Myopia in children remains a major public health problem worldwide,especially in some Asian countries such as China,Singapore and Japan.Although many interventions have been attempted,few has been proven to be effecti...Myopia in children remains a major public health problem worldwide,especially in some Asian countries such as China,Singapore and Japan.Although many interventions have been attempted,few has been proven to be effective in controlling onset and progression of myopia in children.Environmental factors,genetic susceptibility or ethnic differences can affect the efficacy of these interventions.However,many questions remain unclear and even controversial for controlling myopia.China has the biggest population with myopia,especially for children myopia.Thus,it is of importance to present what achievements Chinese scientists have made in the field of myopia control in children.We summarize the current findings on myopia control in children from the Anyang Childhood Eye Study,including epidemiological data,clinical trials,systematic reviews and meta-analyses,and compare them with studies in other countries to find potential clues for controlling myopia in children.展开更多
AIM:To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children,and to assess the risk factors associated with rapid myopia progression.METH...AIM:To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children,and to assess the risk factors associated with rapid myopia progression.METHODS:A total of 285 children,with refractive errors within the range of-6 diopters(D)between 5 and 14 years of age were included.After using 0.01%,or 0.025%,or 0.05% atropine,for about 1y,changes in refraction,axial lengths and frequency of adverse events were analyzed.Logistic regression analyses were performed to evaluate the risk factors associated with rapid myopia progression.RESULTS:The changes in the mean spherical equivalent values were -0.134 D/mo in the before atropine group,-0.070 D/mo in the 0.01% atropine group,-0.047 D/mo in the 0.025% atropine group,and -0.019 D/mo in the 0.05% atropine group,with significant differences between the groups(P〈0.001).The axial elongation was 0.046 mm/mo,0.037 mm/mo,0.025 mm/mo,and 0.019 mm/mo respectively,with significant differences between the groups(P=0.003).The incidence of photophobia and near vision difficulty was not different among the three atropine groups(P=0.425and P=0.356,respectively).Multivariate logistic regression analyses showed that only highly myopic parents were a significant predictive factor of rapid myopia progression in Korean children(odds ratio,8.155;95% confidence interval,3.626-18.342;P〈0.001).CONCLUSION:Treatment with 0.01%,0.025% and 0.05% atropine solution inhibits myopia progression in Korean children in a dose-dependent manner.Children with highly myopic parents preferentially shows a rapid myopia progression rate.展开更多
AIM: To investigate the relationship between higher- order aberration (HOA) and myopic progression in schoolchildren. ·METHODS: Between April 23 2011 and August 29, 2011 in the children’s myopia outpatient clini...AIM: To investigate the relationship between higher- order aberration (HOA) and myopic progression in schoolchildren. ·METHODS: Between April 23 2011 and August 29, 2011 in the children’s myopia outpatient clinic of the West China Hospital of Sichuan University, 148 eyes of 74 schoolchildren were reviewed. HOAs for a 6 -mm pupil were measured with an aberrometer. Myopic progression rate was defined according to the change in spherical equivalent refraction (SER) divided by the time span (years). Subjects with myopic progression rate of ≥0.50 diopters (D) were classified as the ’fast’group and the subjects with myopic progression rate of 【0.50D were classified as the’slow’group. A retrospective study was conducted to compare HOA between the two groups, using root mean square (RMS) values and Zernike coefficients. ·RESULTS: The RMS values of HOA (t =2.316, P =0.02), HOA without Z 4 0 (t =2.224, P =0.03),third-order aberrations (t’ =2.62, P =0.01), and coma (t’ =2.49, P =0.01) were significantly higher in the fast group than those in the slow group. The individual Zernike coefficients of Z 3 -1 (t = -2.072, P =0.04) and Z 5 1 (Z =-2.627, P =0.01) displayed statistically significant differences between the two groups. Significant correlations were found between the RMS values of HOA (r =0.193, P =0.019), RMS values of HOA without Z 4 0 (r =0.23, P =0.005), RMS values of coma(r =0.235,P =0.004),RMS values of third-order aberrations (r =0.243, P =0.003), and the progression rate. · CONCLUSION: Our results provide evidence of a relationship between HOA and myopic progression. In a future prospective longitudinal study, we aim to verify whether HOA is a risk factor for myopic progression.展开更多
