever. The average time from admission to administering the first medication was 72 minutes. Respiratory infections were the leading cause of death, accounting for 83 (30.26%) cases, followed by severe forms of malaria (anemic and neurological) at 23.25%. Among the 271 recorded deaths, 33 (12.18%) received no treatment before their demise, and 136 (50.18%) died within the first 24 hours of hospitalization. The average duration of hospitalization for patients who spent less than 24 hours was 15 hours, while those who died after the 24th hour had an average hospital stay of five days, ranging from one to 41 days. Children under the age of five who were admitted with impaired consciousness had roughly double the risk of dying compared to those without this condition (p = 0.001). Conclusion: The overall mortality rate in the pediatric department at HSMEBG is 8.8%. Acute respiratory infections are the primary cause of death. Improving this rate necessitates reducing consultation and treatment durations. 展开更多
关键词 death children Associated Factors BRAZZAVILLE
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An ongoing concern: Helping children comprehend death 被引量:3
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作者 Sandra L. McGuire Logan S. McCarthy Mary Anne Modrcin 《Open Journal of Nursing》 2013年第3期307-313,共7页
This article addresses the need for anticipatory guidance about death and death education with young children. Children often experience the death of an immediate family member before the age of ten. This number incre... This article addresses the need for anticipatory guidance about death and death education with young children. Children often experience the death of an immediate family member before the age of ten. This number increases if one considers the loss of friends, pets, and other loved ones. However, children experience a death with little or no anticipatory guidance or knowledge about death. Anticipatory guidance can assist the child in having a better understanding of a death when it occurs. Talking about death with children can be difficult for adults. However, it is important to address the topic and realize the impact anticipatory guidance in relation to death can have in assisting with childhood bereavement, anticipatory grief, and anticipatory adaptation. By providing anticipatory education related to death symptoms such as grief, anger, and/or fear, regressive or aggressive behaviors can be prevented or lessened when a death occurs. Age appropriate developmental levels for understanding the concept of death, resources for death education, and literature that can be used for death education are presented. Any resource used for death education with children should be carefully reviewed by the adult for its appropriateness prior to its use. 展开更多
关键词 children death EDUCATION Anticipatory GUIDANCE
