Objective:To explore the detection and clinical significance of immune function, inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection.Methods: A total of 122 children with Mycoplasma pn...Objective:To explore the detection and clinical significance of immune function, inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection.Methods: A total of 122 children with Mycoplasma pneumoniae from September 2015 to February 2017 were selected as the observation group, while 120 healthy children were selected as the control group. The differences of immunoglobulin, T lymphocyte subsets, inflammatory factors and erythrocyte sedimentation rate (ESR) were compared in the two groups, and the correlation between ESR and inflammatory factors was analyzed.Results: There was a significant difference in peripheral blood T lymphocyte level between the two groups;CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group, while CD8+ was significantly higher in the observation group than in the control group. The IgA of the observation group was significantly lower than that of the control group, and there was no significant difference between IgG and the control group, and IgM was significantly higher than that of the control group. The two groups of hypersensitive C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and ESR expression level were significant differences;the hs-CRP, TNF-α, IFN-γ and ESR in the observation group were significantly higher than those in the control group;the ESR of the children with mycoplasma pneumonia was positively correlated with the level of hs-CRP, TNF-α and IFN-γ, which was statistically significant.Conclusions:The cell immunity, humoral immune function of children with Mycoplasma pneumoniae infection are relatively low, and the inflammatory reaction is more severe, and the inflammatory factors of the body are positively related to the level of ESR expression.展开更多
Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children ...Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children with MPP hospitalized from September 2014 to May 2015 were selected as the observation group and divided into two groups of MPP acute period and recovery period on the basis of the infection degree, and 50 healthy children were selected as control group at the same time, detect the immunoglobulin (IgG, IgA, IgM) and complement (C3, C4), peripheral T lymphocyte subsets (CD3+, CD4+, CD8+) and inflammatory factors (IL-2, IL-6, TNF-α, IL-8, IL-10, IL-13) of three groups of infants.Results:immunoglobulin IgG levels of recovery period were significantly higher than that in acute stage and the control group, IgA levels of acute phase and recovery phase were significantly lower than the control group, IgM and complement C3 levels in acute stage were significantly higher than the control group, during the recovery period tended to be normal, complement C4 in acute stage levels were significantly higher than those in recovery period and both higher than the control group. The CD3+, CD4+ and CD4/CD8 ratio of MPP in acute stage and recovery phase were significantly lower than the control group, and these numerical indexes of the recovery period were significantly higher than the acute stage, CD8+ levels in acute stage were significantly higher than that in recovery period and both higher than control group. Compared with the control group ,The levels of inflammatory cytokines IL-2 in the acute phase and recovery phase were significantly decreased, and the recovery period was significantly higher than that in acute stage, the test results that the levels of IL-6, TNF-α, IL-8, IL-10 and IL-13 in acute phase and recovery phase were significantly higher than those in control group and the recovery period was significantly lower than that in the acute stage.Conclusion:The body humoral immune function and cellular immune function damage caused by MP infection in infants and young children could lead to the disorder of immune system and the abnormal expression of inflammatory cytokines. Therefore, Therefore, the real-time monitoring the dynamic level of the indicators can define the infants and young children's condition, improve the recovery rate, and have a certain guiding significance of the clinical diagnosis of infants and young children .展开更多
目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片...目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片口服治疗。研究组在对照组治疗的基础上给予小青龙汤加减治疗。观察两组患者临床疗效、肺功能[用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)以及第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)]、气道高反应性、复发情况,并检测血清白细胞介素(interleukin,IL)-4、IL-5与外周血嗜酸性粒细胞(eosinophil,EOS)水平。结果:研究组有效率91.30%,对照组有效率为76.09%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后FVC、PEF、FEV1水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后最小诱发累积量、促使气道阻力增加至基础值的135%所需要的组胺累积剂量高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-4、IL-5与外周血EOS低于对照组,差异有统计学意义(P<0.05)。研究组复发率为19.05%(8/42),对照组复发率为42.86%(15/35),研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤加减治疗治疗小儿支原体肺炎,能改善患者肺功能,减轻患儿气道高反应性,调节血清IL-4、IL-5水平以及外周血EOS水平,降低复发率。展开更多
目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。...目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。所有患儿均接受布地奈德雾化吸入疗法,普通组患儿采用普通俯卧位机械通气,配合组患儿采用俯卧位机械通气,对比两组患儿的肺功能[用力肺活量(forced vital capacity,FVC)、呼气峰值体积流量(peak expiratory flow,PEF)、第1秒钟用力呼气容积(forced expiratory vol⁃ume in the first second,FEV_(1))]、免疫功能和不良反应发生情况。结果治疗前,两组患儿的肺功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的FVC、PEF、FEV_(1)均高于普通组,差异有统计学意义(P均<0.05)。治疗前,两组患儿的免疫功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的成熟T淋巴细胞(cluster of differentiation 3^(+),CD3^(+))、辅助性T淋巴细胞(cluster of differentiation 4^(+),CD4^(+))、CD4^(+)/CD8^(+)均高于普通组患儿,差异有统计学意义(P均<0.05)。配合组患儿不良反应发生率为3.39%(4/118),低于普通组患儿的5.93%(7/118),差异无统计学意义(χ^(2)=0.858,P>0.05)。结论针对重症肺炎患儿,应用俯卧位机械通气配合布地奈德雾化吸入疗法能实现较为理想的临床效果,患儿肺功能与免疫功能得到了有效改善,且安全性较高。展开更多
文摘Objective:To explore the detection and clinical significance of immune function, inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection.Methods: A total of 122 children with Mycoplasma pneumoniae from September 2015 to February 2017 were selected as the observation group, while 120 healthy children were selected as the control group. The differences of immunoglobulin, T lymphocyte subsets, inflammatory factors and erythrocyte sedimentation rate (ESR) were compared in the two groups, and the correlation between ESR and inflammatory factors was analyzed.Results: There was a significant difference in peripheral blood T lymphocyte level between the two groups;CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group, while CD8+ was significantly higher in the observation group than in the control group. The IgA of the observation group was significantly lower than that of the control group, and there was no significant difference between IgG and the control group, and IgM was significantly higher than that of the control group. The two groups of hypersensitive C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and ESR expression level were significant differences;the hs-CRP, TNF-α, IFN-γ and ESR in the observation group were significantly higher than those in the control group;the ESR of the children with mycoplasma pneumonia was positively correlated with the level of hs-CRP, TNF-α and IFN-γ, which was statistically significant.Conclusions:The cell immunity, humoral immune function of children with Mycoplasma pneumoniae infection are relatively low, and the inflammatory reaction is more severe, and the inflammatory factors of the body are positively related to the level of ESR expression.