Purpose: To observe the refractive status, especially the tendency for evolution of high myopia, in eyes of Chinese school children from Xi’an city.Methods: The study was conducted in 11514 eyes of the 5757students a...Purpose: To observe the refractive status, especially the tendency for evolution of high myopia, in eyes of Chinese school children from Xi’an city.Methods: The study was conducted in 11514 eyes of the 5757students aged between 7~18 years in Xi’an city primary and high schools. The inclusion criterion was >-6D of the spherical equivalent refraction. The object ophthalmic examinations were done, included non-cycloplegic objective refraction, visual acuity, intraocular pressure, fundus evaluation by ophthalmologists and nurses with professional training. Specially designed questionnaires were filled in and the data were statistically analyzed with SPSS10.0.Results: Of 11514 eyes, the detection rate was 81.4%(9376eyes) for myopia and 5.3%(615 eyes) for high myopia. High myopia was found in 2.6%.(300 eyes).of right eyes, 2.7%(315 eyes) in left eyes, and 2.4%(275 eyes) were in boys and 2.9%(340 eyes) in girls. Among 12 school grades, the detection rates of high myopia increased significantly with student age, with 0.9% in the 1stgrade of primary school and12.5% in the 3rd year of senior middle school. The average refractive error of spherical equivalent refraction was(-7.43±1.29) D with 95% confidence interval(-7.54,-7.33). No significant differences were found between the right and left eyes or both genders. The distribution of myopic severity was lowest(-6D).in primary school students younger than 12 years,was higher(-8D) in junior middle school students older than13 years, and highest(-13D) in senior middle school students.Conclusion: A continuous growth was evident in the severity of high myopia throughout 12 years of primary and middle school except for the first year of primary school, with growth occurring in two transitional stages between the senior primary and junior middle school years, and between the junior and senior middle school years. The distribution of high myopia was lowest, at-6D, in primary school, increased to-8D in junior middle school, and progressed to-10D in senior middle school, indicating a high risk of development of pathologic myopia during the students’ later lifespan. The adolescent period of 13 to 18 years of age in middle school is a critical period for the development of pathological myopia over-8D.展开更多
●AIM:To assess the influence of near work,time outdoor and parental myopia on the prevalence of myopia in school children in Aba,Nigeria.●METHODS:Primary and secondary school children aged between 8 and 15 y were ra...●AIM:To assess the influence of near work,time outdoor and parental myopia on the prevalence of myopia in school children in Aba,Nigeria.●METHODS:Primary and secondary school children aged between 8 and 15 y were randomly recruited from 12 schools in Aba.Information on family history,near work and outdoor activity was obtained using myopia risk factor questionnaire.Cycloplegic refraction was performed using autorefraction technique.Myopia was defined as spherical equivalent refraction(SER)≤-0.50 D in the poorer eye.Data were analysed for 1197(male:538 and female:659)children with full relevant data.●RESULTS:Risk of developing myopia was positively associated with parental myopia[odds ratio(OR):6.80;95%CI,2.76-16.74;P<0.01)for one myopic parent and(OR:9.47;95%CI,3.88-23.13;P<0.01)for two myopic parents,longer daily reading hour(OR:1.21;95%CI,1.03-1.42;P=0.02)and less time outdoors(OR:0.8;95%CI,0.74-0.87;P<0.01).●CONCLUSION:Parental history of myopia is the most important risk factor associated with myopia.In addition,children with both parents being myopic has increased odds of developing myopia than those with one myopic parent.It is recommended therefore,that children spend more time outdoors as this could reduce the prevalence and progression of myopia.展开更多
Introduction: Myopia is the refractive anomaly of the eye in which the conjugate focus of the retina is at some finite point in front of the eye, when the eye is not accommodating. Myopia is else known as short-sighte...Introduction: Myopia is the refractive anomaly of the eye in which the conjugate focus of the retina is at some finite point in front of the eye, when the eye is not accommodating. Myopia is else known as short-sightedness and is considered as one of the most frequent causes of reduced vision especially in adolescents. Adolescence is one of the life periods when most cases are diagnosed with myopia. Purpose: The aim of this study was to identify myopia in pre-school and school children (3 - 9 years old in Prishtina), to determine the prevalence of myopia among other refractive anomalies in cases included in the study;compare the prevalence of myopia in this population in Prishtina to other countries in the world;determine the effect of hereditary and socio-economic factors on the prevalence of myopia;and determine the degrees of myopia in our cases included in our study. Materials and Methods: This was a cross-sectional study involving 1027 pre-school children and pupils from 4 schools in Prishtina, aged 3 - 9 years old, who were screened for refractive anomalies, with a special focus on the incidence of myopia in this age group. The data were collected by screening children in the institutions of pre-school and primary