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Descriptive and Analytical Study of Factors Associated with Mortality in Severe Malaria among Children in Dakar Emergency Departments from July to December 2022
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作者 Aliou Thiongane Abou Ba +14 位作者 Fatou Ly Aliou A. Ndongo Djibril Boiro Younoussa Kéita Idrissa Basse Babacar Niang Indou Dême Ly Yaye Joor Dieng Djenaba Fafa Cissé Ndiogou Seck Lamine Thiam Papa Moctar Faye Amadou Lamine Fall Assane Sylla Ousmane Ndiaye 《Open Journal of Pediatrics》 2023年第6期866-878,共13页
Background: Malaria is the most widespread parasitic disease and remains a public health priority worldwide. The severe form is fatal if not treated early and appropriately. The aim was to carry out a descriptive and ... Background: Malaria is the most widespread parasitic disease and remains a public health priority worldwide. The severe form is fatal if not treated early and appropriately. The aim was to carry out a descriptive and analytical study of the factors associated with mortality during severe malaria in children attending emergency departments in Dakar, Senegal. Methods: This is a prospective, observational and analytical study conducted over a 6-month period (July 1 to December 31, 2022), focusing on children hospitalized for severe malaria according to WHO severity criteria. Results: A total of 403 patients were hospitalized, including 78 cases of severe malaria (19.35%). Males predominated (60.26%) (sex ratio 1.51). The average age was 6.56 years [8 months - 14 years], with the [5 - 10 years] age group the most represented (40.26%). The average consultation time was 5.33 days (1 - 19 days). The main reasons for consultation were fever (70.51%), vomiting (24.35%) and convulsions (14.10%). Biological signs of severity were severe anemia (17.95%), renal failure (6.4%) and hypoglycemia (3.85%). Thrombocytopenia was noted in 52.56% of patients, including 32.05% of severe cases (sis in 61.41% of cases. Hyponatremia was noted in 39.74% of cases and hyperkalemia in 2 patients. Artesunate was the main drug used (93.59% of cases). Mortality was estimated at 1.5%. Factors leading to death were coma (P < 0.01), respiratory distress (P Conclusion: Malaria is still a public health problem, with a high mortality rate in emergency departments. Reducing this mortality rate requires effective management of the factors associated with death. 展开更多
关键词 children MALARIA death Factors
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A Warm Death Trip——An Interpretation of The Great Blue Yonder from the Dead Children Narrative Perspective
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作者 黄洁 《海外英语》 2015年第21期195-197,共3页
