In the present experiments,68 cases of chronic superficial gastritis with insufficieney of Spleen Yang were randomly divided into electrical heat acupuncture group（EHAG,n=32）,filiform needling group（FNG,n=19）and m...In the present experiments,68 cases of chronic superficial gastritis with insufficieney of Spleen Yang were randomly divided into electrical heat acupuncture group（EHAG,n=32）,filiform needling group（FNG,n=19）and medication group（MG,n=17）.Bilateral Zusanli（ST 36）,Neiguan（PC 6）,Sanyinjiao（SP 6）and Hegu（LI 4）were selected for both EHAG andFNG.The needles applied at Zusanli and Neiguan in EHAG were connected to a DR 2-1 electricalheat acupuncture apparatus.The main drug administered in MG was Weimeisu.Thirty treatmentsmade a course,and the treatment was given once daily.The therapeutic effects were evaluated after 3courses of treatment.The results were as follows:The total effective rate was 90.63％ in EHAG,63.16％ in FNG and 29.41％ in MG.There was a remarkable difference in therapeutic effects amongthe three groups（X^2=19.20,P【0.01）.展开更多
The pediatric body of pure yang,the liver is often more than enough,the spleen is often insufficient,Yang moving surplus,and Yin essence is insufficient,at the same time,children are the body of immature yin and yang,...The pediatric body of pure yang,the liver is often more than enough,the spleen is often insufficient,Yang moving surplus,and Yin essence is insufficient,at the same time,children are the body of immature yin and yang,prone to imbalance of yin and Yang,so deficiency of phlegm accumulation and endogenous liver wind,feel ill at ease,dysfunction of lung qi,Insufficiency of kidney yin are the fundamental pathogenesis of children with tic syndrome.This article discusses the relationship between children with tic syndrome and the five Zang-organs,and how to regulate the viscera through regulating the spleen and stomach system,treating both manifestation and root cause of disease,and put forward a new treatment that the spleen and stomach system should be taken as the center to regulate the five Zang-organs in children with tic syndrome,which should be resolved in order of importance and urgency and treated in stages.展开更多
School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin D provision in children of all age ...School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin D provision in children of all age groups has not still resulted in implementation of mass prophylaxis of hypovitaminosis D. There are several factors on which blood concentration of 25 （OH） D--calcidiol-depends. However, it is evident that among numerous factors we should orient on several most significant and develop correction scheme for the deficient condition in every region. Aim： to assess vitamin D levels in adolescents residing in Moscow, to correct their calcidiol status based on a baseline blood concentration of the transport metabolite. Materials and methods： 769 adolescents aged 11-18 years were examined and their blood concentration of 25 （OH） D was determined. Then, 218 patients were randomized to 2 groups： the treatment group received food supplement ＂Minisun~ Vitamin D3＂ in tablets, the control group received placebo. Cholecalciferol dosage was prescribed depending on the baseline calcidiol level in patients. The study continued for 6 months, after that blood was re-withdrawn for calcidiol level. Results： low calcidiol provision was observed among school children： median 25 （OH） D was 16.3 [11.4-20.8] ng/mL, only 5.2% of patients had normal blood concentration of calcidiol. There-examination showed significant differences in vitamin D status in the treatment and control group, in the meantime, during cholecalciferol supplementation, median 25 （OH） D in patients of the treatment group was increased from 16.2 [ 12.25-19.3] ng/mL to 24.2 [21.05-26.4] ng/mL （p 〈 0.001）. Conclusions： the larger part of child population--70.6% has 25 （OH） D concentration 〈 20 ng/mL, cholecalciferol doses used in the study allow eliminating calcidiol deficiency and overcome the boundary of 20 ng/mL, but for normalization of vitamin D status in blood of adolescents residing in Moscow higher dosages shall be used which is to be confirmed by further studies.展开更多