school education, including 2 primary schools and two kindergarten during a two-year period 2010-2012 in Prishtina. Results: On the screening of pre-school and school children for refractive anomalies, were included 1027 subjects of ages 3 - 9 years old. Of the 1027 children screened 536 (52.2%) were male and 491 (47.8%) were female. Statistically, the prevalence of refractive anomalies in the total population studied is significant based on the resulting value (P Conclusions: The Prishtina study is a report of prevalence of myopia among pre-school and school-age children in the municipality. The study reveals that refractive error and myopia were significantly common finding among the study group, and the prevalence was found to be even higher in children within the school age-group. The number of newly diagnosed myopia was significant, suggesting the need for a robust school eye health programme, regular assessment of school children for refractive error and provision of timely refractive corrections.展开更多
AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and comparison.METHODS:The refractive error in 9...AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and comparison.METHODS:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without cycloplegia.The data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were calculated.RESULTS:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,respectively.However,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable range.For J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable range.Readers can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed together.However,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.展开更多
Uncorrected refractive error(URE) is a major health problem among school children. This study was aimed to determine the frequency and patterns of URE across 4 gradients of residential densities(urban, exurban, sub...Uncorrected refractive error(URE) is a major health problem among school children. This study was aimed to determine the frequency and patterns of URE across 4 gradients of residential densities(urban, exurban, suburban and rural). This was a cross-sectional study of school children from 3 districts in Yogyakarta and 1 district near Yogyakarta, Indonesia. The information regarding age, sex, school and school grader were recorded. The Snellen's chart was used to measure the visual acuity and to perform the subjective refraction. The district was then divided into urban, suburban, exurban and rural area based on their location and population. In total, 410 school children were included in the analyses(urban=79, exurban=73, suburban=160 and rural=98 school children). Urban school children revealed the worst visual acuity(P〈0.001) and it was significant when compared with exurban and rural. The proportion of URE among urban, suburban, exurban and rural area were 10.1%, 12.3%, 3.8%, and 1%, respectively, and it was significant when compared to the proportion of ametropia and corrected refractive error across residential densities(P=0.003). The risk of URE development in urban, suburban, exurban, and rural were 2.218(95%CI: 0.914-5.385), 3.019(95%CI: 1.266-7.197), 0.502(95%CI: 0.195-1.293), and 0.130(95%CI:0.017-0.972), respectively. Urban school children showed the worst visual acuity. The school children in urban and suburban residential area had 2 and 3 times higher risk of developing the URE.展开更多
AIM: To study effects of orthokeratology(Ortho-k) on accommodation function in myopic children. METHODS: A prospective, non-randomized, case-control study was performed from September to October 2016. Eighty-three...AIM: To study effects of orthokeratology(Ortho-k) on accommodation function in myopic children. METHODS: A prospective, non-randomized, case-control study was performed from September to October 2016. Eighty-three children with myopia were divided into two groups. One group was treated with the rigid contact lens for overnight Ortho-k, and the other was treated with single-vision spectacle lens(SVL). Accommodation function were assessed by accommodative amplitude(AA), accommodative sensitivity(AS), accommodative lag(Lag), negative relative accommodation(NRA), and positive relative accommodation(PRA) before and 1, 3, 6 and 12 mo after treated. RESULTS: Totally 72 myopic children were finished the follow-up: 37 in Ortho-k group and 35 in SVL group. Wearing time had a significant effect on AA, AS, Lag, and NRA of myopic children in two groups(all P〈0.05). Meanwhile, there was an interaction effect between wearing time and wearing types(FAA=5.3, FAS=45.5, FLag=7.0, FNRA=3.7, all P〈0.05). However, the between-group difference of AA(F=0.1), AS(F=3.2), Lag(F=1.1), NRA(F=0.3), and PRA(F=0.1) showed no significance. AA, AS, NRA, Lag and PRA were improved significantly in Ortho-k group within 1 to 6 mo after wearing. CONCLUSION: Wearing Ortho-k can improve the accommodation function of myopic children, which might be one of the mechanisms for myopia control.展开更多