When it comes to the death,it can be gruesome or be dolente.However,the death also can be warm and be a new start of life.It is because we regard the death from different perspective that we show different attitude to... When it comes to the death,it can be gruesome or be dolente.However,the death also can be warm and be a new start of life.It is because we regard the death from different perspective that we show different attitude to the death.The novel The Great Blue Yonder which described the experience of the little protagonist died as a ghost wandering in the mortal world interpreted the death by fairy tale.In his wandering trip,he experience not only tears but also laughter.The more important experience he realized was that he took a new look at love and comprehended the significance of life.Because of the dislocation between narrative perspective and narrative contents,the abnormal narrative perspective owns the unique artistic charm.This thesis aims to interpret the Great Blue Yonder by taking the abnormal narrative perspective as the point of view from the dual narrative perspective of the ghosts and the children.The abnormal narrative perspective is endowed with the unique aesthetic effect because of its own aesthetic properties.It will make a great fresh aesthetic feast to readers. 展开更多
关键词 the dead ghost narrative perspective the children narrative perspective death The great blue yonder
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程序性死亡配体1在儿童急性髓系白血病中的表达及对耐药的影响
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作者 马平 田亮 +6 位作者 周建文 毛彦娜 栗春香 何永艳 王亚峰 平玉豪 刘炜 《安徽医药》 CAS 2024年第7期1446-1450,共5页
目的研究程序性死亡配体1(PD-L1)在儿童初治急性髓系白血病(AML)中的表达及对白血病细胞耐药的影响。方法收集2020年1月至2021年1月郑州大学附属儿童医院血液肿瘤科收治的初诊40例AML病儿骨髓标本,收集同期进行骨髓检查正常病儿的骨髓标... 目的研究程序性死亡配体1(PD-L1)在儿童初治急性髓系白血病(AML)中的表达及对白血病细胞耐药的影响。方法收集2020年1月至2021年1月郑州大学附属儿童医院血液肿瘤科收治的初诊40例AML病儿骨髓标本,收集同期进行骨髓检查正常病儿的骨髓标本18例作为正常对照组,比较两组骨髓中PD-L1的表达量,并分析初治AML病儿PD-L1的表达量与其临床特征之间的关系;慢病毒构建PD-L1过表达、干扰PD-L1表达的AML细胞,细胞活力检测试剂盒(CCK8)检测细胞增殖能力,并计算细胞对柔红霉素的药物敏感性;凋亡实验检测经柔红霉素诱导的细胞凋亡水平。结果与正常对照组0.887±0.064相比,初治儿童AML病儿骨髓单个核细胞PD-L1的表达量2.927±0.271显著增高(t=7.34,P<0.001);根据一个疗程诱导化疗是否达完全缓解(CR),将初治AML病儿一个疗程达CR者定义为CR组,将未达CR者定义为NR组,相较于CR组的2.346±0.190,NR组PD-L1基因的表达量5.249±0.662显著增高(t=4.22,P=0.003);病儿不同发病年龄,性别,法、美、英(FAB)分型,白细胞计数,预后分层间PD-L1基因相对表达量比较均差异无统计学意义(P>0.05),而1个疗程诱导化疗是否达CR与PD-L1基因相对表达量差异有统计学意义(P=0.018);过表达PD-L1的Molm-13细胞对柔红霉素具有更高的IC50值,更低的凋亡率;干扰PD-L1表达的THP1细胞对柔红霉素具有更低的IC50值,更高的凋亡率。结论PD-L1在初治AML病儿中表达增高,且PD-L1的高表达与1个疗程诱导治疗是否达CR显著相关;PD-L1可以促进AML细胞增殖、抑制凋亡,从而导致化疗耐药。 展开更多
关键词 白血病 髓样 急性 程序性死亡配体1 儿童 化疗耐药 柔红霉素
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急性髓系白血病患儿柔红霉素耐药与PD-L1蛋白表达相关
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作者 宋丽丽 管玉洁 +1 位作者 马平 李宁 《基础医学与临床》 CAS 2024年第6期833-839,共7页
目的研究急性髓系白血病(AML)患儿柔红霉素(DNR)耐药与程序性死亡受体配体-1(PD-L1)蛋白表达的相关性。方法选取2016年1月至2022年12月郑州大学附属儿童医院收治的110例AML患儿骨髓样本作为研究组,以50名骨髓正常供体骨髓样本作为对照... 目的研究急性髓系白血病(AML)患儿柔红霉素(DNR)耐药与程序性死亡受体配体-1(PD-L1)蛋白表达的相关性。方法选取2016年1月至2022年12月郑州大学附属儿童医院收治的110例AML患儿骨髓样本作为研究组,以50名骨髓正常供体骨髓样本作为对照组。培养人AML细胞系HL60、THP-1、U-937、Molm-13,Western blot检测PD-L1蛋白表达量。构建LV-PD-L1-shRNA、LV-PD-L1-WT-OE慢病毒载体,分析PD-L1对Molm-13细胞DNR耐药的影响及机制。结果研究组PD-L1蛋白表达量高于对照组,AML细胞系中PD-L1蛋白表达量高于健康骨髓单个核细胞(BMMC)(P<0.05),PD-L1表达与AML患儿白细胞计数、骨髓原始细胞比率、预后危险分层、两个标准化学治疗方案后疾病缓解情况有关(P<0.05)。PD-L1高表达组总生存率低于PD-L1低表达组(P<0.05)。与LV-PD-L1-WT-OE组比较,LV-PD-L1-shRNA组PD-L1 mRNA表达量降低、细胞增殖活性降低、凋亡率升高(P<0.05),LV-PD-L1-shRNA可提高Molm-13细胞对DNR的敏感性。TCGA数据库分析显示,6-磷酸葡萄糖脱氢酶(G6PD)可能为PD-L1潜在的目标基因。结论PD-L1在儿童AML中高表达,与患儿化疗耐药有关,其可能通过调控G6PD引起DNR耐药。 展开更多