目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温...目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温肾汤治疗,2周为1个疗程,两组均治疗2个疗程。比较治疗前后两组患者中医症状评分(畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛)、肾功能相关损伤指标(24 h Pro、BUN、Ccr和GFR)及肾纤维化相关指标(CTGF、CIV、PCⅢ和BMP-7)变化情况及临床疗效。结果:对照组临床总有效率为77.1%(37/48),观察组临床总有效率为91.7%(44/48),差异有统计学意义(P<0.05);治疗后两组患者畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛的中医症状评分均较治疗前显著降低(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者24 h Pro、BUN水平均较治疗前显著降低(P<0.05),Ccr、GFR水平显著升高(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者CTGF、CIV及PCⅢ水平较治疗前明显降低(P<0.05),BMP-7水平明显升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论:温肾汤可以有效改善慢性肾功能不全脾肾阳虚证患者的肾功能,降低蛋白尿,显著抑制肾脏纤维化。展开更多
[目的]结合数据挖掘及网络药理学,探讨运脾法治疗儿童功能性便秘的用药规律及作用机制。[方法]收集562例功能性便秘患儿病案,采用SPSS Statistic 24.0软件进行聚类分析,SPSS Modeler 18.0软件进行关联规则分析,Liquorice软件进行复杂网...[目的]结合数据挖掘及网络药理学,探讨运脾法治疗儿童功能性便秘的用药规律及作用机制。[方法]收集562例功能性便秘患儿病案,采用SPSS Statistic 24.0软件进行聚类分析,SPSS Modeler 18.0软件进行关联规则分析,Liquorice软件进行复杂网络分析,得出核心方药。运用中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、中药分子机制生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)数据库筛选核心方活性成分及靶点,通过基因组注释数据平台(Genome Annotation Database Platform,GeneCards)数据库筛选功能性便秘相关靶点,取交集后获得预测靶标。基于蛋白质基因相互作用分析(Search Tool for the Retrieval of Interacting Genes/Proteins,STRING)数据库构建靶基因蛋白互作网络(protein-protein interaction,PPI),利用Cytoscape 3.8.0软件建立核心方成分-便秘-靶点网络图,借助Network Analyzer工具进行拓扑分析,确定核心靶点。基于STRING数据库,使用R语言4.2.2进行基因本体(gene ontology,GO)功能富集与京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析。[结果]所纳病案包含1121诊次方药记录,各疗程的症状改善率在86%~97%,便秘三大主症的改善率均在90%左右。涉及中药119味,药性以寒、平为主,药味以苦、甘居多,归经多属胃、脾。通过药物关联、聚类和复杂网络分析得到9味药物构成的核心组方。核心组方调治便秘的主要活性成分为槲皮素、甲基庚烯酮、胆汁三烯、烟酸、木犀草素、山柰酚、汉黄芩素。关键靶点包括前列腺素内过氧化物合酶2(prostaglandin-endoperoxide synthase 2,PTGS2)、V-Jun肉瘤病毒17癌基因同源物(V-Jun sarcoma virus 17 oncogene homolog,JUN)、蛋白激酶B1(protein kinase B1,AKT1)、磷酸肌醇-3-激酶调节亚基1(phosphoinositide-3-kinase regulatory subunit 1,PIK3R1)、磷脂酰肌醇-3-激酶α催化亚基(phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alpha isoform,PIK3CA)。对炎症相关通路如磷脂酰肌醇-3-激酶/蛋白激酶B(phosphatidylinositol-3-kinase/protein kinase B,PI3K/AKT)的调节可能是核心组方改善便秘的作用机制。[结论]运脾法治疗小儿便秘核心方包括麸炒枳实、厚朴、生白术、鸡内金、焦山楂、连翘、决明子、火麻仁、胡黄连,其主要成分可能通过影响炎症因子水平、修复肠道黏膜以恢复肠道平滑肌功能,改善便秘症状,对运脾法的临床应用及儿童功能性便秘的中医药治疗有一定借鉴意义。展开更多
文摘In the present experiments,68 cases of chronic superficial gastritis with insufficieney of Spleen Yang were randomly divided into electrical heat acupuncture group（EHAG,n=32）,filiform needling group（FNG,n=19）and medication group（MG,n=17）.Bilateral Zusanli（ST 36）,Neiguan（PC 6）,Sanyinjiao（SP 6）and Hegu（LI 4）were selected for both EHAG andFNG.The needles applied at Zusanli and Neiguan in EHAG were connected to a DR 2-1 electricalheat acupuncture apparatus.The main drug administered in MG was Weimeisu.Thirty treatmentsmade a course,and the treatment was given once daily.The therapeutic effects were evaluated after 3courses of treatment.The results were as follows:The total effective rate was 90.63％ in EHAG,63.16％ in FNG and 29.41％ in MG.There was a remarkable difference in therapeutic effects amongthe three groups（X^2=19.20,P【0.01）.
文摘The pediatric body of pure yang,the liver is often more than enough,the spleen is often insufficient,Yang moving surplus,and Yin essence is insufficient,at the same time,children are the body of immature yin and yang,prone to imbalance of yin and Yang,so deficiency of phlegm accumulation and endogenous liver wind,feel ill at ease,dysfunction of lung qi,Insufficiency of kidney yin are the fundamental pathogenesis of children with tic syndrome.This article discusses the relationship between children with tic syndrome and the five Zang-organs,and how to regulate the viscera through regulating the spleen and stomach system,treating both manifestation and root cause of disease,and put forward a new treatment that the spleen and stomach system should be taken as the center to regulate the five Zang-organs in children with tic syndrome,which should be resolved in order of importance and urgency and treated in stages.