AIM:To explore the topographic distribution features of choroidal thickness(CT)and retinal nerve fiber layer thickness(RNFLT),and determine the relationship between CT and ocular parameters in school-aged children.MET...AIM:To explore the topographic distribution features of choroidal thickness(CT)and retinal nerve fiber layer thickness(RNFLT),and determine the relationship between CT and ocular parameters in school-aged children.METHODS:The healthy school-aged children with low myopia or emmetropia in Wenzhou were recruited for this cross-sectional study.With high-density optical coherence tomography(HD-OCT)combined with MATLAB software,the CT and RNFLT values in the macular area were measured at different locations and compared.Statistical analyses were performed to evaluate the correlation between CT and ophthalmic parameters,such as spherical equivalent(SE)and the axial length(AL).RESULTS:A total of 279 school-aged children with 8.00±1.35 years of mean age(range,6-10 y)were included.The mean AL was 23.66±0.86 mm.The mean CT in CT-C(264.31±48.93μm)was thicker than that in CT-N1(249.54±50.52μm),and the average CT in the parafoveal region was also thicker than that in CT-N2(235.65±50.63μm).The subfoveal CT also varied substantially across refractive errors(P<0.001),and those with myopia(250.59±47.01μm)exhibited a thinner choroid compared with those with emmetropia(278.74±48.06μm).CT positively correlated with AL(y=11.12 x-4.15;R^2=0.18),and positively correlated with SE(y=90.07 x+17.916;R^2=14.2).The average RNFLT was thickest in the peripapillary region(236.35±19.03μm),the mean RNFLT-S(131.10±15.16μm)was thicker than the RNFLT-I(128.20±16.59μm),and the mean RNFLT-T(76.54±11.99μm)was thicker than the RNFLT-N(64.28±8.55μm).The variations in the RNFLT between quadrants did differ between those with myopia and emmetropia(P<0.05).CONCLUSION:We establish demographic information for the choroid and RNFLT.These findings provide information that should be considered in future analyses of the CT and RNFLT in OCT studies in school-aged children.展开更多
基金This work was supported by the capital health research and development of special(2016-4-2056)the Ministry of Science and Technology,the Major International(Regional)Joint Research Project of the National Natural Science Foundation of China(81120108007)+3 种基金the Major State Basic Research Development Program of China(’973’Program,2011CB504601)a Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(#RGPIN/131-2013)Beijing Nova Program(Z121107002512055)the National Natural Science Foundation of China(81300797).
文摘Myopia in children remains a major public health problem worldwide,especially in some Asian countries such as China,Singapore and Japan.Although many interventions have been attempted,few has been proven to be effective in controlling onset and progression of myopia in children.Environmental factors,genetic susceptibility or ethnic differences can affect the efficacy of these interventions.However,many questions remain unclear and even controversial for controlling myopia.China has the biggest population with myopia,especially for children myopia.Thus,it is of importance to present what achievements Chinese scientists have made in the field of myopia control in children.We summarize the current findings on myopia control in children from the Anyang Childhood Eye Study,including epidemiological data,clinical trials,systematic reviews and meta-analyses,and compare them with studies in other countries to find potential clues for controlling myopia in children.
基金Supported by the Catholic Medical Center Research Foundation made in the program year of 2018(No.5-2018-B0001-00006)
文摘AIM:To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children,and to assess the risk factors associated with rapid myopia progression.METHODS:A total of 285 children,with refractive errors within the range of-6 diopters(D)between 5 and 14 years of age were included.After using 0.01%,or 0.025%,or 0.05% atropine,for about 1y,changes in refraction,axial lengths and frequency of adverse events were analyzed.Logistic regression analyses were performed to evaluate the risk factors associated with rapid myopia progression.RESULTS:The changes in the mean spherical equivalent values were -0.134 D/mo in the before atropine group,-0.070 D/mo in the 0.01% atropine group,-0.047 D/mo in the 0.025% atropine group,and -0.019 D/mo in the 0.05% atropine group,with significant differences between the groups(P〈0.001).The axial elongation was 0.046 mm/mo,0.037 mm/mo,0.025 mm/mo,and 0.019 mm/mo respectively,with significant differences between the groups(P=0.003).The incidence of photophobia and near vision difficulty was not different among the three atropine groups(P=0.425and P=0.356,respectively).Multivariate logistic regression analyses showed that only highly myopic parents were a significant predictive factor of rapid myopia progression in Korean children(odds ratio,8.155;95% confidence interval,3.626-18.342;P〈0.001).CONCLUSION:Treatment with 0.01%,0.025% and 0.05% atropine solution inhibits myopia progression in Korean children in a dose-dependent manner.Children with highly myopic parents preferentially shows a rapid myopia progression rate.