关键词 儿童急性髓系白血病 柔红霉素 耐药 程序性死亡受体配体-1
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2009-2023年天津市某儿童医院住院儿童死亡病例分析
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作者 程方 赵旻鹏 +1 位作者 张冉冉 李丽静 《医学新知》 CAS 2024年第8期861-870,共10页
目的分析2009—2023年天津市某儿科医院住院儿童死亡病例特点。方法收集天津市某儿童医院2009—2023年住院儿童的病案首页信息,分析2009—2013年、2014—2018年、2019—2023年三个时间段死亡病例的性别、年龄、疾病系统及死亡病种情况... 目的分析2009—2023年天津市某儿科医院住院儿童死亡病例特点。方法收集天津市某儿童医院2009—2023年住院儿童的病案首页信息,分析2009—2013年、2014—2018年、2019—2023年三个时间段死亡病例的性别、年龄、疾病系统及死亡病种情况。结果2009—2023年,住院患儿共678145例,其中876例死亡,死亡率为0.13%;三个时间段的死亡率分别为0.28%、0.16%、0.06%,整体呈递减趋势(χ^(2)=383.962,P<0.01)。男性儿童死亡率(0.12%)显著低于女性儿童死亡率(0.15%)(χ^(2)=303.785,P<0.01)。婴儿期死亡人数最多(263例),青春期死亡人数最少(61例)。死亡疾病系统顺位在三个时间段的变化方面,循环系统疾病从第六位上升至第三位,肿瘤从第九位上升至第六位,先天性畸形、变形和染色体异常从第三位降至第八位。前十位死亡病种中,重症肺炎在三个时间段中均排名第一;急性淋巴细胞白血病顺位由2009—2013年的第九位上升至2019—2023年的第三位。新生儿期排名第一的死亡病种为新生儿呼吸衰竭,婴儿期、幼儿期、学龄前期及学龄期排名第一的死亡病种均为重症肺炎,青春期排名第一的死亡病种为海绵窦脓肿。结论2009—2023年间天津市住院儿童死亡率明显下降,儿科临床和预防工作应继续重点关注婴儿期的重症肺炎、脓毒血症患儿,以及海绵窦脓肿等病种,同时应加强对循环系统、某些传染病和寄生虫病、意外伤害、恶性肿瘤的预防和控制,以有效降低住院患儿死亡率。 展开更多
关键词 住院儿童 死亡病例 死亡率 死亡病种
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2011年-2020年苏州工业园区5岁以下儿童死亡监测分析
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作者 孙雨玥 王丹丹 +3 位作者 树明华 周慧 陈小芳 吴蕾 《中国血液流变学杂志》 CAS 2024年第2期284-289,共6页
目的了解苏州工业园区2011年—2020年5岁以下儿童死亡率(U5MR)变化趋势及其流行病学特征,为制定妇幼卫生政策提供参考依据。方法收集2011年—2020年园区各级医疗机构上报的5岁以下儿童死亡个案,采用SAS 9.4软件对资料进行统计描述和统... 目的了解苏州工业园区2011年—2020年5岁以下儿童死亡率(U5MR)变化趋势及其流行病学特征,为制定妇幼卫生政策提供参考依据。方法收集2011年—2020年园区各级医疗机构上报的5岁以下儿童死亡个案,采用SAS 9.4软件对资料进行统计描述和统计推断。结果U5MR、新生儿(<28 d)死亡率(NMR)、婴儿(<1岁)死亡率(IMR)和1~4岁儿童死亡率分别为2.82‰、1.51‰、2.18‰、0.64‰;U5MR(χ^(2)趋势=0.24,P>0.05)变化较小,1~4岁儿童死亡率逐年呈缓慢下降趋势(χ^(2)趋势=7.41,P=0.0065);新生儿、婴儿(28 d~1岁)、1~4岁儿童死亡占比分别为53.50%、23.89%、22.61%;5岁以下儿童主要死因前三位:早产或低出生体重(16.24%)、先天性心脏病(11.78%)、意外窒息(7.96%)。结论园区5岁以下儿童死亡率控制在一个较低水平范围内;通过继续提升辖区内各医疗卫生机构产/儿科水平、完善妇幼保健服务网络、加强孕期及围产期保健管理、继续规范实施出生缺陷三级预防工作等手段对早产儿或低出生体重儿和先天性心脏病予以重点干预。 展开更多
关键词 5岁以下儿童 死亡率 死因
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幼儿死亡主题绘本的内容分析及教育启示——基于NVivo12.0的编码分析
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作者 但菲 陈萌尧 《陕西学前师范学院学报》 2024年第11期29-36,共8页
死亡教育不仅是让幼儿理性认识死亡的重要途径,更是珍惜美好生活的心理健康教育的基石,死亡主题绘本作为死亡教育的重要载体之一具有巨大的教育价值。基于质性分析软件NVivo12.0对49本幼儿死亡主题绘本进行编码分析,结果发现,此类绘本... 死亡教育不仅是让幼儿理性认识死亡的重要途径,更是珍惜美好生活的心理健康教育的基石,死亡主题绘本作为死亡教育的重要载体之一具有巨大的教育价值。基于质性分析软件NVivo12.0对49本幼儿死亡主题绘本进行编码分析,结果发现,此类绘本内容涉及死亡特征和死亡的情绪性反应两大核心节点;将死亡主题绘本融入到幼儿的死亡教育,能够提高幼儿对死亡的科学认知,形成积极的生活态度,促进情绪情感发展。基于此进一步提出了对死亡主题绘本的选择与应用以及相关主题绘本创编的五点启示:消除成人自身的死亡恐惧、把握绘本内容的适读性和针对性、尊重幼儿的情绪情感反应、辩证看待绘本的死亡文化性以及创作与我国文化结合的死亡主题绘本。 展开更多
关键词 死亡教育 幼儿死亡主题绘本 编码分析
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2013—2022年房山区5岁以下儿童死亡情况分析 被引量:1
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作者 隗秋连 《临床医学研究与实践》 2024年第15期29-32,37,共5页