文摘School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin D provision in children of all age groups has not still resulted in implementation of mass prophylaxis of hypovitaminosis D. There are several factors on which blood concentration of 25 （OH） D--calcidiol-depends. However, it is evident that among numerous factors we should orient on several most significant and develop correction scheme for the deficient condition in every region. Aim： to assess vitamin D levels in adolescents residing in Moscow, to correct their calcidiol status based on a baseline blood concentration of the transport metabolite. Materials and methods： 769 adolescents aged 11-18 years were examined and their blood concentration of 25 （OH） D was determined. Then, 218 patients were randomized to 2 groups： the treatment group received food supplement ＂Minisun~ Vitamin D3＂ in tablets, the control group received placebo. Cholecalciferol dosage was prescribed depending on the baseline calcidiol level in patients. The study continued for 6 months, after that blood was re-withdrawn for calcidiol level. Results： low calcidiol provision was observed among school children： median 25 （OH） D was 16.3 [11.4-20.8] ng/mL, only 5.2% of patients had normal blood concentration of calcidiol. There-examination showed significant differences in vitamin D status in the treatment and control group, in the meantime, during cholecalciferol supplementation, median 25 （OH） D in patients of the treatment group was increased from 16.2 [ 12.25-19.3] ng/mL to 24.2 [21.05-26.4] ng/mL （p 〈 0.001）. Conclusions： the larger part of child population--70.6% has 25 （OH） D concentration 〈 20 ng/mL, cholecalciferol doses used in the study allow eliminating calcidiol deficiency and overcome the boundary of 20 ng/mL, but for normalization of vitamin D status in blood of adolescents residing in Moscow higher dosages shall be used which is to be confirmed by further studies.
文摘目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温肾汤治疗,2周为1个疗程,两组均治疗2个疗程。比较治疗前后两组患者中医症状评分(畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛)、肾功能相关损伤指标(24 h Pro、BUN、Ccr和GFR)及肾纤维化相关指标(CTGF、CIV、PCⅢ和BMP-7)变化情况及临床疗效。结果:对照组临床总有效率为77.1%(37/48),观察组临床总有效率为91.7%(44/48),差异有统计学意义(P<0.05);治疗后两组患者畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛的中医症状评分均较治疗前显著降低(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者24 h Pro、BUN水平均较治疗前显著降低(P<0.05),Ccr、GFR水平显著升高(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者CTGF、CIV及PCⅢ水平较治疗前明显降低(P<0.05),BMP-7水平明显升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论:温肾汤可以有效改善慢性肾功能不全脾肾阳虚证患者的肾功能,降低蛋白尿,显著抑制肾脏纤维化。
文摘[目的]结合数据挖掘及网络药理学,探讨运脾法治疗儿童功能性便秘的用药规律及作用机制。[方法]收集562例功能性便秘患儿病案,采用SPSS Statistic 24.0软件进行聚类分析,SPSS Modeler 18.0软件进行关联规则分析,Liquorice软件进行复杂网络分析,得出核心方药。运用中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、中药分子机制生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)数据库筛选核心方活性成分及靶点,通过基因组注释数据平台(Genome Annotation Database Platform,GeneCards)数据库筛选功能性便秘相关靶点,取交集后获得预测靶标。基于蛋白质基因相互作用分析(Search Tool for the Retrieval of Interacting Genes/Proteins,STRING)数据库构建靶基因蛋白互作网络(protein-protein interaction,PPI),利用Cytoscape 3.8.0软件建立核心方成分-便秘-靶点网络图,借助Network Analyzer工具进行拓扑分析,确定核心靶点。基于STRING数据库,使用R语言4.2.2进行基因本体(gene ontology,GO)功能富集与京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析。[结果]所纳病案包含1121诊次方药记录,各疗程的症状改善率在86%~97%,便秘三大主症的改善率均在90%左右。涉及中药119味,药性以寒、平为主,药味以苦、甘居多,归经多属胃、脾。通过药物关联、聚类和复杂网络分析得到9味药物构成的核心组方。核心组方调治便秘的主要活性成分为槲皮素、甲基庚烯酮、胆汁三烯、烟酸、木犀草素、山柰酚、汉黄芩素。关键靶点包括前列腺素内过氧化物合酶2(prostaglandin-endoperoxide synthase 2,PTGS2)、V-Jun肉瘤病毒17癌基因同源物(V-Jun sarcoma virus 17 oncogene homolog,JUN)、蛋白激酶B1(protein kinase B1,AKT1)、磷酸肌醇-3-激酶调节亚基1(phosphoinositide-3-kinase regulatory subunit 1,PIK3R1)、磷脂酰肌醇-3-激酶α催化亚基(phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alpha isoform,PIK3CA)。对炎症相关通路如磷脂酰肌醇-3-激酶/蛋白激酶B(phosphatidylinositol-3-kinase/protein kinase B,PI3K/AKT)的调节可能是核心组方改善便秘的作用机制。[结论]运脾法治疗小儿便秘核心方包括麸炒枳实、厚朴、生白术、鸡内金、焦山楂、连翘、决明子、火麻仁、胡黄连,其主要成分可能通过影响炎症因子水平、修复肠道黏膜以恢复肠道平滑肌功能,改善便秘症状,对运脾法的临床应用及儿童功能性便秘的中医药治疗有一定借鉴意义。