基金Sichuan Province Scientific Plan Project,China (No. 2010SZ0087)
文摘AIM: To investigate the relationship between higher- order aberration (HOA) and myopic progression in schoolchildren. ·METHODS: Between April 23 2011 and August 29, 2011 in the children’s myopia outpatient clinic of the West China Hospital of Sichuan University, 148 eyes of 74 schoolchildren were reviewed. HOAs for a 6 -mm pupil were measured with an aberrometer. Myopic progression rate was defined according to the change in spherical equivalent refraction (SER) divided by the time span (years). Subjects with myopic progression rate of ≥0.50 diopters (D) were classified as the ’fast’group and the subjects with myopic progression rate of 【0.50D were classified as the’slow’group. A retrospective study was conducted to compare HOA between the two groups, using root mean square (RMS) values and Zernike coefficients. ·RESULTS: The RMS values of HOA (t =2.316, P =0.02), HOA without Z 4 0 (t =2.224, P =0.03),third-order aberrations (t’ =2.62, P =0.01), and coma (t’ =2.49, P =0.01) were significantly higher in the fast group than those in the slow group. The individual Zernike coefficients of Z 3 -1 (t = -2.072, P =0.04) and Z 5 1 (Z =-2.627, P =0.01) displayed statistically significant differences between the two groups. Significant correlations were found between the RMS values of HOA (r =0.193, P =0.019), RMS values of HOA without Z 4 0 (r =0.23, P =0.005), RMS values of coma(r =0.235,P =0.004),RMS values of third-order aberrations (r =0.243, P =0.003), and the progression rate. · CONCLUSION: Our results provide evidence of a relationship between HOA and myopic progression. In a future prospective longitudinal study, we aim to verify whether HOA is a risk factor for myopic progression.
基金Supported by Shaanxi Province Scientific&Technology Committee(No.2009K17-02)
文摘Purpose: To observe the refractive status, especially the tendency for evolution of high myopia, in eyes of Chinese school children from Xi’an city.Methods: The study was conducted in 11514 eyes of the 5757students aged between 7~18 years in Xi’an city primary and high schools. The inclusion criterion was >-6D of the spherical equivalent refraction. The object ophthalmic examinations were done, included non-cycloplegic objective refraction, visual acuity, intraocular pressure, fundus evaluation by ophthalmologists and nurses with professional training. Specially designed questionnaires were filled in and the data were statistically analyzed with SPSS10.0.Results: Of 11514 eyes, the detection rate was 81.4%(9376eyes) for myopia and 5.3%(615 eyes) for high myopia. High myopia was found in 2.6%.(300 eyes).of right eyes, 2.7%(315 eyes) in left eyes, and 2.4%(275 eyes) were in boys and 2.9%(340 eyes) in girls. Among 12 school grades, the detection rates of high myopia increased significantly with student age, with 0.9% in the 1stgrade of primary school and12.5% in the 3rd year of senior middle school. The average refractive error of spherical equivalent refraction was(-7.43±1.29) D with 95% confidence interval(-7.54,-7.33). No significant differences were found between the right and left eyes or both genders. The distribution of myopic severity was lowest(-6D).in primary school students younger than 12 years,was higher(-8D) in junior middle school students older than13 years, and highest(-13D) in senior middle school students.Conclusion: A continuous growth was evident in the severity of high myopia throughout 12 years of primary and middle school except for the first year of primary school, with growth occurring in two transitional stages between the senior primary and junior middle school years, and between the junior and senior middle school years. The distribution of high myopia was lowest, at-6D, in primary school, increased to-8D in junior middle school, and progressed to-10D in senior middle school, indicating a high risk of development of pathologic myopia during the students’ later lifespan. The adolescent period of 13 to 18 years of age in middle school is a critical period for the development of pathological myopia over-8D.