目的 分析房山区5岁以下儿童死亡率变化趋势及不同年龄儿童死亡原因的变化情况,针对5岁以下儿童死亡的主要原因,制定综合有效的管理措施,降低新生儿及婴儿死亡率。方法 采用北京市妇幼信息系统5岁以下儿童死亡监测网络收集2013—2022年... 目的 分析房山区5岁以下儿童死亡率变化趋势及不同年龄儿童死亡原因的变化情况,针对5岁以下儿童死亡的主要原因,制定综合有效的管理措施,降低新生儿及婴儿死亡率。方法 采用北京市妇幼信息系统5岁以下儿童死亡监测网络收集2013—2022年5岁以下儿童死亡个案报告卡,统计儿童死亡率及不同年龄段死亡构成比,分析新生儿、婴儿根本死因及顺位情况。结果 2019—2022年早期新生儿、新生儿、婴儿死亡率大体上呈下降趋势,早期新生儿死亡率下降幅度最大。2019—2021年早期新生儿死亡的构成比大体上呈下降趋势。10年期间持续年份较长的根本死因顺位第一位是早产或低出生体重、出生窒息的新生儿,早产或低出生体重的婴儿;第二位是早产或低出生体重、出生窒息的新生儿,出生窒息、先天性心脏病的婴儿;第三位是其他先天异常的新生儿及婴儿。结论 加强孕妇围产期保健管理及高危孕妇孕期早期干预,督促定期随诊,提高高危孕妇分娩前的评估水平,提升产科医生孕期及分娩时的诊治技术、新生儿科医生危重新生儿安全转运评估质量及新生儿复苏技术成功水平,是降低新生儿及婴儿死亡的关键措施。 展开更多
关键词 新生儿 婴儿 5岁以下儿童 死亡根本原因
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肺炎支原体肺炎患儿血清microR-146a、sPD-L2与疾病严重程度及预后的关系研究
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作者 李华风 段林林 张云 《国际检验医学杂志》 CAS 2024年第13期1552-1557,共6页
目的 研究肺炎支原体肺炎(MPP)患儿血清微小RNA(miR)-146a、可溶性程序性死亡配体2(sPD-L2)水平,分析二者与MPP病情严重程度的关系及对预后的预测价值。方法 选取2019年2月至2021年6月临汾市人民医院收治的89例MPP患儿,根据病情严重程... 目的 研究肺炎支原体肺炎(MPP)患儿血清微小RNA(miR)-146a、可溶性程序性死亡配体2(sPD-L2)水平,分析二者与MPP病情严重程度的关系及对预后的预测价值。方法 选取2019年2月至2021年6月临汾市人民医院收治的89例MPP患儿,根据病情严重程度分为重症组(50例)和轻症组(39例)。根据MPP患儿预后分为预后良好组(70例)和预后不良组(19例)。以同期体检的50例健康儿童为对照组。采用实时荧光定量PCR检测各组血清miR-146a水平。采用酶联免疫吸附试验检测血清sPD-L2水平。采用Pearson相关性分析MPP患儿血清miR-146a与sPD-L2水平的相关性。采用Logistic回归分析影响MPP患儿预后不良的因素。采用受试者工作特征曲线分析血清miR-146a、sPD-L2对MPP患儿预后不良的预测效能。结果 对照组、轻症组及重症组血清miR-146a水平依次降低(P<0.05),而sPD-L2水平依次升高(P<0.05)。MPP患儿血清miR-146a与sPD-L2水平呈负相关(r=-0.735,P<0.001)。预后不良组发热持续时间、胸腔积液比例、C反应蛋白、重症MPP患儿比例及血清sPD-L2水平均高于预后良好组(P<0.05),而血清miR-146a水平低于预后良好组(P<0.05)。重症MPP、血清sPD-L2是MPP患儿预后不良的独立危险因素,miR-146a是保护因素(P<0.05)。血清miR-146a、sPD-L2二者联合预测MPP患儿预后不良的曲线下面积为0.915(95%CI:0.861~0.949),高于miR-146a、sPD-L2单项指标预测的0.844(95%CI:0.801~0.886)和0.859(95%CI:0.814~0.897)(Z=4.780、4.023,均P<0.05)。结论 MPP患儿血清miR-146a水平降低,sPD-L2水平升高,二者与MPP疾病严重程度有关,且二者联合检测对MPP预后不良具有较高的预测价值。 展开更多
关键词 肺炎支原体肺炎 微小RNA-146a 可溶性程序性死亡配体2 儿童 严重程度 预后
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宁波市二级及以上医疗机构2019-2021年儿童住院患者疾病统计分析
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作者 罗胜兰 《智慧健康》 2024年第18期13-16,共4页
目的统计分析宁波市二级及以上医疗机构2019—2021年儿童住院病例疾病构成情况,旨在为疾病监测、疾病预防提供数据支持,为区域卫生规划和医疗保障等部门政策的制定提供参考依据。方法从浙江卫生健康信息网络直报系统导出宁波市二级及以... 目的统计分析宁波市二级及以上医疗机构2019—2021年儿童住院病例疾病构成情况,旨在为疾病监测、疾病预防提供数据支持,为区域卫生规划和医疗保障等部门政策的制定提供参考依据。方法从浙江卫生健康信息网络直报系统导出宁波市二级及以上医疗机构2019—2021年住院病例的年龄、性别、住院日期、主要诊断、主要诊断编码、离院方式等数据,采用SAS9.4软件对数据进行描述性统计分析。结果2019—2021年宁波市二级及以上医疗机构儿童住院患者累计出院169210例,男性多于女性(1.52∶1);不同年龄段分组结果显示,儿童患者住院人数随着年龄增长基本呈递增的趋势(Z=34.69,P<0.001)。学龄期出院病例最多,占比为25.85%;其次为学龄前期,占比为20.98%。呼吸系统疾病,起源于围生期的某些情况,泌尿生殖系统疾病,损伤、中毒和外因的某些其他后果和消化系统疾病位居疾病顺位前五,精神和行为障碍疾病是位次上升最快的疾病。结论呼吸系统疾病和起源于围生期的某些情况是宁波市儿童的主要疾病;肺炎、新生儿黄疸、损伤中毒、抑郁发作均为各系统的主要病种,严重威胁着儿童的生命健康,应根据疾病特征制定相应的防控措施。 展开更多
关键词 儿童疾病 疾病谱 死亡谱 疾病顺位
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2008—2022年上海市九亭社区5岁以下儿童死亡情况调查分析
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作者 周静 《妇儿健康导刊》 2024年第19期66-69,共4页