文摘Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children with MPP hospitalized from September 2014 to May 2015 were selected as the observation group and divided into two groups of MPP acute period and recovery period on the basis of the infection degree, and 50 healthy children were selected as control group at the same time, detect the immunoglobulin (IgG, IgA, IgM) and complement (C3, C4), peripheral T lymphocyte subsets (CD3+, CD4+, CD8+) and inflammatory factors (IL-2, IL-6, TNF-α, IL-8, IL-10, IL-13) of three groups of infants.Results:immunoglobulin IgG levels of recovery period were significantly higher than that in acute stage and the control group, IgA levels of acute phase and recovery phase were significantly lower than the control group, IgM and complement C3 levels in acute stage were significantly higher than the control group, during the recovery period tended to be normal, complement C4 in acute stage levels were significantly higher than those in recovery period and both higher than the control group. The CD3+, CD4+ and CD4/CD8 ratio of MPP in acute stage and recovery phase were significantly lower than the control group, and these numerical indexes of the recovery period were significantly higher than the acute stage, CD8+ levels in acute stage were significantly higher than that in recovery period and both higher than control group. Compared with the control group ,The levels of inflammatory cytokines IL-2 in the acute phase and recovery phase were significantly decreased, and the recovery period was significantly higher than that in acute stage, the test results that the levels of IL-6, TNF-α, IL-8, IL-10 and IL-13 in acute phase and recovery phase were significantly higher than those in control group and the recovery period was significantly lower than that in the acute stage.Conclusion:The body humoral immune function and cellular immune function damage caused by MP infection in infants and young children could lead to the disorder of immune system and the abnormal expression of inflammatory cytokines. Therefore, Therefore, the real-time monitoring the dynamic level of the indicators can define the infants and young children's condition, improve the recovery rate, and have a certain guiding significance of the clinical diagnosis of infants and young children .
文摘目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片口服治疗。研究组在对照组治疗的基础上给予小青龙汤加减治疗。观察两组患者临床疗效、肺功能[用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)以及第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)]、气道高反应性、复发情况,并检测血清白细胞介素(interleukin,IL)-4、IL-5与外周血嗜酸性粒细胞(eosinophil,EOS)水平。结果:研究组有效率91.30%,对照组有效率为76.09%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后FVC、PEF、FEV1水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后最小诱发累积量、促使气道阻力增加至基础值的135%所需要的组胺累积剂量高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-4、IL-5与外周血EOS低于对照组,差异有统计学意义(P<0.05)。研究组复发率为19.05%(8/42),对照组复发率为42.86%(15/35),研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤加减治疗治疗小儿支原体肺炎,能改善患者肺功能,减轻患儿气道高反应性,调节血清IL-4、IL-5水平以及外周血EOS水平,降低复发率。
文摘目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。所有患儿均接受布地奈德雾化吸入疗法,普通组患儿采用普通俯卧位机械通气,配合组患儿采用俯卧位机械通气,对比两组患儿的肺功能[用力肺活量(forced vital capacity,FVC)、呼气峰值体积流量(peak expiratory flow,PEF)、第1秒钟用力呼气容积(forced expiratory vol⁃ume in the first second,FEV_(1))]、免疫功能和不良反应发生情况。结果治疗前,两组患儿的肺功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的FVC、PEF、FEV_(1)均高于普通组,差异有统计学意义(P均<0.05)。治疗前,两组患儿的免疫功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的成熟T淋巴细胞(cluster of differentiation 3^(+),CD3^(+))、辅助性T淋巴细胞(cluster of differentiation 4^(+),CD4^(+))、CD4^(+)/CD8^(+)均高于普通组患儿,差异有统计学意义(P均<0.05)。配合组患儿不良反应发生率为3.39%(4/118),低于普通组患儿的5.93%(7/118),差异无统计学意义(χ^(2)=0.858,P>0.05)。结论针对重症肺炎患儿,应用俯卧位机械通气配合布地奈德雾化吸入疗法能实现较为理想的临床效果,患儿肺功能与免疫功能得到了有效改善,且安全性较高。