基金Supported by the University of KwaZulu-Natal(UKZN)Developing Research Innovation,Localisation and Leadership in South Africa(DRILL).DRILL,is a NIH D43 grant(D43TW010131)awarded to UKZN in 2015 to support a research training and induction programme for early career academics.
文摘●AIM:To assess the influence of near work,time outdoor and parental myopia on the prevalence of myopia in school children in Aba,Nigeria.●METHODS:Primary and secondary school children aged between 8 and 15 y were randomly recruited from 12 schools in Aba.Information on family history,near work and outdoor activity was obtained using myopia risk factor questionnaire.Cycloplegic refraction was performed using autorefraction technique.Myopia was defined as spherical equivalent refraction(SER)≤-0.50 D in the poorer eye.Data were analysed for 1197(male:538 and female:659)children with full relevant data.●RESULTS:Risk of developing myopia was positively associated with parental myopia[odds ratio(OR):6.80;95%CI,2.76-16.74;P<0.01)for one myopic parent and(OR:9.47;95%CI,3.88-23.13;P<0.01)for two myopic parents,longer daily reading hour(OR:1.21;95%CI,1.03-1.42;P=0.02)and less time outdoors(OR:0.8;95%CI,0.74-0.87;P<0.01).●CONCLUSION:Parental history of myopia is the most important risk factor associated with myopia.In addition,children with both parents being myopic has increased odds of developing myopia than those with one myopic parent.It is recommended therefore,that children spend more time outdoors as this could reduce the prevalence and progression of myopia.
文摘Introduction: Myopia is the refractive anomaly of the eye in which the conjugate focus of the retina is at some finite point in front of the eye, when the eye is not accommodating. Myopia is else known as short-sightedness and is considered as one of the most frequent causes of reduced vision especially in adolescents. Adolescence is one of the life periods when most cases are diagnosed with myopia. Purpose: The aim of this study was to identify myopia in pre-school and school children (3 - 9 years old in Prishtina), to determine the prevalence of myopia among other refractive anomalies in cases included in the study;compare the prevalence of myopia in this population in Prishtina to other countries in the world;determine the effect of hereditary and socio-economic factors on the prevalence of myopia;and determine the degrees of myopia in our cases included in our study. Materials and Methods: This was a cross-sectional study involving 1027 pre-school children and pupils from 4 schools in Prishtina, aged 3 - 9 years old, who were screened for refractive anomalies, with a special focus on the incidence of myopia in this age group. The data were collected by screening children in the institutions of pre-school and primary school education, including 2 primary schools and two kindergarten during a two-year period 2010-2012 in Prishtina. Results: On the screening of pre-school and school children for refractive anomalies, were included 1027 subjects of ages 3 - 9 years old. Of the 1027 children screened 536 (52.2%) were male and 491 (47.8%) were female. Statistically, the prevalence of refractive anomalies in the total population studied is significant based on the resulting value (P Conclusions: The Prishtina study is a report of prevalence of myopia among pre-school and school-age children in the municipality. The study reveals that refractive error and myopia were significantly common finding among the study group, and the prevalence was found to be even higher in children within the school age-group. The number of newly diagnosed myopia was significant, suggesting the need for a robust school eye health programme, regular assessment of school children for refractive error and provision of timely refractive corrections.
基金Supported by the National Natural Science Foundation of China(No.81873683).
文摘AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and comparison.METHODS:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without cycloplegia.The data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were calculated.RESULTS:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,respectively.However,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable range.For J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable range.Readers can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed together.However,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.