目的调查分析2008—2022年上海市九亭社区5岁以下儿童死亡情况。方法收集2008—2022年九亭社区5岁以下儿童死亡资料、出生统计、死亡统计,分析死亡情况和死因构成情况。结果2008—2022年九亭社区活产数为32526;<7 d、7~<28 d、28 ... 目的调查分析2008—2022年上海市九亭社区5岁以下儿童死亡情况。方法收集2008—2022年九亭社区5岁以下儿童死亡资料、出生统计、死亡统计,分析死亡情况和死因构成情况。结果2008—2022年九亭社区活产数为32526;<7 d、7~<28 d、28 d~<1岁、1~5岁儿童死亡率分别为1.44‰、0.37‰、0.58‰和0.95‰;九亭社区0~5岁儿童死亡率逐年下降。0~5岁儿童死亡原因主要包括早产、低出生体重、先天性心脏病、溺水、交通意外、意外窒息、出生窒息、刑事案件、先天性多发畸形、严重出生畸形、肺炎、癫痫、新生儿呼吸窘迫综合征等。结论2008—2022年上海市九亭社区5岁以下儿童死亡率逐年下降,死亡原因主要包括低出生体重、早产、先天性疾病、意外伤害等。相关部门应进一步落实儿童保健工作,加强健康宣教,保障儿童健康成长。 展开更多
关键词 九亭社区 0~5岁儿童 死亡率 死亡原因
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Validation of a pediatric bedside tool to predict time to death after withdrawal of life support
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作者 Ashima Das Ingrid M Anderson +3 位作者 David G Speicher Richard H Speicher Steven L Shein Alexandre T Rotta 《World Journal of Clinical Pediatrics》 2016年第1期89-94,共6页
AIM: To evaluate the accuracy of a tool developed to predict timing of death following withdrawal of life support in children. METHODS: Pertinent variables for all pediatric deaths(age ≤ 21 years) from 1/2009 to 6/20... AIM: To evaluate the accuracy of a tool developed to predict timing of death following withdrawal of life support in children. METHODS: Pertinent variables for all pediatric deaths(age ≤ 21 years) from 1/2009 to 6/2014 in our pediatric intensive care unit(PICU) were extracted through a detailed review of the medical records. As originally described, a recently developed tool that predicts timing of death in children following withdrawal of life support(dallas predictor tool [DPT]) was used to calculate individual scores for each patient. Individual scores were calculated for prediction of death within 30 min(DPT30) and within 60 min(DPT60). For various resulting DPT30 and DPT60 scores, sensitivity, specificity and area under the receiver operating characteristic curve were calculated.RESULTS: There were 8829 PICU admissions resulting in 132(1.5%) deaths. Death followed withdrawal of life support in 70 patients(53%). After excluding subjects with insufficient data to calculate DPT scores, 62 subjects were analyzed. Average age of patients was 5.3 years(SD: 6.9), median time to death after withdrawal oflife support was 25 min(range; 7 min to 16 h 54 min). Respiratory failure, shock and sepsis were the most common diagnoses. Thirty-seven patients(59.6%) died within 30 min of withdrawal of life support and 52(83.8%) died within 60 min. DPT30 scores ranged from-17 to 16. A DPT30 score ≥-3 was most predictive of death within that time period, with sensitivity = 0.76, specificity = 0.52, AUC = 0.69 and an overall classification accuracy = 66.1%. DPT60 scores ranged from-21 to 28. A DPT60 score ≥-9 was most predictive of death within that time period, with sensitivity = 0.75, specificity = 0.80, AUC = 0.85 and an overall classification accuracy = 75.8%.CONCLUSION: In this external cohort, the DPT is clinically relevant in predicting time from withdrawal of life support to death. In our patients, the DPT is more useful in predicting death within 60 min of withdrawal of life support than within 30 min. Furthermore, our analysis suggests optimal cut-off scores. Additional calibration and modifications of this important tool could help guide the intensive care team and families considering DCD. 展开更多
关键词 death ORGAN DONATION children DONATION AFTER circulatory death
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2017—2021年广西5岁以下儿童意外死亡情况分析 被引量:3
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作者 雷利志 姚慧 +3 位作者 玉群 曾萼 邓泽彬 何仲彪 《中国初级卫生保健》 2023年第7期81-84,共4页
目的:分析2017—2021年广西5岁以下儿童意外死亡情况,为降低广西5岁以下儿童意外死亡率提供参考依据。方法:利用广西“桂妇儿健康服务信息管理系统”收集2017—2021年广西5岁以下儿童死亡报告卡和广西妇幼卫生年报数据,分析广西5岁以下... 目的:分析2017—2021年广西5岁以下儿童意外死亡情况,为降低广西5岁以下儿童意外死亡率提供参考依据。方法:利用广西“桂妇儿健康服务信息管理系统”收集2017—2021年广西5岁以下儿童死亡报告卡和广西妇幼卫生年报数据,分析广西5岁以下儿童意外死亡原因、死亡率及变化趋势。结果:2017—2021年广西5岁以下儿童因意外伤害死亡3212人,意外死亡率为105.46/10万,意外死亡占5岁以下儿童死亡的22.77%。其中,农村儿童意外死亡率(109.64/10万)高于城市儿童(96.46/10万),1~4岁儿童(69.05/10万)意外死亡率高于婴儿(36.41/10万),男童意外死亡率(118.20/10万)高于女童(91.03/10万)。意外死亡构成比的分析结果显示,意外死亡儿童中,70.98%为农村儿童,65.47%为1~4岁儿童,59.43%为男童。意外死因排名中,意外窒息排在第1位,占35.74%,主要发生在婴儿期;溺水、交通意外分别排在第2、3位,占比分别为28.64%和14.04%,主要发生在1~4岁儿童。结论:意外死亡仍是广西5岁以下儿童死亡的主要死因,2017—2021年5岁以下儿童意外死亡率无明显变化,<3岁儿童、农村儿童、男童是意外伤害预防的重点人群,应针对不同年龄儿童制定相应的防范措施,降低儿童意外死亡率。 展开更多
关键词 意外伤害 死亡 5岁以下儿童 广西
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Medicolegal autopsies in children: Experience of a department of Legal Medicine in Brazil
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作者 Manoel Eugenio dos Santos Modelli Marco Agassiz de Almeida Vasques Riccardo Pratesi 《Forensic Medicine and Anatomy Research》 2013年第3期40-46,共7页
Purposes: The purpose of this study was to determine the pattern of mortality in children’s Federal District. Knowledge of the epidemiology of injuries is essential for planning, implementation and evaluation of prev... Purposes: The purpose of this study was to determine the pattern of mortality in children’s Federal District. Knowledge of the epidemiology of injuries is essential for planning, implementation and evaluation of preventive measures. Methods: We analyzed the forensic examination documents of all children under 12 years sent to the IML-DF, during 2010. The data analyzed included age, gender, cause of death (i.e.natural or external), mechanism of death (traffic accident, asphyxia, firearm injuries, poisoning, heat injuries) and the medical cause of death. Results: A large number of children (n = 123 total;n = 71 males, n = 52 females) were examined in the IML-DF, Brasília, Brazil. Mean age was 37.96 months, with a median of 12 months, and 21% of children were younger than 1 month. There were 62 cases (33 males and 29 female) classified as natural deaths. The average age for natural deaths was 18.72 months. Most cases of natural death occurred in the first year of life (n = 50), being prevalent in the first month of life (n = 24). Among the 