基金Supported by Department of Ophthalmology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
文摘Uncorrected refractive error(URE) is a major health problem among school children. This study was aimed to determine the frequency and patterns of URE across 4 gradients of residential densities(urban, exurban, suburban and rural). This was a cross-sectional study of school children from 3 districts in Yogyakarta and 1 district near Yogyakarta, Indonesia. The information regarding age, sex, school and school grader were recorded. The Snellen's chart was used to measure the visual acuity and to perform the subjective refraction. The district was then divided into urban, suburban, exurban and rural area based on their location and population. In total, 410 school children were included in the analyses(urban=79, exurban=73, suburban=160 and rural=98 school children). Urban school children revealed the worst visual acuity(P〈0.001) and it was significant when compared with exurban and rural. The proportion of URE among urban, suburban, exurban and rural area were 10.1%, 12.3%, 3.8%, and 1%, respectively, and it was significant when compared to the proportion of ametropia and corrected refractive error across residential densities(P=0.003). The risk of URE development in urban, suburban, exurban, and rural were 2.218(95%CI: 0.914-5.385), 3.019(95%CI: 1.266-7.197), 0.502(95%CI: 0.195-1.293), and 0.130(95%CI:0.017-0.972), respectively. Urban school children showed the worst visual acuity. The school children in urban and suburban residential area had 2 and 3 times higher risk of developing the URE.
基金Supported by Special Scientific Research Program of Shaanxi Provincial Education Department(No.17JK0662)
文摘AIM: To study effects of orthokeratology(Ortho-k) on accommodation function in myopic children. METHODS: A prospective, non-randomized, case-control study was performed from September to October 2016. Eighty-three children with myopia were divided into two groups. One group was treated with the rigid contact lens for overnight Ortho-k, and the other was treated with single-vision spectacle lens(SVL). Accommodation function were assessed by accommodative amplitude(AA), accommodative sensitivity(AS), accommodative lag(Lag), negative relative accommodation(NRA), and positive relative accommodation(PRA) before and 1, 3, 6 and 12 mo after treated. RESULTS: Totally 72 myopic children were finished the follow-up: 37 in Ortho-k group and 35 in SVL group. Wearing time had a significant effect on AA, AS, Lag, and NRA of myopic children in two groups(all P〈0.05). Meanwhile, there was an interaction effect between wearing time and wearing types(FAA=5.3, FAS=45.5, FLag=7.0, FNRA=3.7, all P〈0.05). However, the between-group difference of AA(F=0.1), AS(F=3.2), Lag(F=1.1), NRA(F=0.3), and PRA(F=0.1) showed no significance. AA, AS, NRA, Lag and PRA were improved significantly in Ortho-k group within 1 to 6 mo after wearing. CONCLUSION: Wearing Ortho-k can improve the accommodation function of myopic children, which might be one of the mechanisms for myopia control.
基金Supported by Zhejiang Province University Student Planted Talent Plan(No.2015R413023)Public Welfare Social Development Science and Technology Project of Wenzhou Science and Technologies Bureau(No Y20160443).
文摘AIM:To explore the topographic distribution features of choroidal thickness(CT)and retinal nerve fiber layer thickness(RNFLT),and determine the relationship between CT and ocular parameters in school-aged children.METHODS:The healthy school-aged children with low myopia or emmetropia in Wenzhou were recruited for this cross-sectional study.With high-density optical coherence tomography(HD-OCT)combined with MATLAB software,the CT and RNFLT values in the macular area were measured at different locations and compared.Statistical analyses were performed to evaluate the correlation between CT and ophthalmic parameters,such as spherical equivalent(SE)and the axial length(AL).RESULTS:A total of 279 school-aged children with 8.00±1.35 years of mean age(range,6-10 y)were included.The mean AL was 23.66±0.86 mm.The mean CT in CT-C(264.31±48.93μm)was thicker than that in CT-N1(249.54±50.52μm),and the average CT in the parafoveal region was also thicker than that in CT-N2(235.65±50.63μm).The subfoveal CT also varied substantially across refractive errors(P<0.001),and those with myopia(250.59±47.01μm)exhibited a thinner choroid compared with those with emmetropia(278.74±48.06μm).CT positively correlated with AL(y=11.12 x-4.15;R^2=0.18),and positively correlated with SE(y=90.07 x+17.916;R^2=14.2).The average RNFLT was thickest in the peripapillary region(236.35±19.03μm),the mean RNFLT-S(131.10±15.16μm)was thicker than the RNFLT-I(128.20±16.59μm),and the mean RNFLT-T(76.54±11.99μm)was thicker than the RNFLT-N(64.28±8.55μm).The variations in the RNFLT between quadrants did differ between those with myopia and emmetropia(P<0.05).CONCLUSION:We establish demographic information for the choroid and RNFLT.These findings provide information that should be considered in future analyses of the CT and RNFLT in OCT studies in school-aged children.