62 cases analyzed, six were stillborns, 13 suffered intrauterine fetal distress (e.g. placental insufficiency, prematurity and meconium aspiration), 36 had lung problems (e.g. Acute respiratory distress syndrome (ARDS), bronchopneumonia, pulmonary hemorrhage, interstitial pneumonitis and infant respiratory distress syndrome (IRDS)), five had neurologicalproblems (e.g. hydrocephalus, hydranencephaly,convulsive seizures and meningitis) and two had undetermined cause of death. There were also isolated cases of heart disease, leukemia, diabetic ketoacidosis, peritonitis causedby acute appendicitisand amniotic bandsyndrome. There were 61 cases of deaths from external causes, as a consequence of the following: blunt instrument, firearm, physical agent (i.e.heat), physicochemical agent (i.e.asphyxia) and chemical agent (i.e.poisoning). Conclusions: The profile of deaths from external causesin this developing country follows a trend similar to trends reported in the literature for other developing countries. The majority of deaths are accidental, with traffic accidents being the most frequent cause, followed by asphyxia (i.e.aspiration of gastric contents and drownings). Sporadic cases of poisoning, injuries from firearms, accidents and fires also occur. 展开更多
关键词 Forensic AUTOPSIES VIOLENT deathS children MORTALITY Developing Country Patterns of MORTALITY
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儿童文学死亡书写的可能、限度及启示 被引量:3
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作者 吴翔宇 迂卓 《三峡大学学报(人文社会科学版)》 2023年第2期11-17,29,115,共9页
在现代儿童文学中,得益于儿童观的现代革新及对儿童文学分层的理性认知,“死亡”已不再是话语禁忌而成为被接纳的议题。在对死亡“写什么”与“怎么写”的表述中,受制于儿童文学文类的杂糅而衍生出对死亡阐释的可能性及阈限。在历史化... 在现代儿童文学中,得益于儿童观的现代革新及对儿童文学分层的理性认知,“死亡”已不再是话语禁忌而成为被接纳的议题。在对死亡“写什么”与“怎么写”的表述中,受制于儿童文学文类的杂糅而衍生出对死亡阐释的可能性及阈限。在历史化动态发展的语境中,儿童文学的死亡书写并不止于生命之殇的疼痛体验,而是同青少年的成长议题有机融合,从而扩充了死亡书写的长度、宽度与深度,这对于儿童文学自我封闭的本质主义起到了理论纠偏作用。同时,以死亡书写延展的生命重量对因幻想而衍生的文化轻逸产生了抵制效应。当然,死亡书写进入儿童文学文本也应是有限度的,如何针对儿童文学分层结构采用对应的叙事策略是问题的关键所在。 展开更多
关键词 死亡书写 儿童文学 话语禁忌 可能性 限制
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25例儿童患者应用免疫检查点抑制剂的不良反应调查和分析
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作者 杜丰 李哲 +1 位作者 郑英明 李新刚 《中国医院用药评价与分析》 2023年第12期1521-1523,1527,共4页
目的:调查和分析免疫检查点抑制剂在儿童患者应用中的不良反应。方法:回顾性调查2019年1月1日至2022年9月15日于该院接受程序性死亡受体1(PD-1)/程序性死亡受体配体1(PD-L1)抑制剂治疗各类恶性实体肿瘤和血液系统肿瘤的25例儿童患者(<... 目的:调查和分析免疫检查点抑制剂在儿童患者应用中的不良反应。方法:回顾性调查2019年1月1日至2022年9月15日于该院接受程序性死亡受体1(PD-1)/程序性死亡受体配体1(PD-L1)抑制剂治疗各类恶性实体肿瘤和血液系统肿瘤的25例儿童患者(<18周岁)病历(共137次入院记录),记录患儿接受治疗期间发生的所有不良反应信息,并进行严重程度分级、相关性评价和影响因素分析。结果:25例使用PD-1/PD-L1抑制剂的患儿中,16例患儿合计发生20次不良反应。患儿发生的不良反应主要为发热(8例,发生率为32%)、氨基转移酶升高(3例,发生率为12%)和凝血功能障碍(2例,发生率为8%),此外还有白细胞计数降低、咳嗽、皮疹、腹泻、便潜血、乏力及食欲减退(各1例,发生率均为4%)等;其中,1—2级不良反应19次,3—5级不良反应共1次;相关性为“很可能”的不良反应共15次。4例患儿在发生不良反应后再次接受治疗,有2例出现了新的不良反应。经分析,并发症涉及3个及以上系统对不良反应的发生率有显著影响。结论:儿童患者使用PD-1/PD-L1抑制剂时,其不良反应发生情况与成人有所差异,较成人而言需要更多关注。临床需注意用药监护,提高儿童用药的安全性。 展开更多
关键词 儿童 程序性死亡受体1/程序性死亡受体配体1抑制剂 免疫治疗 不良反应 相关性评价
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